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פברואר 21, 2016
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Date:15רביעיינואר 2020הרצאה
Surface Modification by Molecular/Atomic Layer Deposition of Functional Thin Films
More information שעה 11:00 - 12:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Malachi Noked
Chemistry Department, Bar Ilan Universityמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Atomic/Molecular layer deposition (ALD/MLD) are based on the...» Atomic/Molecular layer deposition (ALD/MLD) are based on the use of hetero- and homo-bifunctional organic or metal-organic compounds that vaporize, chemisorb onto and react with an appropriately functionalized surface. Both ALD and MLD allow temporal separation of any number of precursors, each of which produces self-limiting adsorption/reaction on the surface so that typical uptake is limited to ~one monolayer of any given precursor. This leads to growth controlled at the monolayer level and self-limiting reactions that have shown extreme conformality, even into ultra-high-aspect-ratio and porous substrates.
In my talk I will show how utilization of carefully chosen M/ALD process enables functionalization of interfaces. I will show to sides of the coins for surface modification; namely turning “inert” interface into functional interface/interphase (e.g. inert interface into enantioselective interface) or by changing active interface into inert interface (e.g. protection layer on reactive surface in batteries).
In the enantioselective example I will address a question with both fundamental and applicative significance: can we grow molecularly thin films from the vapor phase, which maintain a desirable chemical property originated from the source precursor. This question can be exemplified by a variety of chemical properties, such as MLD of enantioselective thin films from chiral building blocks (e.g. volatile amino acids), thin film deposition of molecular traps, and more.
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Date:16חמישיינואר 2020הרצאה
Solid State NMR of low abundant quadrupolar nuclei achieved through extended coherence lifetimes
More information שעה 09:30 - 10:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Daniel Jardon-Alvarez
Dept. Materials and Interfaces, WISמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Less is more! By using extremely low power refocusing π puls...» Less is more! By using extremely low power refocusing π pulses in echo train sequences the coherence lifetime, T2, of the central transition of half-integer quadrupolar nuclei can be largely extended. This effect is particularly impactful in systems dilute in NMR active nuclei, where sources of decoherence are scarce. Crucial to this lifetime extension is the avoidance of coherence transfer to short-lived non-symmetric “killing” transitions. For 17O in polycrystalline α-quartz we were able to retain coherent magnetization for over four minutes on the transverse plane. This translates into enormous sensitivity gains for echo train acquisition after addition of the long living echoes. By combining satellite population transfer schemes with a low power CPMG on 17O in quartz, we obtain over a 1000-fold sensitivity enhancement compared to a spectrum from a free induction decay acquired at a more typical rf field strength. This enhancement allows the acquisition of a highly resolved 17O spectrum within less than one hour, despite its low natural abundance and a spin-lattice relaxation time of approximately 900 s. In this talk I will present a thorough analysis of the effects of pulse power on the echo intensity, coherence lifetime and line shape integrity. Finally, we apply this approach on various crystalline and glassy inorganic solids, including other low sensitivity nuclei, such as 33S and 45Ca, showing that it can be beneficial for a large number of systems.
