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April 29, 2015
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Date:22MondayJune 2015Lecture
Monoubiquitination as a Novel Proteasomal Degradation Signal: Mechanistic and Biomedical Implications
More information Time 14:00 - 15:00Title Cancer Club SeminarLecturer Aaron Ciechanover
Cancer and Vascular Biology Research Center, The Rappaport faculty of Medicine and Research Institute, Technion-Israel Institute of technology, HaifaOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about The ‘canonical’ hallmark of the proteaso...» The ‘canonical’ hallmark of the proteasomal recognition signal is a polyubiquitin chain. Recently, it has become clear that the signal is far more complex and diverse, and contains information derived from both ubiquitin and the substrate. Thus, the proteasome can recognize substrates modified by a single (monoubiquitination) or several single (multiple monoubiquitinations) ubiquitins, short chains (oligoubiquitination), and possibly also long chains (polyubiquitination). We have recently shown that the p105 NF-B precursor is processed to the p50 active subunit of the transcriptional regulator following multiple monoubiquitination, and that this process is probably mediated by the KPC1 ubiquitin ligase. Overexpression of the ligase with excessive generation of p50 results in strong tumor suppression. -
Date:23TuesdayJune 2015Lecture
To be announced
More information Time 10:00 - 11:00Location Gerhard M.J. Schmidt Lecture HallLecturer To be announced
To be announcedOrganizer Department of Biomolecular SciencesContact -
Date:23TuesdayJune 2015Lecture
Conformational Changes in Neurotransmitter Transporters: Roles in Mechanism and Regulation
More information Time 10:00 - 11:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Rudnick Gary
Department of Pharmacology, Yale UniversityOrganizer Department of Biomolecular SciencesContact -
Date:23TuesdayJune 2015Lecture
GeneAnalytics and VarElect: NGS Gene-Set Flavors and Phenotype-Based Prioritization
More information Time 11:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Gil Stelzer
Dept. of Molecular Genetics, WIS and (Gil Stelzer) LifeMap Sciences Inc.Contact Abstract Show full text abstract about We present GeneAnalytics, a novel and simple to use gene-set...» We present GeneAnalytics, a novel and simple to use gene-set analysis website, and VarElect, a phenotype interpretation tool which provides phenotype-dependent variant prioritization. GeneAnalytics was developed for biological researchers, allowing them to get an impression of the underlying biological processes occurring in their input gene-sets, e.g. a list of differentially expressed genes. GeneAnalytics searches for shared function and expression, without the need for a bioinformatician. Its expression-based analysis is powered by LifeMap Discovery®, which associates between genes and specific tissues, cells and diseases through a sophisticated analysis of manually curated and proprietary gene expression data of normal and diseased tissues and cells. Function-based analysis is based on shared diseases, pathways, Gene Ontology terms, and compounds. VarElect prioritizes a gene list in relation to phenotype/disease related keywords, via disease association, gene function, publications and various other data. VarElect also finds indirect associations, such as through shared pathways or interacting proteins. Both GeneAnalytics and VarElect leverage: GeneCards® – the human gene database, MalaCards – the human diseases database, PathCards- the biological pathways database and LifeMap Discovery® – the embryonic development and stem cells database.
This seminar will describe both systems, as well as highlight case studies from the Department of Molecular Genetics that were elucidated by their insights.
