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אפריל 27, 2017
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Date:18ראשוןדצמבר 2022הרצאה
Structure and Dynamics of Polyelectrolyte Complex Network under Electric Field
More information שעה 11:00 - 12:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Eyal Zussman
Dept Mechanical Engineering, Technionמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Electrostatic interactions between polyelectrolyte (PE) ch...»
Electrostatic interactions between polyelectrolyte (PE) charges and dissociated counterions provide PEs with intriguing properties and significantly determine their conformation and dynamics. This research shows how weak PE chains form a global network when they are oppositely charged and how strong electric fields lead to orientational order. The development of controlled drug release and responsive structures is demonstrated by the use of ordered PE with tunable intermolecular interactions.
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Date:18ראשוןדצמבר 2022הרצאה
Estimating Climate Change Mitigation Potential Through Dryland Forestation Actions
More information שעה 13:00 - 14:00כותרת SAERI - Sustainability and Energy Research Initiative Seminar Seriesמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Shani Rohatyn-Blitz, PhD
Coordinator for Research and Foreign Relations Forestry Division, KKL-JNF Israelמארגן בית הספר למחקר - מכון ויצמן למדעצרו קשר -
Date:18ראשוןדצמבר 2022הרצאה
From atomic imaging and functionalizing of inorganic 2D materials to molecular imaging of organic 2D materials
More information שעה 14:00 - 15:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Ute Kaiser
Ulm University, Materials Science Electron Microscopyמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about In this lecture, the theoretical and technical base for atom...» In this lecture, the theoretical and technical base for atomic imaging of defects in inorganic 2D materials in the low-voltage transmission electron microscope SALVE will be discussed. Atomic defects can significantly change the properties of the material: Using 2D-TMDs and 2D-TMPTs and corresponding heterostructures, this is shown experimentally and verified by corresponding quantum mechanical calculations. We also use the electron beam for the targeted formation of new phases in the inorganic 2D matrix. Since the interaction cross-sections of electron beam and organic 2D materials differ strongly from the inorganic case, we explore highest-resolution imaging conditions for 2D polymers and various 2D MOFs and show that there is a trend towards lower voltage TEM as well. We may conclude that low-voltage TEM and low-dimensional materials are just made for each other. -
Date:19שנידצמבר 2022כנסים
EKARD symposium 2022
More information שעה 08:00 - 18:00יושב ראש Yardena Samuels -
Date:19שנידצמבר 2022הרצאה
A spectral T^{+}A^{-}G^{+} of episodic memory
More information שעה 13:00 - 14:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Michael J. Kahana
Edmund J. and Louise W. Kahn Term Professor of Psychology University of Pennsylvaniaמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:20שלישידצמבר 2022הרצאה
A direct MS approach for identifying damaged DNA in cancerous cells
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Joanna Stimpson
Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about DNA can be damaged by chemicals in our surroundings, and occ...» DNA can be damaged by chemicals in our surroundings, and occurs at the nucleophilic sites on the strand. Of particular interest is alkylation at the O6-position of guanine, which goes on to cause G:C -> A:T mutations. These mutations cause genomic instability and are linked to the onset of colorectal cancer (CRC). Identifying the extent and diversity of O6-guanine alkylation informs us on the exposure cancer patients have undergone.
Here we have developed a mass spectrometry based approached to identify damaged DNA. The method is based on the DNA repair protein MGMT, which directly removes alkylation from O6-alkyl guanine. MGMT can be used to probe the type and extent of O6-alkylation.
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Date:20שלישידצמבר 2022הרצאה
Extracellular Matrix Mechanics in Disease States
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Joshua M. Grolman
Materials Science and Engineering Technion - Israel Institute of Technologyמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:21רביעידצמבר 2022הרצאה
Israel Quantum Information Theory Day
More information שעה 09:30 - 09:30מיקום מרכז כנסים על-שם דויד לופאטימארגן מרכז למדע וטכנולוגיה קוונטיתדף בית צרו קשר תקציר Show full text abstract about The Israel Quantum Information Theory day brings together re...» The Israel Quantum Information Theory day brings together researchers, postdoctoral scholars and Ph.D. students from Israel working on the theory of quantum computation and information processing for a day of scientific talks, research discussions and social interaction.
