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אפריל 27, 2017

  • Date:20חמישייולי 2023

    Student seminar

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    שעה
    11:15 - 12:30
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מארגן
    הפקולטה לפיזיקה
    צרו קשר
    סימפוזיונים
  • Date:23ראשוןיולי 2023

    Using weather regimes in the context of sub-seasonal forecasting for the Extratropics: the role of synoptic-scale processes in regime predictability, modulation by the MJO and stratosphere, and link to surface weather

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    שעה
    11:00 - 11:00
    מיקום
    M. Magaritz seminar room
    מרצהChristian Grams
    Karlsruhe Institute of Technology
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    תקצירShow full text abstract about Sub-seasonal forecasting aims to predict the mean weather co...»
    Sub-seasonal forecasting aims to predict the mean weather conditions on weekly time-scales 2-6 weeks ahead. In the midlatitudes, lLarge-scale, quasi-stationary, recurrent, and persistent flow patterns, so-called weather regimes, explain sub-seasonal weather variability in the European region. However, forecast skill and predictability for regimes are mostly very poor on sub-seasonal forecast horizons. In this presentation we shed light on how synoptic-scale processes, affect the predictability and forecast skill of North Atlantic-European weather regimes. We focus on the upper-tropospheric divergent outflow due to latent heat release in ascending air streams, so-called warm conveyor belts (WCBs). We find evidence that a misrepresentation of diabatic WCB outflow at onset of regimes characterised by blocking anticyclones is likely the cause for vanishing regime skill on sub-seasonal time scales. At the same time results suggest that a correct representation of WCB activity might be a window of forecast opportunity for regimes. We further discuss how the occurrence of regimes is modulated by the state of the winter stratosphere and the MJO, which provide another window of forecast opportunity for weather regimes on sub-seasonal time scales. Interestingly, we find again that WCB activity related to synoptic-scale weather systems modulate the MJO teleconnections towards North America and Europe. We conclude that knowledge about physical and dynamical processes on synoptic scales is key for exploiting the potential windows of forecast opportunity for weather regimes on sub-seasonal time scales.

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  • Date:23ראשוןיולי 2023

    Using artificial intelligence to help cows go green

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    שעה
    13:00 - 14:00
    כותרת
    SAERI Seminar Series
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    מרצהDr. Yaniv Altshuler
    MIT Media Lab
    מארגן
    בית הספר למחקר - מכון ויצמן למדע
    צרו קשר
    הרצאה
  • Date:24שנייולי 2023

    Systems Biology Seminar 2022-2023

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    שעה
    10:00 - 11:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מארגן
    מכון עזריאלי למערכות ביולוגיות
    צרו קשר
    הרצאה
  • Date:24שנייולי 2023

    The safety pharmacology of Syk inhibitors: Cardiovascular complications resulting from off-target tyrosine kinase inhibition

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    שעה
    14:00 - 15:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהMs. Marieke Van Daele
    Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, UK Centre of Membrane Proteins and Receptors, University of Birmingham and Nottingham, The Midlands, UK
    מארגן
    המכון לחקר הטיפול בסרטן עש דואק
    צרו קשר
    הרצאה
  • Date:24שנייולי 2023

    Scientific Council Meeting

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    שעה
    14:00 - 16:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    צרו קשר
    אירועים אקדמיים
  • Date:25שלישייולי 2023

    To be announced

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    שעה
    10:00 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    מרצהSubhajit Singha
    Dept. of Biomolecular Sciences - WIS
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    הרצאה
  • Date:26רביעייולי 2023

    Metastases are just a touch away: Thin membranous connections (TMCs) between tumor cells and macrophages promote tumor cell extravasation

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    שעה
    11:00 - 12:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהDr. Alessandro Genna
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY
    מארגן
    המכון לחקר הטיפול בסרטן עש דואק
    צרו קשר
    הרצאה
  • Date:30ראשוןיולי 202303חמישיאוגוסט 2023

    9th Prrague-Weizmann Summer School in Drug Discovery

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    יושב ראש
    Haim Michael Barr
    כנסים
  • Date:03חמישיאוגוסט 2023

