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אפריל 23, 2012
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Date:17חמישימאי 2012הרצאה
Neuronal Avalanches in the Resting MEG of the Human Brain
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Oren Shriki
National Institute of Mental Health, Bethesda, Marylandמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about A major goal in systems neuroscience is to characterize norm...» A major goal in systems neuroscience is to characterize normal cortical dynamics. Numerous in vitro and in vivo studies demonstrated that ongoing cortical dynamics are characterized by cascades of activity across many spatial scales, termed neuronal avalanches. Avalanche dynamics are identified by¬ two measures (1) a power law in the size distribution of activity cascades, with an exponent of -3/2 and (2) a branching parameter of 1, which reflects a balance in the propagation of cortical activity at the border of premature termination and potential exponential blow up. Here we analyzed resting state brain activity recorded using MEG from more than 100 healthy human subjects. We identified discrete events in the MEG signal and segmented them into cascades, using multiple timescales. Cascade-size distributions were found to obey power laws. At the timescale where the branching parameter was close to the critical value of 1, the power law exponent was -3/2, in line with expectations for neuronal avalanches. This behavior was robust to scaling of the number of sensors and to coarse-graining the sensor resolution. As controls, phase-shuffled data with the same power spectrum or empty-scanner data did not exhibit neuronal avalanches. These results indicate that normal resting cortical dynamics are well described by a critical branching process. Both theory and experiments suggest that cortical networks with such critical, scale-free dynamics optimize various types of information processing. Neuronal avalanches could thus provide a biomarker for disorders in information processing, paving the way for novel quantification of normal and pathological cortical states. -
Date:17חמישימאי 2012הרצאה
"How DNA thermodynamics specify chromosome structure and function"
More information שעה 14:00 - 15:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Andrew Travers
MRC laboratory of Molecular Biology, Cambridge, UKמארגן המחלקה לביולוגיה מולקולרית של התא , המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:17חמישימאי 2012הרצאה
"Evolution Teaches Protein Prediction"
More information שעה 15:00 - 16:00מיקום בניין הלן ומילטון קימלמןמרצה Prof. Burkhard Rost
Bioinformatics, Technische Universität München, Germanyמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:17חמישימאי 2012הרצאה
The Faculty of Mathematics and Computer Science - graduation ceremony of 2012
More information שעה 16:00 - 16:00מיקום בניין יעקב זיסקינדמארגן הפקולטה למתמטיקה ומדעי המחשבדף בית צרו קשר -
Date:20ראשוןמאי 2012הרצאה
Uplift and Exhumation across the High Himalaya in Mt. Everest area.
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Dr. Itai Haviv
Geological & Environmental Sciences Ben-Gurion Universityמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:20ראשוןמאי 2012הרצאה
Physicists' view of auto- and para-crine signaling in T-cell communication
More information שעה 13:00 - 13:00מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Prof. Oleg Krichevsky
Molecular Biophysics Lab, Ben-Gurion Universityמארגן מרכז לפיזיקה ביולוגית עש קלורצרו קשר תקציר Show full text abstract about Cells of the immune system secrete various small proteins &a...» Cells of the immune system secrete various small proteins – cytokines that can bind the receptors of the secreting cell itself (in an autocrine loop), or to other cells in the organ(paracrine signaling). The cytokine binding to the receptor causes a chain of signaling events that determine the fate of the receiving cell: its survival, differentiation and proliferation. Based on our measurements of interleukin-2 (IL-2) signaling, I will address two questions: 1) the efficiency of the autocrine loop, i.e. the probability of the cytokine molecule binding to the cell it has been secreted from, and, 2) the spatial extent of paracrine communication: how far from the secreting cell the cytokine field extends.
