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Prof. Eytan Domany
Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glassesCollaboration with: A. P. Young (UCSC)Development of tools and algorithms for large scale data analysis. Bioinformatics.Analysis of high-throughput biological data (in particular, gene expression data)Collaboration with: Several research groups at Weizmann, in the USA and in Europe; see below.Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))Development of antigen chips, applications for autoimmune diseases (with I. Cohen)Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));Glioblastoma; (with M. Hegi, R. Stupp (CHUV))Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))
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Prof. Rivka Dikstein
Transcriptional control of coding and non-coding genesMechanism of rapid transcriptional induction of NF-kappaB target genesThe mammalian core promoter diversityLinks between mammalian transcription and translation through common regulatory elementsTranscriptional control of microRNA genesThe role of TFIID subunits in embryonic stem cell pluripotency and self renewalTranslation initiationUnique translation initiation of mRNAs containing TISU elementBiological significance of TISU-mediated translation initiationLinks between mammalian transcription and translation through TISU
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Prof. Nava Dekel
Molecular characterization of the ovulatory cascadeMechanisms involved in successful implantation.Regulation of the meiotic cell cycle: use of rodent oocytes as a model system.Cell-to-cell communication: regulation of expression, posttranslational modification, degradation and function of the gap junction proteins, Cx43 and Cx37.
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Prof. Hadassa Degani
Perfusion and angiogensis in lung cancer: The role of the bronchial and pulmonary vascular network using Fluorescence and magnetic resonance imaging methodsMolecular magnetic resonance imaging of the estrogen receptorCollaboration with: Professors David Milstein and Joel Sussman, Weizmann InstituteSynthesis of new, high affinity ligands of the estrogen receptor as probes for molecular imagingStructuaral studies (x-ray crystalography and NMR) of the estrogen receptor - targeted ligands complexFunctional activities and molecular imaging of the new targeted ligands in estrogen receptor positive huaman breast cancer cellsMechanisms of lymphatic metastasis in breast cancer; In vivo fluorescence and magnetic resonanc imagingAdvanced non invasive MRI methods for breast cancer detection and diagnosis ; clinical investigationsCollaboration with: Dr. Myra Shapiro, Meir medical Center3D Tracking of the mammary tree using diffusion tensor magnetic resonance imagingAdvanced methods for analysis of dynamic contrast enhanced MRI based on a combined model free and model based method.Hyperpolarized magnetic resonance spectroscopy and imaging of cancer metabolism; searching for novel metabolic markers of cancerCollaboration with: Professor Lucio Frydman, Weizmann InstituteRenal function through sodium grandients; Non-invasive, high resolution sodium MRI.Collaboration with: Dr. Edna Haran, Weizmann InstituteEstrogen regulation of angiogenesis and perfusion of breast cancer; from molecular mechanisms to functional MRI of the microvascular physiology
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