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Prof. Avri Ben-Ze'ev
Epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and Wnt target genes in colon cancer metastasisThe interplay between the role of beta-catenin in cell adhesion and signaling during colon cancer development.The molecular basis and signaling roles of nerve cell adhesion receptors in colon cancer metastasisThe role of novel beta-catenin target genes in tumor development and metastasis
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Prof. Avi Ben-Nun
Neuroimmunology, pathogenic autoimmunity, myelin/neuronal repair, and treatment of autoimmune diseases in central nervous system (CNS):T-cell pathogenesis and regulation in autoimmune diseases of the CNS.Effects of functional epistasis between HLA class-II alleles on genetic predisposition to multiple sclerosis (MS) in humanized HLA-Tg mice and MS patients.Defining major pathogenic MS-related myelin/neuronal epitopes in HLA-transgenic (Tg) mice.Antigen-based immune-specific approaches to therapy (and mechanisms) of MS and other T-cell mediated autoimmune diseases.Myelin/neuronal repair by adult neural stem cells in mice with chronic MS-like disease.
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Dr. Haim Beidenkopf
Topological phases of matter:Collaboration with: Claudia Felser, Max Planck Institute, Dresden, Germany Joseph Checkelsky, MIT, USATopological insulatorsWeak topological insulatorsTopological superconductorsCrystalline topological InsulatorsHelical nanowiresScanning tunneling microscopySemiconducting nanowiresCollaboration with: Hadas Shtrikman, WIStopological superconductivityMajorana modeslow-dimensional systemstopological nanowiresNanowires grown of topological materialsmolecular beam epitaxy (MBE)
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Prof. Ed Bayer
Structural and functional aspects of the multi-enzyme cellulosome complex from cellulose-degrading bacteria.The cohesin-dockerin couple - Protein-protein interactions that mediate recognition and specificity in cellulosome assembly.Cellulose-binding domains as models for protein-sugar interactions.Bioinformatics of cellulases and cellulosome componentsComparative genomics of cellulosome components.Structure determination of cellulosome components.Enzymology of cellulosomes for conversion of biomass to biofuelsDesigner cellulosomes - Selective engineering of chimaeric cellulosome constructs for nanotechnology.Avidin-biotin system - Mutated avidins and streptavidins
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Dr. Avraham Roi
The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?
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Dr. Ori Avinoam
The mechanisms of protein mediated membrane sculpting in health and diseaseSpatial and temporal organization of the molecular machines driving vesicle formation.Endocytosis and membrane trafficking in eukaryotes.Caveolae in muscle biogenesis, homeostasis and atrophy.Cell-to-cell fusionImaging Across ScalesCorrelative light and 3D electron microscopy at room temperature and in cryo.Advanced light microscopy techniques.
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