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September 01, 2016

  • Date:08MondayApril 2019

    IMM Guest seminar- Dr. Tomer Hertz will lecture on "A journey into influenza antigenic space using systems serology".

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    Time
    13:00 - 13:00
    Location
    Wolfson Building for Biological Research
    LecturerDr. Tomer Hertz
    Tomer Hertz received his PhD in computational neuroscience from the Hebrew University in the field of machine learning and pattern recognition. His then joined Microsoft Research as a potdoctoral student in computational immunology focusing developing and applying algorithms for MHC-peptide binding and also for HLA supertype classification. He then joined the Fred Hutch Cancer Research Center where he has been a faculty member in the Vaccine and Infectious Disease Division for 7 years focusing on immunological research in both Influenza and HIV as disease models. In 2014, he joined the department of immunology at Ben-Gurion University of the Negev in Israel where he heads a systems immunology lab that studies the role of immune history and its effect on vaccination and natural infection, modeling peptide:MHC:TCR interactions, and novel methods for the analysis of high-dimensional immunological data.
    Organizer
    Department of Systems Immunology
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    AbstractShow full text abstract about Vaccination is an effective tool for preventing influenza in...»
    Vaccination is an effective tool for preventing influenza infection. A variety of factors have been shown to impact the observed heterogeneity and inter-individual variations in immune responses following vaccination including age, gender, ethnicity and immunological history (the individual's memory antibody repertoire to previously encountered pathogens and vaccines). Throughout life individuals are infected by and vaccinated with multiple influenza strains and develop a broad and diverse influenza Ab repertoire. We have been developing a novel low-volume antigen microarray assay for profiling influenza immunological history, and used it to assess the effects of immune history on vaccine-induced immunogenicity and protection, using samples from an influenza vaccine efficacy trial, as well as to characterize the maternal fetal transfer of influenza specific antibodies.
    Lecture
  • Date:08MondayApril 2019

    Emergence and stability of a Brownian motor

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    Time
    14:15 - 14:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerAlex Feigel
    Hebrew University
    Organizer
    Department of Physics of Complex Systems
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    AbstractShow full text abstract about A Brownian motor rectifies thermal noise and creates useful ...»
    A Brownian motor rectifies thermal noise and creates useful work. Here we address how this machine can emerge without predefined energy minimum in a system out of thermal equilibrium. Intuitively, Brownian motor as any artificial or biological machine should degrade with time. I will show that on contrary, a system with multiple degrees of freedom out of thermal equilibrium can be stable at a state that generates useful work.

    It is demonstrated with the help of ab initio analysis of a modified Feynman-Smoluchowski ratchet with two degrees of freedom. Out of thermal equilibrium, an environment imposes effective mechanical forces on nano-fabricated devices as well as on microscopic chemical or biological systems. Thus out of thermal equilibrium environment can enforce a specific steady state on the system by creating effective potentials in otherwise homogeneous configuration space.

    I present an ab initio path from the elastic scattering of a single gas particle by a mechanical system to the transition rate probability between the states of the system with multiple degrees of freedom, together with the corresponding Masters-Boltzmann equation and the average velocities of the system’s degrees of freedom as functions of the macroscopic parameters of the out-of-equilibrium environment. It results in Onsager relations that include the influence of the different degrees of freedom on each other.

    An interesting finding is that some of these forces persist even in a single temperature environment if the thermodynamic limit does not hold. In addition, the spatial asymmetry of the system’s stable state, together with the corresponding directed motion, may possess preferred chiral symmetry.

    Lecture
  • Date:10WednesdayApril 201911ThursdayApril 2019

    Advanced Electron Microscopy Symposium

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    Time
    08:00 - 08:00
    Location
    The David Lopatie Conference Centre
    Chairperson
    Sharon G. Wolf
    Organizer
    Department of Chemical Research Support
    Conference
  • Date:10WednesdayApril 2019

    Cut along dotted line: kirigami materials and device applications

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    LecturerProf. Max Shtein
    Professor of Materials Science and Engineering, Chemical Engineering; University of Michigan
    Organizer
    Department of Molecular Chemistry and Materials Science
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    AbstractShow full text abstract about Simple 2-dimensional cut and fold patterns can be transforme...»
    Simple 2-dimensional cut and fold patterns can be transformed into 3-dimensional shapes upon stretch-ing. We use this simple approach to develop mechanical metamaterials with several interesting proper-ties and applications. I will describe ways of tuning properties via geometric structure, and discuss ex-amples of how this can be used to achieve superior performance in mechanics, photonics, electronics, sensors, and other areas.

