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December 01, 2013
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Date:30SundayJuly 2017Lecture
Joint Chemical Physics and Materials and Interfaces Seminar
More information Time 11:00 - 11:00Title Label-free protein electronic detection with an electrolyte-gated organic field-effect transistor-based immunosensorLocation Perlman Chemical Sciences BuildingLecturer Prof. Luisa Torsi
University of Bari, ItalyOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Organic bio-electronics represents one of the most exciting ...» Organic bio-electronics represents one of the most exciting directions in printable electronics, promising to deliver new technologies for healthcare and human well‐being. Among the others, organic field-effect transistors have been proven to work as highly performing sensors. Selectivity is achieved by integrating a layer of functional biological recognition elements, directly coupled with an electronic interface. The devices were shown to reach detection limits down to the picomolar (10-12 M) range with highly repeatable responses (within few percentage of standard deviation) even for hundreds of reiterated measurements.
In this lecture recent developments in the field of organic and printable electronics implemented to probe biological interfaces will be discussed highlighting the importance of the interplay among disciplines such as organic electronics, analytical chemistry and biochemistry to reach a comprehensive understanding of the underpinning phenomena. It will also be shown that applications can lead to label-free electronic biosensors with unprecedented detection limits and selectivity. Notably, the extremely good sensing performance level can be rationalized by quantifying electrostatic and capacitance contributions characterizing the surface confined biological recognition elements interacting with their affinity ligands. Examples of the detection of clinical relevant biomarkers will be provided too.
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Date:30SundayJuly 2017Lecture
“Gadd45 Diverse Stress Response Functions in Cancer, Autophagy, Sepsis & Senescence”
More information Time 15:00 - 16:00Location Wolfson Building for Biological ResearchLecturer Professor Dan A. Liebermann
Professor of The Fels Institute for Cancer Research and Molecular biology Professor of Medical Genetics & Molecular Biochemistry Temple Univ. School of MedicineOrganizer Department of Molecular Cell BiologyContact -
Date:31MondayJuly 2017Lecture
Targeting the mitochondria as a novel therapeutic strategies for Acute Myeloid Leukemia
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Aaron Shimmer
Princess Margaret Cancer Centre, University Health Network, University of Toronto, CanadaOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Our understanding of the molecular mutations associated with...» Our understanding of the molecular mutations associated with acute myeloid leukemia (AML) has improved, but most of these mutations are not directly “drugable”. Thus, new therapeutic approaches for AML may need to target pathways and biological vulnerabilities downstream of these genetic mutations. We recently demonstrated that AML cells and stem cells have dysregulated mitochondrial characteristics and an increased reliance on oxidative phosphorylation and mitochondrial metabolism. I will discuss our findings related to mitochondrial biology in AML and therapeutic strategies that target these pathways. I will also describe our new findings linking new mitochondrial metabolism with differentiation of AML cells and stem cells. -
Date:02WednesdayAugust 2017Lecture
Targetting Growth Factor Signalling to Reduce the Impact of Colon Cancer
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Anthony Burgess
Laboratory Head at the Walter and Eliza Hall Institute, AustraliaOrganizer Department of Immunology and Regenerative BiologyContact -
Date:08TuesdayAugust 2017Lecture
Personalized Immunotherapy for Lung Cancer
More information Time 14:00 - 15:00Title Cancer Research Club SeminarLocation Max and Lillian Candiotty BuildingLecturer Prof. Roy S. Herbst
Director, Thoracic Oncology Research Program, Yale Comprehensive Cancer Center, Yale School of Medicine, USAOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Despite advances in the treatment of cancer, with novel mole...» Despite advances in the treatment of cancer, with novel molecularly targeted therapies and drug combinations, lung cancer continues to be one of the leading causes of cancer death worldwide. For this reason, significant efforts have been made to examine the interaction between cancer and the immune system. This has led to the discovery of the programmed death 1 (PD1) and ligand (PDL1) pathway, which was found to play a key role in immune evasion by cancer cells and the formation of a tumor microenvironment. Blockade of this pathway enables the ability of the innate immune system to activate their anticancer responses and to reverse the tumor microenvironment. Newly approved drugs, such as nivolumab and pembrolizumab, have mechanisms of action that inhibit PD1, while others like atezolizumab, block PDL1. Although, responses with these drugs have shown significant activity in some patients, only 20-30% of patients respond overall. In this talk, mechanistic studies to identify predictive markers of response will be discussed along with markers of resistance (both primary and acquired). In addition, novel combinations of immunotherapy with chemotherapy, targeted therapy and even chemotherapy will be explored. -
