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Prof. Eitan Bibi
Structure/function studies of the <I>E. coli</I> multidrug transporter, MdfA.Collaboration with: Klaas Martinus Pos, Goethe University, Frankfurt, Germany Hassane Mchaourab, Vanderbilt University, Nashville, TN, USA Melissa Brown, Flinders University, Adelaide SA, AustraliaThe multidrug recognition pocket of MdfA (genetic and biochemical studies)3D crystallization of MdfAMechanism of MdfA-mediated multidrug transport (proton/drug antiport)Conformational behavior of MdfAMembrane protein biogenesis in E. coliCollaboration with: Gert Bange, Philipps University Marburg, GermanyFtsY, the essential prokaryotic SRP-receptor: biogenesis and functionMembrane targeting and association of ribosomes in E. coli.Membrane targeting and association of mRNAs encoding membrane proteins
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Prof. Alexander D. Bershadsky
Integrin-mediated cell-matrix adhesions as mechanosensors: molecular requirements for the force-induced focal adhesion growth.Cell-cell contact-dependent regulation of the actin cytoskeleton and microtubule system: Role of p120 catenin and other components of cadherin adhesion complex.Role of myosin-driven contractility in the retrograde surface flow and cell motility.Cooperation between neuregulin, ErbB-family receptors, and cell surface heparan sulfate proteoglycans in the regulation of cell motility and morphogenesis.
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Prof. Brian Berkowitz
Development of chemical methods for remediation of water polluted by organic compounds and heavy metals.Fluid flow and chemical transport in groundwater systems.Percolation, scaling and statistical physics models of structural and dynamic processes in geological formations.Experimental and theoretical analysis of reactive transport and precipitation/dissolution patterns in porous media.
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Prof. Avri Ben-Ze'ev
Epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and Wnt target genes in colon cancer metastasisThe interplay between the role of beta-catenin in cell adhesion and signaling during colon cancer development.The molecular basis and signaling roles of nerve cell adhesion receptors in colon cancer metastasisThe role of novel beta-catenin target genes in tumor development and metastasis
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Prof. Avi Ben-Nun
Neuroimmunology, pathogenic autoimmunity, myelin/neuronal repair, and treatment of autoimmune diseases in central nervous system (CNS):T-cell pathogenesis and regulation in autoimmune diseases of the CNS.Effects of functional epistasis between HLA class-II alleles on genetic predisposition to multiple sclerosis (MS) in humanized HLA-Tg mice and MS patients.Defining major pathogenic MS-related myelin/neuronal epitopes in HLA-transgenic (Tg) mice.Antigen-based immune-specific approaches to therapy (and mechanisms) of MS and other T-cell mediated autoimmune diseases.Myelin/neuronal repair by adult neural stem cells in mice with chronic MS-like disease.