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Date:20ראשוןמאי 2012הרצאה
"Heat storage for solar thermal power plants"
More information שעה 13:15 - 13:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Abraham Kribus
School of Mechanical Engineering, Faculty of Engineering, Tel Aviv Universityמארגן הפקולטה לכימיהצרו קשר -
Date:20ראשוןמאי 2012הרצאה
Comparing Apples and Oranges: the search for a common subjective value representation in the brain
More information שעה 14:30 - 14:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Dino Levy
Center for Neural Science, New York University, NYמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about The ability of human subjects to choose between disparate ki...» The ability of human subjects to choose between disparate kinds of rewards suggests that the neural circuits for valuing different reward types must converge. Economic theory suggests that these convergence points represent the subjective values (SVs) of different reward types on a common scale for comparison. I will describe two studies related to this theory. First, to directly examine this theory and to map the neural circuits for reward valuation, we had food and water deprived subjects make risky choices for money, food and water both in and out of a brain scanner. In the second study we sought to determine whether the risk preferences of these same rewards change as a function of internal state.
We found that risk preferences across reward types were highly correlated. We also found that partially distinct neural networks represent the SV of monetary and food rewards and that these distinct networks showed specific convergence points. In addition, we show that subjects tend to converge to a similar, weakly risk-averse attitude when deprived.
These results may suggest that partially distinct valuation networks for different reward types converge on a unified valuation network, which enables a direct comparison between different reward types and hence guides valuation and choice. When healthy humans are sated they show heterogeneity of risk preferences, but when deprived a convergence point appears to emerge. It is as if evolution pressure, when resources are scarce, drives humans to a similar level of risk aversion but allows heterogeneity when resources are plentiful.
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Date:20ראשוןמאי 2012הרצאה
“Take a lame female hyena and boil it in oil: A look at classical Islamic medicine”
More information שעה 16:15 - 16:15מיקום אולם ע"ש דולפי ולולה אבנרמרצה LeighChipman
Hebrew and Bar-Ilan Universityמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about During the Middle Ages (roughly 600-1500 CE), the physicians...» During the Middle Ages (roughly 600-1500 CE), the physicians of the Islamic world were renowned for their efficient prevention and treatment of illnesses. Authors like Avicenna (Ibn Sina) and Rhazes (al-Razi) composed medical encyclopedias that were used in Latin translations in European medical schools down to the 18th century, and in their Arabic original, are still used in India in the present day. Moses Maimonides (the Rambam) rose to become head of the Jewish community of Egypt not only because of his halachic knowledge, but also due to his prestige as one of Saladin’s physicians.
This lecture will present a brief outline of major aspects of medical theory and practice in the pre-modern Islamic world. I will discuss the emergence of an Islamic medicine from its Greek, Persian and Arabian antecedents; developments in therapy, especially in pharmacy and surgery; medical training and medical ethics; the place of Jewish physicians and pharmacists within the medical marketplace; and alternatives to learned medicine.
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Date:21שנימאי 2012הרצאה
Bioinformatics workshop: What can I learn from DNA binding regions (ChIP-Seq peaks) using web tools?
More information שעה 09:30 - 12:00מיקום בניין ע"ש משפחת הרי לויןמרצה Dr. Dena Leshkowitz
Bioinformatics unit Weizmann Institute of Scienceצרו קשר תקציר Show full text abstract about In this workshop we will learn how extract biological knowle...» In this workshop we will learn how extract biological knowledge from a list of genomic regions which represent the DNA binding site of proteins.
The regions are termed peaks and are usually a result of a ChIP-Seq experiment which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify binding sites of DNA-associated proteins.
In the workshop we will learn how to search for relevant public peak data and how to analyze the data in order to associate it with genes, find biological enrichments and motif enrichments.
The tools we will use are web based and include:
GREAT (http://great.stanford.edu/public/html/splash.php) ,
Cistrome (http://cistrome.org/), Genomatix (commercial - http://www.genomatix.de/applications/ChIP-Seq.html)
and MEME-ChIP (http://meme.sdsc.edu/meme/doc/meme-chip.html)
Registration is required.
