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אפריל 27, 2017
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Date:20חמישייולי 2023סימפוזיונים
Student seminar
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמארגן הפקולטה לפיזיקהצרו קשר -
Date:23ראשוןיולי 2023הרצאה
Using weather regimes in the context of sub-seasonal forecasting for the Extratropics: the role of synoptic-scale processes in regime predictability, modulation by the MJO and stratosphere, and link to surface weather
More information שעה 11:00 - 11:00מיקום M. Magaritz seminar roomמרצה Christian Grams
Karlsruhe Institute of Technologyמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about Sub-seasonal forecasting aims to predict the mean weather co...» Sub-seasonal forecasting aims to predict the mean weather conditions on weekly time-scales 2-6 weeks ahead. In the midlatitudes, lLarge-scale, quasi-stationary, recurrent, and persistent flow patterns, so-called weather regimes, explain sub-seasonal weather variability in the European region. However, forecast skill and predictability for regimes are mostly very poor on sub-seasonal forecast horizons. In this presentation we shed light on how synoptic-scale processes, affect the predictability and forecast skill of North Atlantic-European weather regimes. We focus on the upper-tropospheric divergent outflow due to latent heat release in ascending air streams, so-called warm conveyor belts (WCBs). We find evidence that a misrepresentation of diabatic WCB outflow at onset of regimes characterised by blocking anticyclones is likely the cause for vanishing regime skill on sub-seasonal time scales. At the same time results suggest that a correct representation of WCB activity might be a window of forecast opportunity for regimes. We further discuss how the occurrence of regimes is modulated by the state of the winter stratosphere and the MJO, which provide another window of forecast opportunity for weather regimes on sub-seasonal time scales. Interestingly, we find again that WCB activity related to synoptic-scale weather systems modulate the MJO teleconnections towards North America and Europe. We conclude that knowledge about physical and dynamical processes on synoptic scales is key for exploiting the potential windows of forecast opportunity for weather regimes on sub-seasonal time scales.
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Date:23ראשוןיולי 2023הרצאה
Using artificial intelligence to help cows go green
More information שעה 13:00 - 14:00כותרת SAERI Seminar Seriesמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Yaniv Altshuler
MIT Media Labמארגן בית הספר למחקר - מכון ויצמן למדעצרו קשר -
Date:24שנייולי 2023הרצאה
Systems Biology Seminar 2022-2023
More information שעה 10:00 - 11:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימארגן מכון עזריאלי למערכות ביולוגיותצרו קשר -
Date:24שנייולי 2023הרצאה
The safety pharmacology of Syk inhibitors: Cardiovascular complications resulting from off-target tyrosine kinase inhibition
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Ms. Marieke Van Daele
Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, UK Centre of Membrane Proteins and Receptors, University of Birmingham and Nottingham, The Midlands, UKמארגן המכון לחקר הטיפול בסרטן עש דואקצרו קשר -
Date:24שנייולי 2023אירועים אקדמיים
Scientific Council Meeting
More information שעה 14:00 - 16:00מיקום מרכז כנסים על-שם דויד לופאטיצרו קשר -
Date:25שלישייולי 2023הרצאה
To be announced
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Subhajit Singha
Dept. of Biomolecular Sciences - WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:26רביעייולי 2023הרצאה
Metastases are just a touch away: Thin membranous connections (TMCs) between tumor cells and macrophages promote tumor cell extravasation
More information שעה 11:00 - 12:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. Alessandro Genna
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NYמארגן המכון לחקר הטיפול בסרטן עש דואקצרו קשר -
Date:30ראשוןיולי 202303חמישיאוגוסט 2023כנסים
9th Prrague-Weizmann Summer School in Drug Discovery
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Haim Michael Barr -
Date:03חמישיאוגוסט 2023הרצאה
Special Guest Seminar by Dr. Monther Abu-Remaileh
More information שעה 13:00 - 14:00כותרת Neurodegeneration: Intra-Lysosomal Lipid Metabolism in the Driver's Seatמיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Monther Abu-Remaileh מארגן המחלקה לנוירוביולוגיה מולקולריתצרו קשר -
Date:07שניאוגוסט 2023הרצאה
Special guest Seminar
More information שעה 11:00 - 12:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Deborah Hung מארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:08שלישיאוגוסט 2023הרצאה
Seminar for PhD thesis defense
More information שעה 16:00 - 17:00כותרת "Deciphering the role of transcription factor cooperativity in binding specificity”מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Offir Lupo מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:10חמישיאוגוסט 2023הרצאה
TMEDs: the Translocators in Unconventional Protein Secretion
More information שעה 14:30 - 15:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Prof. Liang Ge
Tsinghua University, Beijing Chinaמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Protein secretion typically involves the conventional pathwa...» Protein secretion typically involves the conventional pathway, where secretory cargoes containing a signal peptide are transported into the endoplasmic reticulum (ER) through the SRP-SEC61 system and then released via ER-Golgi trafficking. However, our understanding of protein secretion has recently undergone a revolution with the discovery of multiple secretory proteins that lack a signal peptide. These include interleukin-1beta, TGF2, and Tau, which are secreted through unconventional protein secretion (UcPS) involving vesicle trafficking as a major pathway.
