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נובמבר 02, 2015

  • Date:30שנינובמבר 2015

    Flux controls flux – how microbes regulate their metabolism

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    שעה
    09:15 - 11:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Matthias Heinemann
    Molecular systems biology University of Groningen
    מארגן
    המחלקה לאימונולוגיה מערכתית
    צרו קשר
    הרצאה
  • Date:30שנינובמבר 2015

    "Comparative studies of intrinsically disordered proteins"

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    שעה
    11:00 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Jane Clarke
    Department of Chemistry, University of Cambridge
    מארגן
    הפקולטה לכימיה
    צרו קשר
    תקצירShow full text abstract about In my laboratory we use a multidisciplinary approach to stud...»
    In my laboratory we use a multidisciplinary approach to study protein folding - how the linear sequence of amino acids in a polypeptide chain determines the structure to which it folds, the pathway by which it folds, and how it avoids misfolding. That is, how the primary sequence defines the entire energy landscape for folding.

    It has recently become apparent that many proteins are not, in fact folded, but they play important roles in the cell. These intrinsically disordered protein challenge the structure : function paradigm, and they have attracted significant interest from investigators in the fields of structural biology, bioinformatics and theory, but, relatively little work has been done using standard biophysical kinetics techniques pioneered in studies of protein folding

    Many key protein-protein interactions are driven by assembly of complexes where one or both partner proteins are intrinsically disordered before binding. In this case the free energy of binding has to compensate for the energetic cost of folding. We are comparing the folding of a number of different folding-upon binding systems to ask some fundamental questions about the mechanisms of folding upon binding: What is the importance of residual structure? What role does the ordered partner play? What is the mechanism of assembly? And, perhaps most fundamentally – what is the function of disorder? I will describe some of our recent findings.
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  • Date:30שנינובמבר 2015

    Restoration of tumor suppression: challenges and therapeutic opportunities

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    שעה
    11:00 - 11:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהProf. Ygal Haupt
    Peter MacCallum Cancer Centre, Melbourne, Australia
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:30שנינובמבר 2015

    "Skeletal Molding of Chiral Pool Compounds: C–C and C–H Bond Activation of Pinene"

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    שעה
    14:00 - 14:00
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהDr. Ahmad Masarwa
    UNIVERSITY OF CALIFORNIA, BERKELEY
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    הרצאה
  • Date:30שנינובמבר 2015

    Real-space condensation in mass transport models: statics, dynamics, and large deviations

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    שעה
    14:15 - 14:15
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהOri Hirschberg, Technion
    מארגן
    המחלקה לפיזיקה של מערכות מורכבות
    צרו קשר
    תקצירShow full text abstract about The formation of traffic jams on highways, the clustering of...»
    The formation of traffic jams on highways, the clustering of particles in shaken granular gases, and the emergence of macroscopically-linked hubs in complex networks are all examples of real-space condensation. This phase transition, in which a finite fraction of the “mass” in a macroscopic system is concentrated in a microscopic fraction of its volume, is rather ubiquitous in nonequilibrium systems. In this talk, I shall present some of the insights into these phenomena garnered from the study of prototypical toy models. After reviewing static properties of the condensation transition, I shall focus on two unexpected features recently discovered: (1) Spatial correlations, which generically exist in driven systems, may give rise to a collective motion of the condensate through the system. The mechanism behind this motion is explained using simplified models, and shown to be rather generic. (2) When the current flowing through a system is conditioned to have highly atypical values, condensates may form in systems that otherwise do not condense. I will present microscopic and macroscopic approaches to analyze this novel scenario of condensation.

