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June 01, 2018
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Date:15ThursdayNovember 2018Lecture
Cancer Volatolomics: From Evidence to Point-of-Care Diagnostics
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. Hossam Haick
Department of Chemical Engineering and the Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, HaifaOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about The current talk will present evidences that each cancer has...» The current talk will present evidences that each cancer has its own unique volatile molecular print and, therefore, the presence of one cancer would not screen out others. Based on this concept, a new generation of biomedical devices for achieving personalized diagnosis of various cancers in a noninvasive, inexpensive and portable manner via various body fluids (e.g., breath or skin) will be presented and discussed. -
Date:18SundayNovember 201823FridayNovember 2018Conference
5th European Conference on Trapped ions
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Roee Ozeri -
Date:18SundayNovember 2018Lecture
The role of ocean circulation in the climate’s response to anthropogenic emissions
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Dr. Rei Chemke
Columbia UniversityOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about The effects of ocean circulation on the climate’s response t...» The effects of ocean circulation on the climate’s response to anthropogenic emissions at low and high latitudes are examined. At high latitudes, we examine the effects of ocean circulation on the North Atlantic sea surface temperature, which has large climate impacts in the Northern Hemisphere. In recent years and in climate projections a cooling trend is found in the North Atlantic surface (the North Atlantic warming hole). Using observations and large ensemble of model simulations, we find that since the beginning of 21st century there has been a reduction in surface meridional heat advection, which cools the North Atlantic midlatitudes and is part of an emerged forced response to anthropogenic emissions and not part of internal climate variability, and thus projected to continue in coming decades.
At low latitudes, the Hadley cell plays an important role in setting the strength and position of the hydrological cycle. Climate projections show a weakening of the Hadley cell, together with widening of its vertical and meridional extents. These changes are projected to have profound global climatic impacts. Current theories for the Hadley cell response to increased greenhouse gases account only for atmospheric and oceanic thermodynamic changes, but not for oceanic circulation changes. Here, the effects of ocean circulation changes on the Hadley cell response to increased greenhouse gases are examined. First, using a hierarchy of ocean-model configurations under increased greenhouse gases or arctic sea-ice loss, we show that, by cooling the surface and atmosphere, ocean circulation contracts and strengthens the Hadley cell, and thus reduces its projected response.
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Date:18SundayNovember 2018Lecture
Molecular Genetics Departmental Seminars 2018-2019
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchOrganizer Department of Molecular GeneticsContact -
Date:18SundayNovember 2018Lecture
Molecular Genetics Departmental Seminars 2018-2019
More information Time 13:00 - 13:00Title “Dynamics of a morphogen gradient shapes gastrulation”Location Arthur and Rochelle Belfer Building for Biomedical ResearchOrganizer Department of Molecular GeneticsContact -
Date:19MondayNovember 2018Lecture
Special Guest Seminar
More information Time 10:00 - 10:00Title The making of an organ- A roadmap towards pancreatic islet formationLocation Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Nadav Sharon
Department of stem cells and regenerative biology, Harvard UniversityOrganizer Department of Molecular GeneticsContact -
Date:19MondayNovember 2018Lecture
Chemical and Biological Physics Guest Seminar
More information Time 10:30 - 10:30Title Internal Waves in the Ocean: what we know and what we do notLocation Perlman Chemical Sciences BuildingLecturer Prof Yuri Lvov
Mathematical Sciences Department, Rensselaer Polytechnic Institute, Troy, NYOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about The term “ocean waves” typically evokes images of surface wa...» The term “ocean waves” typically evokes images of surface waves shaking ships during storms in the open ocean, or breaking rhythmically near the shore. Yet much of the ocean wave action takes place far underneath the surface, and consists of surfaces of constant
density being disturbed and modulated. These -internal waves- are ubiquitous in the ocean, contain a large amount of ocean energy, and play an important role in the ocean circulation since they transfer energy from large to small scales and thus provide a link between climatological forcing and small-scale dissipation.
Yet, despite internal wave ubiquity, energy, and decades of study we still do not understand how the energy cascades through the internal wave spectrum.
In this talk the traditional wave turbulence formulation of internal wave interaction will be discussed, and rebutted: internal waves are too nonlinear to be accurately described by the kinetic equation. So we are in the midst of something gloriously messy and nonlinear. We
will propose an alternative formulation based on the hypothesis of scale separated (nonlocal) interactions in momentum space.
