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October 05, 2015
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Date:01SundayNovember 2015Lecture
Chewing rocks – physiology and mechanisms of iron-oxidizing bacteria and their habitats on modern and ancient earth
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Andreas Kappler
University of TubingenOrganizer Department of Earth and Planetary SciencesContact -
Date:01SundayNovember 2015Lecture
Switching miRNAs on and off on an evolutionary and physiological time scales
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Yonit Hoffman
Tzachi Pilpel's group, Dept. of Molecular GeneticsOrganizer Department of Molecular GeneticsContact -
Date:01SundayNovember 2015Lecture
The molecular and phenotypic landscape of host-pathogen interactions
More information Time 14:00 - 15:00Location Raoul and Graziella de Picciotto Building for Scientific and Technical SupportLecturer Prof. Roi Avraham Organizer Department of Immunology and Regenerative BiologyContact -
Date:02MondayNovember 201505ThursdayNovember 2015Academic Events
SAAC Reviews
More information Time All dayContact -
Date:02MondayNovember 2015Lecture
Quantitative fate mapping of hematopoiesis in situ
More information Time 09:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchOrganizer Department of Systems ImmunologyHomepage Contact -
Date:03TuesdayNovember 2015Lecture
Eukaryotic gene regulation as frequency modulation
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchOrganizer Department of Systems ImmunologyHomepage Contact -
Date:03TuesdayNovember 2015Lecture
Agonizing minds: The Monod-Jacobs explorations of gene and enzyme regulation
More information Time 10:00 - 11:00Location Wolfson Building for Biological ResearchLecturer Prof. Dan Tawfik
Dept.of Biological Chemistry-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about This seminar regards the history of science, and specificall...» This seminar regards the history of science, and specifically the discoveries of the molecular mechanisms of gene and enzyme regulation by Jacques Monod (1910-1976) and Francois Jacobs (1920-2013).
The physiological adaptation of microorganism to catabolize a given sugar upon its appearance in the growth medium has been noticed in yeast around 1900. Yet it took nearly half a century, and the relentless minds of Jacques Monod, later joined by Francois Jacob, to unravel the molecular mechanisms that underlie this adaption, or induction as it became known. The anxious, agonizing minds of Jacobs and Monod, their obsession with ‘big questions’, combined with experimental ingenuity, led to the textbook paradigms of the Lac operon and gene regulation, and of allosteric enzyme regulation.
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Date:03TuesdayNovember 2015Lecture
From design-by-evolution to evolution-by-design – the case of CLL
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Dan Landau
Broad Institute, Cambridge, MA, USAOrganizer Department of Molecular GeneticsContact -
Date:03TuesdayNovember 2015Lecture
Looking at proteins in live cells at atomic resolution: From Science Fiction to Science Reality
More information Time 14:00 - 15:00Location Raoul and Graziella de Picciotto Building for Scientific and Technical SupportLecturer Philip Selenko Organizer Department of Immunology and Regenerative BiologyContact -
Date:03TuesdayNovember 2015Lecture
Transmission of mechanical force: the role of the AmotL2 /cadherin complex in normal development and cancer
More information Time 14:00 - 14:00Location Wolfson AuditoriumLecturer Professor Lars Holmgren
Department of Oncology-Pathology, Cancer Center Karolinska Institute, Stockholm, SwedenOrganizer Department of Molecular Cell BiologyContact -
Date:04WednesdayNovember 2015Lecture
Developmental axon pruning requires destabilization of cell adhesion by JNK signaling
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Oren Schuldiner
Dept. of Molecular Cell Biology, WISContact -
Date:04WednesdayNovember 2015Lecture
G-INCPM-Special Seminar - Prof. Miguel Weil, Head of the Cell Screening Facility for Personalized Medicine, Department of Cell Research and Immunology, Tel-Aviv Univ. - Novel approach for Personalized Medicine of rare diseases
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Prof. Miguel Weil
Head of the Cell Screening Facility for Personalized Medicine, Department of Cell Research and Immunology, Tel-Aviv Univ.Organizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Personalized medicine aims the tailoring of strategies to de...» Personalized medicine aims the tailoring of strategies to detect, treat, and prevent disease based on an individual’s genetic fingerprint or makeup. Although several advances have been made in molecular profiling technologies to obtain and analyze vast amount of personal information, this technologies has yet to prove their use for drug-personalized treatment.
