לוח שנה משולב

Zoom LInk: https://weizmann.zoom.us/j/97917323609?pwd=OGpCVzNKWGlCSS9lbTIyS0FtN1lHUT09

Recent experiments have demonstrated that rapid rupture fronts, akin to earthquakes, mediate the transition to frictional motion. Moreover, once these dynamic rupture fronts ("laboratory earthquakes" ) are created, their singular form, dynamics and arrest are well-described by fracture mechanics. Ruptures, however, need to be created within initially rough frictional interfaces, before they are able to propagate. This is the reason that ``static friction coefficients” are not well-defined; frictional ruptures can nucleate for a wide range of applied forces. A critical open question is, therefore, how the nucleation of rupture fronts actually takes place. We experimentally demonstrate that rupture front nucleation is prefaced by slow nucleation fronts. These nucleation fronts, which are self-similar, are not described by fracture mechanics. They emerge from initially rough frictional interfaces at a well-defined stress threshold, evolve at characteristic velocity and time scales governed by stress levels, and propagate within a frictional interface to form the initial rupture from which fracture mechanics take over. These results are of fundamental importance to questions ranging from earthquake nucleation and prediction to processes governing material failure.

Contamination of drinking water sources by a variety of organic and inorganic compounds demands more efficacious and reliable treatment technologies. However, conventional water treatment technologies remain chemically demanding, energy intensive, and ineffective in removing key trace contaminants. As such, nanotechnology-based approaches have been increasingly explored to enhance or replace traditional remediation methods because of the high reactivity and tunable-properties of nanomaterials. In her talk, Dr. Zucker will provide an overview on the current status of nano-enabled water decontamination, including promising opportunities and barriers for implementation. Specifically, the application of molybdenum disulfide (MoS2) for heavy metal removal will be extensively discussed as a case study, where material properties, removal mechanisms, and large-scale applications are optimized.

The hippocampus and related medial temporal lobe structures (entorhinal cortex, perirhinal cortex, etc.) play a vital role in transforming experience into long-term memories that are then stored in the cortex, however the cellular mechanisms which designate single neurons to be part of a memory trace remain unknown. Part of the difficulty in addressing the mechanisms of transformation of short-term to long-term memories is the distributed nature of the resulting “engram” at synapses throughout the cortex. We therefore used a behavioral paradigm dependent on both the hippocampus and neocortex that enabled us to generate memory traces rapidly and reliably in a specific cortical location, by training rodents to associate the direct electrical microstimulation of the primary sensory neocortex with a reward. We found that medial-temporal input to neocortical Layer 1 (L1) gated the emergence of specific firing responses in subpopulations of Layer 5 pyramidal neurons marked by increased burstiness related to apical dendritic activity. Following learning and during memory retrieval, these neocortical responses became independent of the medial-temporal influence but continued to evoke behaviour with single bursts sufficient to elicit a correct response. These findings suggest that L1 is the locus for hippocampal-dependent associative learning in the neocortex, where memory engrams are established in subsets of pyramidal neurons by enhancing the sensitivity of tuft dendrites to contextual inputs and driving burst firing.

Zoom link to join- https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09

Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070