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אפריל 29, 2015
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Date:01שלישידצמבר 2015הרצאה
Sponges - ancient organisms innovative research
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Dr. Ray Keren
Department of Zoology, Tel Aviv Universityמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:01שלישידצמבר 2015הרצאה
Systematic dissection of the role of dendritic cells in driving immune responses: from pathogen sensing to tumor elimination
More information שעה 11:30 - 11:30מיקום בניין וולפסון למחקר ביולוגימרצה Dr. Oren Parnas
Broad Instituteמארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:01שלישידצמבר 2015הרצאה
Blood sweat and tears: Social chemosignaling in human health and disease
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Noam Sobel
Department of Neurobiology, WISמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Most animals communicate using social chemosignals, namely c...» Most animals communicate using social chemosignals, namely chemicals emitted by one member of the species, which then produce chemical and behavioral changes in other members of the species. Such communication is prevalent in insects and terrestrial mammals, and mounting evidence implies that it is also common in human behavior, albeit primarily at a subliminal level. Human social chemosignals are responsible for a host of effects ranging from driving menstrual synchrony in women to conveying fear across individuals. Here I will describe our findings on mechanisms of human chemosignaling in both health and disease. Based on these findings I will argue that in contrast to common notions, humans are highly olfactory animals. -
Date:02רביעידצמבר 2015הרצאה
Sphingosine-1-phosphate: a key regulator of the link between inflammation and cancer
More information שעה 11:00 - 11:00מיקום בניין וולפסון למחקר ביולוגימרצה Prof. Sarah Spiegel
Professor and Chair, Department of Biochemistry and Molecular Biology Virginia Commonwealth University School of Medicine, USAמארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר -
Date:02רביעידצמבר 2015הרצאה
Do rare decays point to physics beyond the Standard Model
More information שעה 11:00 - 11:00מיקום Technion, Lidow 502מרצה Sebastian Jaeger
University of Sussexמארגן המחלקה לפיזיקה של חלקיקים ואסטרופיזיקהדף בית צרו קשר -
Date:02רביעידצמבר 2015הרצאה
The Emergence of Pattern in Random Processes
More information שעה 11:15 - 12:30מיקום בניין לפיזיקה על-שם נלה וליאון בנוזיומרצה Will Newman מארגן מרכז לאסטרופיסיקה עש נלה וליאון בנוזיוצרו קשר תקציר Show full text abstract about We consider both time series as well as spatial distribution...» We consider both time series as well as spatial distributions (in 1-4 dimensions).
In the first, we observe that time series for individual and independently deviating random variables can manifest pattern through the emergence of peak-to-peak sequences that are visible to the eye yet fail all Fourier analysis schemes and reveal a seeming periodicity of 3-events per cycle. We note that this can explain observations of apparent cycles in mammalian animal populations. We consider models, as well, based on the Langevin equation of kinetic theory and the Smolouchowski relation that present circumstances where the apparent period can vary from 3-4 and, for a special subclass of problems, to periods between 2 and 3. We explore how cataloged observational data from global earthquake catalogues, magnetospheric AL index observations, Old Faithful Geyser eruption data, and the performance of the Standard & Poor's 500 index (percent daily variation) manifest different degrees of statistical agreement with the theory we derived. We present a simple model for many mammalian population cycles whose underlying phenomenological basis has strong biological implications.
We then employ directed graphs to explore nearest-neighbor relationships and isolate the character of spatial clustering in 1-4 dimension. We observe that the one-dimensional problem is formally equivalent to that presented by peak-to-peak sequences in time series and also demonstrates a mean number of points per cluster of 3 in one dimension. We then take the first moment of each of the clusters formed, and observed that they too form clusters.