    References:
    “Dynamic kirigami structures for integrated solar tracking.” Nature Comm. 6, 8092 (2015)
    “A kirigami approach to engineering elasticity in nanocomposites through patterned defects.” Na-ture Mater., 14 (2015) 785
    “An Electric Eel-Inspired Artificial Soft Power Source from Stacked Hydrogels.” Nature, 552 (2017) 214

    Lecture
  • Date:10WednesdayApril 2019

    Synthetic Reactions Assisted by Photons

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    Time
    11:00 - 12:00
    Location
    Helen and Milton A. Kimmelman Building
    LecturerProf. Masahiro Murakami
    Department of Synthetic Chemistry and Biological Chemistry, Kyoto University
    Organizer
    Department of Molecular Chemistry and Materials Science
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    Lecture
  • Date:11ThursdayApril 2019

    Epigenetic pathways as targets in human disease

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    Time
    11:00 - 12:00
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Shelley Berger
    Organizer
    Department of Immunology and Regenerative Biology
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    Lecture
  • Date:11ThursdayApril 2019

    Prof. Barak Dayan - The second Quantum revolution: How the strangest effect in nature gives rise to new technologies

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    Time
    12:00 - 12:00
    Title
    The second Quantum revolution: How the strangest effect in nature gives rise to new technologies
    Location
    Dolfi and Lola Ebner Auditorium
    LecturerProf. Barak Dayan
    Organizer
    Communications and Spokesperson Department
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    Lecture
  • Date:11ThursdayApril 2019

    Special Guest Seminar with prof. Johannes Herrmann

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    Time
    12:00 - 12:00
    Title
    Mitochondrial Biogenesis: A huge challenge for eukaryotic cells
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerProf. Dr. Johannes Herrmann
    Department of Cell Biology, University of Kaiserslautern, Germany
    Organizer
    Department of Molecular Genetics
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    Lecture
  • Date:11ThursdayApril 2019

    Applying cancer unique metabolism for patients’ diagnosis and therapy

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    Time
    14:00 - 15:00
    Title
    Cancer Research Club
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Ayelet Erez
    Depasrtment of Biological Regulation Weizmann Institute
    Organizer
    Department of Immunology and Regenerative Biology
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    Lecture
  • Date:14SundayApril 201915MondayApril 2019

    Symposium Honoring the 90th Birthday of Prof. Ernest Winocour- Viruses, Gene Therapy

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    Time
    08:00 - 08:00
    Location
    The David Lopatie Conference Centre
    Chairperson
    Moshe Oren
    Conference
  • Date:14SundayApril 2019

    From patterns to function in dryland ecosystems

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    Time
    11:00 - 11:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerEhud Meron
    Ben Gurion University
    Organizer
    Department of Earth and Planetary Sciences
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    Lecture
  • Date:14SundayApril 2019

    Mechanisms of longevity and cancer-resistance: lessons from long-lived animals

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    Time
    11:00 - 11:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerProf. Vera Gorbunova & Prof. Andrei Seluanov
    Department of Biology, University of Rochester Rochester, NY, USA
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    Lecture
  • Date:14SundayApril 2019

    M.Sc thesis: Electronic Structure of Halide Perovskites from a Screened Range-separated Hybrid Functional

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    Time
    14:00 - 15:00
    Location
    Perlman Chemical Sciences Building
    LecturerGalit Cohen
    Dept. Materials and Interfaces
    Organizer
    Department of Molecular Chemistry and Materials Science
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    Lecture
  • Date:15MondayApril 2019

    Life Science Colloquium

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    Time
    11:00 - 12:00
    Title
    Mechanical LINCages to the nucleus in cell polarity, migration and disease
    Location
    Wolfson Building for Biological Research
    LecturerProf. Gregg Gundersen
    Columbia University Medical Center
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    Colloquia
  • Date:15MondayApril 2019

    "Bulk Metallic Glasses: A High, but Narrow Path to Success"

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    Time
    11:00 - 12:15
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Jan Schroers
    Yale University
    Organizer
    Faculty of Chemistry
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    AbstractShow full text abstract about Bulk metallic glasses combine plastic like processing with s...»
    Bulk metallic glasses combine plastic like processing with superb high-strength metal properties. Their processing opportunities originate from their high thermal stability, which has been explored for novel metal processing methods such as fused filament fabrication to 3D print, stretch blowmolding to fabricate previously unachievable shapes for metals, and micro- nanofabrication.
    As BMGs are metastable, processing has to avoid crystallization, structural relaxation, and reduction of fictive temperature. We show here that minute structural changes, realized through processing conditions, can cause drastic effects on mechanical properties. Specifically, we reveal a flaw tolerance behavior of metallic glasses, a critical volume fraction of crystallinity for embrittlement, and a mechanical glass transition behavior. We will offer a mechanistic understanding based on local atomistic events controlling brittleness and ductility in metallic glasses.
    Utilizing suggested metallic glass paradigm requires careful considerations of all these phenomena to form high-strength metals like plastics with consistently high fracture toughness.
    Lecture
  • Date:15MondayApril 2019

    IMM Guest seminar- Dr. Michael Berger will lecture on "Mitochondrial matrix compartment energetics limits hypoxia tolerance during CD8 T cell priming".