Registration: https://tinyurl.com/2rxsuykb
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Date:21רביעידצמבר 2022הרצאה
Chemical and Biological Physics Guest Seminar
More information שעה 15:00 - 15:00כותרת Quantum simulations and interfaces with Rydberg atomsמיקום בניין פרלמן למדעי הכימיהמרצה Prof David Petrosyan, Prof. Gershon Kurizki
IESL, FORTH, Greeceמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about Atoms in the highly excited Rydberg states possess unique pr...» Atoms in the highly excited Rydberg states possess unique properties, including long lifetimes and huge dipole moments, which facilitate their use in various quantum technology applications. I will discuss recent progress in quantum simulations of many-body physics with strongly-interacting Rydberg atoms and coherent interfaces of Rydberg atoms with superconducting microwave resonators and optical photons, and present some of our results in this research. -
Date:22חמישידצמבר 2022סימפוזיונים
Physics Hybrid Colloquium
More information שעה 11:15 - 12:30כותרת New Astrophysical Puzzles from Studies of Low Mass Galaxies beyond the Milky Wayמיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Dr. Shani Danieli
Princeton University - New Jerseyמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about Low-mass galaxies provide an essential testing ground for th...» Low-mass galaxies provide an essential testing ground for theoretical predictions of cosmology. Their number densities, structures, and internal dynamics provide some of the most interesting clues to the nature of dark matter and the theory of galaxy formation on small scales. Recent advances in telescope instrumentation and image analysis techniques have enabled comprehensive investigations of such low surface brightness galaxies. I will present results from novel observations of low-mass galaxies beyond our local galactic neighborhood, uncovering their significant diverseness and new astrophysical puzzles. I will discuss some of the follow-up observations of these extragalactic low-mass galaxies, focusing on their dark matter content and intriguing globular cluster populations. I will conclude by briefly discussing ongoing and future surveys that collectively have the potential to unveil the physics of dark matter. -
Date:25ראשוןדצמבר 2022הרצאה
Lightning, Biology, and Evolution
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Colin Price
Tel Aviv Universityמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about Most electrical activity in vertebrates and invertebrates oc...» Most electrical activity in vertebrates and invertebrates occurs at extremely low frequencies (ELF), with characteristic maxima below 50 Hz. The origin of these frequency maxima is unknown and remains a mystery. We propose that over billions of years during the evolutionary history of living organisms on Earth, the natural electromagnetic resonant frequencies in the atmosphere, continuously generated by global lightning activity, provided the background electric fields for the development of cellular electrical activity. In some animals, the electrical spectrum is difficult to differentiate from the natural background atmosphericelectric field produced by lightning. In this talk I will present evidence for the link between the natural ELF fields and those found in many living organisms, including humans. Furthermore, recent experiments show links between the ELF fields and photosynthesis in plants.