We have developed a novel approach that could solve this existing gap between the identification of disease biomarkers within the acquired personalized biological data and their potential for drug-personalized treatment. We use image based high content analysis (HCA) to identify the disease phenotype in cells from patients with neurodegenerative and rare diseases. This technology obtains the personal biological information from multiple images taken from thousands of cells isolated from skin biopsies of patients allowing us to identify specific disease signatures or disease phenotypes based on the ! individual’s cell biology. These disease signatures will enable us to screen thousands of drugs on patient cells and to isolate potential drugs for personalized treatment. This approach will contribute a great deal to the evolving field of personalized medicine in general and to the field of diagnosis and treatment of incurable neurodegenerative and rare diseases. The Cell Screening Facility for Personalized Medicine (CSFPM) which is part of the new Blavatnik Center for Drug Development (BCDD) at TAU, aims to find potential drugs for treatment of rare diseases like Amyotrophic Lateral Sclerosis (ALS), Familial Dysautonomia (FD), Duchenne Muscular Dystrophy (DMD), Adult Polyglucosan Body Disease (APBD) and others.
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Date:04WednesdayNovember 2015Cultural Events
Dira Lehaskir - Children's Theatre
More information Time 17:30 - 19:00Location Michael Sela AuditoriumHomepage Contact -
Date:05ThursdayNovember 2015Lecture
Magnetic Resonance Seminar
More information Time 09:30 - 09:30Title In-cell NMR and EPR methods to derive high-resolution insights into the structure(s) and dynamics of a human amyloid protein in differentmammalian cell typesLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Phil Selenko
Leibniz Institute of Molecular Pharmacology (FMP Berlin)Organizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Abstract: Here, I present an overview of the various NMR and...» Abstract: Here, I present an overview of the various NMR and EPR methods that we used
to derive the first full-scale atomic-resolution description of an intrinsically disordered
human amyloid protein in five different mammalian cell types, including cells of neuronal
and non-neuronal origins. Furthermore, I present an outlook towards using these tools to
studying intracellular aggregation processes and preliminary data on different aggregate
structures that form in response to cellular stress conditions. -
Date:05ThursdayNovember 2015Lecture
Clathrin-coated pits mature by continuous bending and remodeling of the coat
More information Time 10:00 - 10:00Location Max and Lillian Candiotty BuildingLecturer Prof. Ori Avinoam Organizer Department of Immunology and Regenerative BiologyContact -
Date:05ThursdayNovember 2015Colloquia
Ergodicity, entanglement and many-body localization in quantum dynamics
More information Time 11:15 - 12:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Ehud Altman
WISOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Do quantum many-body systems necessarily come to thermal equ...» Do quantum many-body systems necessarily come to thermal equilibrium after a long enough time evolution? The conventional wisdom has long been that they do and that, in the process, any quantum information encoded in the initial state is lost irretrievably. Thus the dynamics of many-interacting particles becomes effectively classical. But these ingrained notions of thermalization and ergodicity have recently been called into question. In this talk I will discuss how ergodicity can break down in disordered quantum systems through the phenomenon of many-body localization. In contrast to thermalizing fluids, quantum correlations can persist through time evolution of the localized state even at high energy densities. Thus, investigating the many-body localization transition offers a concrete route to address fundamental unsolved questions concerning the boundary between classical and quantum physics in the macroscopic world. I will emphasize the important role that quantum entanglement plays in current attempts to understand this fascinating dynamical phase transition. Finally I will present recent progress in confronting the emerging theoretical understanding of many-body localization with experimental tests using systems of ultra-cold atoms. -