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Date:16חמישיינואר 2020הרצאה
Special Guest Seminar with Dr, Michael E. Ward
More information שעה 11:00 - 12:00כותרת “Converging Mechanisms of FTD and ALS”מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Michael E. Ward
Inherited Neurodegenerative Disease Unit, NINDS, NIH, Bethesda, MD, USAמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:16חמישיינואר 2020סימפוזיונים
The three jewels in the crown of the LHC
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Yossi Nir
Weizmann Institute of Scienceמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about The ATLAS and CMS experiments have made three major discover...» The ATLAS and CMS experiments have made three major discoveries: The discovery of an elementary spin-zero particle, the discovery of the mechanism that makes the weak interactions short-range, and the discovery of the mechanism that gives the third generation fermions their masses. I explain how this progress in our understanding of the basic laws of Nature was achieved. -
Date:16חמישיינואר 2020הרצאה
Cracking the Core: Utilizing Refitted Core Sequences in the Assessment of the Levantine Middle to Upper Paleolithic Transition
More information שעה 11:30 - 12:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Annie Melton
University of Minnesotaצרו קשר תקציר Show full text abstract about Much remains to be understood regarding the Middle to Upper ...» Much remains to be understood regarding the Middle to Upper Paleolithic transition, particularly in the Levant. A longstanding debate is the presence or absence of cultural continuity during this transitional period in the Levant. Few studies, though, have been conducted in order to quantitatively address this question. Here, I will discuss a quantitative approach to identifying cultural transmission processes in the Levant utilizing refitted stone tool core reduction sequences. With refitted sequences from Boker Tachtit (Israel) and Taramsa-1 (Egypt), I hope to quantitatively assess the similarity in lithic production strategies utilizing attribute analyses of known cultural-transmission proxies. Though in the early stages of data collection, this project has already been successful in the digitization and thus long-term preservation of archaeological materials which will facilitate their access to future researchers with future questions. -
Date:16חמישיינואר 2020הרצאה
Pharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Boaz Tirosh מארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:16חמישיינואר 2020הרצאה
Changes in electrophysiological activity in the amygdala - dACC circuit under the effects of different anesthetic drugs at different doses
More information שעה 14:30 - 14:30מיקום בניין לחקר המוח על-שם נלה וליאון בנוזיומרצה Eilat Kahana (PhD Thesis Defense)
Prof. Rony Paz Lab, Dept of Neurobiologyמארגן המחלקה למדעי המוחצרו קשר -
Date:19ראשוןינואר 202020שניינואר 2020כנסים
Brain Health Molecules Mechanisms and Disease
More information שעה 08:00 - 08:00יושב ראש Oren Schuldinerדף בית -
Date:19ראשוןינואר 2020הרצאה
Guest seminar- Dr. Livnat Jerby-Arnon, will lecture on "Dissecting immune evasion mechanisms in cancer using single-cell technologies”
More information שעה 10:00 - 11:00מיקום בניין וולפסון למחקר ביולוגימארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:19ראשוןינואר 2020הרצאה
Soil Spectroscopy throughout the Years: Availabilities and Capabilities
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Eyal Ben-Dor
Department of Geography Porter School of Environment and Earth Sciences Faculty of Exact Sciences Tel Aviv University Israelמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about The soil spectroscopy discipline has been progressed over th...» The soil spectroscopy discipline has been progressed over the past two decades quite remarkably. Many portable point spectrometers became available through that time where recently also image spectrometers have become quite popular. The technology was used in the laboratory, field, and airborne levels and provided a new capability for a rapid and quantitative view of a large number of samples. At the same time platforms were also developed to carry the new family of sensors for remote sensing applications of large areas using ground and airborne vehicles ( manned and un-manned) and recently even satellites. This progress has led to a large number of activities in exploiting the spectroscopy for many applications within the soil science discipline. As the data acquisition increases and the soil spectral database has been enlarged, a new technique to compile soil spectral database together with methods to effectively analyze them has also been developed. To that end, activities to deal with the data mining process using big databases were successfully adopted from other disciplines while also designed especially for the soil spectroscopy activity. The results demonstrated that soil spectroscopy could be used for many applications from different domains such as soil mapping, precision agriculture, and laboratory work and can progress the soil science discipline quite forward. In this talk, we will review the history of soil spectroscopy from the first spectrometer and platform to the present situation. A particular emphasis will be given to the recent applications that have been developed in our group and to the future capability of this critical technology from all perspectives and to the new horizon it may open as expressed by space agencies such as NASA, ESA, ASI, JAXA, ISA and DLR.
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Date:19ראשוןינואר 2020הרצאה
PhD Thesis Defense - Brainstem encoding of active sensing in the vibrissal system
More information שעה 11:30 - 11:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Coralie Ebert (PhD Thesis Defense)
Prof. Ehud Ahissar Lab Dept of Neurobiology, WISמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Perception is an active process, requiring the integration o...» Perception is an active process, requiring the integration of both proprioceptive and exteroceptive information. In the rat’s vibrissal system, a classical model for the study of active sensing, previous works explored the relative contribution of the two information streams at the peripheral, thalamic and cortical levels. However, this issue was never addressed in the brainstem, and was only indirectly inferred from its thalamic projections. The current work addressed this gap in our knowledge by performing the first comparative study of the encoding of whisking and touch signals in the oralis, interpolaris and paratrigeminal nuclei. We also examined possible mechanisms for TIPs (Touch Induced Pumps) generation, a touch reflexive behavior mediated by the brainstem. By combining induction of artificial TIPs in anesthetized animals and computational models, we showed that passive retraction of the whisker pad is the most plausible mechanism for TIPs generation. Overall, our findings bridge a critical gap in our knowledge of the vibrissal system, providing the first characterization of responses to active touch in the trigeminal brainstem, the first evidence that the paratrigeminal nucleus is involved in the processing of vibrissal information and a novel mechanism for TIPs generation. -
Date:19ראשוןינואר 2020הרצאה
Departmental Seminar - Molecular Genetics Dept.
