Integrated Calendar

The proteins that mediate the three pillars of energy metabolism – synthesis of acetyl CoA, oxidation of acetyl CoA via the TCA cycle to generate NADH, and utilization of NADH by the electron transport chain to generate ATP – have long been the focus of investigation. In contrast, much less is known about the role of lipids in the production of energy. Recent studies show that cardiolipin, the signature lipid of the mitochondrial membrane, plays a key role in all three pathways of energy metabolism. This knowledge is expected to provide insight into the mechanisms underlying cardiomyopathy in Barth syndrome, a life-threatening genetic disorder of cardiolipin metabolism.

Presence of the hot (kTe ~ 3 - 10 KeV) rarefied gas in the clusters of galaxies (most massive gravitationally bound objects in the Universe) leads to the appearance of "shadows" in the angular distribution of the Cosmic Microwave Background (CMB) Radiation and permits to measure the peculiar velocities of these clusters relative to the unique coordinate frame where CMB is isotropic. I plan to describe the physics leading to these observational effects. Planck spacecraft, ground based South Pole and Atacama Cosmology Telescopes discovered recently more than thousand of unknown before Clusters of Galaxies at high redshifts detecting these "shadows" and traces of kinematic effect, demonstrating the correlation of the hot gas velocities with mass concentrations on large scales. Giant ALMA submillimeter interferometer in Atacama desert resolved recently strong shocks between merging clusters of galaxies.
Newly discovered clusters of galaxies permit to study the rate of growth of the large scale structure of the Universe and open an independent way to measure key cosmological parameters of our Universe.
I plan to mention Russian - German Spectrum-X/eRosita space mission under preparation for the launch in the March of 2018. This mission will be able to detect all (hundred thousand !) rich clusters of galaxies in the observable Universe and up to 3 millions of accreting supermassive black holes (in Active Galactic Nuclei) during 4 year long X-Ray sky survey. S3 and S4 ground based CMB research programs promise to reach similar or even higher sensitivities and detect up to a million of clusters and groups of galaxies containing hot gas.