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אפריל 29, 2015
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Date:22שנייוני 2015הרצאה
Monoubiquitination as a Novel Proteasomal Degradation Signal: Mechanistic and Biomedical Implications
More information שעה 14:00 - 15:00כותרת Cancer Club Seminarמרצה Aaron Ciechanover
Cancer and Vascular Biology Research Center, The Rappaport faculty of Medicine and Research Institute, Technion-Israel Institute of technology, Haifaמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר תקציר Show full text abstract about The ‘canonical’ hallmark of the proteaso...» The ‘canonical’ hallmark of the proteasomal recognition signal is a polyubiquitin chain. Recently, it has become clear that the signal is far more complex and diverse, and contains information derived from both ubiquitin and the substrate. Thus, the proteasome can recognize substrates modified by a single (monoubiquitination) or several single (multiple monoubiquitinations) ubiquitins, short chains (oligoubiquitination), and possibly also long chains (polyubiquitination). We have recently shown that the p105 NF-B precursor is processed to the p50 active subunit of the transcriptional regulator following multiple monoubiquitination, and that this process is probably mediated by the KPC1 ubiquitin ligase. Overexpression of the ligase with excessive generation of p50 results in strong tumor suppression. -
Date:23שלישייוני 2015הרצאה
To be announced
More information שעה 10:00 - 11:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה To be announced
To be announcedמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:23שלישייוני 2015הרצאה
Conformational Changes in Neurotransmitter Transporters: Roles in Mechanism and Regulation
More information שעה 10:00 - 11:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Rudnick Gary
Department of Pharmacology, Yale Universityמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:23שלישייוני 2015הרצאה
GeneAnalytics and VarElect: NGS Gene-Set Flavors and Phenotype-Based Prioritization
More information שעה 11:00 - 11:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Gil Stelzer
Dept. of Molecular Genetics, WIS and (Gil Stelzer) LifeMap Sciences Inc.צרו קשר תקציר Show full text abstract about We present GeneAnalytics, a novel and simple to use gene-set...» We present GeneAnalytics, a novel and simple to use gene-set analysis website, and VarElect, a phenotype interpretation tool which provides phenotype-dependent variant prioritization. GeneAnalytics was developed for biological researchers, allowing them to get an impression of the underlying biological processes occurring in their input gene-sets, e.g. a list of differentially expressed genes. GeneAnalytics searches for shared function and expression, without the need for a bioinformatician. Its expression-based analysis is powered by LifeMap Discovery®, which associates between genes and specific tissues, cells and diseases through a sophisticated analysis of manually curated and proprietary gene expression data of normal and diseased tissues and cells. Function-based analysis is based on shared diseases, pathways, Gene Ontology terms, and compounds. VarElect prioritizes a gene list in relation to phenotype/disease related keywords, via disease association, gene function, publications and various other data. VarElect also finds indirect associations, such as through shared pathways or interacting proteins. Both GeneAnalytics and VarElect leverage: GeneCards® – the human gene database, MalaCards – the human diseases database, PathCards- the biological pathways database and LifeMap Discovery® – the embryonic development and stem cells database.
This seminar will describe both systems, as well as highlight case studies from the Department of Molecular Genetics that were elucidated by their insights.
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Date:23שלישייוני 2015הרצאה
Redox-modulated photosynthetic energy dissipation
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Bat Chen Wolf
Lab. of Prof. Avihai Danon, Dept. of Plant & Environmental Sciencesמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:23שלישייוני 2015הרצאה
"Catalysis on Steroids: Physical Principles Underpinning Enzyme Catalysis and Prospects for Rational Design"
More information שעה 14:00 - 15:15מיקום בניין הלן ומילטון קימלמןמרצה Dr. Stephen Dr. Fried
MRC Lab of Molecular Biology University of Cambridgeמארגן הפקולטה לכימיהצרו קשר -
Date:24רביעייוני 2015הרצאה
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information שעה 13:15 - 14:30מרצה Venkatesan Thirumalai
NUSNNI-NanoCore, National University of Singaporeמארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24רביעייוני 2015הרצאה
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information שעה 13:15 - 14:30מרצה Venkatesan Thirumalai
NUSNNI-NanoCore, National University of Singaporeמארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24רביעייוני 2015הרצאה
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information שעה 13:15 - 14:30מרצה Venkatesan Thirumalai
NUSNNI-NanoCore, National University of Singaporeמארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24רביעייוני 2015הרצאה
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information שעה 13:15 - 14:30מרצה Venkatesan Thirumalai
NUSNNI-NanoCore, National University of Singaporeמארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24רביעייוני 2015הרצאה
Opportunity for Oxides in Electronics, Optics, Magnetics, Memory, Energy and Health
More information שעה 13:15 - 14:30מרצה Venkatesan Thirumalai
NUSNNI-NanoCore, National University of Singaporeמארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about I will give examples from various fields to show the ubiquit...» I will give examples from various fields to show the ubiquity of oxides for a number of applications. Compared to dominantly covalent semiconductors like silicon and the III-V or II-VI materials oxides are primarily ionic bonded and also have extensive oxygen bonding and the oxygen bonds play a crucial role in determining the property of the material and give oxides a level of diversity not seen in covalent semiconductors.
