Pages

April 29, 2015

  • Date:22MondayJune 2015

    Monoubiquitination as a Novel Proteasomal Degradation Signal: Mechanistic and Biomedical Implications

    More information
    Time
    14:00 - 15:00
    Title
    Cancer Club Seminar
    LecturerAaron Ciechanover
    Cancer and Vascular Biology Research Center, The Rappaport faculty of Medicine and Research Institute, Technion-Israel Institute of technology, Haifa
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    AbstractShow full text abstract about The ‘canonical’ hallmark of the proteaso...»
    The ‘canonical’ hallmark of the proteasomal recognition signal is a polyubiquitin chain. Recently, it has become clear that the signal is far more complex and diverse, and contains information derived from both ubiquitin and the substrate. Thus, the proteasome can recognize substrates modified by a single (monoubiquitination) or several single (multiple monoubiquitinations) ubiquitins, short chains (oligoubiquitination), and possibly also long chains (polyubiquitination). We have recently shown that the p105 NF-B precursor is processed to the p50 active subunit of the transcriptional regulator following multiple monoubiquitination, and that this process is probably mediated by the KPC1 ubiquitin ligase. Overexpression of the ligase with excessive generation of p50 results in strong tumor suppression.
    Lecture
  • Date:23TuesdayJune 2015

    To be announced

    More information
    Time
    10:00 - 11:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerTo be announced
    To be announced
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:23TuesdayJune 2015

    Conformational Changes in Neurotransmitter Transporters: Roles in Mechanism and Regulation

    More information
    Time
    10:00 - 11:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Rudnick Gary
    Department of Pharmacology, Yale University
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:23TuesdayJune 2015

    GeneAnalytics and VarElect: NGS Gene-Set Flavors and Phenotype-Based Prioritization

    More information
    Time
    11:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Gil Stelzer
    Dept. of Molecular Genetics, WIS and (Gil Stelzer) LifeMap Sciences Inc.
    Contact
    AbstractShow full text abstract about We present GeneAnalytics, a novel and simple to use gene-set...»
    We present GeneAnalytics, a novel and simple to use gene-set analysis website, and VarElect, a phenotype interpretation tool which provides phenotype-dependent variant prioritization. GeneAnalytics was developed for biological researchers, allowing them to get an impression of the underlying biological processes occurring in their input gene-sets, e.g. a list of differentially expressed genes. GeneAnalytics searches for shared function and expression, without the need for a bioinformatician. Its expression-based analysis is powered by LifeMap Discovery®, which associates between genes and specific tissues, cells and diseases through a sophisticated analysis of manually curated and proprietary gene expression data of normal and diseased tissues and cells. Function-based analysis is based on shared diseases, pathways, Gene Ontology terms, and compounds. VarElect prioritizes a gene list in relation to phenotype/disease related keywords, via disease association, gene function, publications and various other data. VarElect also finds indirect associations, such as through shared pathways or interacting proteins. Both GeneAnalytics and VarElect leverage: GeneCards® – the human gene database, MalaCards – the human diseases database, PathCards- the biological pathways database and LifeMap Discovery® – the embryonic development and stem cells database.
    This seminar will describe both systems, as well as highlight case studies from the Department of Molecular Genetics that were elucidated by their insights.
    Lecture
  • Date:23TuesdayJune 2015

    Redox-modulated photosynthetic energy dissipation

    More information
    Time
    11:15 - 11:15
    Location
    Ullmann Building of Life Sciences
    LecturerBat Chen Wolf
    Lab. of Prof. Avihai Danon, Dept. of Plant & Environmental Sciences
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    Lecture
  • Date:23TuesdayJune 2015

    "Catalysis on Steroids: Physical Principles Underpinning Enzyme Catalysis and Prospects for Rational Design"

    More information
    Time
    14:00 - 15:15
    Location
    Helen and Milton A. Kimmelman Building
    LecturerDr. Stephen Dr. Fried
    MRC Lab of Molecular Biology University of Cambridge
    Organizer
    Faculty of Chemistry
    Contact
    Lecture
  • Date:24WednesdayJune 2015

    Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health

    More information
    Time
    13:15 - 14:30
    LecturerVenkatesan Thirumalai
    NUSNNI-NanoCore, National University of Singapore
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about I will give examples from various fields to show the ubiquit...»
    I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
    It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
    For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
    In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
    Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
    Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.

    Lecture
  • Date:24WednesdayJune 2015

    Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health

    More information
    Time
    13:15 - 14:30
    LecturerVenkatesan Thirumalai
    NUSNNI-NanoCore, National University of Singapore
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about I will give examples from various fields to show the ubiquit...»
    I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
    It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
    For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
    In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
    Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
    Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
    Lecture
  • Date:24WednesdayJune 2015

    Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health

    More information
    Time
    13:15 - 14:30
    LecturerVenkatesan Thirumalai
    NUSNNI-NanoCore, National University of Singapore
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about I will give examples from various fields to show the ubiquit...»
    I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
    It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
    For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
    In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
    Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
    Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.

