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January 01, 2013
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Date:04MondayNovember 2024Lecture
Midrasha on Groups Seminar
More information Time 14:15 - 16:00Title Dynamical tilings, mean dimension, and shift embeddability for actions of amenable groupsLocation Jacob Ziskind BuildingLecturer Petr Naryshkin
Alfréd Rényi Institute of MathematicsOrganizer Department of MathematicsContact Abstract Show full text abstract about We start by introducing the problem of shift embeddability a...» We start by introducing the problem of shift embeddability and recalling the theorem of Gutman, Qiao, and Tsukamoto, which gives a satisfying answer for actions of Z^d. For actions of arbitrary amenable groups, we define property URPC (which asks for the existence of certain tilings) and show how it is useful for the question at hand. We then describe how it can often be obtained from an a priori much weaker condition. Throughout the talk, we highlight the new ideas that were required to go beyond the case of Z^d.
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Date:05TuesdayNovember 2024Lecture
Seminar for PhD thesis defense
More information Time 11:30 - 11:30Title Epithelial Tissue Regeneration by Compensatory Proliferation After Ionizing Radiation is Controlled by the Apical Caspase 9 Ortholog DroncLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Tslil Braun Organizer Department of Molecular GeneticsContact -
Date:06WednesdayNovember 2024Lecture
Machine Learning and Statistics Seminar
More information Time 11:15 - 12:15Title Spectral TransformersLocation Jacob Ziskind BuildingLecturer Elad Hazan
PrincetonOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about We'll discuss a new technique for sequence modeling for...» We'll discuss a new technique for sequence modeling for prediction tasks with long range dependencies and fast inference/generation. At the heart of the method is a new formulation for state space models (SSMs) based on learning linear dynamical systems with the spectral filtering algorithm.
This gives rise to a novel sequence prediction architecture we call a spectral state space model.
Spectral state space models have two primary advantages. First, they have provable robustness properties as their performance depends on neither the spectrum of the underlying dynamics nor the dimensionality of the problem. Second, these models are constructed with fixed convolutional filters that do not require learning while still outperforming SSMs in both theory and practice.The resulting models are evaluated on synthetic dynamical systems and long-range prediction tasks of various modalities. These evaluations support the theoretical benefits of spectral filtering for tasks requiring very long range memory.
The talk will be self-contained, but here is a link to more information about spectral filtering.
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Date:06WednesdayNovember 2024Lecture
LS Luncheon
More information Time 12:00 - 14:00Title From blind spots to insights: uncovering mechanisms of epiProteome regulationLocation Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Yifat Merbl Contact -
Date:07ThursdayNovember 2024Lecture
Stromal and Immune Plasticity Shape The Metastatic Microenvironment
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Neta Erez
Faculty of Medical & Health Sciences, Tel Aviv University.Organizer Moross Integrated Cancer Center (MICC)Contact -
Date:10SundayNovember 202413WednesdayNovember 2024International Board
the 76th Annual General meeting of the International Board 2024
More information Time All dayLocation The David Lopatie Conference CentreContact -
Date:10SundayNovember 2024Lecture
Special Guest Seminar
More information Time 11:00 - 12:00Title Central simple representations and superelliptic jacobiansLocation Jacob Ziskind BuildingLecturer Yuri Zarkhin
Pennsylvania State UniversityOrganizer Department of MathematicsContact Abstract Show full text abstract about Let p be an odd prime and f(x) a polynomial of degree at le...» Let p be an odd prime and f(x) a polynomial of degree at least 5 with complex coefficients and without repeated roots. Suppose that all the coefficients of f(x) lie in a subfield K such that:
1) K contains a primitive p-th root of unity -
Date:10SundayNovember 2024Lecture
Late Oxygenation of Marine Environments Revealed by Dolomite U-Pb Dating
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Uri Ryb
Hebrew University of JerusalemOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about causal relationships between evolution and oxygenation of th...» causal relationships between evolution and oxygenation of the ocean are
vigorously debated. At the heart of these uncertainties are inconsistencies
among reconstructed timelines for the rise of O2 in marine habitats. Attempts to
reconstruct the timing of marine oxygenation are often based on redox-sensitive
geochemical proxies that are prone to post-depositional alteration. Thus,
developing new proxies, more resistant to such alteration, is an important
direction forward for constraining major changes in atmospheric and marine
oxygen levels. Here, we utilize U–Pb dating in dolomite to reconstruct their
(re)crystallization ages and initial 207Pb/206Pb ratios; we find that they are
systematically younger and lower than expected, respectively. These
observations are explained by the resetting of the U–Pb system long after
deposition, followed by further evolution in a closed system. Initial 207Pb/206Pb
ratios have decreased from expected terrestrial values in the interval between
deposition and (re)crystallization, consistent with U decay, and can therefore be
used to reconstruct the initial 238U/206Pb ratios during deposition. Within our
dataset initial 238U/206Pb ratios remained low in Proterozoic to mid-Paleozoic
samples and increased dramatically in samples from the late-Paleozoic–early-
Mesozoic Eras. This rise is attributed to a higher ratio of U to Pb in seawater that
in turn influenced the fluid composition of carbonate crystallization sites.