We observe the emergence of a hierarchy of clusters and the emergence of universal cluster numbers, analogous to branching ratios and, possibly, Feigenbaum numbers. These, in turn, are related to fractals as well as succularity and lacunarity, although the exact nature of this connection has not been identified. Finally, we show how hierarchical clustering emerging from random distributions may help provide an explanation for observations of hierarchical clustering in cosmology via the virial theorem and simulation results relating to the gravitational stabilization in a self-similar way of very large self-gravitating ensembles. -
Date:02רביעידצמבר 2015הרצאה
Towards a No-Lose Theorem for Naturalness
More information שעה 13:00 - 13:00מיקום Technion, Lidow 502מרצה Gabriel Lee
Technionמארגן המחלקה לפיזיקה של חלקיקים ואסטרופיזיקהצרו קשר תקציר Show full text abstract about http://arxiv.org/abs/1509.04284 ...» http://arxiv.org/abs/1509.04284
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Date:02רביעידצמבר 2015אירועי תרבות
הקאמרטה הישראלית ירושלים -גברת הביטי
More information שעה 20:00 - 22:00מיקום אודיטוריום מיכאל סלעצרו קשר -
Date:03חמישידצמבר 2015הרצאה
Single cell analysis of HSV-1 infection (Virology Club meeting)
More information שעה 10:00 - 11:00כותרת Oren Kobiler from TAU will talk about "Single cell analysis of HSV-1 infection"מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Oren Kobiler
Single cell analysis of HSV-1 infectionצרו קשר -
Date:03חמישידצמבר 2015סימפוזיונים
Perturbations to worm sleep, weak and strong
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה David Biron
Chicago Universityמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about Sleep may be universal in the animal kingdom. Yet, the roles...» Sleep may be universal in the animal kingdom. Yet, the roles of sleep in organizing living mat-ter and the underlying reason for this universality remain controversial. Fundamental ques-tions under debate include the boundaries of this universality (do all animals sleep?), natural history (when did sleep evolve?), and core function (what for, originally?). The roundworm C. elegans is the simplest model system in which these questions can be addressed.
A key feature distinguishing sleep from other states of decreased activity is its intricate home-ostatic regulation: following disruptions, ‘restoring forces’ extend or modify sleep to compen-sate for the loss. This talk will describe measurements of three regimes of perturbations to worm sleep. We have shown that weak and intermediate perturbations reveal distinct man-ners in which small losses of worm sleep are compensated for. In addition, we have shown that stronger perturbations, causing substantial but nonlethal loss to worms sleep, inflicts long-term deficits. These deficits and the protective mechanisms that mitigate them are ex-pected to be directly linked to functions of sleep in this (phylogenetically) ancient model.
These findings add to the list of similarities between worm and vertebrate sleep and open the door to a better understanding of sleep’s core functions.
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Date:03חמישידצמבר 2015הרצאה
Long Range Gene Regulation during Vertebrate Development and Evolution
More information שעה 12:00 - 12:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Denis Duboule
School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerlandצרו קשר -
Date:03חמישידצמבר 2015הרצאה
הרצאה שנתית במדעי הרוח על שם חיים ויצמן
More information שעה 19:30 - 21:00כותרת הגאופוליטיקה המשתנה של המזרח התיכוןמיקום אודיטוריום מיכאל סלעמרצה Prof. Uzi Rabi
Head of The Moshe Dayan Center for Middle Eastern and African studies, Tel Aviv Universityמארגן יד חיים וייצמןצרו קשר -
Date:05שבתדצמבר 2015אירועי תרבות
בן בן ברוך - סטנד אפ
More information שעה 21:00 - 22:30מיקום אודיטוריום מיכאל סלעדף בית צרו קשר -
Date:06ראשוןדצמבר 2015הרצאה
Depositional controls on preserved sulfur isotope signals in modern and ancient marine sediments
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה David Fike
Washington Universityמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:06ראשוןדצמבר 2015הרצאה
Chemical Physics Lunch Club Seminar
More information שעה 12:30 - 12:30כותרת Understanding Isomerization - Insight from hybrid QM/MM molecular dynamics simulationsמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Igor Schapiro
Hebrew University and Max Planck Institute for Chemical Energy Conversion, Mülheim an der Ruhr, Germanyמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about The primary event of vision in the vertebrate eye is the hig...» The primary event of vision in the vertebrate eye is the highly selective and efficient photoisomerization of 11-cis-retinal protonated Schiff base (RPSB) bound to the visual protein rhodopsin (Rh). With a ~100% selectivity, ~65% quantum yield, and ~200 fs product appearance time, this isomerization is considered the archetype of a photochemical reaction optimized by nature to achieve a specific molecular response.
