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Prof. Irun R. Cohen
Autoimmune T cells and tissue maintenance in the nervous systemCollaboration with: M. SchwartzAutoimmunity to hsp60 and the development of subunit vaccines against infectious diseases.Regulation of immune inflammation by small carbohydrate moleculesCollaboration with: O. LiderAutoimmunity to p53 and the development of systemic lupus erythematosusCollaboration with: V. RotterAutoimmune diabetes: Pathogenesis and immune therapy.
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Prof. Michel Revel
Applications of IL-6 Chimera and Interferon-beta in neurology, hematopoiesis, and oncology.Collaboration with: J. ChebathInterleukin-6 Chimera, a superactivator of the gp130 receptor system: role in nerve myelination, neuroprotection and in the development of neuro-glial cells from embryonic tissues and stem cells.Collaboration with: J. ChebathTransdifferentiation of neural crest cell derived melanoma into myelinating Schwann cell. Genes controlling cell growth, differentiation, melanogenesis and synthesis of myelin proteins.Collaboration with: J. Chebath
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Prof. Abraham Arcavi
Research on cognitive characteristics of non academically oriented math students.Collaboration with: Dr. Ronnie KarsentyDesign of curriculum materials as a research based activityCollaboration with: Dr. Sue MagidsonLong-term design of a new curriculum for grades 10, 11 and 12 for non-academically oriented students.Collaboration with: Dr. Nurit Hadas
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Prof. Varda Rotter
Molecular mechanisms controlling the expression of p53 in normal cells and its deregulation in cancer cellsInvolvement of p53 in cell differentiation and apoptosis: <I>in vivo</I> and in vitro models.Cellular proteins that specifically complex with the p53 protein.Cellular proteins that are induced upstream or downstream to the p53 protein following genotoxic stress.
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Prof. David Milstein
Organometallic chemistry and catalysisBond activation by electron-rich transition metal complexes.Rational design of homogeneous catalysis and synthetic methodology based on transition metal complexes.Impact of molecular order on catalysis and reactivity.Generation and stabilization of elusive (potentially biologically active) molecules
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Prof. Matityahu Fridkin
Chemical-Biological and Clinical studies on novel drugs, primarily of peptidic nature,related to therapy of infectious ,inflamatory and neoplastic diseases.Collaboration with: Y. Koch I. Gozes (TAU ) I. Offek (TAU ) R. Catane (TEL-HASHOMER )Anticancer, Antibacterial AntiinflammatoryNovel synthetic and analytical methdologies are being developed.Solid-phase synthesisClassical solution chemistryCombinatorial technologiesStudies include: drug design, pro-drugs, long-acting drugs and drug delivery.Collaboration with: Y. ShechterNovel iron chelatores as potential drugs for neurodegenarative diseasesCollaboration with: M. Youdim ( Technio9n )small-moleculesamino acids and peptides
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Prof. Eytan Domany
Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glassesCollaboration with: A. P. Young (UCSC)Development of tools and algorithms for large scale data analysis. Bioinformatics.Analysis of high-throughput biological data (in particular, gene expression data)Collaboration with: Several research groups at Weizmann, in the USA and in Europe; see below.Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))Development of antigen chips, applications for autoimmune diseases (with I. Cohen)Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));Glioblastoma; (with M. Hegi, R. Stupp (CHUV))Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))
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Prof. Yoseph Imry
Mesoscopic physics: persistent currents, classical and quantum fluctuations, quantum interference effects on transport, decoheherce.Collaboration with: see below.Effects of interaction on localization and on single-electron resonances. Many-electron effects and phase-shifts. Dephasing of Quantum interference in mesoscopics. Quantum noise and its detection. Effects of quantum fluctuations on nanosuperconductors.Collaboration with: Y. Levinson, A. Aharony and E. Entin-Wohlman (TAU and BGU), Y. Ovadyahu and A. schiller (HU), P. Silvestrov (Leiden), M. Schechter and P, Stamp (UBC).