Date:09WednesdayAugust 2017Lecture
Beating the Thermodynamic Limit: Photo-Activation of n-Doping in Organic Semiconductors
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Antoine Kahn
Dept. Electrical Engineering, Princeton UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:09WednesdayAugust 2017Academic Events
Council of Professors
More information Time 15:00 - 17:00Location The David Lopatie Conference CentreContact -
Date:12SaturdayAugust 2017Cultural Events
Astrith Baltsan - Jerusalem of Gold
More information Time 21:15 - 21:15Location Michael Sela AuditoriumContact -
Date:15TuesdayAugust 2017Lecture
Genome wide identification of genes mediating cancer resistance
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof.Eytan Ruppin
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, and Blavatnik School of Computer Science University of Maryland, College Park, MD, USAOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Most patients with advanced cancer eventually acquire resist...» Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interactions, where the reduction in cancer cell viability caused by targeted gene inactivation is rescued by the adaptive alteration of another gene (the rescuer). Here we perform a genome-wide identification of SR-mediated resistance determinants by analyzing the tumor transcriptomics and survival data of 10,000 cancer patients. Predicted SR interactions are validated versus publicly available resistance data and new experimental screens that we have conducted. We show that the SR interactions successfully predict cancer patients’ response and emerging resistance and that the targeting of predicted rescuer genes re-sensitizes resistant cancer cells. These results provide novel rationale-based combinatorial approaches for proactively overcoming therapy resistance. Finally, going beyond targeted therapy, we show that the SR analysis can successfully predict molecular alterations conferring resistance to immunotherapy in melanoma patients.
[Work led by Avinash Das and Joo Sang Lee in my lab, in collaboration with the labs of Silvio Gutkind (UCSD), Cyril Benes (MGH), Keith Flaherty & Genevieve Boland (MGH) and Meenhard Herlyn (Wistar).] -
Date:17ThursdayAugust 2017Lecture
Functional dissection of decision-related activity in the primate dorsal stream
More information Time 12:30 - 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Dr. Leor Katz
University of Texas at AustinOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The study of perceptual decision-making is key to understand...» The study of perceptual decision-making is key to understanding complex cognitive behavior. Two decades of recordings in primate parietal cortex suggest that neurons in the lateral intraparietal (LIP) cortex integrate sensory evidence from upstream neurons (presumably MT) in favor of making a decision. However, the causal role of LIP in decision-making had not been tested directly.
In this talk, I will present recent experiments that tested whether area LIP—which exhibits strong decision-related activity—is causally related to perceptual decision-making. In contrast to the generally accepted model, we found that inactivation in area LIP had no measurable impact on decision-making behavior (despite having exerted effects in a control task). This finding suggests that strong decision-related activity does not guarantee a causal role in decision-making. To better understand the MT-LIP circuit we then applied a Generalized Linear Model (GLM) to simultaneously recorded MT and LIP neurons. We found that much of MT & LIP responses may be interpreted in simple sensorimotor terms, as opposed to appealing to nuanced cognitive phenomena. These results shift our understanding of decision-related activity in the primate brain and motivate new approaches to further dissecting the circuit.
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Date:29TuesdayAugust 2017Lecture
AMO Special Seminar
More information Time 13:15 - 14:30Title Quantum Simulation of Lattice Gauge Theories: from Analog to DigitalLocation Edna and K.B. Weissman Building of Physical SciencesOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about Gauge theories are not only important and fundamental in mod...» Gauge theories are not only important and fundamental in modern physics, they also present some hard, challenging puzzled waiting to be solved.