    Special Guest Seminar by Dr. Monther Abu-Remaileh

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    שעה
    13:00 - 14:00
    כותרת
    Neurodegeneration: Intra-Lysosomal Lipid Metabolism in the Driver's Seat
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהDr. Monther Abu-Remaileh
    מארגן
    המחלקה לנוירוביולוגיה מולקולרית
    צרו קשר
    הרצאה
  • Date:07שניאוגוסט 2023

    Special guest Seminar

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    שעה
    11:00 - 12:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהProf. Deborah Hung
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    הרצאה
  • Date:08שלישיאוגוסט 2023

    Seminar for PhD thesis defense

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    שעה
    16:00 - 17:00
    כותרת
    "Deciphering the role of transcription factor cooperativity in binding specificity”
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהOffir Lupo
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:10חמישיאוגוסט 2023

    TMEDs: the Translocators in Unconventional Protein Secretion

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    שעה
    14:30 - 15:30
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    מרצהProf. Liang Ge
    Tsinghua University, Beijing China
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Protein secretion typically involves the conventional pathwa...»
    Protein secretion typically involves the conventional pathway, where secretory cargoes containing a signal peptide are transported into the endoplasmic reticulum (ER) through the SRP-SEC61 system and then released via ER-Golgi trafficking. However, our understanding of protein secretion has recently undergone a revolution with the discovery of multiple secretory proteins that lack a signal peptide. These include interleukin-1beta, TGF2, and Tau, which are secreted through unconventional protein secretion (UcPS) involving vesicle trafficking as a major pathway.
    The mechanism by which UcPS cargoes enter into the vesicle has been unclear due to the absence of a signal peptide. In our previous work, we identified a membrane protein called TMED10, localized in the ER-Golgi intermediate compartment (ERGIC), as a potential translocator that regulates the entry of UcPS cargoes into the ERGIC, thus initiating vesicle trafficking (Cell, 2020). In this study, we discovered that not only TMED10 but also other TMED family proteins serve as cargo translocators in UcPS. These TMED proteins individually and cooperatively regulate the translocation of different sets of UcPS cargoes into secretory vesicles, leading to diversified regulation of UcPS under various conditions.
    The ERGIC functions as a crucial station for translocation due to its unique lipid composition. Sphingomyelin stimulates translocation, while cholesterol antagonizes this effect. TMED10 forms a channel with two open states, and a high current state is associated with translocation activity. Together, our findings suggest that TMEDs represent a novel class of protein channels involved in the distinct translocation and release of numerous UcPS cargoes. This sheds new light on the intricate processes underlying protein secretion.
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  • Date:15שלישיאוגוסט 2023

    Intra-host evolution of HIV env after broadly-neutralizing antibody infusion

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    שעה
    14:00 - 15:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהDr. Frida Belinky
    Virus Persistence and Dynamics Section Immunology Laboratory Vaccine Research Center National Institute of Allergy and Infectious Diseases National Institutes of Health
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    הרצאה
  • Date:16רביעיאוגוסט 2023

    A HOXB4-initiated and -dependent myeloid leukemia: implications for origin and targeted cure of clonal proliferative disease

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    שעה
    11:00 - 12:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהDr. Norman Iscove
    University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    הרצאה
  • Date:28שניאוגוסט 2023

    Special Guest seminar with Dr. Raul Andino

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    שעה
    14:30 - 15:30
    כותרת
    Understanding cellular and molecular mechanisms underlying virus transmission
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Raul Andino
    University of California San Francisco
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:29שלישיאוגוסט 2023

    Special Guest Seminar with Prof. Judith Frydman

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    שעה
    10:00 - 11:00
    כותרת
    “Molecular Origami: The TRiCky business of folding proteins in the cell”
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Judith Frydman
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:30רביעיאוגוסט 2023

    Ultra-Repellent Aerophilic Surfaces Underwater”

