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February 18, 2016
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Date:09SundayFebruary 2025Lecture
The Clore Center for Biological Physics
More information Time 12:45 - 14:15Title The role of promiscuous molecular recognition in the evolution of self-incompatibility in plantsLocation Nella and Leon Benoziyo Physics LibraryLecturer Dr. Tamar Friedlander
Lunch at 12:45Organizer Clore Center for Biological PhysicsContact Abstract Show full text abstract about How do biological networks evolve and expand? We study these...» How do biological networks evolve and expand? We study these questions in the context of the plant collaborative-non-self recognition self-incompatibility system. Self-incompatibility evolved to avoid self-fertilization among plants. It relies on specific molecular recognition between highly diverse proteins expressed in the female and male reproductive organs, such that the combination of proteins an individual possesses determines its mating partners, defining distinct ‘mating specificities’. Although a few dozen mating specificities are known from population surveys, previous models struggled to pinpoint the evolutionary trajectories by which new specificities evolved. We construct a novel theoretical framework, synthesizing evolutionary and biophysical models, that crucially affords interaction promiscuity and multiple distinct partners per protein, as is seen in empirical findings. We demonstrate spontaneous self-organization of the population into distinct 'classes' with full between-class compatibility and a dynamic long-term balance between class emergence and decay.Our work highlights the importance of molecular recognition promiscuity to network evolvability. Promiscuity was found in additional systems suggesting that our framework could be more broadly applicable. FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/ -
Date:09SundayFebruary 2025Lecture
PhD Thesis Defense - Noam Galili Darnell -Prof Itay Tirosh lab
More information Time 13:00 - 15:00Title Deciphering Glioma Organization and Chromosome Copy Number VariabilityLocation Zoom -
Date:11TuesdayFebruary 2025Cultural Events
Tu Bishvat event
More information Time 10:00 - 12:00Location Michael Sela Auditorium -
Date:11TuesdayFebruary 2025Lecture
Special Guest Seminar
More information Time 11:00 - 12:00Location Max and Lillian Candiotty Building
AuditoriumLecturer Dr. Omri Wurtzel Organizer Department of Immunology and Regenerative BiologyContact -
Date:11TuesdayFebruary 2025Academic Events
PhD Defense- Paula Carolina Kotli, Prof. Elisabetta Boaretto Lab
More information Time 11:00 - 12:00Location Nella and Leon Benoziyo Building for Plant and Environmental Sciences
591Lecturer Insights into the process of animal domestication in the Southern Levant using peptidomics analysis Contact -
Date:11TuesdayFebruary 2025Lecture
Information processing in the vomeronasal system
More information Time 12:30 - 14:00Location Schmidt Lecture HallLecturer Prof. Yoram Ben-Shaul
The vomeronasal system is essential for processing chemical signals from other organisms. While it shares many similarities with the main olfactory system, it features distinct properties that likely reflect its unique physiological functions. In my talk, I will provide an overview of past and current efforts to better understand the physiology of this still poorly understood chemosensory system.Organizer Department of Brain SciencesContact -
Date:11TuesdayFebruary 2025Lecture
"Lights, Camera, Action!" Towards Light and Time-Resolved Studies of the Bestrhodopsins.
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Gil Hecht Organizer Department of Chemical and Structural Biology -
Date:11TuesdayFebruary 2025Lecture
The cytokine TNF-α downregulates dopamine D1-like receptor-induced Arc and BDNF synaptic proteins.