More information שעה 13:00 - 13:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:19ראשוןינואר 2020הרצאה
Shade maps for prioritizing municipal microclimatic action in hot climates
More information שעה 13:00 - 14:00כותרת SAERI seminar serirs - Sustainability and Energy Research Initiativeמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Prof. Or Aleksandrowicz
Faculty of Architecture and Town Planning Technion - Israel Institute of Technologyמארגן בית הספר למחקר - מכון ויצמן למדעצרו קשר -
Date:19ראשוןינואר 2020הרצאה
The reference map technique for simulating complex materials and
More information שעה 13:15 - 13:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Christopher Rycroft
Harvardמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about > Conventional computational methods often create a dilem...» > Conventional computational methods often create a dilemma for fluid–structure interaction problems. Typically, solids are simulated using a Lagrangian approach with grid that moves with the material, whereas fluids are simulated using an Eulerian approach with a fixed spatial grid, requiring some type of interfacial coupling between the two different perspectives. Here, a fully Eulerian method for simulating structures immersed in a fluid will be presented. By introducing a reference map variable to model finite-deformation constitutive relations in the structures on the same grid as the fluid, the interfacial coupling problem is highly simplified. The method is particularly well suited for simulating soft, highly-deformable materials and many-body contact problems, and several examples will be presented. This is joint work with Ken Kamrin (MIT). -
Date:20שניינואר 2020הרצאה
IMM Guest seminar-Dr. Adi Barzel, will lecture on “Therapeutic Gene Targeting With or Without Nucleases.“
More information שעה 13:00 - 14:00מיקום בניין וולפסון למחקר ביולוגימרצה Dr. Adi Barzel
Dr. Adi Barzel is President of the Israeli Society of Gene and Cell Therapy and a senior lecturer in the Department of Biochemistry at Tel Aviv University. Dr. Barzel is a co-founder of LogicBio Therapeutics (NASDAQ: LOGC), a public gene therapy company developing transformational medicines for children with devastating disorders. He is also the chair of the international conference on lymphocyte engineering. Dr. Barzel is an expert in homologous recombination and gene targeting. He is a Summa cum Laude graduate of the Adi Lautman interdisciplinary program for outstanding students. He has earned his Ph.D. in genetics from the laboratory of Professor Martin Kupiec at Tel Aviv University and was subsequently a postdoctoral fellow at the Mark Kay lab at Stanford University.מארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:20שניינואר 2020הרצאה
Self-assembled Electrolytes: Conserved media with non-equilibrium properties and why should we care about it?
