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September 01, 2016
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Date:08MondayApril 2019Lecture
IMM Guest seminar- Dr. Tomer Hertz will lecture on "A journey into influenza antigenic space using systems serology".
More information Time 13:00 - 13:00Location Wolfson Building for Biological ResearchLecturer Dr. Tomer Hertz
Tomer Hertz received his PhD in computational neuroscience from the Hebrew University in the field of machine learning and pattern recognition. His then joined Microsoft Research as a potdoctoral student in computational immunology focusing developing and applying algorithms for MHC-peptide binding and also for HLA supertype classification. He then joined the Fred Hutch Cancer Research Center where he has been a faculty member in the Vaccine and Infectious Disease Division for 7 years focusing on immunological research in both Influenza and HIV as disease models. In 2014, he joined the department of immunology at Ben-Gurion University of the Negev in Israel where he heads a systems immunology lab that studies the role of immune history and its effect on vaccination and natural infection, modeling peptide:MHC:TCR interactions, and novel methods for the analysis of high-dimensional immunological data.Organizer Department of Systems ImmunologyContact Abstract Show full text abstract about Vaccination is an effective tool for preventing influenza in...» Vaccination is an effective tool for preventing influenza infection. A variety of factors have been shown to impact the observed heterogeneity and inter-individual variations in immune responses following vaccination including age, gender, ethnicity and immunological history (the individual's memory antibody repertoire to previously encountered pathogens and vaccines). Throughout life individuals are infected by and vaccinated with multiple influenza strains and develop a broad and diverse influenza Ab repertoire. We have been developing a novel low-volume antigen microarray assay for profiling influenza immunological history, and used it to assess the effects of immune history on vaccine-induced immunogenicity and protection, using samples from an influenza vaccine efficacy trial, as well as to characterize the maternal fetal transfer of influenza specific antibodies. -
Date:08MondayApril 2019Lecture
Emergence and stability of a Brownian motor
More information Time 14:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Alex Feigel
Hebrew UniversityOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about A Brownian motor rectifies thermal noise and creates useful ...» A Brownian motor rectifies thermal noise and creates useful work. Here we address how this machine can emerge without predefined energy minimum in a system out of thermal equilibrium. Intuitively, Brownian motor as any artificial or biological machine should degrade with time. I will show that on contrary, a system with multiple degrees of freedom out of thermal equilibrium can be stable at a state that generates useful work.
It is demonstrated with the help of ab initio analysis of a modified Feynman-Smoluchowski ratchet with two degrees of freedom. Out of thermal equilibrium, an environment imposes effective mechanical forces on nano-fabricated devices as well as on microscopic chemical or biological systems. Thus out of thermal equilibrium environment can enforce a specific steady state on the system by creating effective potentials in otherwise homogeneous configuration space.
I present an ab initio path from the elastic scattering of a single gas particle by a mechanical system to the transition rate probability between the states of the system with multiple degrees of freedom, together with the corresponding Masters-Boltzmann equation and the average velocities of the system’s degrees of freedom as functions of the macroscopic parameters of the out-of-equilibrium environment. It results in Onsager relations that include the influence of the different degrees of freedom on each other.
An interesting finding is that some of these forces persist even in a single temperature environment if the thermodynamic limit does not hold. In addition, the spatial asymmetry of the system’s stable state, together with the corresponding directed motion, may possess preferred chiral symmetry.
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Date:10WednesdayApril 201911ThursdayApril 2019Conference
Advanced Electron Microscopy Symposium
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Sharon G. WolfOrganizer Department of Chemical Research Support -
Date:10WednesdayApril 2019Lecture
Cut along dotted line: kirigami materials and device applications
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Max Shtein
Professor of Materials Science and Engineering, Chemical Engineering; University of MichiganOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Simple 2-dimensional cut and fold patterns can be transforme...» Simple 2-dimensional cut and fold patterns can be transformed into 3-dimensional shapes upon stretch-ing. We use this simple approach to develop mechanical metamaterials with several interesting proper-ties and applications. I will describe ways of tuning properties via geometric structure, and discuss ex-amples of how this can be used to achieve superior performance in mechanics, photonics, electronics, sensors, and other areas.