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Date:25ראשוןדצמבר 2022הרצאה
RNA-Lipid Nanoparticles 2.0: From Gene Silencing to Genome Editing
More information שעה 11:00 - 12:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Dan Peer
Laboratory of Precision NanoMedicine, Tel Aviv Universityמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Accumulating work points out relevant genes and signaling pa...» Accumulating work points out relevant genes and signaling pathways hampered in human disorders as potential candidates for therapeutics. Developing nucleic acid-based tools to manipulate gene expression, such as siRNAs, mRNA and genome editing strategies, open up opportunities for personalized medicine. Yet, although major progress was achieved in developing RNA targeted delivery carriers, mainly by utilizing monoclonal antibodies (mAbs) for targeting, their clinical translation has not occurred. In part because of massive development and production requirements and high batch-to-batch variability of current technologies, which relies on chemical conjugation. Here we present a self-assembled modular platform that enables to construct theoretically unlimited repertoire of RNA targeted carriers. The platform self-assembly is based on a membrane-anchored lipoprotein, incorporated into RNA-loaded novel, unique lipid nanoparticles that interact with the antibody Fc domain. We show that a simple switch of 8 different mAbs, redirects specific uptake of siRNAs by diverse leukocyte subsets in vivo. The platform therapeutic potential is demonstrated in an inflammatory bowel disease model, by targeting colon macrophages to reduce inflammatory symptoms, and in Mantle Cell Lymphoma xenograft model, by targeting cancer cells to induce cell death and improve survival. In addition, I will discuss novel approach for delivering modified mRNA to specific cell types in vivo utilizing this platform. I will also share some data on mRNA vaccines for COVID19 and Finally, I will share new data showing very high efficiency genome editing in glioma and metastatic ovarian cancer. This modular delivery platform can serve as a milestone in turning precision medicine feasible.
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Date:26שנידצמבר 2022סימפוזיונים
One hundred years of electrified interfaces: What’s new with the theories of Debye and Onsager?
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. David Andelman
School of Physics, Tel Aviv Universityמארגן הפקולטה לכימיהדף בית צרו קשר תקציר Show full text abstract about The Poisson-Boltzmann theory stems from the pioneering works...» The Poisson-Boltzmann theory stems from the pioneering works of Debye and Onsager and is considered even today as the benchmark of ionic solutions and electrified interfaces. It has been instrumental during the last century in predicting charge distributions and interactions between charged surfaces, membranes, electrodes as well as macromolecules and colloids. The electrostatic model of charged fluids, on which the Poisson-Boltzmann description rests and its statistical mechanical consequences have been scrutinized in great detail. Much less, however, is understood about its probable shortcomings when dealing with various aspects of real physical, chemical, and biological systems. After reviewing the Poisson-Boltzmann theory, I will discuss several extensions and modifications to the seminal works of Debye and Onsager as applied to ions and macromolecules in confined geometries. These novel ideas include the effect of dipolar solvent molecules, finite size of ions, ionic specificity, surface tension, and conductivity of concentrated ionic solutions. -
Date:27שלישידצמבר 2022כנסים
SAMPL 2022 Workshop - Bringing Science, Technology and Medicine Together
More information שעה 08:00 - 18:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Yonina Eldar -
Date:27שלישידצמבר 2022הרצאה
iSCAR seminar
More information שעה 09:00 - 10:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Yossi Buganim
"The different paths governing the creation of artificial embryo stem cells"מארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:27שלישידצמבר 2022הרצאה
ATFS-1 coordinates mitochondrial network expansion and peroxisome biogenesis in the model organism Caenorhabditis elegans
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Tomer Shpika
Dept. of Molecular, Cell and Cancer Biology. University of Massachusetts Medical Schoolמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about As organisms develop, individual cells generate mitochondria...» As organisms develop, individual cells generate mitochondria and peroxisomes to fulfill their physiological requirements. A decline, or dysfunction in these organelles is associated with ageing and a vast array of clinical manifestations including metabolic disorders and neurodegenerative diseases. Despite this, it is unknown how mitochondrial network expansion and peroxisome biogenesis is scaled to cell growth, and how cells maintain the organelles’ function during stress. The mitochondrial unfolded protein response (UPRmt) is a protective signaling pathway mediated by the transcription factor ATFS-1. Using genetic and biochemical approaches in the model organism Caenorhabditis elegans we demonstrate that ATFS-1 mediates an adaptable mitochondrial network expansion program and a peroxisomal retrograde response that is active throughout normal development. These findings as well as the therapeutic potential and future directions of my studies will be presented. -
Date:27שלישידצמבר 2022הרצאה
“Intelligentsia of Nano-Architected Hierarchical Materials”
More information שעה 11:15 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Julia Greer
California Institute of Technologyמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Creation of reconfigurable and multi-functional materials ca...» Creation of reconfigurable and multi-functional materials can be achieved by incorporating architecture into material design. In our research, we design and fabricate three-dimensional (3D) nano-architected materials that can exhibit superior and often tunable thermal, photonic, electrochemical, biochemical, and mechanical properties at extremely low mass densities (lighter than aerogels), which renders them useful and enabling in technological applications. Dominant properties of such meta-materials are driven by their multi-scale nature: from characteristic material microstructure (atoms) to individual constituents (nanometers) to structural components (microns) to overall architectures (millimeters and above).