This is joined work with Dr. Kurt Polzin from whoi.edu
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Date:20TuesdayNovember 2018Lecture
Nuclear Genome Nanostructure Imaging at Single Molecule Resolution
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Christoph Cremer
1Institute of Molecular Biology (IMB) & Max-Planck Institute for Chemistry, D-55128 Mainz/Germany; 2Institute for Pharmacy and Molecular Biotechnology (IPMB), University Heidelberg & Kirchhoff-Institute for Physics (KIP), D-69120 Heidelberg/Germany e-mail: c.cremer@imb-mainz.de; cremer@kip.uni-heidelberg.de www.optics.imb-mainz.deOrganizer Department of Molecular GeneticsContact Abstract Show full text abstract about Super-resolution fluorescence microscopy allows quantitative...» Super-resolution fluorescence microscopy allows quantitative studies of nuclear genome organization on the nanoscale1. Here we report on results obtained by single molecule localization microscopy (SMLM). SMLM has made possible to explore chromatin nanostructure down to the imaging of single histones, of short oligosequences, or single DNA sites; presently, an intranuclear optical resolution down to the 5 nm range has been achieved. Applying a novel SMLM technique (fBALM)2, the DNA distribution across entire nuclei at nanoscale resolution was quantitatively determined, localizing in individual nuclear optical sections up to ~4 million individual DNA bound single fluorophore molecule positions, corresponding to about one position per nucleosome. Intensity profile analyses of the intranuclear DNA distributions indicated sharp transitions between high-density domains and low-density compartments, with differences up to almost two orders of magnitude; compacted regions had a minimum diameter down to ca. 50 nm diameter. In contrast to these results, conventional resolution imaging of the same nuclear sites indicated only small differences in the compaction of different regions, combined with very smooth density transitions. Taken together, the quantitative compaction estimates support models of a nuclear organization based on highly compartmentalized chromatin nanostructures3. -
Date:20TuesdayNovember 2018Lecture
Genetics with no sex— Somatic recombination in plant cells.
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Avraham Levi
Dept. of Plant and Environmental Sciences- WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Homologous recombination is an engine of genetic diversity i...» Homologous recombination is an engine of genetic diversity in evolution and in plant breeding. This process typically occurs during meiosis when homologous chromosomes pair and exchange DNA segments. It is a stochastic and infrequent process; closely linked genes rarely recombine and it is limited to sexual reproduction. We showed recently that inter-homologues recombination can be targeted at specific loci, using a CRISPR-Cas-induced DNA double strand break in plant somatic tissues. We discuss the mechanisms of somatic recombination and the prospect for redesigning chromosomes in a targeted manner in crops with or without sexual reproduction. -
Date:20TuesdayNovember 2018Lecture
Carbopalladation Cascades – Not only syn, but also anti
More information Time 11:00 - 12:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Dr. Daniel B. Werz
University of BraunschweigOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about A characteristic feature of carbopalladation reactions is th...» A characteristic feature of carbopalladation reactions is the syn-attack of the organopalladium
species LnX[Pd]-R on the reacting π-system.[1] Such a step results in
compounds bearing Pd and R on the same side of the originating alkene moiety.
Embedded into longer domino sequences complex structures are efficiently obtained by
a repetition of this syn-carbopalladation step. In this way, linear oligoynes were cyclized
in a dumbbell-mode and led to benzene-type structures or higher oligoenes.[1]
We exploited this chemistry to synthesize not only chromans, isochromans[2] and
dibenzopentafulvalenes,[3] but also to access the most truncated π-helicenes which only
consist of a Z,Z,Z,..-oligoene chain that is fixed in an all s-cis arrangement.[4] All these
domino processes are based on a syn-carbopalladation cascade.
However, a carbopalladation cascade involving formal anti-carbopalladation steps opens
new avenues to create compounds with tetrasubstituted double bonds (Scheme 1). Such
a process was realized, and mechanistically and computationally investigated. The
synthetic potential was demonstrated for the preparation of various oligocyclic
frameworks (including natural products) by making use of a variety of different
terminating processes.[5] -
Date:20TuesdayNovember 2018Lecture
Development of Memory Systems in the Human Brain
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Noa Ofen
Department of Psychology Institute of Gerontology and Merrill Palmer Institute for Child Development Wayne State University, DetroitOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Episodic memory – the ability to encode, maintain and retrie...» Episodic memory – the ability to encode, maintain and retrieve information – is critical for everyday functioning at all ages, yet little is known about the development of episodic memory systems and their brain substrates. In this talk, I will present data from a series of studies with which we begin to identify how brain development underlies changes in episodic memory throughout childhood and adolescence. Using structural MRI data, I will present evidence demonstrating how brain development sets limits on cognitive developmnet. I will show that individual differences in fine structural measures of the hippocampus, a region known to be critical for episodic memory, and the prefrontal cortex (PFC), a region that shows protracted structural development, partially explain age-related improvement in episodic memory. Using functional neuroimaging methods including functional MRI (fMRI) and electrocorticography (ECoG), I will present our ongoing attempts to characterize the neural correlates of episodic memory development. Evidence from fMRI studies suggest that age differences in episodic memory functioning may primarily relate to age differneces in PFC activation and connectivity patterns. Intracranial evidence further underscores the role of the PFC in memory and reveals that spatiotemporal propagation of frontal activity supports memory formation in children. I will highlight the challenges in investigaitons of brain-behavior relations in pediatric populations and discuss how advances in methodologies provide unique opportunities for moving towards a mechanistic understanding of developmental changes. -
Date:21WednesdayNovember 201823FridayNovember 2018Lecture
Minerva Workshop on Lie Algebras and Related Topics
More information Time All dayLocation Elaine and Bram Goldsmith Building for Mathematics and Computer SciencesOrganizer Department of MathematicsHomepage Contact -
Date:21WednesdayNovember 2018Lecture
Imm Special Guest Seminar: Prof.Bertie Gottgens, will lecture about "A Single Cell Molecular Roadmap of Early Embryonic Blood Cell Development”
More information Time 10:00 - 11:00Location Max and Lillian Candiotty BuildingLecturer Prof.Bertie Gottgens Organizer Department of Systems ImmunologyContact -
Date:21WednesdayNovember 2018Lecture
Novel Nanophotonics in the Ultrafast Transmission Electron Microscope
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Ido Kaminer
Department of Electrical Engineering and Solid State Institute, TechnionOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about We will discuss new science and applications enabled by the ...» We will discuss new science and applications enabled by the ultrafast interactions of electrons and laser pulses inside electron microscopes.