Accordingly, we interpret the temporal shift in initial 238U/206Pb ratios to reflect
a late-Paleozoic increase in oxygenation of marine environments, corroborating
previously documented shifts in some redox-sensitive proxies. This timeline is
consistent with evolution-driven mechanisms for the oxygenation of late
Paleozoic marine environments and with suggestions that Neoproterozoic and
early Paleozoic animals thrived in oceans that overall and on long time scales
were oxygen-limited compared to the modern ocean. -
Date:10SundayNovember 2024Lecture
The Clore Center for Biological Physics
More information Time 13:15 - 14:30Title Two-Part Seminar: Predicting antibiotic resistance & AI-driven scienceLocation Nella and Leon Benoziyo Physics LibraryLecturer Prof. Roy Kishony
Technion -Faculty of Biology, Department of Bioinformatics and Systems BiologyOrganizer Clore Center for Biological PhysicsContact Abstract Show full text abstract about In this two-part talk, I will try to cover two separate line...» In this two-part talk, I will try to cover two separate lines of research: Machine learning of antibiotic resistance and AI-driven Science. In the first half, I will describe our efforts to understand and predict antibiotic resistance at the single patient level. I will describe a series of experimental-computational methodologies for following and identifying recurrent patterns in the evolution of antibiotic resistance in the lab and in the clinic. Combined with machine-learning approaches applied to electronic patient records, these tools lead to predictive diagnostics of antibiotic resistance and algorithms for personalized treatments of microbial infections. In the second part of the talk, we will shift gear and talk about AI-driven science. I will describe and demo “data-to-paper”: a platform that autonomously guides LLMs (like ChatGPT) to perform entire research cycles. Provided with data alone, data-to-paper can raise hypotheses, design research plans, write and debug analysis codes, generate and interpret results, and write complete research papers. Automatic information-tracing through the process creates manuscripts in which results, methods and data are programmatically chained. Our work thereby demonstrates a potential for AI-driven acceleration of scientific discovery while enhancing, rather than jeopardizing, traceability, transparency and verifiability. I will describe the strengths of the approach as well as limitations and challenges.
Prof. Kishony would be available to discuss with students and
postdocs after his seminar (2:15 pm - 3 pm).
So we encourage interested students and postdocs to stay after his talk!
FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/
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Date:11MondayNovember 2024Lecture
Midrasha on Groups Seminar
More information Time 11:15 - 12:15Title Reading Alan TuringLocation Jacob Ziskind BuildingLecturer Avi Wigderson
IAS PrincetonOrganizer Department of MathematicsContact Abstract Show full text abstract about I will discuss some well-known and less-known papers of Turi...» I will discuss some well-known and less-known papers of Turing, exemplify the scope of deep, prescient ideas he put forth, and mention follow-up work on these by the Theoretical CS community.
No special background will be assumed.
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Date:11MondayNovember 2024Lecture
Foundations of Computer Science Seminar
More information Time 11:15 - 12:15Title Reading Alan TuringLocation Jacob Ziskind BuildingLecturer Avi Wigderson
IASOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about I will discuss some well-known and less-known papers of Turi...» I will discuss some well-known and less-known papers of Turing, exemplify the scope of deep, prescient ideas he put forth, and mention follow-up work on these by the Theoretical CS community.
No special background will be assumed.
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Date:11MondayNovember 2024Lecture
PhD thesis defense- Avia Mizrachi
More information Time 14:00 - 15:00Title Phenotypic variability and cell fate determination in marine diatoms in response to environmental stressLocation Nella and Leon Benoziyo Building for Plant and Environmental SciencesOrganizer Department of Plant and Environmental SciencesContact -
Date:11MondayNovember 2024Lecture
Midrasha on Groups Seminar
More information Time 14:15 - 16:00Title High-dimensional expansion and soficity of groupsLocation Jacob Ziskind BuildingLecturer Andreas Thom
TU DresdenOrganizer Department of MathematicsContact Abstract Show full text abstract about For d≥4 and p a sufficiently large prime, we construct a lat...» For d≥4 and p a sufficiently large prime, we construct a lattice Γ≤PSp2d(ℚp), such that its universal central extension cannot be sofic if Γ satisfies some weak form of stability in permutations. In the proof, we make use of high-dimensional expansion phenomena and, extending results of Lubotzky, we construct new examples of cosystolic expanders over arbitrary finite abelian groups. This is joint with with Lukas Gohla.