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Date:23TuesdayJune 2015Lecture
Redox-modulated photosynthetic energy dissipation
More information Time 11:15 - 11:15Location Ullmann Building of Life SciencesLecturer Bat Chen Wolf
Lab. of Prof. Avihai Danon, Dept. of Plant & Environmental SciencesOrganizer Department of Plant and Environmental SciencesContact -
Date:23TuesdayJune 2015Lecture
"Catalysis on Steroids: Physical Principles Underpinning Enzyme Catalysis and Prospects for Rational Design"
More information Time 14:00 - 15:15Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Stephen Dr. Fried
MRC Lab of Molecular Biology University of CambridgeOrganizer Faculty of ChemistryContact -
Date:24WednesdayJune 2015Lecture
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information Time 13:15 - 14:30Lecturer Venkatesan Thirumalai
NUSNNI-NanoCore, National University of SingaporeOrganizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24WednesdayJune 2015Lecture
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information Time 13:15 - 14:30Lecturer Venkatesan Thirumalai
NUSNNI-NanoCore, National University of SingaporeOrganizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24WednesdayJune 2015Lecture
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information Time 13:15 - 14:30Lecturer Venkatesan Thirumalai
NUSNNI-NanoCore, National University of SingaporeOrganizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24WednesdayJune 2015Lecture
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information Time 13:15 - 14:30Lecturer Venkatesan Thirumalai
NUSNNI-NanoCore, National University of SingaporeOrganizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24WednesdayJune 2015Lecture
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information Time 13:15 - 14:30Lecturer Venkatesan Thirumalai
NUSNNI-NanoCore, National University of SingaporeOrganizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24WednesdayJune 2015Lecture
A neural basis for persistence in learned behavioral states
More information Time 15:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Misha Ahrens
HHMI Janelia Research CampusOrganizer Department of Brain SciencesContact -
Date:25ThursdayJune 2015Colloquia
Schrödinger’s Rainbow: The Renaissance in Quantum Optical Interferometry Slides
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Jonathan Dowling
LSUOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Over the past 20 years bright sources of entangled photons h...» Over the past 20 years bright sources of entangled photons have led to a renaissance in quan-tum optical interferometry. These photon sources have been used to test the foundations of quantum mechanics and implement some of the spooky ideas associated with quantum en-tanglement such as quantum teleportation, quantum cryptography, quantum lithography, quantum computing logic gates, and sub-shot-noise optical interferometers. I will discuss some of these advances and the unification of optical quantum imaging, metrology, and in-formation processing. -
Date:25ThursdayJune 2015Lecture
The T-Body Approach for Cancer Therapy and Beyond
More information Time 14:00 - 14:45Title Special Seminar 2015 Israel Prize in Life Sciences Research RecipientLocation Wolfson Building for Biological ResearchOrganizer Department of Systems ImmunologyContact -
Date:25ThursdayJune 2015Lecture
Life Science Lecture - Prof. Irit Sagi
More information Time 15:00 - 15:00Title Extracellular proteolysis: a bystander or a partner in a crime?Location Dolfi and Lola Ebner AuditoriumLecturer Prof. Irit Sagi
Department of Biological RegulationContact -
Date:25ThursdayJune 2015Lecture
Peletron meeting
More information Time 16:00 - 18:00Contact -
Date:28SundayJune 201530TuesdayJune 2015Conference
Genome Regulation in 3D
More information Time All dayLocation The David Lopatie Conference CentreChairperson Amos TanayHomepage Contact -
Date:28SundayJune 2015Lecture
Chemical Physics Guest Seminar
More information Time 11:00 - 11:00Title ERGODICITY VIOLATION AND AGEING: FROM GRANULAR GASES TO LIVING CELLSLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof Ralf Metzler
University of PotsdamOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about In 1905 Einstein formulated the laws of diffusion, and in 19...» In 1905 Einstein formulated the laws of diffusion, and in 1908 Perrin published his Nobel-prize winning studies determining Avogadro's number from diffusion measurements. With similar, more refined techniques the diffusion behaviour in complex systems such as the motion of tracer particles in living biological cells is nowadays measured with high precision. Often the diffusion turns out to deviate from Einstein's laws. This talk will discuss the basic mechanisms leading to anomalous diffusion as well as point out the physical consequences. In particular the unconventional behaviour of non-ergodic, ageing systems will be addressed within the framework of different stochastic processes [1,2].
The effects of non-ergodicity and ageing will be analysed in more detail for specific physical systems such as the motion of particles in granular gases, tracer diffusion in flexible gels and in living biological cells, as well as in quenched energy landscapes. Moreover, many-particle effects with interactions will be addressed.
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Date:28SundayJune 2015Lecture
Searching for new regulators of ER to Golgi traffic
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Sefi Geva
Maya Schuldiner's group, Dept. of Molecular Genetics, WISContact -
Date:29MondayJune 2015Colloquia
"How long is all the DNA in your body, and how do you physically protect it?"
More information Time 11:00 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Dennis Discher
University of PennsylvaniaOrganizer Faculty of ChemistryContact