References:
“Dynamic kirigami structures for integrated solar tracking.” Nature Comm. 6, 8092 (2015)
“A kirigami approach to engineering elasticity in nanocomposites through patterned defects.” Na-ture Mater., 14 (2015) 785
“An Electric Eel-Inspired Artificial Soft Power Source from Stacked Hydrogels.” Nature, 552 (2017) 214
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Date:10WednesdayApril 2019Lecture
Synthetic Reactions Assisted by Photons
More information Time 11:00 - 12:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Masahiro Murakami
Department of Synthetic Chemistry and Biological Chemistry, Kyoto UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:11ThursdayApril 2019Lecture
Epigenetic pathways as targets in human disease
More information Time 11:00 - 12:00Location Max and Lillian Candiotty BuildingLecturer Prof. Shelley Berger Organizer Department of Immunology and Regenerative BiologyContact -
Date:11ThursdayApril 2019Lecture
Prof. Barak Dayan - The second Quantum revolution: How the strangest effect in nature gives rise to new technologies
More information Time 12:00 - 12:00Title The second Quantum revolution: How the strangest effect in nature gives rise to new technologiesLocation Dolfi and Lola Ebner AuditoriumLecturer Prof. Barak Dayan Organizer Communications and Spokesperson DepartmentHomepage Contact -
Date:11ThursdayApril 2019Lecture
Special Guest Seminar with prof. Johannes Herrmann
More information Time 12:00 - 12:00Title Mitochondrial Biogenesis: A huge challenge for eukaryotic cellsLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Dr. Johannes Herrmann
Department of Cell Biology, University of Kaiserslautern, GermanyOrganizer Department of Molecular GeneticsContact -
Date:11ThursdayApril 2019Lecture
Applying cancer unique metabolism for patients’ diagnosis and therapy
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. Ayelet Erez
Depasrtment of Biological Regulation Weizmann InstituteOrganizer Department of Immunology and Regenerative BiologyContact -
Date:14SundayApril 201915MondayApril 2019Conference
Symposium Honoring the 90th Birthday of Prof. Ernest Winocour- Viruses, Gene Therapy
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Moshe Oren -
Date:14SundayApril 2019Lecture
From patterns to function in dryland ecosystems
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Ehud Meron
Ben Gurion UniversityOrganizer Department of Earth and Planetary SciencesContact -
Date:14SundayApril 2019Lecture
Mechanisms of longevity and cancer-resistance: lessons from long-lived animals
More information Time 11:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Vera Gorbunova & Prof. Andrei Seluanov
Department of Biology, University of Rochester Rochester, NY, USAContact -
Date:14SundayApril 2019Lecture
M.Sc thesis: Electronic Structure of Halide Perovskites from a Screened Range-separated Hybrid Functional
More information Time 14:00 - 15:00Location Perlman Chemical Sciences BuildingLecturer Galit Cohen
Dept. Materials and InterfacesOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:15MondayApril 2019Colloquia
Life Science Colloquium
More information Time 11:00 - 12:00Title Mechanical LINCages to the nucleus in cell polarity, migration and diseaseLocation Wolfson Building for Biological ResearchLecturer Prof. Gregg Gundersen
Columbia University Medical CenterContact -
Date:15MondayApril 2019Lecture
"Bulk Metallic Glasses: A High, but Narrow Path to Success"
More information Time 11:00 - 12:15Location Max and Lillian Candiotty BuildingLecturer Prof. Jan Schroers
Yale UniversityOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Bulk metallic glasses combine plastic like processing with s...» Bulk metallic glasses combine plastic like processing with superb high-strength metal properties. Their processing opportunities originate from their high thermal stability, which has been explored for novel metal processing methods such as fused filament fabrication to 3D print, stretch blowmolding to fabricate previously unachievable shapes for metals, and micro- nanofabrication.
As BMGs are metastable, processing has to avoid crystallization, structural relaxation, and reduction of fictive temperature. We show here that minute structural changes, realized through processing conditions, can cause drastic effects on mechanical properties. Specifically, we reveal a flaw tolerance behavior of metallic glasses, a critical volume fraction of crystallinity for embrittlement, and a mechanical glass transition behavior. We will offer a mechanistic understanding based on local atomistic events controlling brittleness and ductility in metallic glasses.
Utilizing suggested metallic glass paradigm requires careful considerations of all these phenomena to form high-strength metals like plastics with consistently high fracture toughness. -
Date:15MondayApril 2019Lecture
IMM Guest seminar- Dr. Michael Berger will lecture on "Mitochondrial matrix compartment energetics limits hypoxia tolerance during CD8 T cell priming".
