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March 17, 2016
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Date:06TuesdayDecember 2016Lecture
Subcellular Roles of mTOR in Sciatic Nerve Injury
More information Time 10:30 - 11:00Location Wolfson Building for Biological ResearchLecturer Dr. Maraco Terenzio
Members - Dept. of Biomolecular SciencesOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about mTOR is an atypical Ser/Thr kinase that belongs to the PI3K ...» mTOR is an atypical Ser/Thr kinase that belongs to the PI3K family and a key sensor of cellular nutritional state, which regulates a vast array of biological processes. Several lines of evidence have highlighted the importance of mTOR signalling in the regeneration of both the central nervous system (CNS) and the peripheral nervous system (PNS). Though localized changes in mTORC1 activity have been documented in axons and linked to synaptic plasticity, it is still unclear whether mTOR peripheral localization and local activation in the sciatic nerve (SN) plays an important role in retrograde survival signalling after injury. Here we show that mTOR mRNA is present in the sciatic nerve and that its protein levels increase after sciatic nerve crush (SNC) at the site of lesion within 3 hr after injury. Mass-spectrometry analyses of SN axoplasm showed that the axonal pool of mTOR is active and responsible for the local activation of two of its downstream kinases, p70S6K and S6, directly at the site of the lesion. Direct monitoring of protein translation revealed that mTOR activation is responsible for most of the early local translational response in the sciatic nerve after injury. Furthermore, local pharmacological inhibition of mTOR at the SNC site by Torin1 impaired the subsequent conditioning lesion response of dorsal root ganglia (DRG) sensory neurons, and caused a reduction of the survival of large proprioceptor DRG neurons after the injury.
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Date:06TuesdayDecember 2016Lecture
Spectral sum rules for conformal field theories in arbitrary dimensions
More information Time 10:30 - 10:30Location Newe ShalomLecturer Justin David
BANGLOREOrganizer Department of Particle Physics and AstrophysicsHomepage Contact Abstract Show full text abstract about We derive a spectral sum rule in the shear channel for confo...» We derive a spectral sum rule in the shear channel for conformal field theories in general d> 2 dimensions held at finite temperature. The sum rule result from the OPE of the stress tensor at high frequency as well as the hydrodynamic behaviour of the theory at low frequencies. The sum rule states that a weighted integral of the spectral density over frequencies is proportional to the energy density of the theory. We show that the proportionality constant can be written in terms the Maldacena-Hofman variables t_2, t_4 which rely on data which determines the three point function of the stress tensor of the CFT. For theories which admit a two derivative gravity dual this proportionality constant is given by d/2(d+1) . We then use causality constraints and obtain bounds on the sum rule which are valid for any conformal field theory. We illustrate the sum rule by applying it to well studied conformal field theories in d=3, 4, 6. dimensions -
Date:06TuesdayDecember 2016Lecture
“Visualizing nanoscale assembly and fabrication in solution using in situ TEM”
More information Time 11:00 - 12:15Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Stephen Hashmi
Department of Biological Sciences & Physics National University of SingaporeOrganizer Department of Molecular Chemistry and Materials Science , Department of Molecular Chemistry and Materials ScienceContact -
Date:06TuesdayDecember 2016Lecture
The eco-hydrology of forest density reduction
More information Time 11:15 - 11:15Location Ullmann Building of Life SciencesLecturer Prof. Naomi (Christina) Tague
Bren School of Environmental Science and Management University of California, Santa Barbara, USAOrganizer Department of Plant and Environmental SciencesContact Abstract Show full text abstract about Ecosystem responses to climatic droughts range from increase...» Ecosystem responses to climatic droughts range from increased frequency of stomatal closure and declines in carbon assimilation to plant mortality and increased vulnerability to insects/pathogens and fire. Forest thinning is often posited as a management practice that can reduce mitigate these forest drought responses and may have implications for groundwater recharge and streamflow. There are still relatively few field-based studies of thinning impacts on forest water use. Most of these studies focus only on responses in the first 1-2 years following thinning and show substantial cross-site differences in responses. To extend and better understand field-based findings, we utilize a fully coupled model of ecosystem carbon cycling and hydrology to estimate forest water use, carbon sequestration, regrowth rates and indicators of water stress for different thinning densities. We compare results across climate, topography and soils. For the California Sierra, results emphasize the importance of plant accessible subsurface water storage capacity (PAWSC). We find that a first-order control on system response to thinning is the interactions between PAWSC and climate. We also show that a critical information gap is estimates of the degree to which neighboring trees share water. We conclude by suggesting model applications and new measurements that could be used to help guide decision-making with respect to thinning by accounting for how these multiple controls on thinning ecohydrology interact. -
Date:06TuesdayDecember 2016Lecture
5D N=1 GAUGE THEORIES VIA 5-BRANE WEB
More information Time 12:00 - 12:00Location Newe ShalomLecturer Futoshi Yagi
TechnionOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Due to the recent development of type IIB 5-brane web techni...» Due to the recent development of type IIB 5-brane web technique, we are able to study wider class of 5d N=1 gauge theories from the brane constructions. After reviewing this recent development, we focus on a new 5-brane web configuration for 5d N=1 gauge theories with 6d UV fixed points. We observe from brane web that Kaluza-Klein mode of the 6d N=(1,0) SCFT compactified on S^1 is realized as an instanton particle in the corresponding 5d N=1 gauge theory. We also observe that various 5d N=1 gauge theories have identical 6d UV fixed point. We check these observations by computing BPS partition functions for some examples. -
Date:06TuesdayDecember 2016Lecture
MCB - Students seminar
More information Time 12:15 - 12:15Title TBALocation Wolfson Building for Biological ResearchOrganizer Department of Molecular Cell BiologyContact -
Date:06TuesdayDecember 2016Lecture
Trans-generational epigenetic memory of environmental change in C. elegans
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Ben Lehner
EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, Barcelona, SpainContact -
Date:06TuesdayDecember 2016Lecture
AMOS journal club
More information Time 13:15 - 14:30Location Edna and K.B. Weissman Building of Physical SciencesOrganizer Department of Physics of Complex SystemsContact -
Date:06TuesdayDecember 2016Cultural Events
Sublimation of Love - Russian theater
More information Time 20:00 - 20:00Location Michael Sela AuditoriumContact -
Date:07WednesdayDecember 2016Lecture
Trust none of what you hear and less of what you see: Living with caspases and dying without them
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Eli Arama
Dept. of Molecular Genetics, WISContact -
Date:07WednesdayDecember 2016Lecture
The airway transcriptome as a biomarker for lung cancer detection and prevention
More information Time 12:00 - 13:00Location Camelia Botnar BuildingLecturer Prof. Avrum Spira
Director of the Boston Medical Center Cancer Center at Boston University OnContact -
Date:08ThursdayDecember 2016Lecture
Magnetic Resonance Seminar
More information Time 09:30 - 09:30Title Functional Roles of Disordered Proteins:Revisiting the Structure:Function ParadigmLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Haribabu Arthanari
Dept. Biological Chemistry & Molecular Pharmacology (BCMP,Harvard UniversityOrganizer Department of Chemical and Biological PhysicsContact -
Date:08ThursdayDecember 2016Colloquia
Paul Dirac – the theorists’ theorist
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Graham Farmelo
NAOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Although Paul Dirac was one of the founders of quantum mecha...» Although Paul Dirac was one of the founders of quantum mechanics, his peers always perceived him as an outsider, with a unique approach to the subject that was often hard to understand. In this talk, I explain how he came to have such an unusual perspective and why it enabled him to be so productive. In particular, I want to describe the origins of his passion for the idea that mathematical beauty is crucially important to theoreticians who seek the fundamental laws of nature.
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Date:08ThursdayDecember 2016Lecture
Spinal cord injuries and brain reorganisation
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof Neeraj Jain
National Brain Research Centre, Manesar, Haryana, IndiaOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Adult mammalian brains show remarkable plasticity in respons...» Adult mammalian brains show remarkable plasticity in response to deafferentations due to injuries. Lesions of dorsal columns of the spinal cord at cervical levels deafferent sensory inputs from parts of the body below the level of the lesion. Chronic dorsal column injuries in monkeys result in expansion of intact chin inputs into the deafferented hand regions of the primary and secondary somatosensory cortex (area 3 and area S2), ventroposterior lateral nucleus of the thalamus and cuneate nucleus of the brain stem. Our recent evidence suggests that the key plastic change takes place in the brain stem nuclei, perhaps due to axonal growth from the trigeminal nucleus into the cuneate nucleus. This reorganization is then propagated upstream resulting a brain-wide reorganization.
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Date:08ThursdayDecember 2016Cultural Events
The Israel Camerata Jerusalem
More information Time 20:00 - 20:00Title Sing to the Lord a New SongLocation Michael Sela AuditoriumContact -
Date:10SaturdayDecember 2016Cultural Events
Meni Ozeri - Stand up
More information Time 21:00 - 21:00Location Michael Sela AuditoriumContact -
Date:11SundayDecember 2016Lecture
A Metabolic Gene Cluster Determines β-Diketone Biosynthesis in Wheat and Barley
More information Time 10:30 - 10:30Location Ullmann Building of Life SciencesLecturer Shelly Hen Avivi
Prof. Asaph Aharoni's lab., Dept. of Plant & Environmental SciencesOrganizer Department of Plant and Environmental SciencesContact -
Date:11SundayDecember 2016Lecture
Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Eden Yifrach
Maya Schuldiner's group, Dept. of Molecular Genetics,WISOrganizer Department of Molecular GeneticsContact -
Date:12MondayDecember 2016Colloquia
Life Science Colloquium
More information Time 11:00 - 12:00Title Regulatory T Cells and Control of InflammationLocation Dolfi and Lola Ebner AuditoriumLecturer Prof. Alexander Rudensky
Memorial Sloan Kettering CancerContact -
Date:12MondayDecember 2016Lecture
The Role of Philantropy in Science Education
More information Time 14:30 - 15:45Title Departmental Seminar- Science TeachingLocation Gerhard M.J. Schmidt Lecture HallLecturer Eli Hurvitz Organizer Department of Science TeachingContact