Date:05ThursdayNovember 2015Lecture
Mechanics of stiffness sensing by migrating cancer cells
More information Time 13:15 - 13:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer David J. Odde
Department of Biomedical Engineering, University of MinnesotaOrganizer Clore Center for Biological PhysicsContact Abstract Show full text abstract about We have developed a mathematical/computational model for how...» We have developed a mathematical/computational model for how cells sense the mechanical stiffness of their environment, and how that in turn affects cell migration. I will present our findings on both the theoretical predictions of the model, and the experimental testing of it in vitro using U251 glioma cells on gels of controlled mechanical compliance and surface chemistry. -
Date:08SundayNovember 201511WednesdayNovember 2015International Board
The 67th Annual General Meeting of the International Board
More information Time All dayContact -
Date:08SundayNovember 2015Lecture
The MYCN oncoprotein and the emergence of chemotherapy resisters
More information Time 11:00 - 12:00Location Raoul and Graziella de Picciotto Building for Scientific and Technical SupportOrganizer Department of Immunology and Regenerative BiologyContact -
Date:08SundayNovember 2015Lecture
Stabilization of the Dead Sea level Is the Red Sea-Dead Sea Water Conveyance a feasible solution?
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Michael Bayth Organizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Stabilization of the Dead Sea (DS) level Is the Red Sea-Dea...» Stabilization of the Dead Sea (DS) level
Is the Red Sea-Dead Sea Water Conveyance a feasible solution?
By
Michael Beyth, Geological Survey
The seminar will discuss the:
• Limnological background-DS a hypersaline terminal lake.
• Environmental impacts of the DS level decline-sinkholes and infrastructure.
• The idea- from 1840.
• Is the Red Sea – Dead Sea Conveyance a feasible solution?-the only solution to manage the DS level.
• The recent feasibility study 2008-2013.
The three major goals for the project defined in this recent study were: 1. to stabilize the Dead Sea water level by conveying up to 1,200 MCM/y of reject; 2. to desalinate up to 850 MCM/y mainly for Jordan; 3. to serve as a symbol of peace between the three Beneficiary Parties, Jordan, Israel and the Palestinian Authority. The project was managed by the World Bank navigated by the Steering Committee of the Beneficiary Parties,. This study followed Harza (1996) pre-feasibility study.
Six reports were published
• Tech./econo. feasibility study by Coyne et Bellier.
• Environmental and social assesment by ERM.
• Dead Sea Study by Tahal&GSI.
• Red Sea study by Tethis&IINS,Jur.Uni., IOLR.
• Study of Alternatives by Allen, Malkawi and Tsur.
• Chemical industry analysis study (Zbranek).
The reports are available at Web-site (www.worldbank.org/rds).
Pilot-first phase –tender stage now
• a limited desalination plant of ~80 MCM/y at Aqaba.
• 35 MCM/y of desalinated water will be bought by Israel and transferred to the Israeli Arava Valley.
• The rest will be used by Jordan for Aqaba and dilution of the DISI aquifer pipeline to Amman.
• The reject brine together with more sea water (should be 200 MCM/y together) will be piped to the Lisan "Lagoon", at the south-east corner of the Dead Sea.
• Possible small Hydro-Electric plant will be built in Ghor Pipa, Jordan, producing ~30 MW.
• On December 9th 2013 an MOU was signed in Washington by Israel, Jordan and the Palestinian Authority, speaking also about Israel to sell to Jordan another 50 MCM/y from Lake Kinneret and about Israel to sell the Palestinian Authority another 20-30 MCM/y of water through the current water supply system.
• On February 26th 2015 an implementation agreement was signed between Israel and Jordan that defines the implement process of the Red – Dead Pilot, including water swap between the countries.
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