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    שעה
    11:00 - 12:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהDr. Alexander B. Tesler
    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about Wetting describes the ability of liquids to maintain contact...»
    Wetting describes the ability of liquids to maintain contact with a solid surface, a phenomenon that is ubiquitous in nature.1 However, in engineering and medical applications, contact of solid surfaces with aqueous media leads to undesirable phenomena such as corrosion, chemo- and biofouling, which have extremely negative economic, health, and environmental impacts. Therefore, control of wetting on solid surfaces is key to mitigating its detrimental effects. The latter can be achieved by minimizing the contact of the solid substrate with aqueous media, so-called superhydrophobic surfaces (SHS). Although SHS have been studied for decades to overcome wetting challenges,2 they are still rarely used in engineering applications.
    When immersed underwater, a special type of SHS can trap air on its surface, so-called air plastron, also known as an aerophilic surface. To date, plastrons have been reported to be impractical for underwater engineering due to their short lifetime. Here, I will describe aerophilic surfaces made of titanium alloy (Ti) with an extended lifetime of plastron conserved for months underwater.3 The extended methodology was developed to unambiguously describe the wetting regime on such aerophilic surfaces since conventional goniometric measurements are simply impractical. My aerophilic surfaces drastically reduce the adhesion of blood, and when immersed in aqueous media, prevent the adhesion of bacteria, and marine organisms such as barnacles, and mussels. Applying thermodynamic stability theories, we describe a generic strategy to achieve long-term stability of plastron on aerophilic surfaces for demanding and hitherto unattainable applications.

    (1) Quéré, D. Wetting and Roughness. Annual Review of Materials Research 2008, 38 (1), 71-99.
    (2) Cassie, A. B. D.; Baxter, S. Wettability of porous surfaces. Transactions of the Faraday Society 1944, 40, 546-551.
    (3) Tesler, A.B.;* Kolle, S.; Prado, L.H.; Thievessen, I.; Böhringer, D.; Backholm, M.; Karunakaran, B.; Nurmi, H.A.; Latikka, M.; Fischer, L.; Stafslien, S.; Cenev, Z.M.; Timonen, J.V.I.; Bruns, M.; Mazare, A.; Lohbauer, U.; Virtanen, S.; Fabry, B.; Schmuki, P.; Ras, R.H.A.; Aizenberg, J.; Goldmann, W.H. Long-Lasting Aerophilic Metallic Surfaces Underwater. Nature Materials 2023, accepted. *Corresponding author
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  • Date:30רביעיאוגוסט 2023

    Understanding spontaneous neuronal activity with neurophotonics

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    שעה
    12:30 - 13:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Anna Devor
    Chief Editor of Neurophotonics SPIE Associate Director, Neurophotonics Center, Boston University
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about The last decade has seen a rapid advance of neurophotonic te...»
    The last decade has seen a rapid advance of neurophotonic technologies, in large part thanks to the BRAIN Initiative as well as other large-scale neuroscience projects in the US and around the world. We now have a large array of diverse experimental and computational tools to study the brain across species, scales, levels of description, in animals and humans. Notably, the lion’s share of these technologies falls under the general umbrella of neurophotonics. This lecture will focus on several microscopic neurophotonic technologies in the context of understanding spontaneous neuronal and neurovascular activity in the mouse cerebral cortex.
    Among these tools is optically transparent Windansee electrode arrays that can be combined with optical imaging. Combining Windansee recordings with two-photon imaging and biophysical modeling, we show that spontaneous inputs to layer 1 were coded by a selective, sparse sub-population of local neurons. This is in contrast with earlier studies in the same system where each instance of a sensory input activated a different subset of neurons indicating redundancy in coding. Because selective coding by a few “oracle” neurons is nonredundant, we are tempted to speculate that the health of internally generated brain activity may be more vulnerable to damage or disease compared to that in response to external stimuli.

    Light refreshments before the seminar
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  • Date:04שניספטמבר 2023

    High-speed atomic force microscopy captures a rare oligomeric state of an ion channel

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    שעה
    10:00 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    מרצהDr. Shifra Lansky
    Cornell University, New York
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    תקצירShow full text abstract about Transient receptor potential (TRP) channels are a large, euk...»
    Transient receptor potential (TRP) channels are a large, eukaryotic ion-channel superfamily that control diverse physiological functions. To date, more than 210 structures from over 20 TRP-channels have been determined, all are tetramers. Using high-speed atomic force microscopy (HS-AFM), a pioneering technique capable of “filming” single-molecule proteins, we discovered a rare and transient pentameric state for TRPV3, and determined the pentamer structure using single-particle cryo-EM. Our results suggest that the pentamer relates to the pore-dilated state, a structurally-elusive state characterized by increased conductance and permeability to small molecules. These findings lay the foundation for many new directions in ion-channel research, and demonstrate the strength of HS-AFM in discovering transient and rare states of proteins.
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