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November 02, 2015
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Date:30MondayNovember 2015Lecture
Flux controls flux – how microbes regulate their metabolism
More information Time 09:15 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Matthias Heinemann
Molecular systems biology University of GroningenOrganizer Department of Systems ImmunologyContact -
Date:30MondayNovember 2015Colloquia
"Comparative studies of intrinsically disordered proteins"
More information Time 11:00 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Jane Clarke
Department of Chemistry, University of CambridgeOrganizer Faculty of ChemistryContact Abstract Show full text abstract about In my laboratory we use a multidisciplinary approach to stud...» In my laboratory we use a multidisciplinary approach to study protein folding - how the linear sequence of amino acids in a polypeptide chain determines the structure to which it folds, the pathway by which it folds, and how it avoids misfolding. That is, how the primary sequence defines the entire energy landscape for folding.
It has recently become apparent that many proteins are not, in fact folded, but they play important roles in the cell. These intrinsically disordered protein challenge the structure : function paradigm, and they have attracted significant interest from investigators in the fields of structural biology, bioinformatics and theory, but, relatively little work has been done using standard biophysical kinetics techniques pioneered in studies of protein folding
Many key protein-protein interactions are driven by assembly of complexes where one or both partner proteins are intrinsically disordered before binding. In this case the free energy of binding has to compensate for the energetic cost of folding. We are comparing the folding of a number of different folding-upon binding systems to ask some fundamental questions about the mechanisms of folding upon binding: What is the importance of residual structure? What role does the ordered partner play? What is the mechanism of assembly? And, perhaps most fundamentally – what is the function of disorder? I will describe some of our recent findings. -
Date:30MondayNovember 2015Lecture
Restoration of tumor suppression: challenges and therapeutic opportunities
More information Time 11:00 - 11:00Location Wolfson Building for Biological ResearchLecturer Prof. Ygal Haupt
Peter MacCallum Cancer Centre, Melbourne, AustraliaOrganizer Department of Molecular Cell BiologyContact -
Date:30MondayNovember 2015Lecture
"Skeletal Molding of Chiral Pool Compounds: C–C and C–H Bond Activation of Pinene"
More information Time 14:00 - 14:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Ahmad Masarwa
UNIVERSITY OF CALIFORNIA, BERKELEYOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:30MondayNovember 2015Lecture
Real-space condensation in mass transport models: statics, dynamics, and large deviations
More information Time 14:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Ori Hirschberg, Technion Organizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about The formation of traffic jams on highways, the clustering of...» The formation of traffic jams on highways, the clustering of particles in shaken granular gases, and the emergence of macroscopically-linked hubs in complex networks are all examples of real-space condensation. This phase transition, in which a finite fraction of the “mass” in a macroscopic system is concentrated in a microscopic fraction of its volume, is rather ubiquitous in nonequilibrium systems. In this talk, I shall present some of the insights into these phenomena garnered from the study of prototypical toy models. After reviewing static properties of the condensation transition, I shall focus on two unexpected features recently discovered: (1) Spatial correlations, which generically exist in driven systems, may give rise to a collective motion of the condensate through the system. The mechanism behind this motion is explained using simplified models, and shown to be rather generic. (2) When the current flowing through a system is conditioned to have highly atypical values, condensates may form in systems that otherwise do not condense. I will present microscopic and macroscopic approaches to analyze this novel scenario of condensation.
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Date:30MondayNovember 2015Cultural Events
Afternoon Music "Shlomo Ydov " - Free Entrance
More information Time 16:30 - 17:30Location Michael Sela AuditoriumHomepage Contact -
Date:01TuesdayDecember 2015Lecture
From metabolism to persistence and back
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Matthias Heinemann
Molecular systems biology University of GroningenOrganizer Department of Systems ImmunologyContact -
Date:01TuesdayDecember 2015Lecture
Sponges - ancient organisms innovative research
More information Time 11:15 - 11:15Location Ullmann Building of Life SciencesLecturer Dr. Ray Keren
Department of Zoology, Tel Aviv UniversityOrganizer Department of Plant and Environmental SciencesContact -
Date:01TuesdayDecember 2015Lecture
Systematic dissection of the role of dendritic cells in driving immune responses: from pathogen sensing to tumor elimination
More information Time 11:30 - 11:30Location Wolfson Building for Biological ResearchLecturer Dr. Oren Parnas
Broad InstituteOrganizer Department of Systems ImmunologyContact -
Date:01TuesdayDecember 2015Lecture
Blood sweat and tears: Social chemosignaling in human health and disease
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Noam Sobel
Department of Neurobiology, WISOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Most animals communicate using social chemosignals, namely c...» Most animals communicate using social chemosignals, namely chemicals emitted by one member of the species, which then produce chemical and behavioral changes in other members of the species. Such communication is prevalent in insects and terrestrial mammals, and mounting evidence implies that it is also common in human behavior, albeit primarily at a subliminal level. Human social chemosignals are responsible for a host of effects ranging from driving menstrual synchrony in women to conveying fear across individuals. Here I will describe our findings on mechanisms of human chemosignaling in both health and disease. Based on these findings I will argue that in contrast to common notions, humans are highly olfactory animals. -
Date:02WednesdayDecember 2015Lecture
Sphingosine-1-phosphate: a key regulator of the link between inflammation and cancer
More information Time 11:00 - 11:00Location Wolfson Building for Biological ResearchLecturer Prof. Sarah Spiegel
Professor and Chair, Department of Biochemistry and Molecular Biology Virginia Commonwealth University School of Medicine, USAOrganizer Department of Molecular Cell BiologyContact -
Date:02WednesdayDecember 2015Lecture
Do rare decays point to physics beyond the Standard Model
More information Time 11:00 - 11:00Location Technion, Lidow 502Lecturer Sebastian Jaeger
University of SussexOrganizer Department of Particle Physics and AstrophysicsHomepage Contact -
Date:02WednesdayDecember 2015Lecture
The Emergence of Pattern in Random Processes
More information Time 11:15 - 12:30Location Nella and Leon Benoziyo Physics BuildingLecturer Will Newman Organizer Nella and Leon Benoziyo Center for AstrophysicsContact Abstract Show full text abstract about We consider both time series as well as spatial distribution...» We consider both time series as well as spatial distributions (in 1-4 dimensions).