The mechanism by which UcPS cargoes enter into the vesicle has been unclear due to the absence of a signal peptide. In our previous work, we identified a membrane protein called TMED10, localized in the ER-Golgi intermediate compartment (ERGIC), as a potential translocator that regulates the entry of UcPS cargoes into the ERGIC, thus initiating vesicle trafficking (Cell, 2020). In this study, we discovered that not only TMED10 but also other TMED family proteins serve as cargo translocators in UcPS. These TMED proteins individually and cooperatively regulate the translocation of different sets of UcPS cargoes into secretory vesicles, leading to diversified regulation of UcPS under various conditions.
The ERGIC functions as a crucial station for translocation due to its unique lipid composition. Sphingomyelin stimulates translocation, while cholesterol antagonizes this effect. TMED10 forms a channel with two open states, and a high current state is associated with translocation activity. Together, our findings suggest that TMEDs represent a novel class of protein channels involved in the distinct translocation and release of numerous UcPS cargoes. This sheds new light on the intricate processes underlying protein secretion.
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Date:15שלישיאוגוסט 2023הרצאה
Intra-host evolution of HIV env after broadly-neutralizing antibody infusion
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Frida Belinky
Virus Persistence and Dynamics Section Immunology Laboratory Vaccine Research Center National Institute of Allergy and Infectious Diseases National Institutes of Healthמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:16רביעיאוגוסט 2023הרצאה
A HOXB4-initiated and -dependent myeloid leukemia: implications for origin and targeted cure of clonal proliferative disease
More information שעה 11:00 - 12:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. Norman Iscove
University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canadaמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:28שניאוגוסט 2023הרצאה
Special Guest seminar with Dr. Raul Andino
More information שעה 14:30 - 15:30כותרת Understanding cellular and molecular mechanisms underlying virus transmissionמיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Raul Andino
University of California San Franciscoמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:29שלישיאוגוסט 2023הרצאה
Special Guest Seminar with Prof. Judith Frydman
More information שעה 10:00 - 11:00כותרת “Molecular Origami: The TRiCky business of folding proteins in the cell”מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Judith Frydman מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:30רביעיאוגוסט 2023הרצאה
Ultra-Repellent Aerophilic Surfaces Underwater”
More information שעה 11:00 - 12:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Alexander B. Tesler
Friedrich-Alexander-Universität Erlangen-Nürnberg, Germanyמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Wetting describes the ability of liquids to maintain contact...» Wetting describes the ability of liquids to maintain contact with a solid surface, a phenomenon that is ubiquitous in nature.1 However, in engineering and medical applications, contact of solid surfaces with aqueous media leads to undesirable phenomena such as corrosion, chemo- and biofouling, which have extremely negative economic, health, and environmental impacts. Therefore, control of wetting on solid surfaces is key to mitigating its detrimental effects. The latter can be achieved by minimizing the contact of the solid substrate with aqueous media, so-called superhydrophobic surfaces (SHS). Although SHS have been studied for decades to overcome wetting challenges,2 they are still rarely used in engineering applications.
