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Prof. Zippora Shakked
Crystal structure and solution studies of DNA oligomers.Collaboration with: Donald Crothers (Yale University)DNA regulatory elementsDNA bending by adenine-thymine tractsStructural and biochemical studies of proteins involved in transcriptional regulation.The tumor-suppressor protein p53 and its interaction with DNA and the basal transcription machineryThe leukemia-related RUNX1(AML1) transcription regulator
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Prof. Yechiel Shai
Membrane-protein interaction and molecular recognition within the membrane milieu. Implication to the function and structure of membrane proteins.Assembly and organization of pore forming toxins and ion channels in membranes: Studies with isolated fragments and intact proteins.Molecular mechanism of membrane fusion and its inhibition: Studies with HIV and Sendai Virus.Molecular basis for cell selectivity by cytolytic antimicrobial peptides.
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Prof. Idit Shachar
Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemiaCollaboration with: Dr Michal Haran, Kaplan Medical centerFollow the mechanisms controlling homing of immune cells in health and disease.Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.
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Prof. Menahem Segal
Intracellular calcium and structural/functional plasticity in cultured neurons.Collaboration with: Dr. Eduard KorkotianHuman Embryonic Stem Cells of Fragile X patientsCollaboration with: Prof. Dalit Ben Yosef (TAU)Network activity in cultured neuronsCollaboration with: Professor Elisha Moses (Physics)
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Prof. Michal Schwartz
Brain-immune axis in Health and Diseases; from gene to behaviorCollaboration with: Prof. Ido AmitImmunotherapy to defeat Alzheimer’s diseaseMicrobiome and Alzheimer’s diseaseCollaboration with: Prof. Eran ElinavDiabetes as a risk factor in Alzheimer’s diseaseCollaboration with: Prof. Naomi Habib, Hebrew University; Prof. Anna Greka, Broad Institute, Boston, USA.The Spleen –Brain axis in Alzheimer’s diseaseFamilial Alzheimer’s diseaseCollaboration with: Prof. Judit Aaron, Rambam hospital; Prof. Falik, Hagalil Hospital.ALS profiling at the transcriptomic levelCollaboration with: Prof. Ido AmitImmuno-Proteasome in Alzheimer’s diseaseCollaboration with: Dr. Yifat Marbl
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Prof. Oren Schuldiner
A genetic dissection of developmental axon regenerationMolecular mechanisms of neuronal remodeling during development: Developmental axon pruning in DrosophilaThe role of cell-cell interaction in regulating developmental axon pruningThe role of intracellular signaling in regulating developmental axon pruningThe role of trafficking in regulating developmental axon pruningGlia and their effect on neuronal growth and remodeling
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Prof. Maya Schuldiner
Uncovering tethers, functions and regulators of membrane contact sites in yeastMitochondria-ER contact sitesPeroxisome-Lipid Droplet contact sitesNucleus-Mitochondria contact sitesThe proteome of contact sitesTargeting and translocation to OrganellesUncovering a role for the Ssh1, the alternative, translocon in yeastDeciphering targeting of proteins to mitochondriaTargeting of membrane proteins to peroxisomesTargeting of low-hydrophobicity SS proteins to the ERTargeting of proteins to the surface of the ERUncovering new peroxisomal proteins and their functionsCollaboration with: Dr. Einat ZalckvarMetabolite transport across the peroxisome membranePeroxisome contact sitesPeroxisome quality controlPeroxisome targetingNew peroxisomal enzymes and their functionsPexophagyPeroxisomes in metabolismNovel methodologies for systematic exploration of yeast organelle protein functionsCreation of versatile yeast librariesHigh throughput electron microscopy techniquesTranslocation sensors
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