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April 28, 2015

  • Date:02TuesdayJune 2015

    Recent advances in Imaging Flow Cytometry – The 3rd Israeli ImagestreamX user meeting

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    Time
    09:00 - 12:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    AbstractShow full text abstract about Imaging Flow Cytometry combines speed, sensitivity, and phen...»
    Imaging Flow Cytometry combines speed, sensitivity, and phenotyping abilities found in flow cytometry with the detailed imagery and functional insight of microscopy, for an extensive range of novel applications. It allows quantitating cellular morphology and the intensity and location of fluorescent probes on, in, or between cells, even in rare sub-populations and highly heterogeneous samples. The wide range of applications used include studying intracellular localization, shape changes and morphology, co-localization, nuclear translocation, cell signaling, T cell – APC interactions, DNA damage and repair, cell death and apoptosis, phagocytosis and internalization, FISH, vesicle trafficking, and many others.
    Lecture
  • Date:02TuesdayJune 2015

    A fully functional Calvin cycle in a heterotrophic host : getting E.coli

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    Time
    11:15 - 11:15
    Title
    to join the Dept. of Plant and Environmental Sciences
    Location
    Ullmann Building of Life Sciences
    LecturerNiv Antonovsky
    Lab. of Prof. Ron Milo, Dept. of Plant and Environmental Sciences
    Organizer
    Department of Plant and Environmental Sciences
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    Lecture
  • Date:02TuesdayJune 2015

    Goal-directed navigation with 3D neural compasses

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    Time
    12:30 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerArseny Finkelstein
    Dept of Neurobiology, WIS
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about Although animals and humans move daily through complex three...»
    Although animals and humans move daily through complex three-dimensional (3D) environments, practically nothing is known about the encoding of 3D head direction in the brain. Moreover, very little is known about how neural circuits represent the location or direction of spatial goals – which is essential for goal-directed navigation.
    In the first part of the talk, I will present the first neural recordings of 3D head-direction cells from the hippocampal formation of flying and crawling bats, and will describe the functional organization and the surprising properties of these neurons. By using the head-direction system as an example, I will also discuss several theoretical considerations for the existence of both pure and conjunctive population codes in the brain.
    In the second part, I will present our new findings that suggest the existence of goal-direction and goal-proximity signals in the bat hippocampus – a vectorial representation that could support goal-directed navigation.
    Lecture
  • Date:02TuesdayJune 2015

    Crystal structure of phoshotransmitter AHP2 and modelling of its interaction with the receiver domain of sensor histidine kinase CKI1 – towards specificity in the multistep phosphorelay signaling in plants

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    Time
    14:00 - 15:00
    Location
    Helen and Milton A. Kimmelman Building
    LecturerDr. Oksana Degtjarik
    Organizer
    Department of Chemical and Structural Biology
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    Lecture
  • Date:03WednesdayJune 2015

    RNA-Protein Macromolecular Assemblies at the Crossroads of Cellular Stress and Neurodegeneration

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    Time
    All day
    Location
    The David Lopatie Conference Centre
    Chairperson
    Eran Hornstein
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    Conference
  • Date:03WednesdayJune 2015

    Forum on Mathematical Principles in Biolog

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    Time
    10:00 - 11:00
    Title
    “Public T cell networks – the immune system’s selfie?”
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerNir Friedman
    Organizer
    Department of Molecular Cell Biology
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    Lecture
  • Date:03WednesdayJune 2015

    From pH-gating to toxin inhibition: structure-function studies of the KcsA potassium channel

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    Time
    10:00 - 11:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Jordan Cill
    Dept.of Chemistry Bar Ilan Univ.
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about KcsA has been extensively studied as a paradigm of structure...»
    KcsA has been extensively studied as a paradigm of structure-function relations in potassium channels. Structure determination of KcsA and several other related channels has revealed many of the molecular features of these membrane-embedded proteins. In this seminar I hope to illuminate certain unexplored aspects of potassium channel behavior using biomolecular NMR. Membrane proteins are notoriously challenging for structural study due to the need to stabilize them in a membrane-mimicking detergent- or lipid-based environment. Thus, the first necessary breakthrough was establishing that NMR is capable of addressing this large molecular assembly estimated at 120-170 kDa depending on choice of detergent. This achievement has laid the foundation for further investigations of KcsA activity, of which I will present two, (i) an under-appreciated pH-dependent oligomerization domain, and (ii) toxin inhibition of channel conduction. Together these examples demonstrate the versatility of solution NMR in uncovering the molecular mechanisms behind biological function involving protein structure and flexibility.

