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ספטמבר 12, 2011

  • Date:21שנימאי 2012

    Bioinformatics workshop: What can I learn from DNA binding regions (ChIP-Seq peaks) using web tools?

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    שעה
    09:30 - 12:00
    מיקום
    בניין ע"ש משפחת הרי לוין
    מרצהDr. Dena Leshkowitz
    Bioinformatics unit Weizmann Institute of Science
    צרו קשר
    תקצירShow full text abstract about In this workshop we will learn how extract biological knowle...»
    In this workshop we will learn how extract biological knowledge from a list of genomic regions which represent the DNA binding site of proteins.

    The regions are termed peaks and are usually a result of a ChIP-Seq experiment which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify binding sites of DNA-associated proteins.

    In the workshop we will learn how to search for relevant public peak data and how to analyze the data in order to associate it with genes, find biological enrichments and motif enrichments.
    The tools we will use are web based and include:
    GREAT (http://great.stanford.edu/public/html/splash.php) ,
    Cistrome (http://cistrome.org/), Genomatix (commercial - http://www.genomatix.de/applications/ChIP-Seq.html)
    and MEME-ChIP (http://meme.sdsc.edu/meme/doc/meme-chip.html)

    Registration is required.
    First you need to register to the BBCU activities here:
    http://bip.weizmann.ac.il/activbin/events (click on the LogIn button)
    and then you need to register to the workshop. (click on the Register button)
    הרצאה
  • Date:21שנימאי 2012

    "Contemporary neuroimmunology: The immunology of the brain and the mind"

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    שעה
    11:00 - 13:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהDr. Michal Schwartz
    WIS
    מארגן
    המחלקה לאימונולוגיה מערכתית
    צרו קשר
    הרצאה
  • Date:21שנימאי 2012

    Faculty of Chemistry Colloquium - Prof. Thomas Walz

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    שעה
    11:00 - 12:30
    כותרת
    USING TWO-DIMENSIONAL CRYSTALS OF AQUAPORIN-0 TO INVESTIGATE LIPID-PROTEIN INTEGRATIONS
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProfessor Thomas Walz
    Department of Cell Biology and Howard Hughes Medical Institute, Harvard Medical School, Boston, USA
    מארגן
    הפקולטה לכימיה
    צרו קשר
    תקצירShow full text abstract about Membrane proteins play crucial roles in many cellular proces...»
    Membrane proteins play crucial roles in many cellular processes such as signaling, nutrient uptake and cell adhesion. Although the lipid bilayer influences many aspects of membrane protein function, our understanding of lipid–protein interactions is limited. Aquaporin-0 (AQP0) is a water channel in the lens membrane, but it also assembles into orthogonal arrays that form membrane junctions between lens fiber cells. In vitro reconstitution of AQP0 with the lipid dimyristoyl phosphatidylcholine (DMPC) yielded large and well ordered double-layered two-dimensional (2D) crystals that allowed electron crystallographic structure determination of AQP0 and its surrounding DMPC bilayer at 1.9 Å resolution. Since AQP0 forms high-quality 2D crystals not only with DMPC but also with various other lipids, AQP0 2D crystals are an ideal model system to investigate lipid–protein interactions. By studying AQP0 2D crystals formed with different lipids, we can begin to address very basic questions in membrane biology, such as the driving forces that define lipid–protein interactions, the effects of hydrophobic mismatch, and the molecular basis of raft formation.
    סימפוזיונים
  • Date:21שנימאי 2012

    Hsp90 Inhibition in Cancer...Now the Fun Begins

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    שעה
    11:00 - 11:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהDr. Safi Bahcall
    President and CEO Synta Pharmaceuticals Corp., Lexington, Ma., USA
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    הרצאה
  • Date:21שנימאי 2012

    Equilibrium States and Time Evolution of Systems with Long-Range Interactions

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    שעה
    14:15 - 14:15
    מיקום
    מעבדה על-שם דני נ. היינמן
    מרצהJoel L. Lebowitz
    Rutgers University
    מארגן
    המחלקה לפיזיקה של מערכות מורכבות
    צרו קשר
    הרצאה
  • Date:21שנימאי 2012

    On ramified covers of algebraic surfaces, and combinatorics of some infinite discrete groups.

