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Prof. Michel Revel
Applications of IL-6 Chimera and Interferon-beta in neurology, hematopoiesis, and oncology.Collaboration with: J. ChebathInterleukin-6 Chimera, a superactivator of the gp130 receptor system: role in nerve myelination, neuroprotection and in the development of neuro-glial cells from embryonic tissues and stem cells.Collaboration with: J. ChebathTransdifferentiation of neural crest cell derived melanoma into myelinating Schwann cell. Genes controlling cell growth, differentiation, melanogenesis and synthesis of myelin proteins.Collaboration with: J. Chebath
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Prof. Yair Reisner
Immature dendritic cells: investigating a novel granule mediated killing mechanism and the therapeutic potential for the prevention of Graft versus Host Disease.Crossing allogeneic and xenogeneic barriers by growing organs in-vivo from embryonic tissues : potential curative approaches for diabetes, hemophilia and lung diseases.Hematopoietic size control: A novel role for coagulation cascade factors in regulating the interplay between dynamic bone structure and long term survival and mobilization of hematopoietic stem cells.Developing a protocol for the production of human central memory CD8 T cells, to induce tolerance in allogeneic stem cell transplantation.Investigating the use of activated CD8 T cells as novel cell therapy for the treatment of autoimmune diseases.Role and mechanism of tolerance induction by activated CD8 T cells: A novel cell therapy for chimerism induction, stem cell transplant engraftment and enhanced Graft versus Lymphoma / Leukemia effect.
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Prof. Orly Reiner
Formation of the brain structure in human is a complex process. One of the most striking features of the human brain is characteristic convolutions. These convolutions are lacking in a severe human brain malformation known as lissencephaly (smooth brain).Identification of genes that are downstream to Lis1 mutation using microarray technology.Study of LIS1 and DCX functions through characterization of protein interactionsAnalysis of the developmental function of LIS1, DCX and Doublecortin-like-kinase using gene targeting in the mouse.Functional Analysis of Genes Involved in Lissencephaly.
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Prof. Itamar Procaccia
Ageing in disordered materialsCollaboration with: George Hentschel, Bhanu Bhowmik, Harish CharanMechanical properties and instabilities in amorphus solidsCollaboration with: Valery Ilyin, George Hentschel, Prasenjit Das, Chandana Mondal, Saikat Roy, Avanish KumarFractal Growth Patterns.Collaboration with: Eviatar B. Procaccia, Arik YochelisDenisty of States in amorphous solidCollaboration with: Avanish Kumar, Prasenjit DasTurbulence in classical and in quantum fluidsCollaboration with: Victor L'vov, Anna Pomyalov
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Prof. Shmuel Pietrokovski
Developing computational methods for using and identifying protein motifs and applying them for the analysis of particular protein families.Developing advanced methods for comparing protein motifs.Applying protein motif comparisons for functional and structural predictions and to database annotation.Analysis of inteins ("protein splicing" elements) and homing endonucleases.Genetic variations in humans and different gene usage in women and menGene variations causing human disease, in particular infertility in men and various cancers.Different gene usage in women and men leading to differential selection between the sexes and allowing the accumulation of deleterious mutations.
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Prof. Gilad Perez
What gives masses to the particles? We believe that it is related to electroweak symmetry breaking which raises the hierarchy problem, the huge gap between the weak and Planck scales. The LHC experiments is addressing some of these questions and at the same time rising new ones. Recent cosmological-observation raised additional puzzles: What is the source of dark matter and energy? We explore experimental and theoretical methods to improve our knowledge regarding these issues. We also propose to use optical atomic clock spectroscopy to Search for Higgs-mediated interactions in atoms at table top experimentsInterpreting a 750 GeV Diphoton Resonance, By Rick S. Gupta, Sebastian Jager, Yevgeny Kats, Gilad Perez, Emmanuel Stamou. arXiv:1512.05332 [hep-ph].Is the Higgs Mechanism of Fermion Mass Generation a Fact? A Yukawa-less First-Two-Generation Model, By Diptimoy Ghosh, Rick Sandeepan Gupta, Gilad Perez. arXiv:1508.01501 [hep-ph].A Universe without weak interactions, By Roni Harnik, Graham D. Kribs, Gilad Perez. hep-ph/0604027. Phys.Rev. D74 (2006) 035006.Probing New Long-Range Interactions by Isotope Shift Spectroscopy By Julian C. Berengut et al.. arXiv:1704.05068 [hep-ph]. 10.1103/PhysRevLett.120.091801. Phys.Rev.Lett. 120 (2018) 091801.Probing Atomic Higgs-like Forces at the Precision Frontier By Cédric Delaunay, Roee Ozeri, Gilad Perez, Yotam Soreq. arXiv:1601.05087 [hep-ph]. 10.1103/PhysRevD.96.093001. Phys.Rev. D96 (2017) no.9, 093001.
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Prof. Israel Pecht
Electron transfer mechanisms in proteins.Collaboration with: Prof. Ole Farver, U. of Copenhagen, Denmark. Prof. Scot Wherland, Washington state university, Pullman , USA.Antigen recognition and trans-membrane signaling by immuno-receptors.Collaboration with: Prof. J. Abramson, WIS.Regulation and inhibition of mediator secretion by Mast cell and basophils. Allergy, Immediate type hypersensitivity.Electron transpot via proteinsCollaboration with: Pro.Mudi Sheves, WIS. Prof. D.Cahen, WIS.Conductance via proteins. Models for bio-electronics
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