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ספטמבר 12, 2011
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Date:21שנימאי 2012הרצאה
Bioinformatics workshop: What can I learn from DNA binding regions (ChIP-Seq peaks) using web tools?
More information שעה 09:30 - 12:00מיקום בניין ע"ש משפחת הרי לויןמרצה Dr. Dena Leshkowitz
Bioinformatics unit Weizmann Institute of Scienceצרו קשר תקציר Show full text abstract about In this workshop we will learn how extract biological knowle...» In this workshop we will learn how extract biological knowledge from a list of genomic regions which represent the DNA binding site of proteins.
The regions are termed peaks and are usually a result of a ChIP-Seq experiment which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify binding sites of DNA-associated proteins.
In the workshop we will learn how to search for relevant public peak data and how to analyze the data in order to associate it with genes, find biological enrichments and motif enrichments.
The tools we will use are web based and include:
GREAT (http://great.stanford.edu/public/html/splash.php) ,
Cistrome (http://cistrome.org/), Genomatix (commercial - http://www.genomatix.de/applications/ChIP-Seq.html)
and MEME-ChIP (http://meme.sdsc.edu/meme/doc/meme-chip.html)
Registration is required.
First you need to register to the BBCU activities here:
http://bip.weizmann.ac.il/activbin/events (click on the LogIn button)
and then you need to register to the workshop. (click on the Register button)
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Date:21שנימאי 2012הרצאה
"Contemporary neuroimmunology: The immunology of the brain and the mind"
More information שעה 11:00 - 13:00מיקום בניין וולפסון למחקר ביולוגימרצה Dr. Michal Schwartz
WISמארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:21שנימאי 2012סימפוזיונים
Faculty of Chemistry Colloquium - Prof. Thomas Walz
More information שעה 11:00 - 12:30כותרת USING TWO-DIMENSIONAL CRYSTALS OF AQUAPORIN-0 TO INVESTIGATE LIPID-PROTEIN INTEGRATIONSמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Professor Thomas Walz
Department of Cell Biology and Howard Hughes Medical Institute, Harvard Medical School, Boston, USAמארגן הפקולטה לכימיהצרו קשר תקציר Show full text abstract about Membrane proteins play crucial roles in many cellular proces...» Membrane proteins play crucial roles in many cellular processes such as signaling, nutrient uptake and cell adhesion. Although the lipid bilayer influences many aspects of membrane protein function, our understanding of lipid–protein interactions is limited. Aquaporin-0 (AQP0) is a water channel in the lens membrane, but it also assembles into orthogonal arrays that form membrane junctions between lens fiber cells. In vitro reconstitution of AQP0 with the lipid dimyristoyl phosphatidylcholine (DMPC) yielded large and well ordered double-layered two-dimensional (2D) crystals that allowed electron crystallographic structure determination of AQP0 and its surrounding DMPC bilayer at 1.9 Å resolution. Since AQP0 forms high-quality 2D crystals not only with DMPC but also with various other lipids, AQP0 2D crystals are an ideal model system to investigate lipid–protein interactions. By studying AQP0 2D crystals formed with different lipids, we can begin to address very basic questions in membrane biology, such as the driving forces that define lipid–protein interactions, the effects of hydrophobic mismatch, and the molecular basis of raft formation. -
Date:21שנימאי 2012הרצאה
Hsp90 Inhibition in Cancer...Now the Fun Begins
More information שעה 11:00 - 11:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. Safi Bahcall
President and CEO Synta Pharmaceuticals Corp., Lexington, Ma., USAמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:21שנימאי 2012הרצאה
Equilibrium States and Time Evolution of Systems with Long-Range Interactions
More information שעה 14:15 - 14:15מיקום מעבדה על-שם דני נ. היינמןמרצה Joel L. Lebowitz
Rutgers Universityמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר -
Date:21שנימאי 2012הרצאה
On ramified covers of algebraic surfaces, and combinatorics of some infinite discrete groups.
More information שעה 15:00 - 15:00מיקום בניין יעקב זיסקינדמרצה Maxim Leyenson
מארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:21שנימאי 2012הרצאה
מפגשים בחזית המדע
More information שעה 19:15 - 21:00מיקום מכון דוידסון לחינוך מדעימארגן יחידת שוהם במכון דוידסוןדף בית צרו קשר -
Date:21שנימאי 2012אירועי תרבות
גיל שוחט ומרינה מקסימליין בלומין
More information שעה 20:30 - 20:30כותרת דולצ'ה ויואצ'המיקום אודיטוריום מיכאל סלעצרו קשר -
Date:22שלישימאי 2012הרצאה
" A bacterial chemotaxis-like signal transduction system leading to biofilms".
More information שעה 10:00 - 10:00מיקום בניין וולפסון למחקר ביולוגימרצה Prof. Caroline Harwood
Department of Microbiology University of Washingtonמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:22שלישימאי 2012הרצאה
Differential analysis of the polarity transform
More information שעה 11:00 - 11:00מיקום בניין יעקב זיסקינדמרצה Shiri Artstein
Tel Aviv Universityמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:22שלישימאי 2012הרצאה
"Py-Im Polyamides – from DNA Recognition to In Vivo Experiments"
More information שעה 11:00 - 11:00כותרת Organic Chemistry - Departmental Seminarמיקום בניין הלן ומילטון קימלמןמרצה Dr. Evgenij Raskatov
California Institute of Technologyמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Abstract: Py-Im polyamides are modular DNA minor groove bin...» Abstract:
Py-Im polyamides are modular DNA minor groove binding molecules with affinities and specificities comparable to those of DNA binding proteins.
Molecules can be constructed to recognize the four letters of the genetic code.
