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מרץ 23, 2015

  • Date:03ראשוןמאי 2015

    Molecular Mechanisms ofTranscription in the Third Domain – from molecules to systems

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    שעה
    10:00 - 10:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Finn Werner
    Structural and Molecular Biology, University College London, London, UK
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    תקצירShow full text abstract about Our laboratory is applying an interdisciplinary and multi sc...»
    Our laboratory is applying an interdisciplinary and multi scalar approach to characterise the molecular mechanisms of transcription and in particular of multisubunit RNA polymerases (RNAPs). We explore model systems from the third domain of life, the Archaea, not only because they are fascinating organisms in their own right but because their transcription apparatus is a model system for – and more biochemically tractable than - eukaryotic RNAPII. Today I will present progress in our understanding of (i) the architecture of transcription initiation complexes, (ii) conformational dynamics of RNAP during the transcription cycle, and (iii) the whole genome-distribution of the basal transcription apparatus and transcription start site mapping. This analysis reveals the underlying molecular nature of the spontaneous DNA melting in archaea, which requires ATP hydrolysis in the RNAPII system. Our data furthermore show that the dynamic recruitment and release of basal factors that guide RNAP through the transcription cycle is modulated by the coupling of transcription and translation, of RNAPs and ribosomes.
    הרצאה
  • Date:03ראשוןמאי 2015

    Saturn > Jupiter: Why Saturn has polar cyclones and why Jupiter may not.

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    שעה
    11:00 - 11:00
    מיקום
    בניין משפחת זוסמן
    מרצהMorgan O'Neill
    Department of Earth and Planetary Sciences Weizmann Institute of Science
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    תקצירShow full text abstract about The poles of Saturn, Uranus and Neptune each have a 'ho...»
    The poles of Saturn, Uranus and Neptune each have a 'hot spot' that is observable from Earth. Saturn, which has been observed in great detail by the orbiting Cassini mission, exhibits Earth-sized hurricane-like cyclones on each pole. These massive cyclones have been present since they were first observed in 2004 and may be permanent. Our study proposes a mechanism for their creation: numerous small, moist convective thunderstorms. These thunderstorms are ubiquitous small scale features on Jupiter and Saturn. Hundreds of simulations suggest that these very small, short-lived storms can build and maintain a deep, rapid, large polar cyclone like we see on Saturn. Furthermore, an exploration of cyclone sensitivity to the deformation radius and total energy input suggests that Uranus and Neptune have transient polar cyclones, and Jupiter will not exhibit them. This last prediction will be tested for the first time next year, when the NASA Juno mission reaches Jupiter and finally observes the Jovian poles.

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  • Date:03ראשוןמאי 2015

    Chemical Physics Lunch Club Seminar

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    שעה
    12:30 - 12:30
    כותרת
    Molecular Collisions coming into Focus
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהSebastiaan Y.T. van de Meerakker
    Radboud University, Nijmegen, Netherlands
    מארגן
    המחלקה לפיזיקה כימית וביולוגית
    צרו קשר
    תקצירShow full text abstract about The study of molecular collisions with the highest possible ...»
    The study of molecular collisions with the highest possible detail has been an important research theme in physical chemistry for decades. Over the last years we have developed methods to get improved control over molecules in a molecular beam [1]. With the Stark decelerator, a part of a molecular beam can be selected to produce bunches of molecules with a computer-controlled velocity and with longitudinal temperatures as low as a few mK. The molecular packets that emerge from the decelerator have small spatial and angular spreads, and have almost perfect quantum state purity. These tamed molecular beams allow for crossed beam scattering experiments with unprecedented levels of precision and sensitivity [2,3].

    I will discuss our most recent results on the combination of Stark deceleration and velocity map imaging. The narrow velocity spread of Stark-decelerated beams results in scattering images with an unprecedented sharpness and angular resolution. This has facilitated the observation of diffraction oscillations in the state-to-state differential cross sections for collisions of NO with rare gas atoms [4]. Observed features in the diffraction pattern result from subtle quantum interference effects, and appear extremely sensitive to the potential energy surfaces governing the scattering process [5].

