לוח שנה משולב

In this talk I will describe a simple model for the growth of a bacterial population under the challenge of ribosome-targeting antibiotics. The model is statistical physics-like in that it makes a coarse-grained description of the growth process, reduced to three variables within the bacterial cell - the antibiotic concentration, the concentration of ribosomes bound to antibiotics and the concentration of unbound ribosomes. Furthermore, there is biological input from empirically established physiological constraints which relate the three variables. Remarkably the model can explain several observations concerning antibiotic action and bacterial growth rate. In particular the growth-dependent bacterial susceptibility is controlled by a single, `universal' parameter and the extreme behaviours correspond to the phenomenological classification into bactericidal and bacteriostatic antibiotics. If time allows I will describe how the predictions of the model are backed up by experimental studies.
Reference:
Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics Philip Greulich, Matthew Scott, Martin R. Evans, Rosalind J. Allen Molecular Systems Biology 11:796 (2015)