In the recent years, quantum information, optics and atomic physics have proposed two new approaches for studying such theories: tensor networks studies and quantum simulation.
In my talk I will discuss the latter, present some analog quantum simulation schemes using ultracold atoms, and focus on a recent, digital formulation of lattice gauge theories that decomposes four-body interactions from two-body ones, allowing for digital quantum simulation schemes with atomic systems. -
Date:31ThursdayAugust 2017Lecture
Next Generation (Chip Based) Gene Synthesis: The Coming Revolution in Pharmaceutical, Food and Environment
More information Time 11:00 - 12:00Location Wolfson Building for Biological ResearchLecturer Prof. Joseph M. Jacobson
Massachusetts Institute of Technology, USAContact -
Date:01FridaySeptember 2017Cultural Events
Nathan's friends - Songs & Smiles
More information Time 20:00 - 20:00Location Michael Sela AuditoriumContact -
Date:04MondaySeptember 2017Lecture
Speech processing in auditory cortex with and without oscillations
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Anne-Lise Giraud
Department of Neuroscience University of Geneva SwitzerlandOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Perception of connected speech relies on accurate syllabic s...» Perception of connected speech relies on accurate syllabic segmentation and phonemic encoding. These processes are essential because they determine the building blocks that we can manipulate mentally to understand and produce speech. Segmentation and encoding might be underpinned by specific interactions between the acoustic rhythms of speech and coupled neural oscillations in the theta and low-gamma band. To address how neural oscillations interact with speech, we used a neurocomputational model of speech processing generating biophysically plausible coupled theta and gamma oscillations. We show that speech could be well decoded from this purely bottom-up artificial network’s low-gamma activity, when the phase of theta activity was taken into account. Because speech is not only a bottom-up process, we set out to develop another type of neurocomputational model that takes into account the influence of linguistic predictions on acoustic processing. I will present preliminary results obtained with such a model and discuss the advantage of incorporating neural oscillations in models of speech processing. -
Date:04MondaySeptember 2017Lecture
Mitochondria at the interface between homeostasis and apoptosis
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. Atan Gross
Dept. of Biological Regulation, Weizmann nInstituteOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Mitochondria are highly dynamic organelles that play fundame...» Mitochondria are highly dynamic organelles that play fundamental roles in pivotal cellular processes including energy production, metabolism, and apoptosis. Our scientific interests evolve around topics related to how these different mitochondrial processes are coordinated to regulate cellular stress responses and cellular fate. Over the years, we discovered a new pathway composed of the nuclear ATM kinase, pro-apoptotic BID, and mitochondrial MTCH2, connecting mitochondria metabolism to stress signals originating from the cell surface and nucleus. More recently, we revealed that MTCH2 is involved in regulating mitochondrial dynamics/fusion, providing a clue to the mechanism by which the pathway regulates mitochondrial function. -
Date:05TuesdaySeptember 2017Lecture
The roles of ATM in DNA damage response: links with base excision repair
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Grigory L Dianov
Dept. of Oncology, Univ. of OXFORDOrganizer Department of Biomolecular SciencesContact -
Date:05TuesdaySeptember 2017Lecture
Studying human evolution using DNA methylation maps of Neanderthals
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. David Gokhman
Department of Genetics, The Hebrew University of JerusalemOrganizer Department of Molecular GeneticsContact -
Date:05TuesdaySeptember 2017Lecture
A phylogenetic approach to decision making
More information Time 12:30 - 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Prof. Thomas Boraud, MD PhD
Directeur de Recherche CNRS, University of BordeauxOrganizer Department of Brain SciencesContact -
Date:05TuesdaySeptember 2017Lecture
AMO Special Seminar
More information Time 13:15 - 14:30Title Nonlinear quantum optics in nanophotonic waveguidesLocation Edna and K.B. Weissman Building of Physical SciencesOrganizer Department of Physics of Complex SystemsContact -
Date:05TuesdaySeptember 2017Academic Events
Scientific Council meeting
More information Time 14:00 - 16:00Location The David Lopatie Conference CentreContact