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Prof. Dan Tawfik
Evolution and mechanism of enzymesMolecular evolution in man-made cell-like compartments.Directed evolution of tailor-made hydrolases (esterases, phosphoesterases, organophosphate hydrolases, and amidases) and DNA-modifying enzymes.Structure, mechanism and evolution of serum paraoxonases (PONs)The role of promiscuity and conformational plasticity in protein evolution.Directed evolution of DNA-methyltransferases and DNase inhibitorsThe stability effects of mutationsProtein evolvabilityChaperones and protein evolution
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Prof. Joel Sussman
3D Structure/function of nervous system proteinsCollaboration with: Israel Silman, Sarel Fleishman, Tamar Unger, Yoav Peleg, Shira Albeck, Orly Dym & Gershom MartinAcetylcholinesterase relation to Alzheimer’s disease & nerve agentsDesign and expression of more stable variants of acetylcholinesteraseMolecular flexibility of acetylcholinesteraseβ-glucosidase: Mutants linked to Gaucher & Parkinson diseaseCollaboration with: Israel Silman & Anthony FutermanVisualization of 3D Protein Structures via new web based tool ProteopediaCollaboration with: Jaime Prilusky & Israel SilmanProteopedia: A way to communicate biomolecular concepts in 3DFoldIndex: Intrinsically Disordered Protein (IDP)
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Prof. Adi Stern
Quantum interference phenomena in the fractional Quantum Hall effect. Electronic transport in strong magnetic fields.Non-abelian electronic states - quantum Hall states, topological superconductors and Majorana fermions.Fractionalized topological phases - how to construct them, how to measure them, and how to use them for topological quantum computationLow density two dimensional electronic systems.One dimensional electronic systems - electronic transport in the presence of interactions.
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Prof. Victor Steinberg
Physical hydrodynamics, hydrodynamics of complex fluids, dynamics of single flexible micro-objects (molecules, membranes, etc) in complex fluid flowsHydrodynamics of polymer solutions. Search for direct relation between elastic turbulence and turbulent drag reduction in various polymer solution flows.Experimental test of the similarity law in von Karman swirling flow driven inertiallyDynamics and conformations of a single polymer molecule in elastic turbulence: 3D imaging of polymer molecules and a random flow.Development of non-invasive local sensors for measurements of stress field in a fluid flow
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Prof. Rotem Sorek
CRISPR-CasPhage biologyRegulation of antibiotics resistanceMicrobiome researchCommunication between virusesComputational microbial genomics and metagenomicsMicrobial transcriptomicsComputational discovery of novel natural antibioticsNext generation sequencing
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