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Prof. David Milstein
Organometallic chemistry and catalysisBond activation by electron-rich transition metal complexes.Rational design of homogeneous catalysis and synthetic methodology based on transition metal complexes.Impact of molecular order on catalysis and reactivity.Generation and stabilization of elusive (potentially biologically active) molecules
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Prof. Matityahu Fridkin
Chemical-Biological and Clinical studies on novel drugs, primarily of peptidic nature,related to therapy of infectious ,inflamatory and neoplastic diseases.Collaboration with: Y. Koch I. Gozes (TAU ) I. Offek (TAU ) R. Catane (TEL-HASHOMER )Anticancer, Antibacterial AntiinflammatoryNovel synthetic and analytical methdologies are being developed.Solid-phase synthesisClassical solution chemistryCombinatorial technologiesStudies include: drug design, pro-drugs, long-acting drugs and drug delivery.Collaboration with: Y. ShechterNovel iron chelatores as potential drugs for neurodegenarative diseasesCollaboration with: M. Youdim ( Technio9n )small-moleculesamino acids and peptides
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Prof. Eytan Domany
Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glassesCollaboration with: A. P. Young (UCSC)Development of tools and algorithms for large scale data analysis. Bioinformatics.Analysis of high-throughput biological data (in particular, gene expression data)Collaboration with: Several research groups at Weizmann, in the USA and in Europe; see below.Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))Development of antigen chips, applications for autoimmune diseases (with I. Cohen)Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));Glioblastoma; (with M. Hegi, R. Stupp (CHUV))Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))
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Prof. Yoseph Imry
Mesoscopic physics: persistent currents, classical and quantum fluctuations, quantum interference effects on transport, decoheherce.Collaboration with: see below.Effects of interaction on localization and on single-electron resonances. Many-electron effects and phase-shifts. Dephasing of Quantum interference in mesoscopics. Quantum noise and its detection. Effects of quantum fluctuations on nanosuperconductors.Collaboration with: Y. Levinson, A. Aharony and E. Entin-Wohlman (TAU and BGU), Y. Ovadyahu and A. schiller (HU), P. Silvestrov (Leiden), M. Schechter and P, Stamp (UBC).
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Prof. Amiram Grinvald
The Interactions between evoked and on-going activity and their potential functional role in cortical processing.Collaboration with: D. Omer, M. TsodyksThe space-time dynamics of cortical activity as revealed by population activity (EEG, LFP and real-time optical imaging) coupled with single-unit and intracellular recordings.Collaboration with: D. Omer, L. Rom M. TsodyksCortical correlates of attention in behaving monkeys.Collaboration with: D. Omer, L. RomThe functional architecture underlying visual perception.Collaboration with: D. Omer, L. Rom,The dynamics of cortical representations in the visual cortex.Collaboration with: S. Naaman
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Prof. Ilan Lampl
Synaptic plasticity inducted by sensory stimulation in the cortexConstruction of receptive field properties in the somatosensory cortexstudying functional connectivity in the barrel cortexMechanisms of adaptation in the cortexNoise and synchrony in the mammalian cortexDynamic properties and mechanisms of ongoing activity in the cortexPatterns in neuronal activity in the cortex
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Prof. Yigal Burstein
Thermophilic enzymesIsolation, characterization and cloning of enzymes from extremophilic microorganisms.Structure, function and thermal stability relationship studies of extremophilic enzymes.Crystalization and determination of the three-dimensional structures of extremophilic enzymes.
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Prof. Lia Addadi
Antibodies that recognize crystal surfaces and 2-dimensional organized patterns.antibody recognition of chiral crystal surfacesstructure of cholesterol/ceramide monolayer mixtures. Molecular organization of lipid raftsPathological crystallizations. Goutantibody recognition of amiloid structuresMechanisms of crystal nucleation and modulation of crystal growth and properties in biomineralization (bone, mollusk shells, echinoderms).Collaboration with: S. WeinerMechanism of cell adhesion using crystal substrates.Collaboration with: B. Geiger
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