When immersed underwater, a special type of SHS can trap air on its surface, so-called air plastron, also known as an aerophilic surface. To date, plastrons have been reported to be impractical for underwater engineering due to their short lifetime. Here, I will describe aerophilic surfaces made of titanium alloy (Ti) with an extended lifetime of plastron conserved for months underwater.3 The extended methodology was developed to unambiguously describe the wetting regime on such aerophilic surfaces since conventional goniometric measurements are simply impractical. My aerophilic surfaces drastically reduce the adhesion of blood, and when immersed in aqueous media, prevent the adhesion of bacteria, and marine organisms such as barnacles, and mussels. Applying thermodynamic stability theories, we describe a generic strategy to achieve long-term stability of plastron on aerophilic surfaces for demanding and hitherto unattainable applications.
(1) Quéré, D. Wetting and Roughness. Annual Review of Materials Research 2008, 38 (1), 71-99.
(2) Cassie, A. B. D.; Baxter, S. Wettability of porous surfaces. Transactions of the Faraday Society 1944, 40, 546-551.
(3) Tesler, A.B.;* Kolle, S.; Prado, L.H.; Thievessen, I.; Böhringer, D.; Backholm, M.; Karunakaran, B.; Nurmi, H.A.; Latikka, M.; Fischer, L.; Stafslien, S.; Cenev, Z.M.; Timonen, J.V.I.; Bruns, M.; Mazare, A.; Lohbauer, U.; Virtanen, S.; Fabry, B.; Schmuki, P.; Ras, R.H.A.; Aizenberg, J.; Goldmann, W.H. Long-Lasting Aerophilic Metallic Surfaces Underwater. Nature Materials 2023, accepted. *Corresponding author
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Date:30רביעיאוגוסט 2023הרצאה
Understanding spontaneous neuronal activity with neurophotonics
More information שעה 12:30 - 13:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Anna Devor
Chief Editor of Neurophotonics SPIE Associate Director, Neurophotonics Center, Boston Universityמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about The last decade has seen a rapid advance of neurophotonic te...» The last decade has seen a rapid advance of neurophotonic technologies, in large part thanks to the BRAIN Initiative as well as other large-scale neuroscience projects in the US and around the world. We now have a large array of diverse experimental and computational tools to study the brain across species, scales, levels of description, in animals and humans. Notably, the lion’s share of these technologies falls under the general umbrella of neurophotonics. This lecture will focus on several microscopic neurophotonic technologies in the context of understanding spontaneous neuronal and neurovascular activity in the mouse cerebral cortex.
Among these tools is optically transparent Windansee electrode arrays that can be combined with optical imaging. Combining Windansee recordings with two-photon imaging and biophysical modeling, we show that spontaneous inputs to layer 1 were coded by a selective, sparse sub-population of local neurons. This is in contrast with earlier studies in the same system where each instance of a sensory input activated a different subset of neurons indicating redundancy in coding. Because selective coding by a few “oracle” neurons is nonredundant, we are tempted to speculate that the health of internally generated brain activity may be more vulnerable to damage or disease compared to that in response to external stimuli.
Light refreshments before the seminar
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Date:04שניספטמבר 2023הרצאה
High-speed atomic force microscopy captures a rare oligomeric state of an ion channel
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Shifra Lansky
Cornell University, New Yorkמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר תקציר Show full text abstract about Transient receptor potential (TRP) channels are a large, euk...» Transient receptor potential (TRP) channels are a large, eukaryotic ion-channel superfamily that control diverse physiological functions. To date, more than 210 structures from over 20 TRP-channels have been determined, all are tetramers. Using high-speed atomic force microscopy (HS-AFM), a pioneering technique capable of “filming” single-molecule proteins, we discovered a rare and transient pentameric state for TRPV3, and determined the pentamer structure using single-particle cryo-EM. Our results suggest that the pentamer relates to the pore-dilated state, a structurally-elusive state characterized by increased conductance and permeability to small molecules. These findings lay the foundation for many new directions in ion-channel research, and demonstrate the strength of HS-AFM in discovering transient and rare states of proteins.