    הרצאה
  • Date:30שנינובמבר 2015

    מנחה מוזיקלית "שלמה יידוב" הכניסה חופשית

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    שעה
    16:30 - 17:30
    מיקום
    אודיטוריום מיכאל סלע
    דף בית
    צרו קשר
    אירועי תרבות
  • Date:01שלישידצמבר 2015

    From metabolism to persistence and back

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    שעה
    10:00 - 11:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Matthias Heinemann
    Molecular systems biology University of Groningen
    מארגן
    המחלקה לאימונולוגיה מערכתית
    צרו קשר
    הרצאה
  • Date:01שלישידצמבר 2015

    Sponges - ancient organisms innovative research

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    שעה
    11:15 - 11:15
    מיקום
    בניין אולמן למדעי החיים
    מרצהDr. Ray Keren
    Department of Zoology, Tel Aviv University
    מארגן
    המחלקה למדעי הצמח והסביבה
    צרו קשר
    הרצאה
  • Date:01שלישידצמבר 2015

    Systematic dissection of the role of dendritic cells in driving immune responses: from pathogen sensing to tumor elimination

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    שעה
    11:30 - 11:30
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהDr. Oren Parnas
    Broad Institute
    מארגן
    המחלקה לאימונולוגיה מערכתית
    צרו קשר
    הרצאה
  • Date:01שלישידצמבר 2015

    Blood sweat and tears: Social chemosignaling in human health and disease

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    שעה
    12:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Noam Sobel
    Department of Neurobiology, WIS
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about Most animals communicate using social chemosignals, namely c...»
    Most animals communicate using social chemosignals, namely chemicals emitted by one member of the species, which then produce chemical and behavioral changes in other members of the species. Such communication is prevalent in insects and terrestrial mammals, and mounting evidence implies that it is also common in human behavior, albeit primarily at a subliminal level. Human social chemosignals are responsible for a host of effects ranging from driving menstrual synchrony in women to conveying fear across individuals. Here I will describe our findings on mechanisms of human chemosignaling in both health and disease. Based on these findings I will argue that in contrast to common notions, humans are highly olfactory animals.
    הרצאה
  • Date:02רביעידצמבר 2015

    Sphingosine-1-phosphate: a key regulator of the link between inflammation and cancer

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    שעה
    11:00 - 11:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהProf. Sarah Spiegel
    Professor and Chair, Department of Biochemistry and Molecular Biology Virginia Commonwealth University School of Medicine, USA
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:02רביעידצמבר 2015

    Do rare decays point to physics beyond the Standard Model

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    שעה
    11:00 - 11:00
    מיקום
    Technion, Lidow 502
    מרצהSebastian Jaeger
    University of Sussex
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    דף בית
    צרו קשר
    הרצאה
  • Date:02רביעידצמבר 2015

    The Emergence of Pattern in Random Processes

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    שעה
    11:15 - 12:30
    מיקום
    בניין לפיזיקה על-שם נלה וליאון בנוזיו
    מרצהWill Newman
    מארגן
    מרכז לאסטרופיסיקה עש נלה וליאון בנוזיו
    צרו קשר
    תקצירShow full text abstract about We consider both time series as well as spatial distribution...»
    We consider both time series as well as spatial distributions (in 1-4 dimensions).
    In the first, we observe that time series for individual and independently deviating random variables can manifest pattern through the emergence of peak-to-peak sequences that are visible to the eye yet fail all Fourier analysis schemes and reveal a seeming periodicity of 3-events per cycle. We note that this can explain observations of apparent cycles in mammalian animal populations. We consider models, as well, based on the Langevin equation of kinetic theory and the Smolouchowski relation that present circumstances where the apparent period can vary from 3-4 and, for a special subclass of problems, to periods between 2 and 3. We explore how cataloged observational data from global earthquake catalogues, magnetospheric AL index observations, Old Faithful Geyser eruption data, and the performance of the Standard & Poor's 500 index (percent daily variation) manifest different degrees of statistical agreement with the theory we derived. We present a simple model for many mammalian population cycles whose underlying phenomenological basis has strong biological implications.
    We then employ directed graphs to explore nearest-neighbor relationships and isolate the character of spatial clustering in 1-4 dimension. We observe that the one-dimensional problem is formally equivalent to that presented by peak-to-peak sequences in time series and also demonstrates a mean number of points per cluster of 3 in one dimension. We then take the first moment of each of the clusters formed, and observed that they too form clusters.
    We observe the emergence of a hierarchy of clusters and the emergence of universal cluster numbers, analogous to branching ratios and, possibly, Feigenbaum numbers. These, in turn, are related to fractals as well as succularity and lacunarity, although the exact nature of this connection has not been identified. Finally, we show how hierarchical clustering emerging from random distributions may help provide an explanation for observations of hierarchical clustering in cosmology via the virial theorem and simulation results relating to the gravitational stabilization in a self-similar way of very large self-gravitating ensembles.
    הרצאה
  • Date:02רביעידצמבר 2015