    [1] S.Y.T. van de Meerakker, H.L. Bethlem, G. Meijer, Nature Physics 4, 595 (2008).
    [2] J.J. Gilijamse, S. Hoekstra, S.Y.T. van de Meerakker, G.C. Groenenboom, G. Meijer,
    Science 313, 1617 (2006).
    [3] M. Kirste, X. Wang, H.C. Schewe, G. Meijer, K. Liu, A. van der Avoird, L.M.C.
    Janssen, K.B. Gubbels, G.C. Groenenboom, S.Y.T. van de Meerakker,
    Science 338, 1060 (2012).
    [4] A. von Zastrow, J. Onvlee, S.N. Vogels, G.C. Groenenboom, A. van der Avoird,
    S.Y.T. van de Meerakker, Nature Chemistry 6, 216 (2014).
    [5] S.N. Vogels, J. Onvlee, A. von Zastrow, G.C. Groenenboom, A. van der Avoird,
    S.Y.T. van de Meerakker, Phys. Rev. Lett. 113, 263202 (2014).
    הרצאה
  • Date:03ראשוןמאי 2015

    The road to recovery: the function of Runx1 in muscle regeneration

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    שעה
    13:00 - 13:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהKfir Umansky
    Yoram Groner's group, Dept. of Molecular Genetics, WIS
    צרו קשר
    הרצאה
  • Date:03ראשוןמאי 2015

    Understanding and Controlling 3D Assembly at the Nanoscale: Directed Assembly of Block Copolymers

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    שעה
    14:00 - 14:00
    מיקום
    בניין פרלמן למדעי הכימיה
    מרצהDr. Tamar Segal-Peretz
    Institute for Molecular Engineering, University of Chicago
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    הרצאה
  • Date:03ראשוןמאי 2015

    Optogenetic fMRI to probe dopaminergic circuits

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    שעה
    14:00 - 17:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Gary Glover
    Stanford University
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    הרצאה
  • Date:03ראשוןמאי 2015

    Towards mapping the Human Brain: imaging function and connectivity from cortical columns to whole brain

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    שעה
    14:00 - 17:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Kamil Ugurbil
    University of Minnesota
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    הרצאה
  • Date:03ראשוןמאי 2015

    Cracking Mesoscopic Coding Principles in the Human Brain with Ultra-High Field Functional Magnetic Resonance Imaging

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    שעה
    14:00 - 17:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Dr. Rainer Goebel
    Maastricht University
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    הרצאה
  • Date:04שנימאי 2015

    Thiophene Rust in Organic Electronics

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    שעה
    11:00 - 12:00
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהProf. Luis Campos
    From Columbia University, New York, USA
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    הרצאה
  • Date:04שנימאי 2015

    Student Seminar

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    שעה
    12:15 - 12:15
    כותרת
    Nitric oxide controls a switch between degenerative and regenerative phases of developmental neuronal remodeling & The role of mutant p53 in the tumorigenesis of mesenchymal stem cells
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהDr. Gabriela Koifman
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:04שנימאי 2015

    Cancer Meets Epitranscriptomics

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    שעה
    14:00 - 14:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהPROF. GIDI RECHAVI
    SHEBA MEDICAL CENTER TEL HASHOMER
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    תקצירShow full text abstract about In the last decade advances in Next Generation Sequencing an...»
    In the last decade advances in Next Generation Sequencing and bioinformatics enabled the unraveling of global RNA modifications and editing. The evolving field of epitranscriptomics proved to be important in cell fate decisions, normal development and disease.
    The lecture will deal with A to I editing-based mechanisms relevant to cancer and with the emerging role
    of m6A methylation in the precise regulation of early embryonic development.
    הרצאה
  • Date:04שנימאי 2015

    The principles of kinetic theory for granular

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    שעה
    14:15 - 14:15
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהMassimo Tessarotto - University of Trieste
    מארגן
    המחלקה לפיזיקה של מערכות מורכבות
    צרו קשר
    הרצאה
  • Date:04שנימאי 2015

    Search for Time-Reversal-Violation in atom traps"