More information שעה 14:15 - 14:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה BGU, Dr. Arik Yochelis מארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about Self-assembly driven by phase separation coupled to Coulombi...» Self-assembly driven by phase separation coupled to Coulombic interactions is fundamental to a wide range of applications, examples of which include soft matter lithography via di-block copolymers, membrane design using poly-electrolytes, and renewable energy applications based on complex nano-materials, such as ionic liquids. I will show by using two continuum case models, ionic liquids and charged polymers, that although self-assembly in electrolytes is a gradient flow system, it surprisingly displays several fundamental features that are related to far from equilibrium (reaction-diffusion) systems and thus, allow for novel realizations, interpretations, and applications to concentrated electrolytes. -
Date:21שלישיינואר 2020הרצאה
What will we eat tomorrow ? Food security in the 21st century
More information שעה 10:00 - 10:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Moshe Goldsmith
Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about The world’s population is expected to grow by 25% in the nex...» The world’s population is expected to grow by 25% in the next 30 years, reaching 9.6 billion by 2050. In order to feed such a large population, there is a global need to increase food production from crops alone by 56%. In addition, global warming is expected to reduce crop yields in low and middle latitude areas and to increase climate instability. A partial solution can be found by transitioning to more resilient and nutritious food crops such as millets and legumes. However, some of these crops contain toxic compounds that pose a health risk if consumed at high amounts. Here we present our attempts to identify and eliminate such a plant toxin in order to produce a cultivar that is safe for large scale consumption. -
Date:21שלישיינואר 2020הרצאה
Cancer-associated fibroblast compositions change with breast-cancer progression and correlate with clinical outcome
More information שעה 10:30 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Gil Friedman
Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Cancer-associated fibroblasts (CAFs) are non-malignant tumor...» Cancer-associated fibroblasts (CAFs) are non-malignant tumor-supporting cells, which are highly abundant in the majority of carcinomas, and carry out distinct cancer related functions. The wide range of CAF activities suggests that CAFs are heterogenous and dynamically change. We analyzed CAFs using index and transcriptional single-cell sorting, at several time-points along breast tumor progression in mice, uncovering distinct subpopulations with transitioning transcriptional programs. We have further stained and analyzed sections of human breast tumors, and found that the two main CAF subpopulations are also present in human breast cancer, and that their ratio is associated with disease outcome -
Date:21שלישיינואר 2020הרצאה
PhD defense presentation by Lihi Radomir (Shachar Lab)
More information שעה 10:30 - 12:30כותרת “SLAM receptors in maintenance of B cells in health and autoimmunity.”מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Lihi Radomir מארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:21שלישיינואר 2020הרצאה
Towards Advanced Materials: From Unique Peptidomimetics to High-Performance Thermosets
More information שעה 11:00 - 12:00מיקום בניין הלן ומילטון קימלמןמרצה Dr. Revital Kaminker
UC Santa Barbaraמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about High-performance materials with elevated operating temperatu...» High-performance materials with elevated operating temperatures and robust mechanical properties, are essential for a wide variety of emerging applications, such as in functional adhesives, automobiles, aerospace, and coatings. Polyhexahydrotriazines (PHT) are new promising high-performance thermosets exhibiting enhanced thermal and mechanical properties.1 The performance and utility of PHT-based materials is further enhanced by the ability to design new material properties based on changes in the molecular structure.2 We demonstrated a new solvent-free approach for the fabrication of PHT based on low-melting-point diamines enabling the production of adhesives with comparable properties to well-established epoxy adhesives. Furthermore, these versatile materials could be degraded at different rates in acidic conditions based on the nature of the starting diamine molecular structure. Controlling the degradation is extremely valuable in composites and adhesives in order to be able to recycle and rework the materials.
In the second part of my talk I will show how the ability to control and adapt peptide conformation is crucial for the rational design and control of their function.3,4 We demonstrated by end-to-end distance measurements using Double Electron-Electron Resonance (DEER) EPR method that we can tune the conformations of the backbone while maintaining the sequence of the side-chains. Interestingly, tuning of the backbone has an effect on peptide propensity to aggregate or stabilize nanoparticles. Such knowledge is critical for designing new materials for various biotechnological applications.
1. J. M. García, G. O. Jones, K. Virwani, B. D. McCloskey, D. J. Boday, G. M. ter Huurne, H. W. Horn, D. J. Coady, A. M. Bintaleb, A. M. S. Alabdulrahman, F. Alsewailem, H. A. A. Almegren, J. L. Hedrick. Science 2014, 344, 732–735.
2. R. Kaminker, E. B. Callaway, N. D. Dolinski, S. M. Barbon, M. Shibata, H. Wang, J. Hu, C. J. Hawker. Solvent-Free Synthesis of High-Performance Polyhexahydrotriazine (PHT) Thermosets. Chem. Mater. 2018, 30, 8352–8358.
3. R. Kaminker, I. Kaminker, W. R. Gutekunst, Y. Luo, S.-H. Lee, J. Niu, C. J. Hawker, S. Han. Tuning Conformation and Properties of Peptidomimetic Backbones through Dual N/Cα-Substitution. Chem. Commun. 2018, 54, 5237–5240.
4. R. Kaminker, A. Anastasaki, W. R. Gutekunst, Y. Luo, S.-H. Lee, C. J. Hawker. Tuning of Protease Resistance in Oligopeptides through N-alkylation. Chem. Commun. 2018, 54, 9631–9634.