    Lecture
  • Date:03WednesdayJune 2015

    Some Exact Results on Quenched Disorder

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    Time
    13:15 - 14:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerZohar Komargodski
    Weizmann Institute
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about We investigate several questions that concern with disorder ...»
    We investigate several questions that concern with disorder using three main methods:
    A. A controlled expansion in the heat capacity critical exponent.
    B. Large N models.
    C. AdS/CFT
    In the talk I will probably not get to say much about method C., but I will explain methods A. and B.
    Method A. can be used to derive concrete results about the disordered 3d Ising model. Method B. can be used to derive a certain generalization of the Imry-Ma result and also it leads to some predictions that can be cross-checked using method C. Using method B. one can also obtain closed form RG flows between pure and disordered fixed points.
    Lecture
  • Date:03WednesdayJune 2015

    Integration of Coagulation Signaling in Innate Immunity and Inflammation

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    Time
    14:00 - 15:00
    Title
    Special Guest Seminar
    Location
    Wolfson Building for Biological Research
    LecturerWolfram Ruf, M.D.
    Professor, Department of Immunology and Microbial Science The Scripps Research Institute La Jolla, CA
    Organizer
    Department of Systems Immunology
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    Lecture
  • Date:03WednesdayJune 2015

    Theoretical Principles of Virus-Microbe Dynamics

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    Time
    14:15 - 14:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerProf Joshua Weitz
    Georgia Institute of Technology
    Organizer
    Department of Physics of Complex Systems
    Contact
    Lecture
  • Date:04ThursdayJune 2015

    Options Beyond Academia in Scientific Editing

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    Time
    09:00 - 09:00
    Location
    Wolfson Building for Biological Research
    LecturerProf. Laura M. Zahn
    Senior Editor of SCIENCE
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:04ThursdayJune 2015

    Dirac Electrons — Living on the Edge

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerPablo Jarillo-Herrero
    MIT
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about Over the past decade, the physics of low dimensional electro...»
    Over the past decade, the physics of low dimensional electronic systems has been revolutionized by the discovery of materials with very unusual electronic properties where the behavior of the electrons is governed by the Dirac equation. Among these, graphene has taken center stage due to its ultrarelativistic-like electron dynamics and its potential applications in nanotechnology. Moreover, recent advances in the design and nanofabrication of heterostructures based on van der Waals materials have enabled a new generation of quantum electronic transport experiments in graphene. In this talk I will describe our recent experiments exploring electron-electron interaction driven quantum phenomena in ultra-high quality graphene-based van der Waals heterostructures. In particular I will show two novel realizations of a symmetry-protected topological insulator state, specifically a quantum spin Hall state, characterized by an insulating bulk and conducting counterpropagating spin-polarized states at the system edges. Our experiments establish graphene-based heterostructures as highly tunable systems to study topological properties of condensed matter systems in the regime of strong e-e interactions and I will end my talk with an outlook of some of the exciting directions in the field.
    Colloquia
  • Date:04ThursdayJune 2015

    Virology club 4th meeting

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    Time
    12:00 - 13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerYossi Shaul
    The evolution toolkit in viral genome miniaturization
    Contact
    Lecture
  • Date:04ThursdayJune 2015

    Explanations for inter-individual variations in the human immune response to tumors and pathogens

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    Time
    12:30 - 12:30
    Location
    Wolfson Building for Biological Research
    LecturerDr. Nir Hacohen
    Massachusetts General Hospital Ctr. for Immunology and Inflammatory Diseases
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:07SundayJune 201511ThursdayJune 2015

    ICSG2015 - Deep Sequencing Meets Structural Biology

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    Time
    All day
    Location
    The David Lopatie Conference Centre
    Chairperson
    Joel Sussman
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    Contact
    Conference
  • Date:07SundayJune 2015

    From yeast mating to Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disorder

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    Time
    10:00 - 10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerProf. Susan Michaelis
    Dept. of Cell Biology, John Hopkins School of Medicine, Baltimore, USA
    Organizer
    Department of Molecular Genetics
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    Lecture
  • Date:07SundayJune 2015

