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Prof. Alexander D. Bershadsky
Integrin-mediated cell-matrix adhesions as mechanosensors: molecular requirements for the force-induced focal adhesion growth.Cell-cell contact-dependent regulation of the actin cytoskeleton and microtubule system: Role of p120 catenin and other components of cadherin adhesion complex.Role of myosin-driven contractility in the retrograde surface flow and cell motility.Cooperation between neuregulin, ErbB-family receptors, and cell surface heparan sulfate proteoglycans in the regulation of cell motility and morphogenesis.
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Prof. Michal Schwartz
The cross-talk between the immune and nervous systems autoimmunity as a mechanism of tissue repair: Molecular, cellular, physiological and behavioral aspects.Immunological aspects of neuronal loss in neurodegenerative and mental disorders (Alzheimers, ALS, Huntingdon, Glaucoma).Spinal cord injury and repairDevelopment of vaccination for neurodegenerative disorders.Neurogenesis (stem cells) and inflammation in the CNS.
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Prof. Zippora Shakked
Crystal structure and solution studies of DNA oligomers.Collaboration with: Donald Crothers (Yale University)DNA regulatory elementsDNA bending by adenine-thymine tractsStructural and biochemical studies of proteins involved in transcriptional regulation.The tumor-suppressor protein p53 and its interaction with DNA and the basal transcription machineryThe leukemia-related RUNX1(AML1) transcription regulator
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Prof. Irun R. Cohen
Autoimmune T cells and tissue maintenance in the nervous systemCollaboration with: M. SchwartzAutoimmunity to hsp60 and the development of subunit vaccines against infectious diseases.Regulation of immune inflammation by small carbohydrate moleculesCollaboration with: O. LiderAutoimmunity to p53 and the development of systemic lupus erythematosusCollaboration with: V. RotterAutoimmune diabetes: Pathogenesis and immune therapy.
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Prof. Michel Revel
Applications of IL-6 Chimera and Interferon-beta in neurology, hematopoiesis, and oncology.Collaboration with: J. ChebathInterleukin-6 Chimera, a superactivator of the gp130 receptor system: role in nerve myelination, neuroprotection and in the development of neuro-glial cells from embryonic tissues and stem cells.Collaboration with: J. ChebathTransdifferentiation of neural crest cell derived melanoma into myelinating Schwann cell. Genes controlling cell growth, differentiation, melanogenesis and synthesis of myelin proteins.Collaboration with: J. Chebath
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Prof. Abraham Arcavi
Research on cognitive characteristics of non academically oriented math students.Collaboration with: Dr. Ronnie KarsentyDesign of curriculum materials as a research based activityCollaboration with: Dr. Sue MagidsonLong-term design of a new curriculum for grades 10, 11 and 12 for non-academically oriented students.Collaboration with: Dr. Nurit Hadas
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Prof. Varda Rotter
Molecular mechanisms controlling the expression of p53 in normal cells and its deregulation in cancer cellsInvolvement of p53 in cell differentiation and apoptosis: <I>in vivo</I> and in vitro models.Cellular proteins that specifically complex with the p53 protein.Cellular proteins that are induced upstream or downstream to the p53 protein following genotoxic stress.
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