לוח שנה משולב

Microbial cells are remarkable in their abilities to adapt to different environments while maintaining cellular homeostasis. How cells coordinate the various events within the cell cycle, notably cell division and DNA replication, remains an outstanding problem for cells of all domains of life. I will discuss our current understanding of cell cycle regulation in microbes, including recent results demonstrating a tight coupling between DNA replication and cell division in E. coli.

Neuron-glia interactions are key for proper myelination in the brain and for its functionality. To study neuron-glia interaction roles in brain development we focus on the genetic disorder Williams syndrome (WS). WS is a multisystemic neurodevelopmental disorder caused by a de-novo hemizygous deletion of ~26 genes from chromosome 7q11.23. We previously revealed surprising aberrations in myelination and brain development in a novel mouse model for the hypersociability phenotype associated with WS, as a result of a neuronal deletion of the transcription factor Gtf2i, which is one of the genes deleted in WS. In this talk, I will present our recent findings focused on altered white matter and brain development in WS, and discuss potential molecular and cellular explanations for the neurodevelopmental deficits in WS. Specifically, I will present evidence for mitochondrial dysfunction in neurons, and what are the microglial responses to the resultant myelination deficits. Furthermore, to study the implication of our studies from mouse models on human condition, I will show our new data on the altered epigenome of human frontal cortex tissue from WS compared to controls. Finally, I will present our approaches to develop new therapeutic approaches and will update on our clinical trial focused on ameliorating white matter deficits in WS.
Hybrid seminar
Zoom link:
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421

Zoom Link: https://weizmann.zoom.us/j/95894806650?pwd=c21JSFRhcUZaalROaUlBWnh4T25yZz09



Low-dimensional materials, such as 2D monolayers, 1D nanowires, and 0D quantum dots and molecules, are rich with new phenomena. The reduced dimensionality, strong interactions, and topological effects lead to new emergent degrees of freedom of fundamental interest and promise for future applications, such as energy-efficient computation and quantum information. Thermal transport, which is sensitive to all energy-carrying degrees of freedom and their interactions, provides a discriminating probe to study these materials and identify their emergent excitations. However, thermal measurement in low dimensions is dominated by the lattice, requiring an approach to isolate the electronic contribution. In this talk, I will discuss how the measurement of nonlocal voltage fluctuations in a multiterminal device can reveal the electronic heat transported across a low-dimensional bridge. We use 2D graphene as an electronic noise thermometer, demonstrating quantitative electronic thermal conductance measurement over a wide temperature range in an array of dimensionalities: 2D graphene, 1D nanotubes, 0D localized electron chains, and 3D, microscale bulk materials. I will discuss ongoing work revealing electron hydrodynamics, interaction-mediated plasmon hopping, spin waves in a magnetic insulator, and a crossover from phonon to spin transport in a bulk spin liquid candidate material.

The study of past warm climates with high atmospheric CO2 concentrations provides important tools for understanding present trends and developing mitigation strategies for future scenarios. The Pliocene is the last long lasting warm interval characterized by similar global climate circulation patterns and continental settings as today. Reconstructing Pliocene climate change from well-dated geological archives provides valuable insights into the climate forcing and pathways that modulated the transfer of heat and humidity and disentangle regional impacts without anthropogenic influence. To address this challenge, the current presentation shows initial results from a comprehensive study that amalgamates high-resolution multi-proxy analyses from both marine and lacustrine records from the Levant region aiming to provide an important reference for future climate and environment change scenarios under high atmospheric CO2 concentrations.