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
AuditoriumLecturer Dr. Omar Benjamín Rivera Maya -
Date:16SundayFebruary 2025Lecture
Interactions between cyclones and mesoscale eddies in the Mediterranean Sea
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental Sciences
M. Magaritz seminar roomLecturer Ehud Strobach Organizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Mesoscale eddies dominate global ocean kinetic energy and ar...» Mesoscale eddies dominate global ocean kinetic energy and are responsible for efficiently transferring ocean properties. The influence of ocean eddies in the western boundary currents on storm tracks has been studied in recent years, and their importance in regulating mid-latitude precipitation is now recognized. Unlike western boundary currents, mesoscale eddies in the Mediterranean Sea (MS) are smaller and less intense. Yet, the MS is rich in mesoscale activity, and its proximity to densely populated regions suggests that even a small change may have a large impact, which remains underexplored. In this talk, I present several recent studies in which we investigated the interactions between mesoscale eddies and cyclones in the Mediterranean region. These studies focused on specific Mediterranean tropical-like cyclones (medicanes), analyzing their evolution under different sea conditions using observations and model simulations. We find that mesoscale eddies in the MS can change the intensity and track of cyclones and, consequently, affect their resulting rainfall distribution over land. In general, warm-core eddies tend to intensify cyclones and increase precipitation above them relative to cold-core eddies. Additionally, we observe a general increase in surface ocean biogeochemical properties, such as phytoplankton and chlorophyll, following cyclone passages. This increase is driven by upwelling and vertical mixing, though the relative importance of these processes differs between warm- and cold-core eddies. -
Date:16SundayFebruary 2025Lecture
The Clore Center for Biological Physics
More information Time 12:45 - 14:30Title Learning from learning systemsLocation physics Drory auditoriumLecturer Prof. Omri Barak
Lunch at 12:45Contact Abstract Show full text abstract about The word “learning” often conjures images of school or other...» The word “learning” often conjures images of school or other human endeavors. Neuroscientists have used the word for a wide range of phenomena in the animal kingdom. For those engulfed in python code, perhaps learning is also associated with gradient descent or other technical terms from computer science. What do we gain from using the same name for all these cases?In this talk, I will argue that systems that learn can be useful models of one another. This is because of general principles that seem to transcend specific instances, such as multiplicity of solutions, low-rank perturbations and more. I will demonstrate these properties using several examples. These include representational drift, the connection (or lack thereof) between neural activity and behavior, and more.Throughout the talk I will try to highlight the benefits, dangers and challenges of this approach. -
Date:16SundayFebruary 2025Academic Events
PhD Thesis Defense - Sapir Cohen Shvefel - Samuel lab
More information Time 14:00 - 16:30Location Ullman Building
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Date:17MondayFebruary 2025Lecture
Foundations of Computer Science Seminar
More information Time 11:15 - 12:15Title Abundant resources can trigger reduced consumption: Unveiling the paradox of excessive scroungingLocation Jacob Ziskind Building
Room 1 - 1 חדרLecturer Amos Korman
Haifa UniversityOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about In the 2004 Olympics, the US national basketball team failed...» In the 2004 Olympics, the US national basketball team failed to win the gold medal despite featuring superstars such as LeBron James. This event raises a fundamental question: Why do teams with highly skilled players sometimes underperform compared to teams with less skilled players? In this talk, I will explore situations where such an outcome can be attributed to a surge in free-riding behavior resulting from rational choices by self-interested players. Specifically, I will demonstrate how, under certain incentivizing schemes, improving individual efficiency can inadvertently promote excessive free-riding behavior, ultimately leading to reduced outcomes at both group and individual levels. I will illustrate this phenomenon through two simple games: one on group foraging and the other on workplace cooperation. In the foraging game, an increase in available food can paradoxically lead to a decrease in food consumption, while in the workplace model, replacing workers with more skilled individuals can worsen both individual payoffs and group performance. Based on a joint work with Robin Vacus. -
Date:18TuesdayFebruary 2025Lecture
Cell type dependent computations and learning in primary motor cortex
More information Time 12:30 - 14:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Jackie Schiller Organizer Department of Brain SciencesContact Abstract Show full text abstract about Understanding the input-output function of principal cortica...» Understanding the input-output function of principal cortical neurons and their role in network dynamics is a key milestone in decoding how information is represented and processed in the cortex. Pyramidal neurons act as complex computational units, integrating the activity of thousands of synaptic inputs and transforming them into output patterns. These computations are primarily carried out within an elaborate dendritic tree, which receives extensive synaptic input and converts it into a neural code. However, the nature of dendritic computations in vivo during behaviorally relevant tasks remains unclear.In this talk, I will present our recent findings on the dendritic mechanisms used by layer 5 pyramidal tract (PT) neurons to encode motor information in vivo during various motor tasks. Using two-photon calcium imaging in head-fixed mice, along with a custom experimental and analytical pipeline, we achieved unprecedented resolution in correlating dendritic structure with function. I will discuss how different types of PT neurons process and represent motor information, how these properties are shaped during learning, and the role of thalamocortical inputs in modulating both learning and representation. -
Date:19WednesdayFebruary 2025Lecture
Cell adhesion molecules control distinct spatiotemporal aspects of neuronal remodeling
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Prof. Oren Schuldiner Contact -