    Towards a No-Lose Theorem for Naturalness

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    שעה
    13:00 - 13:00
    מיקום
    Technion, Lidow 502
    מרצהGabriel Lee
    Technion
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about http://arxiv.org/abs/1509.04284 ...»
    http://arxiv.org/abs/1509.04284
    הרצאה
  • Date:02רביעידצמבר 2015

    הקאמרטה הישראלית ירושלים -גברת הביטי

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    שעה
    20:00 - 22:00
    מיקום
    אודיטוריום מיכאל סלע
    צרו קשר
    אירועי תרבות
  • Date:03חמישידצמבר 2015

    Single cell analysis of HSV-1 infection (Virology Club meeting)

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    שעה
    10:00 - 11:00
    כותרת
    Oren Kobiler from TAU will talk about "Single cell analysis of HSV-1 infection"
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהDr. Oren Kobiler
    Single cell analysis of HSV-1 infection
    צרו קשר
    הרצאה
  • Date:03חמישידצמבר 2015

    Perturbations to worm sleep, weak and strong

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    שעה
    11:15 - 12:30
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהDavid Biron
    Chicago University
    מארגן
    הפקולטה לפיזיקה
    צרו קשר
    תקצירShow full text abstract about Sleep may be universal in the animal kingdom. Yet, the roles...»
    Sleep may be universal in the animal kingdom. Yet, the roles of sleep in organizing living mat-ter and the underlying reason for this universality remain controversial. Fundamental ques-tions under debate include the boundaries of this universality (do all animals sleep?), natural history (when did sleep evolve?), and core function (what for, originally?). The roundworm C. elegans is the simplest model system in which these questions can be addressed.

    A key feature distinguishing sleep from other states of decreased activity is its intricate home-ostatic regulation: following disruptions, ‘restoring forces’ extend or modify sleep to compen-sate for the loss. This talk will describe measurements of three regimes of perturbations to worm sleep. We have shown that weak and intermediate perturbations reveal distinct man-ners in which small losses of worm sleep are compensated for. In addition, we have shown that stronger perturbations, causing substantial but nonlethal loss to worms sleep, inflicts long-term deficits. These deficits and the protective mechanisms that mitigate them are ex-pected to be directly linked to functions of sleep in this (phylogenetically) ancient model.

    These findings add to the list of similarities between worm and vertebrate sleep and open the door to a better understanding of sleep’s core functions.
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  • Date:03חמישידצמבר 2015

    Long Range Gene Regulation during Vertebrate Development and Evolution

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    שעה
    12:00 - 12:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Denis Duboule
    School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland
    צרו קשר
    הרצאה
  • Date:03חמישידצמבר 2015

    הרצאה שנתית במדעי הרוח על שם חיים ויצמן

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    שעה
    19:30 - 21:00
    כותרת
    הגאופוליטיקה המשתנה של המזרח התיכון
    מיקום
    אודיטוריום מיכאל סלע
    מרצהProf. Uzi Rabi
    Head of The Moshe Dayan Center for Middle Eastern and African studies, Tel Aviv University
    מארגן
    יד חיים וייצמן
    צרו קשר
    הרצאה
  • Date:05שבתדצמבר 2015

    בן בן ברוך - סטנד אפ

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    שעה
    21:00 - 22:30
    מיקום
    אודיטוריום מיכאל סלע
    דף בית
    צרו קשר
    אירועי תרבות

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