August 01, 2015
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Date:02SundayAugust 2015Cultural Events
Alilot Yichie beTailand
More information Time 21:00 - 22:30Location Michael and Anna Wix AuditoriumHomepage Contact -
Date:03MondayAugust 2015Lecture
Co-translational assembly constrains the structure and folding of homomeric proteins
More information Time 09:30 - 10:30Location Gerhard M.J. Schmidt Lecture Hall
Lecture HallLecturer Dr. Eviatar Natan
MRC Cambridge University UKOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Homomers are pervasive protein complexes in most proteomes t...» Homomers are pervasive protein complexes in most proteomes that involved in all major cellular functions. The three steps in homomer formation are: translation by the ribosome, folding, and assembly into a protein complex. We hypothesize that the relative rates of these three steps are crucial to avoid misassembly in the context of the high nascent chain concentration of the polysome, i.e., the super-complex of multiple translating ribosomes from same mRNA molecule. To examine this, we tested a library of constructs that differ, among other properties, in the N- versus C-terminal position of the assembly (oligomerization) domain. By analyzing the misassembly rates of these constructs in vivo, in vitro and in silico, and by computationally analyzing thousands of native homomers, we show a set of spatiotemporal constraints that act to preserve the integrity of homomers. In conclusion, our results suggest that there has been significant selection in evolution to maintain a balance between translation and assembly. -
Date:04TuesdayAugust 2015Lecture
Solution-Based Electronic Materials: from Flexible Electronics to Cellular Interfaces
More information Time 11:00 - 12:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Prof. Myung-Han YoonOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:05WednesdayAugust 2015Lecture
G-INCPM Seminar - Dr. Eran Elinav, Dept. of Immunology, Weizmann Institute - "Host Microbiome Interactions in Health and Disease"
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized Medicine
AuditoriumLecturer Dr. Eran Elinav
The Department of Immunology, Weizmann InstituteOrganizer Department of Biomolecular Sciences
System BiologyContact Abstract Show full text abstract about The mammalian intestine contains trillions of microbes, a co...» The mammalian intestine contains trillions of microbes, a community that is dominated by members of the domain Bacteria but also includes members of Archaea, Eukarya, and viruses. The vast repertoire of this microbiome functions in ways that benefit the host. The mucosal immune system co-evolves with the microbiota beginning at birth, acquiring the capacity to tolerate components of the community while maintaining the capacity to respond to invading pathogens. The gut microbiota is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche and multiple environmental factors including our nutritional repertoire and bio-geographical location. Moreover, it has been recently highlighted that dysregulation of these genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing to pathologies ranging from chronic inflammation, obesity, the metabolic syndrome and even cancer. We have identified various possible mechanisms participating in the reciprocal regulation between the host and the intestinal microbial ecosystem, and demonstrate that disruption of these factors, in mice and humans, lead to dysbiosis and susceptibility to common multi-factorial disease. Understanding the molecular basis of host-microbiome interactions may lead to development of new microbiome-targeting treatments. -
Date:09SundayAugust 2015Lecture
No nonsense: functional translational readthrough (in humans)
More information Time 11:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Sven Thoms
Department of Pediatrics and Adolescent Medicine, University Medical Center, Georg-August-University Göttingen, Germany.Organizer Department of Molecular GeneticsContact -
Date:09SundayAugust 2015Lecture
Munc13s - Presynaptic Regulators of Short-Term Synaptic Plasticity in Physiology and Pathology
More information Time 13:00Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Dr. Noa Lipstein
Dept of Molecular Neurobiology Max-Planck Institute of Experimental MedicineOrganizer Department of Brain SciencesContact Details Show full text description of Room 113...» Room 113Abstract Show full text abstract about Munc13 proteins are key determinants of synaptic vesicle pri...» Munc13 proteins are key determinants of synaptic vesicle priming and absolutely essential for the completion of the synaptic vesicle cycle at presynaptic active zones. Munc13 function is regulated by three different Ca2+-dependent pathways, and elevations of the presynaptic Ca2+ concentration during neuronal activity leads to a Munc13-dependent increase in the synaptic vesicle priming rate, and consequently to dynamic changes in the efficacy of neurotransmission. I will describe how the Ca2+-dependent regulation of Munc13s affects synaptic signaling in intact circuits, and present the first known synaptopathy caused by a mutation in Munc13-1, which affects a recently discovered interplay between Munc13s, voltage-gated Ca2+ channels, and synaptic vesicle fusogenicity. -