    Lecture
  • Date:24WednesdayJune 2015

    Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health

    More information
    Time
    13:15 - 14:30
    LecturerVenkatesan Thirumalai
    NUSNNI-NanoCore, National University of Singapore
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about I will give examples from various fields to show the ubiquit...»
    I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
    It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
    For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
    In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
    Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
    Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.

    Lecture
  • Date:24WednesdayJune 2015

    Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health

    More information
    Time
    13:15 - 14:30
    LecturerVenkatesan Thirumalai
    NUSNNI-NanoCore, National University of Singapore
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about I will give examples from various fields to show the ubiquit...»
    I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
    It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
    For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
    In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
    Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
    Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.

    Lecture
  • Date:24WednesdayJune 2015

    A neural basis for persistence in learned behavioral states

    More information
    Time
    15:00 - 15:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Misha Ahrens
    HHMI Janelia Research Campus
    Organizer
    Department of Brain Sciences
    Contact
    Lecture
  • Date:25ThursdayJune 2015

    Schrödinger’s Rainbow: The Renaissance in Quantum Optical Interferometry Slides

    More information
    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerJonathan Dowling
    LSU
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about Over the past 20 years bright sources of entangled photons h...»
    Over the past 20 years bright sources of entangled photons have led to a renaissance in quan-tum optical interferometry. These photon sources have been used to test the foundations of quantum mechanics and implement some of the spooky ideas associated with quantum en-tanglement such as quantum teleportation, quantum cryptography, quantum lithography, quantum computing logic gates, and sub-shot-noise optical interferometers. I will discuss some of these advances and the unification of optical quantum imaging, metrology, and in-formation processing.
    Colloquia
  • Date:25ThursdayJune 2015

    The T-Body Approach for Cancer Therapy and Beyond

    More information
    Time
    14:00 - 14:45
    Title
    Special Seminar 2015 Israel Prize in Life Sciences Research Recipient
    Location
    Wolfson Building for Biological Research
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:25ThursdayJune 2015

    Life Science Lecture - Prof. Irit Sagi

    More information
    Time
    15:00 - 15:00
    Title
    Extracellular proteolysis: a bystander or a partner in a crime?
    Location
    Dolfi and Lola Ebner Auditorium
    LecturerProf. Irit Sagi
    Department of Biological Regulation
    Contact
    Lecture
  • Date:25ThursdayJune 2015

    Peletron meeting

    More information
    Time
    16:00 - 18:00
    Contact
    Lecture
  • Date:28SundayJune 201530TuesdayJune 2015

    Genome Regulation in 3D

    More information
    Time
    All day
    Location
    The David Lopatie Conference Centre
    Chairperson
    Amos Tanay
    Homepage
    Contact
    Conference
  • Date:28SundayJune 2015

    Chemical Physics Guest Seminar

    More information
    Time
    11:00 - 11:00
    Title
    ERGODICITY VIOLATION AND AGEING: FROM GRANULAR GASES TO LIVING CELLS
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf Ralf Metzler
    University of Potsdam
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about In 1905 Einstein formulated the laws of diffusion, and in 19...»
    In 1905 Einstein formulated the laws of diffusion, and in 1908 Perrin published his Nobel-prize winning studies determining Avogadro's number from diffusion measurements. With similar, more refined techniques the diffusion behaviour in complex systems such as the motion of tracer particles in living biological cells is nowadays measured with high precision. Often the diffusion turns out to deviate from Einstein's laws. This talk will discuss the basic mechanisms leading to anomalous diffusion as well as point out the physical consequences. In particular the unconventional behaviour of non-ergodic, ageing systems will be addressed within the framework of different stochastic processes [1,2].

    The effects of non-ergodicity and ageing will be analysed in more detail for specific physical systems such as the motion of particles in granular gases, tracer diffusion in flexible gels and in living biological cells, as well as in quenched energy landscapes. Moreover, many-particle effects with interactions will be addressed.
    Lecture
  • Date:28SundayJune 2015

    Searching for new regulators of ER to Golgi traffic

    More information
    Time
    13:00 - 13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerSefi Geva
    Maya Schuldiner's group, Dept. of Molecular Genetics, WIS
    Contact
    Lecture
  • Date:29MondayJune 2015

    "How long is all the DNA in your body, and how do you physically protect it?"

    More information
    Time
    11:00 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Dennis Discher
    University of Pennsylvania
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia

Pages