More information Time 13:00 - 14:00Location Wolfson Building for Biological ResearchLecturer Dr. Michael Berger
The Lautenberg Center for Immunology and Cancer Research, the Hebrew University Medical School.Organizer Department of Systems ImmunologyContact -
Date:15MondayApril 2019Lecture
Genetics, HSP expressomics and proteomics to understand how plants feel the heat and meet the challenges of global warming
More information Time 14:00 - 14:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Pierre Goloubinoff
Department of Plant Molecular Biology, University of Lausanne, SwitzerlandOrganizer Department of Plant and Environmental SciencesHomepage Contact -
Date:15MondayApril 2019Lecture
Growth dynamics and complexity of national economies in the
More information Time 14:15 - 14:15Title Growth dynamics and complexity of national economies in the global trade networkLocation Edna and K.B. Weissman Building of Physical SciencesLecturer A.L. Stella
INFN Univ. of Padova, ItalyOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about Methods of statistical physics allow to explore the quantita...» Methods of statistical physics allow to explore the quantitative nexus among economic growth of a country, diversity of its productions, and evolution in time of its export basket(*). A stochastic model of evolution, calibrated on data for 1238 exports from 223 countries in 21 years, enables counterfactual analyses based on estimates of the part of growth due to resource transfers between different productions. Original use of the Boltzmann-Shannon entropy function leads to the construction of consistent measures of the efficiency of national
economies and of the specialization of productions. Comparisons with dynamical and GDP pc data lead to clear distinctions among developed, developing, underdeveloped and risky countries. Perspective applications of the entropic measures in other fields (ecology, microbiology,..) where diversity has to be estimated from bipartite networks will be shortly outlined.
(Work in collaboration with G. Teza, University of Padova, and M. Caraglio, Katholieke Universiteit Leuven.)
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Date:15MondayApril 2019Lecture
Sustaining Life with Genes and Proteins Designed De Novo
More information Time 16:00 - 17:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Michael Hecht
Dept of Chemistry, Princeton University, NJOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about A key goal of synthetic biology is to design novel proteins ...» A key goal of synthetic biology is to design novel proteins that fold and function in vivo. A particularly challenging objective would be to produce non-natural proteins that don’t merely generate interesting phenotypes, but which actually provide essential functions necessary to sustain life. Successful design of life-sustaining proteins would be a significant step toward constructing entirely artificial “proteomes.” In initia! l work toward this goal providing activities necessary to sustain the growth of living cells. In some cases, the novel proteins rewire gene regulation. In others, the novel protein sustains cell growth by functioning as in vivo, we have designed large libraries of novel proteins encoded by millions of synthetic genes. Many of these proteins fold into stable 3-dimensional structures; and many bind metals, metabolites, and cofactors. Several of the novel proteins function bona fide enzyme that catalyzes an essential biochemical reaction. These results suggest (i) The molecular toolkit of life need not be limited to sequences that already exist in nature; (ii) Synthetic genomes and artificial proteomes can be built from non-natural sequences; (iii) Construction of alternative lifeforms may soon be possible. -
Date:16TuesdayApril 2019Lecture
The mechanics of malaria parasite invasion of the red cell (and beyond): seeking a balanced view of parasite-host contributions to entry
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Jacob Baum
Imperial College London, Dept. of Life Sciences.Organizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Entry of the malaria parasite merozoite, the micron sized ce...» Entry of the malaria parasite merozoite, the micron sized cell responsible for blood-stage malaria infection, into the human red blood cell defines establishment of malaria disease. The process is rapid yet contains a great depth of cell biology, one eukaryotic cell actively penetrating the other. Entry has long been seen as a very parasite-centric process with the merozoite literally driving its way into a passive erythrocyte. This is in marked contrast to other pathogens that utilise host-cell phagocytosis to gain entry to human cells. Has this inbalanced view been over-stated in the case of the merozoite? Recent data from several groups suggests that erythrocyte biophysics (including membrane biophysical properties) also contributes to the process of merozoite entry. Here, I will present our latest insights into the role of both parasite and host cell factors and how they might be contributing to lowering the energy barrier required to get the merozoite inside the human red blood cell. With a particular focus on cell imaging, I will present our vision of invasion being a balanced equation with parasite motor force and host membrane deformability both contributing to allow the blood-stage malaria parasite (and may be beyond the blood stages) get in.