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Date:12TuesdayNovember 2024Lecture
Special Guest Seminar
More information Time 11:00 - 12:00Title EV-DNA Drives Anti-Tumor Immunity and Inhibits MetastasisLocation Max and Lillian Candiotty BuildingLecturer Dr. Inbal Wortzel Organizer Department of Immunology and Regenerative BiologyContact -
Date:13WednesdayNovember 2024Lecture
Piezo2 in sensory neurons controls systemic metabolism by inhibiting adipose thermogenesis
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Eli Zelzer
Department of Molecular GeneticsContact -
Date:13WednesdayNovember 2024Lecture
Machine Learning and Statistics Seminar
More information Time 11:15 - 12:15Title Exact Phase Transitions for Sparse PCA in High DimensionsLocation Jacob Ziskind BuildingLecturer Michael Feldman
WISOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about Sparse principal component analysis (PCA) is a powerful meth...» Sparse principal component analysis (PCA) is a powerful method for low-rank and sparse signal recovery, applicable to covariance estimation, dimension reduction, and feature selection. In this work, we study a generalization of the covariance-thresholding approach to sparse PCA, improving results of R. Krauthgamer, B. Nadler, D. Vilenchik (2015), and Y. Deshpande, A. Montanari (2016). Through random matrix theory, we identify novel phase transition phenomena in high dimensions, providing insight into the limits of signal and support recovery. Our results rely on new concentration bounds for quadratic forms of kernel matrices, which are of independent interest. This research is a collaboration with Theodor Misiakiewicz (Yale) and Elad Romanov (Stanford).
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Date:13WednesdayNovember 2024Lecture
The Clore Center for Biological Physics
More information Time 13:15 - 14:30Title Enzymes as sequence-encoded, viscoelastic catalytic machinesLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Tsvi Tlusty
Center for Soft and Living Matter, Ulsan National Institute of Science and Technology.Organizer Clore Center for Biological PhysicsContact Abstract Show full text abstract about Protein function is the combined product of chemical and mec...» Protein function is the combined product of chemical and mechanical interactions encoded in the gene. Thus, the function of enzymes relies on finetuning the chemical groups at the active site, but also on large-scale mechanical motions, allowing enzymes to bind to substrates selectively, reach the transition state, and release products. We will discuss recent work aiming to probe directly the linkage between these collective internal motions and the functionality of enzymes, using nano-rheological measurements, AI-prediction of point mutation effects, and physical theory. This work proposes a physical view of enzymes as viscoelastic catalytic machines with sequence-encoded mechanical specifications, which are modulated via long-ranged force transduction. -
Date:14ThursdayNovember 2024Lecture
PhD Thesis Defense - Hila Tishler (Prof. Ayelet Erez Lab)
More information Time 11:30 - 11:30Title Enhancing the Sensitivity of Triple Negative Breast Cancers to JAK-STAT Inhibitors by Targeting Arginine AvailabilityLocation Ullmann Building of Life SciencesLecturer Dr. Hila Tishler Organizer Department of Molecular Cell BiologyContact -
Date:14ThursdayNovember 2024Lecture
Revisiting the Neoantigen Approach to Cancer Immunotherapy
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Yardena Samuels
Knell Family Professorial Chair Director, the EKARD Institute for Cancer Diagnosis Research President Elect, European Association for Cancer Research Department of Molecular Cell Biology The Weizmann Institute of ScienceOrganizer Moross Integrated Cancer Center (MICC)Contact -
Date:14ThursdayNovember 2024Lecture
An unconventional journey from, almost, obvious questions to new ideas in exocytosis
More information Time 15:00 - 16:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Ori Avinoam
Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about A wide range of vertebrate secretory glands, such as the exo...» A wide range of vertebrate secretory glands, such as the exocrine pancreas and lung goblet cells, package their cargoes in large vesicles (LSVs). The diameter of these vesicles ranges from 1 to 10 µm, roughly the size of a yeast cell. The membrane surface area and internal volume of these vesicles are orders of magnitude greater than those of conventional vesicles (30–500 nm in diameter), posing formidable challenges for vesicle biogenesis, trafficking, fusion, content release, and the maintenance of apical membrane homeostasis. By asking how cells compensate for the significant membrane load introduced by LSVs at the cell surface, our work uncovered an entirely overlooked mode of exocytosis and revealed key components of the intricate molecular mechanisms underlying LSV fusion and exocytosis in exocrine tissues.