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    שעה
    15:00 - 15:00
    מיקום
    בניין יעקב זיסקינד
    מרצהMaxim Leyenson
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    צרו קשר
    הרצאה
  • Date:21שנימאי 2012

    מפגשים בחזית המדע

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    שעה
    19:15 - 21:00
    מיקום
    מכון דוידסון לחינוך מדעי
    מארגן
    יחידת שוהם במכון דוידסון
    דף בית
    צרו קשר
    הרצאה
  • Date:21שנימאי 2012

    גיל שוחט ומרינה מקסימליין בלומין

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    שעה
    20:30 - 20:30
    כותרת
    דולצ'ה ויואצ'ה
    מיקום
    אודיטוריום מיכאל סלע
    צרו קשר
    אירועי תרבות
  • Date:22שלישימאי 2012

    " A bacterial chemotaxis-like signal transduction system leading to biofilms".

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    שעה
    10:00 - 10:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהProf. Caroline Harwood
    Department of Microbiology University of Washington
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    Differential analysis of the polarity transform

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    שעה
    11:00 - 11:00
    מיקום
    בניין יעקב זיסקינד
    מרצהShiri Artstein
    Tel Aviv University
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    "Py-Im Polyamides – from DNA Recognition to In Vivo Experiments"

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    שעה
    11:00 - 11:00
    כותרת
    Organic Chemistry - Departmental Seminar
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהDr. Evgenij Raskatov
    California Institute of Technology
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about Abstract: Py-Im polyamides are modular DNA minor groove bin...»
    Abstract:
    Py-Im polyamides are modular DNA minor groove binding molecules with affinities and specificities comparable to those of DNA binding proteins.

    Molecules can be constructed to recognize the four letters of the genetic code.

    Recent efforts established that Py-Im polyamides can be employed in cell culture to affect NF-kB dependent gene expression. We further identified that molecules are potent in live animals. Depending on molecular architecture the compounds remain in the mouse circulatory system for up to multiple days, can access subcutaneous tumor xenografts and lead to gene expression changes in vivo.
    הרצאה
  • Date:22שלישימאי 2012

    TBA

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    שעה
    11:15 - 11:15
    מיקום
    בניין אולמן למדעי החיים
    מרצהProf. Ronald Herring
    Professor of Government, White Hall, Cornell University, Ithaca, NY, USA
    מארגן
    המחלקה למדעי הצמח והסביבה
    דף בית
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    "Leveraging Small Numbers in Social Mobilization against Biotechnology: Why Bt Aubergine Diverged from Bt Cotton in India"

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    שעה
    11:15 - 11:15
    מיקום
    בניין אולמן למדעי החיים
    מרצהProf. Ronald J. Herring
    Atkinson Center for a Sustainable Future, Cornell University, USA http://government.arts.cornell.edu/faculty/herring/
    מארגן
    המחלקה למדעי הצמח והסביבה
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    Shedding nonresonant light on polar molecules

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    שעה
    11:15 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProfessor Bretislav Friedrich
    Fritz Haber Institute of the Max Planck Society, Berlin, Germany
    מארגן
    המחלקה לפיזיקה כימית וביולוגית
    צרו קשר
    תקצירShow full text abstract about The hybridization of the rotational states of an anisotropic...»
    The hybridization of the rotational states of an anisotropic molecule by a far-off-resonant optical field imparts angular momentum to the molecule or removes it, which alters the centrifugal term in the molecule’s electronic potential and hence pushes its vibrational and rotational manifolds upward or downward. The angular momentum imparted by the field may suffice to expel the highest vibrational level from the molecular potential. Our numerical simulations applied to the Rb2 and KRb Feshbach molecules indicate for feasible laser pulses that this can be used to accurately recover the square of the vibrational wave function of the expelled state and, by inversion, also the long-range part of the molecular potential.