First you need to register to the BBCU activities here:
http://bip.weizmann.ac.il/activbin/events (click on the LogIn button)
and then you need to register to the workshop. (click on the Register button)
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Date:21שנימאי 2012הרצאה
"Contemporary neuroimmunology: The immunology of the brain and the mind"
More information שעה 11:00 - 13:00מיקום בניין וולפסון למחקר ביולוגימרצה Dr. Michal Schwartz
WISמארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:21שנימאי 2012סימפוזיונים
Faculty of Chemistry Colloquium - Prof. Thomas Walz
More information שעה 11:00 - 12:30כותרת USING TWO-DIMENSIONAL CRYSTALS OF AQUAPORIN-0 TO INVESTIGATE LIPID-PROTEIN INTEGRATIONSמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Professor Thomas Walz
Department of Cell Biology and Howard Hughes Medical Institute, Harvard Medical School, Boston, USAמארגן הפקולטה לכימיהצרו קשר תקציר Show full text abstract about Membrane proteins play crucial roles in many cellular proces...» Membrane proteins play crucial roles in many cellular processes such as signaling, nutrient uptake and cell adhesion. Although the lipid bilayer influences many aspects of membrane protein function, our understanding of lipid–protein interactions is limited. Aquaporin-0 (AQP0) is a water channel in the lens membrane, but it also assembles into orthogonal arrays that form membrane junctions between lens fiber cells. In vitro reconstitution of AQP0 with the lipid dimyristoyl phosphatidylcholine (DMPC) yielded large and well ordered double-layered two-dimensional (2D) crystals that allowed electron crystallographic structure determination of AQP0 and its surrounding DMPC bilayer at 1.9 Å resolution. Since AQP0 forms high-quality 2D crystals not only with DMPC but also with various other lipids, AQP0 2D crystals are an ideal model system to investigate lipid–protein interactions. By studying AQP0 2D crystals formed with different lipids, we can begin to address very basic questions in membrane biology, such as the driving forces that define lipid–protein interactions, the effects of hydrophobic mismatch, and the molecular basis of raft formation. -
Date:21שנימאי 2012הרצאה
Hsp90 Inhibition in Cancer...Now the Fun Begins
More information שעה 11:00 - 11:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. Safi Bahcall
President and CEO Synta Pharmaceuticals Corp., Lexington, Ma., USAמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:21שנימאי 2012הרצאה
Equilibrium States and Time Evolution of Systems with Long-Range Interactions
More information שעה 14:15 - 14:15מיקום מעבדה על-שם דני נ. היינמןמרצה Joel L. Lebowitz
Rutgers Universityמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר -
Date:21שנימאי 2012הרצאה
On ramified covers of algebraic surfaces, and combinatorics of some infinite discrete groups.
More information שעה 15:00 - 15:00מיקום בניין יעקב זיסקינדמרצה Maxim Leyenson
מארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:21שנימאי 2012הרצאה
מפגשים בחזית המדע
More information שעה 19:15 - 21:00מיקום מכון דוידסון לחינוך מדעימארגן יחידת שוהם במכון דוידסוןדף בית צרו קשר -
Date:21שנימאי 2012אירועי תרבות
גיל שוחט ומרינה מקסימליין בלומין
More information שעה 20:30 - 20:30כותרת דולצ'ה ויואצ'המיקום אודיטוריום מיכאל סלעצרו קשר -
Date:22שלישימאי 2012הרצאה
" A bacterial chemotaxis-like signal transduction system leading to biofilms".
More information שעה 10:00 - 10:00מיקום בניין וולפסון למחקר ביולוגימרצה Prof. Caroline Harwood
Department of Microbiology University of Washingtonמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:22שלישימאי 2012הרצאה
Differential analysis of the polarity transform
More information שעה 11:00 - 11:00מיקום בניין יעקב זיסקינדמרצה Shiri Artstein
Tel Aviv Universityמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:22שלישימאי 2012הרצאה
"Py-Im Polyamides – from DNA Recognition to In Vivo Experiments"
More information שעה 11:00 - 11:00כותרת Organic Chemistry - Departmental Seminarמיקום בניין הלן ומילטון קימלמןמרצה Dr. Evgenij Raskatov
California Institute of Technologyמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Abstract: Py-Im polyamides are modular DNA minor groove bin...» Abstract:
Py-Im polyamides are modular DNA minor groove binding molecules with affinities and specificities comparable to those of DNA binding proteins.
Molecules can be constructed to recognize the four letters of the genetic code.
Recent efforts established that Py-Im polyamides can be employed in cell culture to affect NF-kB dependent gene expression. We further identified that molecules are potent in live animals. Depending on molecular architecture the compounds remain in the mouse circulatory system for up to multiple days, can access subcutaneous tumor xenografts and lead to gene expression changes in vivo.