It is frequently argued by the semiconductor community that oxides are prone to defects and hence are inherently unstable for technologies. However, defects in oxides play a crucial role in controlling the material properties and I will illustrate this with the example of ferromagnetism in TiO2 via titanium vacancies. This is achieved by substituting Ta in the place of Ti which leads to a significant donor electron population stimulating the formation of compensating defects such as Ti vacancies and Ti3+. As a function of film thickness one sees ferromagnetism, Kondo scattering and eventually impurity scattering in the same system revealing the diversity of interactions.
For the technologies beyond Moore silicon photonics is evolving at a rapid phase with a corresponding Moore’s law projection extending up to 2025. The area of opportunity is the growth of functional oxides on silicon to build switchable devices which will significantly enhance the capability of the future silicon packages integrating multiple chips.
In today’s computing devices more than 25% of the energy is consumed in memories and a typical server station expends 55% of its energy on memories. Ferroelectric tunnel junctions may play a crucial role in the development of low energy consuming memory devices. I will show results on oxide based ferroelectric tunnel junctions where just two unit cells of barium titanate enable a robust switching of a junction with On/Off ratios exceeding 1000%.
Oxides, because of their chemical stability may be important for applications such as water splitting, CO2 sequestration etc. I will illustrate this with the example of a new class of materials, Sr, Ca and Ba Niobates which show a very unusual band structure when prepared under different oxygen pressures.
Lastly but not the least I will illustrate the potential for oxides in controlling bio processes such as bio film formation cell proliferation and differentiation where the surface chemistry seems to play a crucial role in controlling the processes.
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Date:24רביעייוני 2015הרצאה
A neural basis for persistence in learned behavioral states
More information שעה 15:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Misha Ahrens
HHMI Janelia Research Campusמארגן המחלקה למדעי המוחצרו קשר -
Date:25חמישייוני 2015סימפוזיונים
Schrödinger’s Rainbow: The Renaissance in Quantum Optical Interferometry Slides
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Jonathan Dowling
LSUמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about Over the past 20 years bright sources of entangled photons h...» Over the past 20 years bright sources of entangled photons have led to a renaissance in quan-tum optical interferometry. These photon sources have been used to test the foundations of quantum mechanics and implement some of the spooky ideas associated with quantum en-tanglement such as quantum teleportation, quantum cryptography, quantum lithography, quantum computing logic gates, and sub-shot-noise optical interferometers. I will discuss some of these advances and the unification of optical quantum imaging, metrology, and in-formation processing. -
Date:25חמישייוני 2015הרצאה
The T-Body Approach for Cancer Therapy and Beyond
More information שעה 14:00 - 14:45כותרת Special Seminar 2015 Israel Prize in Life Sciences Research Recipientמיקום בניין וולפסון למחקר ביולוגימארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:25חמישייוני 2015הרצאה
Life Science Lecture - Prof. Irit Sagi
More information שעה 15:00 - 15:00כותרת Extracellular proteolysis: a bystander or a partner in a crime?מיקום אולם ע"ש דולפי ולולה אבנרמרצה Prof. Irit Sagi
Department of Biological Regulationצרו קשר -
Date:25חמישייוני 2015הרצאה
Peletron meeting
More information שעה 16:00 - 18:00צרו קשר -
Date:28ראשוןיוני 201530שלישייוני 2015כנסים
Genome Regulation in 3D
More information שעה כל היוםמיקום מרכז כנסים על-שם דויד לופאטייושב ראש Amos Tanayדף בית צרו קשר -
Date:28ראשוןיוני 2015הרצאה
Chemical Physics Guest Seminar
More information שעה 11:00 - 11:00כותרת ERGODICITY VIOLATION AND AGEING: FROM GRANULAR GASES TO LIVING CELLSמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof Ralf Metzler
University of Potsdamמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about In 1905 Einstein formulated the laws of diffusion, and in 19...» In 1905 Einstein formulated the laws of diffusion, and in 1908 Perrin published his Nobel-prize winning studies determining Avogadro's number from diffusion measurements. With similar, more refined techniques the diffusion behaviour in complex systems such as the motion of tracer particles in living biological cells is nowadays measured with high precision. Often the diffusion turns out to deviate from Einstein's laws. This talk will discuss the basic mechanisms leading to anomalous diffusion as well as point out the physical consequences. In particular the unconventional behaviour of non-ergodic, ageing systems will be addressed within the framework of different stochastic processes [1,2].
The effects of non-ergodicity and ageing will be analysed in more detail for specific physical systems such as the motion of particles in granular gases, tracer diffusion in flexible gels and in living biological cells, as well as in quenched energy landscapes. Moreover, many-particle effects with interactions will be addressed.
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Date:28ראשוןיוני 2015הרצאה
Searching for new regulators of ER to Golgi traffic
More information שעה 13:00 - 13:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Sefi Geva
Maya Schuldiner's group, Dept. of Molecular Genetics, WISצרו קשר -
Date:29שנייוני 2015סימפוזיונים
"How long is all the DNA in your body, and how do you physically protect it?"
More information שעה 11:00 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Dennis Discher
University of Pennsylvaniaמארגן הפקולטה לכימיהצרו קשר