    A combination with a weak electrostatic field can convert second-order alignment by the optical field into a strong first-order orientation that projects up to 90% of the body-fixed dipole moment of a polar molecule on the static field direction. This is the basis of a versatile orientation technique which found applications ranging from molecule optics and spectroscopy to chemistry and surface science. Recent work on OCS molecules has shown how to keep the interaction with the combined fields adiabatic and thereby make the best of the technique.

    The electric dipole-dipole interaction between a pair of polar molecules undergoes an all-out transformation when superimposed by a far-off resonant optical field. The combined interaction potential becomes tunable by variation of wavelength, polarization and intensity of the optical field and its dependence on the intermolecular separation exhibits a crossover from an inverse-power to an oscillating behavior.
    The ability thereby offered to control molecular interactions opens up avenues toward the creation and manipulation of novel phases of ultracold polar gases among whose characteristics is a long-range entanglement of the dipoles' mutual orientation.
    הרצאה
  • Date:22שלישימאי 2012

    N-WASP, an actin regulator in myelinating glia

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    שעה
    12:15 - 12:15
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהNurit Novak
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    From Sound to Meaning –Dynamic Transformations in Auditory Signal-Processing

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    שעה
    12:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהDr. Jonathan Fritz
    Center for Auditory and Acoustic Research University of Maryland, College Park, Maryland
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about How do we make sense of sensory inputs? One important clue m...»
    How do we make sense of sensory inputs? One important clue may be the central role of selective and predictive attention, by focusing limited resources on behaviorally relevant sensory channels and modulating information flow at multiple stages, to improve perception.Our approach is to study the effect of attention on information processing at the single neuron level in the primary auditory cortex (A1) of animals trained on multiple auditory tasks that require selective attention to task-specific salient spectral frequency or temporal cues. Our results demonstrate that when animals actively attend to a task, their auditory cortical neurons can rapidly change their spectrotemporal filter characteristics to improve the animal’s performance. Thus, cortical sensory filters are not fixed, but are highly adaptive, and show dynamic, task-specific transformations during auditory behavior. To study the broader neural circuits involved in attention, we have initiated research on several other components in the network, including secondary auditory cortical areas, nucleus basalis, and the prefrontal cortex (PFC), a brain area known to play a key role in attention and decision-making. In contrast to A1, PFC responses are largely independent of the acoustic properties of sound, and encode an abstract, categorical representation of sound meaning. Recent studies show that electrical stimulation of PFC can elicit receptive field transformations in A1 neurons very similar to the attentional effects observed during behavior. Our working model suggests a top-down instructive role for PFC, and emphasizes the importance of interactions between multiple brain areas during selective attention that lead to matched auditory cortical filters for attended acoustic stimuli, creating a dynamic, evolving neural representation of task-salient sounds and thus optimizing perception on a moment-to-moment basis.

    הרצאה
  • Date:22שלישימאי 2012

    Twitching motility towards the tight junctions

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    שעה
    13:30 - 13:30
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהBenjamin Aroeti, Ph.D.
    Department of Cell and Developmental Biology, Silberman Life Sciences Institute Edmond J. Safra Campus, Givat-Ram The Hebrew University, Jerusalem
    מארגן
    המחלקה לאימונולוגיה מערכתית
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    Twitching motility toward the tight junctions

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    שעה
    13:30 - 13:30
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהProf. Benjamin Aroeti
    Department of Cell & Developmental Biology Alexander Silberman Institute of Life Sciences Faculty of Sciences Hebrew University, Jerusalem
    מארגן
    המחלקה לאימונולוגיה מערכתית
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    "Structural Studies on p53 Protein Family"

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    שעה
    14:00 - 15:00
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהProf. Hector Viadiu
    Dept. of Chemistry and Biochemistry, University of California, San Diego
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    הרצאה
  • Date:22שלישימאי 2012

    Suppression of mRNA structure shapes codon usage at gene start in bacteria

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    שעה
    14:00 - 14:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהKajetan Bentele
    Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany
    צרו קשר
    הרצאה

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