לוח שנה משולב

Aging is characterized by several quantitative regularities: mortality and disease incidence rise exponentially with age, organ function declines linearly, and species with very different lifespans exhibit similarly shaped survival curves. I will present recent developments that unify these quantitative phenomena within the framework of the Saturating Removal (SR) model. The SR model is a biologically motivated stochastic differential equation that describes aging as a damage accumulation process with linearly increasing production with time and saturating removal, with death and disease modeled as first-passage-time processes. I will discuss the statistical properties of the model, including how the exponential mortality increase emerges from a Kramers escape rate over a barrier. I will then present recent results showing how the model organizes aging across species into two distinct aging regimes- ballistic and quasi steady state. Comparing the model to human data, indicates that late-life survival and the extreme-value tail of exceptionally long-lived individuals constrain damage production and removal parameters in human populations. This model can help prioritize longevity interventions. I will discuss future directions and open questions. FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.bio

The dimension of the space of Specht polynomials is n!/e to the nearest integer. I will explain how the search for a combinatorial reason behind this unexpected formula leads to a web of ideas involving Markov models, semigroups, partial representations, exact complexes, and covering problems for distributions on permutations.

Lessons learned from our experience in Pepticom as far as the vision and execution: Business plan, building a team, raising capital, pivoting on ideas, securing deals and more.