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February 18, 2016
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Date:29TuesdayMarch 2016Lecture
Excitation-inhibition interplay in the thalamocortical pathway controls timing of motor actions
More information Time 12:30 - 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Prof. Yifat Prut
Dept of Medical Neurobiology, IMRIC and ELSC,The Hebrew University, Hadassah Medical School, JerusalemOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Proper performance of voluntary movements requires the integ...» Proper performance of voluntary movements requires the integration of both spatial and temporal information about the ensuing movements. The timing of actions is often considered to be dictated by cerebellar output that is relayed to the motor cortex via the motor thalamus. We investigated the mechanisms by which the cerebellar-thalamo-cortical (CTC) system controls temporal properties of motor cortical activity.
We found that in primates the CTC pathway efficiently recruits motor cortical neurons in primary motor and premotor areas. Cortical responses to CTC activation were dominated by prolonged inhibition mediated by a feedforward mechanism. We further found that cortical cells that integrated CTC input fired transiently and synchronously at movement onset, when the timing of action is dictated. Moreover, when preventing the flow of information in the pathway the phasic firing at movement onset was reduced, but the preferred direction of the cells remained unchanged. These changes in neural firing were correlated with altered motor behavior: the monkeys were able to perform the task but with increased reaction and movement times.
These results suggest that the CTC system affects cortical firing by changing the excitation-inhibition balance at movement onset in an extensive network of TC-activated motor cortical neurons. In this manner, the temporal pattern of neural firing is shaped, and firing across groups of neurons is synchronized to generate transiently enhanced firing.
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Date:29TuesdayMarch 2016Cultural Events
Movie - WINDING about Hayarkon river
More information Time 16:30 - 18:30Location Michael Sela AuditoriumContact -
Date:30WednesdayMarch 2016Lecture
ACTION NOW
More information Time 10:00 - 17:00Title WANDERING SEMINARLocation Jacob Ziskind BuildingOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:30WednesdayMarch 2016Lecture
Small Molecule-induced Cell Fate Reprogramming
More information Time 11:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. HongKui Deng
Director of Stem Cell Research Center, Peking University, Beijing, ChinaContact -
Date:31ThursdayMarch 2016Conference
Cultural changes during the Ghassulian period
More information Time All dayLocation The David Lopatie Conference CentreChairperson Elisabetta BoarettoContact -
Date:31ThursdayMarch 2016Colloquia
"Nanostructured Polymer Hybrids"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Ulrich B. Wiesner
Cornell UniversityOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Solutions to global problems including energy conversion and...» Solutions to global problems including energy conversion and storage, clean water and human health require increasingly complex, multi-component hybrid materials with unprecedented control over composition, structure, and order down to the nanoscale. This talk will give examples for the rational design of novel functional hybrid materials starting from nanoparticles and moving into their composites with polymers. These materials are often based on the self-assembly of block copolymers as structure directing molecules for polymer-inorganic hybrid materials. Discussion will include formation of synthetic porous materials with amorphous, polycrystalline, and epitaxially grown single-crystal structures. Experiments will be compared to theoretical predictions to provide physical insights into formation principles. The aim of the described work is to understand the underlying fundamental chemical, thermodynamic and kinetic formation principles enabling generalization of results over a wide class of materials systems. Examples will cover the formation of hierarchical structures at equilibrium as well as via processes far away from equilibrium. Targeted applications of the prepared systems will include the development of fluorescent hybrid probes for nanomedicine, nanostructured hybrids for energy conversion and storage devices, as well as the formation of first self-assembled superconductors. -
Date:31ThursdayMarch 2016Colloquia
On the Discovery of Super-heavy Nuclei
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Sigurd Hofmann
GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany and Institute for Physics, Goethe University, Frankfurt, GermanyOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Scientifically based attempts to synthesize new elements bey...» Scientifically based attempts to synthesize new elements beyond uranium started in the middle of the 1930's, when the atomic model was established and the constituents of the atomic nucleus, protons and neutrons, were known. In this talk I will present a short history from early searches for ‘trans-uraniums’ up to the production and safe identification of shell-stabilized ‘Super-Heavy Nu-clei (SHN)’. The nuclear shell model reveals that these nuclei should be located in a region with closed shells for the protons at Z = 114, 120 or 126 and for the neutrons at N = 184. The outstanding aim of experimental investigations is the exploration of this region of spherical SHN. Experimental methods are described, which allowed for the identification of these nuclei. Systematic studies of heavy ion reactions for the synthesis of SHN revealed production cross-sections which reached values down to one picobarn and even below for the heaviest species. The systematics of measured cross-sections can be understood only on the basis of relatively high fission barriers as predicted for nuclei in and around the island of SHN. A key role in answering some of the open questions plays the synthesis of isotopes of element 120. Attempts aiming for synthesizing this element at the velocity filter SHIP will be reported. Finally, plans are presented for the further development of the experimental set-ups. Efforts performed at various laboratories will eventually reveal the change of shell strength as function of proton and neutron number, the location of the most stable nuclei and how long their lifetime will be, the optimum method of their production, and, possibly, the existence of nucleonic arrangements and shapes, which are presently still objects of speculation.