Recently, we have used a combination of a quantum chemical and a classical force field method (QM/MM) to resolve the isomerization mechanism for the RPSB chromophore in Rh[1]. Important stereoelectronic factors were found that determine the outcome of the photoisomerization. The same protocol was also applied to investigate the photochemical mechanism of the newly discovered Anabaena Sensory Rhodopsin[2] and of a biomimetic molecular switch that works in solution[3].
Using the same computational protocol we have also studied the ground state (thermal) isomerization.[4] The results of the simulations explain the molecular mechanism of thermal noise in rod photoreceptors and make a direct link to experimentally found correlations for night vision.
References:
[1] Schapiro I, Ryazantsev M N, Frutos L M, Ferré N, Lindh R, Olivucci M. J. Am. Chem. Soc. (2011), 133, 3354.
[2] Schapiro I, Ruhman S. Biochim Biophys Acta. (2014), 1837, 589.
[3] Léonard J, Schapiro I, Briand J, Fusi S, Paccani R R, Olivucci M, Haacke S. Chem. Eur. J. (2012), 18, 15296.
[4] Gozem S, Schapiro I, Ferré N, Olivucci M. Science (2012), 33, 6099.
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Date:06ראשוןדצמבר 2015הרצאה
To be announced
More information שעה 13:00 - 13:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:07שנידצמבר 2015כנסים
The 4th Israeli Meeting on Zebrafish as a Model for Biomedical Research
More information שעה 08:30 - 16:45מיקום מרכז כנסים על-שם דויד לופאטידף בית -
Date:07שנידצמבר 2015הרצאה
Regulating Meiotic Recombination in Plants
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Professor Gregory P. Copenhaver
Department of Biology, University of North Carolina at Chapel Hill, USA, Director of Graduate Studies, (Molecular Cellular and Developmental Biology), Editor-in-Chief, PLOS Geneticsמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:07שנידצמבר 2015הרצאה
Cancer Club Seminar - Signaling & communication in breast cancer
More information שעה 14:00 - 15:00מיקום בניין תשתיות ושירותי מחקר על-שם ראול וגרציאלה דה פיצ'וטומרצה Stefan Wiemann
DKFZ Heidelberg, Germanyמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:07שנידצמבר 2015הרצאה
Model of antibiotic action on bacterial population growth
More information שעה 14:15 - 14:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Martin Evans
University of Edinburghמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about In this talk I will describe a simple model for the growth o...» In this talk I will describe a simple model for the growth of a bacterial population under the challenge of ribosome-targeting antibiotics. The model is statistical physics-like in that it makes a coarse-grained description of the growth process, reduced to three variables within the bacterial cell - the antibiotic concentration, the concentration of ribosomes bound to antibiotics and the concentration of unbound ribosomes. Furthermore, there is biological input from empirically established physiological constraints which relate the three variables. Remarkably the model can explain several observations concerning antibiotic action and bacterial growth rate. In particular the growth-dependent bacterial susceptibility is controlled by a single, `universal' parameter and the extreme behaviours correspond to the phenomenological classification into bactericidal and bacteriostatic antibiotics. If time allows I will describe how the predictions of the model are backed up by experimental studies.
Reference:
Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics Philip Greulich, Matthew Scott, Martin R. Evans, Rosalind J. Allen Molecular Systems Biology 11:796 (2015)