Date:19WednesdayFebruary 2025Lecture
How we make superconducting qubits live longer
More information Time 12:30 - 14:00Title Spotlight on Science lecture sponsored by the Staff Scientists CouncilLocation Gerhard M.J. Schmidt Lecture HallLecturer Dr. Fabien Lafont
Spotlight on Science lecture sponsored by the Staff Scientists CouncilContact Abstract Show full text abstract about Classical computers use stable and long-lived units of infor...» Classical computers use stable and long-lived units of information, called bits, to perform computations. In contrast, quantum computers rely on qubits. The downside is that qubits are intrinsically much more prone to error. Two of the biggest challenges in building a practical quantum computer are extending the lifetime of qubits and better detection of errors. In this seminar, I will present our recent work on improving by an order of magnitude the coherence time of a superconducting qubit. A key aspect of this breakthrough was the creation of a large Schrödinger cat state with more than 1,000 photons, which can be used for error correction in quantum systems. In the second part of the talk, I will introduce a novel method for real-time error detection, where we continuously monitor the state of a superconducting element to detect and correct qubit dephasing as it occurs. These developments are important steps towards improving the reliability and performance of quantum systems. -
Date:19WednesdayFebruary 2025Lecture
PhD Thesis Defense - Elinor Gigi - Straussman lab
More information Time 14:30 - 16:00Title The glioblastoma and brain metastases microbiomeLocation Ullmann Building of Life Sciences
201 -
Date:20ThursdayFebruary 2025Lecture
The expanding world of PD-L1 activities and regulation in breast cancer – N-linked glycosylation and beyond
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
AuditoriumLecturer Prof. Adit Ben-Baruch Organizer Dwek Institute for Cancer Therapy Research -
Date:23SundayFebruary 2025Lecture
Submesoscale ocean circulation: plenty of room at the bottom
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental Sciences
M. Magaritz seminar roomLecturer Aviv Solodoch Organizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Sub-mesoscale (SMS, <10 km scale) ocean circulation i...» Sub-mesoscale (SMS, <10 km scale) ocean circulation is characterized by high vorticity and deviation from geostrophic balance. It can result in large effects on biology and chemistry due to the large vertical velocities (x10-100 than mesoscale) and resulting down/up welling circulations, as well as significant effects on material retaining and dispersion. Modelling and observing the Submesoscale is challenging due to stringent demands on spatio-termpoal resolution, and due to its strong interactions with both larger (mesoscale) and smaller (turbulence and waves) circulations. I will report on the first Sub-mesoscale-resolving numerical modelling study in the East Mediterranean Sea, and (likely universal) findings on the patterns of cross-scale energy exchange between the Sub-Mesoscale and mesoscale circulation, which controls the seasonal evolution of both circulations. Secondly I will show in the model boundary current variability can spawn Sub-Mesoscales year-round (while open ocean formation is largely limited to winter). This will be backed by our (and the first) systematic observations of a Sub-mesoscale vortex formed in summertime via boundary current meandering. -
Date:23SundayFebruary 2025Lecture
The Clore Center for Biological Physics
More information Time 13:15 - 14:30Title What can microbes tell us about their environmentLocation Nella and Leon Benoziyo Physics LibraryLecturer Dr. David Zeevi
Lunch at 12:45Contact Abstract Show full text abstract about Microbial communities act as living sensors of their environ...» Microbial communities act as living sensors of their environment, continuously adapting to and recording changes in their surroundings across temporal and spatial scales. This capacity, combined with their central role in global biogeochemical cycles, makes microbes ideal indicators of ecosystem health. However, our understanding of how these communities respond to anthropogenic perturbations remains limited. In this talk, I will present two complementary approaches to decode environmental information from microbial communities. First, I will show that environmental temperature can be accurately predicted from microbial DNA composition alone, revealing fundamental principles of genome-wide thermal adaptation that transcend ecosystem boundaries. This work uncovers how evolutionary pressures shape microbial genomes across diverse habitats and provides insights into long-term community responses to climate change. Second, I will introduce a novel approach for measuring real-time bacterial growth rates in natural environments from a single sample, without prior knowledge on community composition. This method could enable us to track immediate ecological responses to environmental perturbations. By combining these evolutionary and ecological perspectives, we can begin to establish universal principles governing microbial responses to environmental change across different timescales. This multi-scale understanding is crucial for predicting and potentially mitigating the impacts of human activities on microbial ecosystems, from soil degradation to climate change.FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/ -
Date:24MondayFebruary 2025Lecture
Special Guest Seminar
More information Time 10:00 - 11:00Title Extracting the invisible - visual interpretability of deep learning models in cell imagingLocation Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Assaf Zaritsky Abstract Show full text abstract about Deep learning (aka “AI”) has emerged as a powerful technique...» Deep learning (aka “AI”) has emerged as a powerful technique to identify hidden patterns that exceed human intuition in biomedical imaging data. However, this success comes at the cost of interpretability making deep learning a “black box” lacking human meaningful explanations for the models’ decision. Interpretability is especially critical in biomedical domains, because understanding the “cause” for a machine’s prediction is key for the generation of new biological insight and testable hypotheses. In this seminar I will present computational methods that we developed to "reverse-engineer" the model’s decision in an intuitive biologically-meaningful manner and their applications to multiple bioimaging domains. The seminar will be designed for life scientists assuming no prior computational background.