Our research is focused on fabrication and synthesis of nano- and micro-architected materials using 3D lithography, nanofabrication, and additive manufacturing (AM) techniques, as well as on investigating their mechanical, biochemical, electrochemical, electromechanical, and thermal properties as a function of architecture, constituent materials, and microstructural detail. Additive manufacturing (AM) represents a set of processes that fabricate complex 3D structures using a layer-by-layer approach, with some advanced methods attaining nanometer resolution and the creation of unique, multifunctional materials and shapes derived from a photoinitiation-based chemical reaction of custom-synthesized resins and thermal post-processing. A type of AM, vat polymerization, has allowed for using hydrogels as precursors, and exploiting novel material properties, especially those that arise at the nano-scale and do not occur in conventional materials. The focus of this talk is on additive manufacturing via vat polymerization and function-containing chemical synthesis to create 3D nano- and micro-architected metals, ceramics, multifunctional metal oxides (nano-photonics, photocatalytic, piezoelectric, etc.), and metal-containing polymer complexes, etc., as well as demonstrate their potential in some real-use biomedical, protective, and sensing applications. I will describe how the choice of architecture, material, and external stimulus can elicit stimulus-responsive, reconfigurable, and multifunctional response -
Date:27שלישידצמבר 2022הרצאה
Biosynthesis of Plant Natural Products: from the Colours of Beet to Defences in Wheat
More information שעה 11:30 - 12:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Guy Polturak
John Innes Centreמארגן המחלקה למדעי הצמח והסביבהצרו קשר תקציר Show full text abstract about Plants produce a vast range of specialized metabolites that ...» Plants produce a vast range of specialized metabolites that serve various roles, including mediating interactions with their immediate environments and providing defence against (a)biotic stresses. The ‘omics era’ has brought a new golden age for plant specialized metabolism research, vastly accelerating the discovery of novel metabolites and our understanding of their biosynthesis, roles and regulation. Two studies exemplifying omics-driven discovery of metabolic pathways, in beet and in wheat, will be presented:
1. Betalains are red-violet and yellow pigments restricted to order Caryophyllales, which have attracted interest due to their health-promoting properties and use as food colorants. Transcriptomics-led discovery of enzymes catalyzing the last unknown step in betalain biosynthesis in red beet enabled us to heterologously produce these pigments in plants and microbes, providing a valuable platform for studying their in-planta roles and enabling their subsequent utilization as reporter genes and plant transformation markers.
2. Wheat is one of the most widely grown crops in the world but is susceptible to numerous pests and pathogens, leading to major annual losses. Despite its agricultural importance, current knowledge of wheat chemical defenses remains very limited. Using a genome mining approach we uncovered six previously unknown pathogen-induced metabolic pathways in hexaploid bread wheat, which produce a diverse set of molecules and are encoded by biosynthetic gene clusters. Discovery and characterization of these cluster-encoded metabolic pathways provides key insights into the molecular basis of biotic stress responses in wheat, thus opening new potential avenues for improvement of this major food crop.
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Date:27שלישידצמבר 2022הרצאה
Bird nests and nesting behavior
More information שעה 15:30 - 16:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Uri Moran מארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:29חמישידצמבר 202230שישידצמבר 2022הרצאה
Hanukkah STAR - mini workshop 2022
More information שעה כל היוםמיקום בניין יעקב זיסקינדמארגן הפקולטה למתמטיקה ומדעי המחשבדף בית צרו קשר