Such interactions enable novel microscopy techniques with time-correlated measurements and the new method of stimulated electron energy loss spectroscopy (SEELS).
From the standpoint of fundamental science, controlling ultrafast strong-field interactions inside electron microscopes enable exploring new principles for generating extreme ultraviolet and x-ray radiation, as well as novel light-matter interactions in nanostructures and in 2D materials.
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Date:21WednesdayNovember 2018Lecture
Spotlight on Science
More information Time 12:00 - 12:00Title Single-Cell Genomics Reveals a Novel Regulatory Role of the Immune System in ObesityLocation Gerhard M.J. Schmidt Lecture HallLecturer Dr. Diego Jaitin Contact -
Date:22ThursdayNovember 2018Lecture
Small Animal Brain Diffusion Imaging: From White Matter Evolution to Brain Disease Diagnosis
More information Time 10:00 - 11:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Hao Lei
Department State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics, Chinese Academy of SciencesOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about White matter (WM) plays a central role in the long-range con...» White matter (WM) plays a central role in the long-range connection and coordinated communication between different brain regions. Diffusion magnetic resonance imaging (DMRI) uses the diffusion of water molecules as an endogenous probe to characterize WM microstructural integrity in and structural connectivity of the brain. The usefulness of DMRI in clinical settings and basic neuroscience research has been fully demonstrated. Our laboratory has been using DMRI and DMRI-based tractography to study normal and diseased brain of small animals (i.e., rodents and tree shrews) in the last ten years. In this talk, I will share some of these experiences, focusing on two stories. The first is the use of a super-resolution DMRI approach to reveal fine anatomical architecture in the brain of tree shew, and how the WM configuration in this squirrel-like mammal compared with the others on the evolutionary tree. The second is concerning the histological underpinning of dMRI changes in rat models of neurodegenerative diseases. -
Date:22ThursdayNovember 2018Colloquia
Manipulating atoms with light: laser cooling to Bose-Einstein condensation and 51 atomic qubits
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Prof. Vladan Vuletic
Department of Physics, Massachusetts Institute of Technology, USAOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Since the first demonstration of laser cooling and trapping ...» Since the first demonstration of laser cooling and trapping three decades ago, our abilities to manipulate atomic ensembles and individual atoms with light have been substantially extended. Among those novel capabilities, I will discuss a new method how to directly optically cool an atomic gas to form a Bose-Einstein condensate, without any evaporation. I will also discuss the deterministic preparation of a large array of individual atoms with controlled optically induced long-range Ising type interactions for quantum simulation, and potentially, quantum computing.
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Date:22ThursdayNovember 2018Lecture
The Inspirational Brain: Human Non-Olfactory Cognition is Phase-Locked with Sniffing
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Ofer Perl (PhD Thesis Defense)
Noam Sobel Lab, Dept of Neurobiology, WISOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Olfactory stimulus acquisition is perfectly synchronized wit...» Olfactory stimulus acquisition is perfectly synchronized with inhalation, which tunes neuronal ensembles for incoming information. Because olfaction is an ancient sensory system that provided a template for brain evolution, we hypothesized that this link persisted, and therefore sniffs may tune the brain for acquisition of non-olfactory information as well. To test this, we measured nasal airflow and electroencephalography during various non-olfactory cognitive tasks. We observed that participants spontaneously inhale at non-olfactory cognitive task onset, and that such inhalations shift brain functional network architecture. Concentrating on visuospatial perception, we observed that inhalation drove increased task-related brain activity in specific task-related brain regions, and resulted in improved performance accuracy in the visuospatial task. Thus, mental processes with no link to olfaction are nevertheless phase-locked with sniffing, consistent with the notion of an olfaction-based template in the evolution of human brain function. -
Date:22ThursdayNovember 2018Lecture
What would Weizmann, Bialik and Leah Goldberg say about the current situation in Israel for better and for best?
More information Time 19:30 - 21:30Location Dolfi and Lola Ebner AuditoriumOrganizer Yad Chaim WeizmannContact -
Date:25SundayNovember 2018Lecture
TBA
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Yaron Katzir
BGUOrganizer Department of Earth and Planetary SciencesContact