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    שעה
    14:45 - 15:00
    מיקום
    Tel Aviv University
    מרצהDanny Ashery
    Tel-Aviv University
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about Several ways to search for time-reversal-violation in beta d...»
    Several ways to search for time-reversal-violation in beta decay of trapped nuclei will be reviewed. The newly upgraded TRINAT trap system will be described showing the high sensitivity required for such a search. The experimental plans for such experiments will be described.
    הרצאה
  • Date:04שנימאי 2015

    The Curious Case of Tantalum 180

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    שעה
    16:15 - 17:15
    מיקום
    Tel Aviv University
    מרצהNaftali Auerbach
    Tel Aviv University
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about The Ta 180m nucleus is the rarest naturally occurring isotop...»
    The Ta 180m nucleus is the rarest naturally occurring isotope. It exists in an isomeric state with half-life time of 1.2 10**15 years, at an excitation energy of 77 keV and spin J=9. We study the possibility that when irradiated by gamma rays or subjected to Coulomb excitation its decay can be accelerated by the existence of a doorway. We describe the mechanism of such a decay similar to the chaos-assisted tunneling.
    הרצאה
  • Date:05שלישימאי 2015

    DELLA, SPY and hormone signaling in tomato and Arabidopsis

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    שעה
    11:15 - 11:15
    מיקום
    בניין אולמן למדעי החיים
    מרצהProf. David Weiss
    Institute of Plant Sciences and Genetics, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem
    מארגן
    המחלקה למדעי הצמח והסביבה
    צרו קשר
    הרצאה
  • Date:05שלישימאי 2015

    The interaction of synaptic plasticity and scaling and their role in memory dynamics

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    שעה
    12:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהDr. Christian Tetzlaff
    Bernstein Center for Computational Neuroscience, Max-Planck Institute for Dynamics and Self-Organization, Gottingen
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about Many experiments provide evidences that, after learning, hum...»
    Many experiments provide evidences that, after learning, human and animal memories are very dynamic and changeable. Amongst others, one intriguing and counterintuitive effect is the destabilization of memories by recalling them. In addition, some of these destabilized memories can be ‘rescued’ by sleep-induced consolidation while others not. Up to now, the basic principles underlying these effects are widely unknown. In this talk I will present our theoretical model in which the interaction between the biologically well-established processes of synaptic plasticity and scaling enables the formation of memories or rather Hebbian cell assemblies in neural networks. Furthermore, we can show that the dynamics of these cell assemblies are comparable to the intriguing dynamics of human and animal memories described above. Thus, this model serves as a further step to link biological processes on the neuronal scale to behavior on the psychological level.

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  • Date:06רביעימאי 2015

    Forum on Mathematical Principles in Biology

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    שעה
    10:00 - 11:00
    כותרת
    Can we realize Lamarckian evolution in the lab?
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהTzachi Pilpel
    Dept of Molecular Genetics
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:06רביעימאי 2015

    Mapping the resistance potential of Influenza against an antiviral

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    שעה
    10:00 - 11:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Isaiah (Shy) Arkin
    Dept. of Biol. Chem., Hebrew Univ. of Jerusalem
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    הרצאה
  • Date:06רביעימאי 2015

    Radiation Pressure on Photoionized Plasma, Application to Active Galactic Nuclei

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    שעה
    10:15 - 11:15
    מיקום
    מעבדה על-שם דני נ. היינמן
    מרצהAri Laor, Technion
    מארגן
    מרכז לאסטרופיסיקה עש נלה וליאון בנוזיו
    צרו קשר
    תקצירShow full text abstract about Photoionization models calculate the energy transfer from th...»
    Photoionization models calculate the energy transfer from the
    ionizing radiation to the gas. The associated momentum transfer
    is not always included. This radiation pressure will set the density
    structure within the photoionized gas, in particular if the gas is
    not radially accelerating. I will present the results of such
    calculations for photoionized gas in Active Galactic Nuclei, which
    provide a simple explanation for a range of properties observed.
    הרצאה
  • Date:06רביעימאי 2015

    Minimum Free-Energy Paths Obtained from Umbrella Sampling

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    שעה
    11:00 - 11:00
    מיקום
    בניין פרלמן למדעי הכימיה
    מרצהProf. Johannes Kaestner
    Institute for Theoretical Chemistry, University of Stuttgart
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    הרצאה

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