Integrated Calendar

Organisms, tissues and molecules often need to perform multiple tasks. But usually no phenotype can be optimal at all tasks at once. This leads to a fundamental tradeoff. We study this using the concept of Pareto optimality from engineering and economics. Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes- they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons. At the vertices of these polygons are phenotypes that specialize at a single task. We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.

The human race has been reading and writing for only 5,000 years, suggesting that the mechanisms for these processes involve both cultural evolution and biological exaptation. Brain mechanisms of reading are hard to discern because skilled reading is so fast and efficient. Use of ambiguous words allows us to slow down some of these processes and explore the interactions of orthographic, phonological, and semantic processes. We took advantage of the characteristics of Hebrew to explore the relative effects of phonological and semantic ambiguity on access to meaning. Twenty-three participants performed a semantic decision talk on pairs of words. Half the pairs were constituted of two unambiguous words, and in half, the first word was either a homophonic homograph (like bank), or a heterophonic homograph (like tear). Our procedure allowed us to separately examine two stages of the access to meaning: the activation of multiple meanings, and then the selection of the appropriate meaning. Previous imaging studies of ambiguity resolution have not made this distinction. In the first stage, we show that different regions of the left hemisphere respond differentially to homophones and to heterophones in both whole brain analysis and in ROI comparisons of sub-regions of both anterior and posterior regions of the left hemisphere. In the second stage, in meaning selection, we again see different effects that are dependent of the phonological status of the ambiguous word, and also similar effects of the interaction between frequency effects and contextual effects in the two hemispheres. We interpret these findings in the context of a brain model of reading.