In the first, we observe that time series for individual and independently deviating random variables can manifest pattern through the emergence of peak-to-peak sequences that are visible to the eye yet fail all Fourier analysis schemes and reveal a seeming periodicity of 3-events per cycle. We note that this can explain observations of apparent cycles in mammalian animal populations. We consider models, as well, based on the Langevin equation of kinetic theory and the Smolouchowski relation that present circumstances where the apparent period can vary from 3-4 and, for a special subclass of problems, to periods between 2 and 3. We explore how cataloged observational data from global earthquake catalogues, magnetospheric AL index observations, Old Faithful Geyser eruption data, and the performance of the Standard & Poor's 500 index (percent daily variation) manifest different degrees of statistical agreement with the theory we derived. We present a simple model for many mammalian population cycles whose underlying phenomenological basis has strong biological implications.
We then employ directed graphs to explore nearest-neighbor relationships and isolate the character of spatial clustering in 1-4 dimension. We observe that the one-dimensional problem is formally equivalent to that presented by peak-to-peak sequences in time series and also demonstrates a mean number of points per cluster of 3 in one dimension. We then take the first moment of each of the clusters formed, and observed that they too form clusters.
We observe the emergence of a hierarchy of clusters and the emergence of universal cluster numbers, analogous to branching ratios and, possibly, Feigenbaum numbers. These, in turn, are related to fractals as well as succularity and lacunarity, although the exact nature of this connection has not been identified. Finally, we show how hierarchical clustering emerging from random distributions may help provide an explanation for observations of hierarchical clustering in cosmology via the virial theorem and simulation results relating to the gravitational stabilization in a self-similar way of very large self-gravitating ensembles. -
Date:02WednesdayDecember 2015Lecture
Towards a No-Lose Theorem for Naturalness
More information Time 13:00 - 13:00Location Technion, Lidow 502Lecturer Gabriel Lee
TechnionOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about http://arxiv.org/abs/1509.04284 ...» http://arxiv.org/abs/1509.04284
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Date:02WednesdayDecember 2015Cultural Events
The Israel camerata Jerusalem -Madam Look
More information Time 20:00 - 22:00Location Michael Sela AuditoriumContact -
Date:03ThursdayDecember 2015Lecture
Single cell analysis of HSV-1 infection (Virology Club meeting)
More information Time 10:00 - 11:00Title Oren Kobiler from TAU will talk about "Single cell analysis of HSV-1 infection"Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Oren Kobiler
Single cell analysis of HSV-1 infectionContact -
Date:03ThursdayDecember 2015Colloquia
Perturbations to worm sleep, weak and strong
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer David Biron
Chicago UniversityOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Sleep may be universal in the animal kingdom. Yet, the roles...» Sleep may be universal in the animal kingdom. Yet, the roles of sleep in organizing living mat-ter and the underlying reason for this universality remain controversial. Fundamental ques-tions under debate include the boundaries of this universality (do all animals sleep?), natural history (when did sleep evolve?), and core function (what for, originally?). The roundworm C. elegans is the simplest model system in which these questions can be addressed.
A key feature distinguishing sleep from other states of decreased activity is its intricate home-ostatic regulation: following disruptions, ‘restoring forces’ extend or modify sleep to compen-sate for the loss. This talk will describe measurements of three regimes of perturbations to worm sleep. We have shown that weak and intermediate perturbations reveal distinct man-ners in which small losses of worm sleep are compensated for. In addition, we have shown that stronger perturbations, causing substantial but nonlethal loss to worms sleep, inflicts long-term deficits. These deficits and the protective mechanisms that mitigate them are ex-pected to be directly linked to functions of sleep in this (phylogenetically) ancient model.
These findings add to the list of similarities between worm and vertebrate sleep and open the door to a better understanding of sleep’s core functions.
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Date:03ThursdayDecember 2015Lecture
Long Range Gene Regulation during Vertebrate Development and Evolution
More information Time 12:00 - 12:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Denis Duboule
School of Life Sciences, Federal Institute of Technology, Lausanne, SwitzerlandContact -
Date:03ThursdayDecember 2015Lecture
The Annual Chaim Weizmann Lecture in the Humanities
More information Time 19:30 - 21:00Title The Geopolitics of the Middle EastLocation Michael Sela AuditoriumLecturer Prof. Uzi Rabi
Head of The Moshe Dayan Center for Middle Eastern and African studies, Tel Aviv UniversityOrganizer Yad Chaim WeizmannContact -
Date:05SaturdayDecember 2015Cultural Events
Ben Ben Baruch - Stand up
More information Time 21:00 - 22:30Location Michael Sela AuditoriumHomepage Contact