Recent efforts established that Py-Im polyamides can be employed in cell culture to affect NF-kB dependent gene expression. We further identified that molecules are potent in live animals. Depending on molecular architecture the compounds remain in the mouse circulatory system for up to multiple days, can access subcutaneous tumor xenografts and lead to gene expression changes in vivo.
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Date:22שלישימאי 2012הרצאה
TBA
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Prof. Ronald Herring
Professor of Government, White Hall, Cornell University, Ithaca, NY, USAמארגן המחלקה למדעי הצמח והסביבהדף בית צרו קשר -
Date:22שלישימאי 2012הרצאה
"Leveraging Small Numbers in Social Mobilization against Biotechnology: Why Bt Aubergine Diverged from Bt Cotton in India"
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Prof. Ronald J. Herring
Atkinson Center for a Sustainable Future, Cornell University, USA http://government.arts.cornell.edu/faculty/herring/מארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:22שלישימאי 2012הרצאה
Shedding nonresonant light on polar molecules
More information שעה 11:15 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Professor Bretislav Friedrich
Fritz Haber Institute of the Max Planck Society, Berlin, Germanyמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about The hybridization of the rotational states of an anisotropic...» The hybridization of the rotational states of an anisotropic molecule by a far-off-resonant optical field imparts angular momentum to the molecule or removes it, which alters the centrifugal term in the molecule’s electronic potential and hence pushes its vibrational and rotational manifolds upward or downward. The angular momentum imparted by the field may suffice to expel the highest vibrational level from the molecular potential. Our numerical simulations applied to the Rb2 and KRb Feshbach molecules indicate for feasible laser pulses that this can be used to accurately recover the square of the vibrational wave function of the expelled state and, by inversion, also the long-range part of the molecular potential.
A combination with a weak electrostatic field can convert second-order alignment by the optical field into a strong first-order orientation that projects up to 90% of the body-fixed dipole moment of a polar molecule on the static field direction. This is the basis of a versatile orientation technique which found applications ranging from molecule optics and spectroscopy to chemistry and surface science. Recent work on OCS molecules has shown how to keep the interaction with the combined fields adiabatic and thereby make the best of the technique.
The electric dipole-dipole interaction between a pair of polar molecules undergoes an all-out transformation when superimposed by a far-off resonant optical field. The combined interaction potential becomes tunable by variation of wavelength, polarization and intensity of the optical field and its dependence on the intermolecular separation exhibits a crossover from an inverse-power to an oscillating behavior.
The ability thereby offered to control molecular interactions opens up avenues toward the creation and manipulation of novel phases of ultracold polar gases among whose characteristics is a long-range entanglement of the dipoles' mutual orientation.
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Date:22שלישימאי 2012הרצאה
N-WASP, an actin regulator in myelinating glia
More information שעה 12:15 - 12:15מיקום בניין וולפסון למחקר ביולוגימרצה Nurit Novak מארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר -
Date:22שלישימאי 2012הרצאה
From Sound to Meaning –Dynamic Transformations in Auditory Signal-Processing
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Jonathan Fritz
Center for Auditory and Acoustic Research University of Maryland, College Park, Marylandמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about How do we make sense of sensory inputs? One important clue m...» How do we make sense of sensory inputs? One important clue may be the central role of selective and predictive attention, by focusing limited resources on behaviorally relevant sensory channels and modulating information flow at multiple stages, to improve perception.Our approach is to study the effect of attention on information processing at the single neuron level in the primary auditory cortex (A1) of animals trained on multiple auditory tasks that require selective attention to task-specific salient spectral frequency or temporal cues. Our results demonstrate that when animals actively attend to a task, their auditory cortical neurons can rapidly change their spectrotemporal filter characteristics to improve the animal’s performance. Thus, cortical sensory filters are not fixed, but are highly adaptive, and show dynamic, task-specific transformations during auditory behavior. To study the broader neural circuits involved in attention, we have initiated research on several other components in the network, including secondary auditory cortical areas, nucleus basalis, and the prefrontal cortex (PFC), a brain area known to play a key role in attention and decision-making. In contrast to A1, PFC responses are largely independent of the acoustic properties of sound, and encode an abstract, categorical representation of sound meaning. Recent studies show that electrical stimulation of PFC can elicit receptive field transformations in A1 neurons very similar to the attentional effects observed during behavior. Our working model suggests a top-down instructive role for PFC, and emphasizes the importance of interactions between multiple brain areas during selective attention that lead to matched auditory cortical filters for attended acoustic stimuli, creating a dynamic, evolving neural representation of task-salient sounds and thus optimizing perception on a moment-to-moment basis.
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Date:22שלישימאי 2012הרצאה
Twitching motility towards the tight junctions
More information שעה 13:30 - 13:30מיקום בניין וולפסון למחקר ביולוגימרצה Benjamin Aroeti, Ph.D.
Department of Cell and Developmental Biology, Silberman Life Sciences Institute Edmond J. Safra Campus, Givat-Ram The Hebrew University, Jerusalemמארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:22שלישימאי 2012הרצאה
Twitching motility toward the tight junctions
More information שעה 13:30 - 13:30מיקום בניין וולפסון למחקר ביולוגימרצה Prof. Benjamin Aroeti
Department of Cell & Developmental Biology Alexander Silberman Institute of Life Sciences Faculty of Sciences Hebrew University, Jerusalemמארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:22שלישימאי 2012הרצאה
"Structural Studies on p53 Protein Family"
More information שעה 14:00 - 15:00מיקום בניין הלן ומילטון קימלמןמרצה Prof. Hector Viadiu
Dept. of Chemistry and Biochemistry, University of California, San Diegoמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:22שלישימאי 2012הרצאה
Suppression of mRNA structure shapes codon usage at gene start in bacteria
More information שעה 14:00 - 14:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Kajetan Bentele
Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germanyצרו קשר