Date:12WednesdayAugust 2015Cultural Events
"Alilot Yichie beTailand"
More information Time 20:30 - 22:00Location Michael and Anna Wix AuditoriumContact -
Date:13ThursdayAugust 2015Lecture
Plant hormone metabolism during plant -
More information Time 11:15Title microbe interactionLocation Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Prof. Dr. Jutta Ludwig-Mueller
Technische Universitaet Dresden Institute of Botany, GermanyOrganizer Department of Plant and Environmental SciencesContact -
Date:17MondayAugust 2015Lecture
Functional analyses of non-biotrophic fungi -
More information Time 11:15Title wheat interactionsLocation Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Dr. Kostya (Konstantin) Kanyuka
Plant Biology & Crop Science Rothamsted Research, West Common Harpenden, Hertfordshire, UKOrganizer Department of Plant and Environmental SciencesContact -
Date:18TuesdayAugust 2015Cultural Events
Shuliat hakosem - children's theater
More information Time 17:30 - 19:00Location Michael and Anna Wix AuditoriumHomepage Contact Details Show full text description of Musical for the whole family. ...» Musical for the whole family. -
Date:23SundayAugust 2015Lecture
SPECIAL GUEST SEMINAR - Dr. Efrat Shema-Yacoby
More information Time 10:30 - 12:30Location Wolfson Building for Biological Research
AuditoriumLecturer Single-Molecule Epigenomics: Towards Revealing the Histone CodeOrganizer Department of Molecular Cell BiologyContact -
Date:24MondayAugust 2015Lecture
Revisiting the functional architecture of the human brain with intracranial EEG and direct electrical stimulation of the cerebral cortex
More information Time 14:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Josef Parvizi
Neurology and Neurological Sciences, Stanford UniversityOrganizer Department of Brain SciencesContact -
Date:25TuesdayAugust 2015Lecture
PIN-ning down the role of D6PK protein kinase
More information Time 11:15Title and phosphorylation in auxin transportLocation Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Prof. Dr. Claus Schwechheimer
Plant Systems Biology, Center of Life and Food Sciences Weihenstephan, Technische University Muenchen, GermanyOrganizer Department of Plant and Environmental SciencesContact -
Date:25TuesdayAugust 2015Lecture
Some Aspects of External Electric Field-Effects on Small Molecules and their Reactivity
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Prof. Cherif Matta
Dept. of Chemistry & Physics Mount Saint Vincent UniversityOrganizer Department of Chemical and Structural BiologyContact -
Date:27ThursdayAugust 2015Cultural Events
Reshef Levi
More information Time 21:30 - 22:45Title Stand upLocation Michael and Anna Wix AuditoriumHomepage Contact -
Date:31MondayAugust 2015Lecture
A Trajectory's Tale: Kinetic Trap Analysis Identifies Coexisting Origins of Anomalous Dynamics in Proteins
More information Time 11:00Location Edna and K.B. Weissman Building of Physical Sciences
Room ALecturer Yasmine Meroz
Harvard UniversityOrganizer Faculty of Physics
Special SeminarContact Abstract Show full text abstract about Subdiffusion is a hallmark of protein dynamics. Several mode...» Subdiffusion is a hallmark of protein dynamics. Several models predict subdiffusive dynamics, generally either due to some fractional noise or due to trapping dynamics in the underlying energy landscape. However the connection remains unclear, particularly to the underlying energy landscape. We reassess the assumption of a constant single subdiffusive exponent, identifying plateaus in the mean-squared displacement of molecular dynamics trajectories. We associate these with kinetic traps on a minimal model we develop of a hierarchical multibarrier energy landscape, exhibiting a separation of scales in both energy and space. We employ the model to extract the characteristic free energy barriers and length scales associated with the kinetic traps which lead to arrested dynamics. Moreover we identify a second subdiffusive mechanism inherent to the underlying fluctuating process. Lastly we find a relationship between the characteristic energy barriers and the rate of their appea! rance, allowing to reconstruct the effective subdiffusive mean-squared displacement. -
Date:31MondayAugust 2015Lecture
Development of cardiac CEST MRI as a powerful in vivo tool for cell tracking, metabolic imaging, and clinical fibrosis imaging
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
Seminar RoomLecturer Moriel Vandsburger, PhD
Assistant Professor Departments of Physiology and Biomedical Engineering Saha Cardiovascular Research Center Center for Muscle Biology University of KentuckyOrganizer Life SciencesContact