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    Time
    13:00 - 14:00
    Location
    Wolfson Building for Biological Research
    LecturerDr. Michael Berger
    The Lautenberg Center for Immunology and Cancer Research, the Hebrew University Medical School.
    Organizer
    Department of Systems Immunology
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    Lecture
  • Date:15MondayApril 2019

    Genetics, HSP expressomics and proteomics to understand how plants feel the heat and meet the challenges of global warming

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    Time
    14:00 - 14:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerProf. Pierre Goloubinoff
    Department of Plant Molecular Biology, University of Lausanne, Switzerland
    Organizer
    Department of Plant and Environmental Sciences
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    Lecture
  • Date:15MondayApril 2019

    Growth dynamics and complexity of national economies in the

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    Time
    14:15 - 14:15
    Title
    Growth dynamics and complexity of national economies in the global trade network
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerA.L. Stella
    INFN Univ. of Padova, Italy
    Organizer
    Department of Physics of Complex Systems
    Contact
    AbstractShow full text abstract about Methods of statistical physics allow to explore the quantita...»
    Methods of statistical physics allow to explore the quantitative nexus among economic growth of a country, diversity of its productions, and evolution in time of its export basket(*). A stochastic model of evolution, calibrated on data for 1238 exports from 223 countries in 21 years, enables counterfactual analyses based on estimates of the part of growth due to resource transfers between different productions. Original use of the Boltzmann-Shannon entropy function leads to the construction of consistent measures of the efficiency of national
    economies and of the specialization of productions. Comparisons with dynamical and GDP pc data lead to clear distinctions among developed, developing, underdeveloped and risky countries. Perspective applications of the entropic measures in other fields (ecology, microbiology,..) where diversity has to be estimated from bipartite networks will be shortly outlined.

    (Work in collaboration with G. Teza, University of Padova, and M. Caraglio, Katholieke Universiteit Leuven.)

    Lecture
  • Date:15MondayApril 2019

    Sustaining Life with Genes and Proteins Designed De Novo

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    Time
    16:00 - 17:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerProf. Michael Hecht
    Dept of Chemistry, Princeton University, NJ
    Organizer
    Department of Biomolecular Sciences
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    AbstractShow full text abstract about A key goal of synthetic biology is to design novel proteins ...»
    A key goal of synthetic biology is to design novel proteins that fold and function in vivo. A particularly challenging objective would be to produce non-natural proteins that don’t merely generate interesting phenotypes, but which actually provide essential functions necessary to sustain life. Successful design of life-sustaining proteins would be a significant step toward constructing entirely artificial “proteomes.” In initia! l work toward this goal providing activities necessary to sustain the growth of living cells. In some cases, the novel proteins rewire gene regulation. In others, the novel protein sustains cell growth by functioning as in vivo, we have designed large libraries of novel proteins encoded by millions of synthetic genes. Many of these proteins fold into stable 3-dimensional structures; and many bind metals, metabolites, and cofactors. Several of the novel proteins function bona fide enzyme that catalyzes an essential biochemical reaction. These results suggest (i) The molecular toolkit of life need not be limited to sequences that already exist in nature; (ii) Synthetic genomes and artificial proteomes can be built from non-natural sequences; (iii) Construction of alternative lifeforms may soon be possible.
    Lecture
  • Date:16TuesdayApril 2019

    The mechanics of malaria parasite invasion of the red cell (and beyond): seeking a balanced view of parasite-host contributions to entry

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    Time
    10:00 - 11:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerProf. Jacob Baum
    Imperial College London, Dept. of Life Sciences.
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Entry of the malaria parasite merozoite, the micron sized ce...»
    Entry of the malaria parasite merozoite, the micron sized cell responsible for blood-stage malaria infection, into the human red blood cell defines establishment of malaria disease. The process is rapid yet contains a great depth of cell biology, one eukaryotic cell actively penetrating the other. Entry has long been seen as a very parasite-centric process with the merozoite literally driving its way into a passive erythrocyte. This is in marked contrast to other pathogens that utilise host-cell phagocytosis to gain entry to human cells. Has this inbalanced view been over-stated in the case of the merozoite? Recent data from several groups suggests that erythrocyte biophysics (including membrane biophysical properties) also contributes to the process of merozoite entry. Here, I will present our latest insights into the role of both parasite and host cell factors and how they might be contributing to lowering the energy barrier required to get the merozoite inside the human red blood cell. With a particular focus on cell imaging, I will present our vision of invasion being a balanced equation with parasite motor force and host membrane deformability both contributing to allow the blood-stage malaria parasite (and may be beyond the blood stages) get in.
    Lecture

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