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Date:31ThursdayMarch 2016Lecture
Spotlight on Science: Aspects of faith and territories
More information Time 12:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Nira Pereg
Video ArtistOrganizer Department of Life Sciences Core FacilitiesContact -
Date:31ThursdayMarch 2016Cultural Events
Ori Hezkiah - Stand up
More information Time 21:30 - 21:30Location Michael Sela AuditoriumContact -
Date:03SundayApril 2016Lecture
Deciphering Jupiter's internal flow using the Juno gravity measurements and an adjoint based dynamical model
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Dr. Eli Galanti
Earth and Planetary Sciences Weizmann Institute of ScienceOrganizer Department of Earth and Planetary SciencesContact -
Date:03SundayApril 2016Lecture
To be announced
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Santosh Kumar
Adi Kimchi's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:04MondayApril 2016Conference
G-INCPM International Workshop 2016
More information Time All dayLocation The David Lopatie Conference CentreChairperson Berta StruloviciContact -
Date:04MondayApril 2016Lecture
A mechanistic model of Macaque V1 cortex
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Lai-Sang Young
Courant Institute of Mathematical Sciences New York UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about I will report on some recent computational modeling work on ...» I will report on some recent computational modeling work on the Macaque visual cortex. My co-authors Bob Shapley, Logan Chariker and I have constructed a semi-realistic model of LGN-to-4Ca, the input layer to V1 in the magnocellular pathway. As with most modeling work, our aim was to understand how cortex responds to stimuli. To do that, many authors have postulated transducer functions for specific sets of stimuli. We have chosen to take a fundamentally different route: we have chosen to simulate how cortex works, by simulating cortical dynamics on the level of neuron-to-neuron interactions. Using a single network model, we have been able to reproduce as emergent phenomena a fairly comprehensive set of experimental observations, including orientation selectivity, simple and complex cells, gamma rhythms etc. Specific aims of this project were (1) to reconcile the picture of Hubel & Wiesel with the sparseness of LGN, (2) to address the extent to which cortex is driven by feedforward vs recurrent inputs, (3) to replicate and explain the diversity of neuronal responses seen in real cortex, and (4) to connect all of the above to dynamical interactions in local neuronal populations. -
Date:04MondayApril 2016Lecture
Hematopoietic Stem cells and Niches under Stress
More information Time 14:00 - 15:00Title Department of Immunology Special Guest SeminarLocation Wolfson Building for Biological ResearchLecturer Toshio Suda, MD, PhD
Cancer Science Institute, National University of SingaporeOrganizer Department of Systems ImmunologyContact -
Date:04MondayApril 2016Cultural Events
The Israel Camerata Jerusalem
More information Time 20:00 - 22:00Title Lider and other art songsLocation Michael Sela AuditoriumContact -
Date:05TuesdayApril 2016Lecture
Weizmann Women and Science Award 2015 – Prof. Barbara Liskov
More information Time 11:00 - 11:00Title “The Power of abstraction“Location Dolfi and Lola Ebner AuditoriumLecturer Prof. Barbara Liskov
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, USAContact -
Date:05TuesdayApril 2016Lecture
Ecological implications of interplant communication’
More information Time 11:15 - 11:15Location Ullmann Building of Life SciencesLecturer Prof. Ariel Novoplansky
Mitrani Department of Desert Ecology, Blaustein Institutes for Desert Research, Ben-Gurion University of the NegevOrganizer Department of Plant and Environmental SciencesContact -
Date:05TuesdayApril 2016Lecture
Shaping neural circuits by high order synaptic interactions
More information Time 12:30 - 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Dr. Yoram Burak
Racah Institute of Physics and Safra Center for Brain Sciences, Hebrew University of JerusalemOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Local brain circuits are believed to exhibit diverse connect...» Local brain circuits are believed to exhibit diverse connectivity patterns. It is not yet clear to what extent these patterns are hard-wired genetically, or whether they arise during development under the influence of local plasticity mechanisms. In this talk I will address how spike-timing dependent plasticity (STDP) may affect the global structure of a neural circuit. We recently developed a theoretical framework that allows to address the consequences of STDP in recurrent neural circuits of arbitrary connectivity. I will show that in addition to the local influence of STDP on the synapses that connect pairs of neurons reciprocally, STDP induces non-local interactions between synapses of different neurons. These "high-order" interactions, which were neglected in previous studies, can have a pivotal influence on the global structure of a neural network in steady state. As an example, I will consider in the talk the spontaneous formation of two simple structures: wide synfire chains, in which groups of neurons project to each other sequentially, and self connected assemblies - both of which are important models for generation of structured neural dynamics. I will show that with appropriate choice of the biophysical parameters, these ordered structures can emerge autonomously under the influence of STDP and heterosynaptic competition, without exposing the neural network to any structured external inputs during learning. If time permits, I will also present briefly another recent work, concerned with the coding of an animal's position by grid cells in the entorhinal cortex. -
Date:05TuesdayApril 2016Lecture
Predicting the evolutionary pathway to virulence of an RNA virus
More information Time 14:00 - 14:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Adi Stern Organizer Department of Chemical and Structural BiologyContact -
Date:05TuesdayApril 2016Cultural Events
Cinderella - Children's Theater
More information Time 17:30 - 19:00Location Michael Sela AuditoriumContact