    TBA

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    Time
    11:00 - 11:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerDebbie Lindell
    The Faculty of Biology Technion
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:07SundayJune 2015

    Experimental Investiagation of radiative rayleigh-taylor instability In 1 A Ma Gas-Puff Z-Pinch

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    Time
    11:15 - 11:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerP. de Grouchy
    Organizer
    Department of Particle Physics and Astrophysics
    Contact
    AbstractShow full text abstract about A gas-puff z-pinch begins with the injection of a column of ...»
    A gas-puff z-pinch begins with the injection of a column of gas between the electrodes of a pulsed-power driver using a fast valve. This gas is preionized and then cylindrically compressed by discharge of a high current through the column. Using Argon gas, these current-driven implosions are a well-developed, high-intensity source of ~3keV, radiation [1]. Optimization of gas-puff sources depends on manipulation of the radial mass-density and gas-species profiles injected by the puff valve, achieved using multiple concentric nozzles backed by independently pressurized gas plena [2]. In particular, the Rayleigh-Taylor unstable boundary between the lower density current sheath and higher density shell of entrained gas, must be carefully controlled. We present experimental results of the response of this instability to radiative losses during the implosion phase using both Argon (Ar) and Krypton (Kr) gas puffs. Experiments are performed using a 7cm outer diameter, triple-annular nozzle designed, developed and characterized at the Weizmann Institute and fielded on the 200 ns, 1 MA COBRA generator at Cornell University. Time-gated density measurements are recorded by 532 nm small-shift shearing interferometers, acceleration of the boundary by streaked and time-gated x-ray cameras, and plasma temperatures are inferred from 527 nm Thomson scattering across the implosion region. RT amplitude e-folding times of 20 ns are recorded in Kr, 20% faster than in Ar under otherwise identical conditions. Ion temperatures of 100 eV are recorded in Kr shells, ~40% lower than in Ar, and it appears this cooling is responsible for the observed increase in RT growth rate.

    * This work was supported by students and staff of the COBRA facility at Cornell University, and sponsored by the NNSA Stewardship Sciences Academic Programs.
    [1] B. Jones et al. IEEE Trans. Plasma Sci. 42 1145-1152 (2014)
    [2] A. Velikovich et al. Phys. Rev. Lett. 77 853-856 (1996)
    [3] C. Jennings et al. Phys. Plasmas accepted (2015)
    Lecture
  • Date:07SundayJune 2015

    Cell to cell transfer of mRNA

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    Time
    13:00 - 13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Gal Haimovich
    Jeffrey Gerst's group, Dept. of Molecular Genetics, WIS
    Contact
    Lecture
  • Date:08MondayJune 2015

    "Rydberg states of atoms and molecules"

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    Time
    11:00 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Frederic Merkt
    Laboratory of Physical Chemistry, ETH Zurich, Switzerland
    Organizer
    Faculty of Chemistry
    Contact
    AbstractShow full text abstract about Rydberg states are electronically excited states, the spectr...»
    Rydberg states are electronically excited states, the spectral position of which can be described by Rydberg’s well-known formula. The physical properties of these states become very unusual at high values of the principal quantum number n: Their polarizability scales as n7, the van der Waals interaction between two Rydberg atoms or molecules as n11, the maximal electric dipole that can be induced by an electric field as n2, the threshold field for field ionization as n-4, the spacing between adjacent states of a given Rydberg series as n-3, the absorption cross section from the ground state as n-3, the transition moment between neighboring Rydberg states as n2, their lifetime as n3, etc. These physical properties and their rapid variation with n form the basis of a growing number of applications of Rydberg states in chemistry and physics.

    The talk will begin with an overview of the properties of Rydberg states and their applications in physics and chemistry. I shall then present specific applications of Rydberg states my group is interested in. In the first, we use Rydberg states to carry out precision measurements of dissociation and ionization energies of molecules to test quantum electrodynamics calculations in small molecular systems such as H2 and He2. In the second, we exploit the large dipole moments of Rydberg states to control the translational motion of atoms and molecules, and develop methods to accelerate, focus, deviate and reflect beams of cold atoms and molecules, the latest experiments being carried out near the surface of chips. In the third, we study ion-molecule reactions at low temperatures within the Rydberg-electron orbit.
    Colloquia

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