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June 01, 2015
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Date:02WednesdaySeptember 2015Lecture
G-INCPM Special Seminar - Dr. Michael Angelo, MD, Instructor, Department of Pathology, Stanford University School of Medicine - High dimensional, immunohistochemical imaging in clinical tissue biopsies using multiplexed ion beam imaging (MIBI)
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Dr. Michael Angelo, MD
Instructor, Department of Pathology Stanford University School of MedicineOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Multiplexed ion beam imaging (MIBI) is a novel approach to i...» Multiplexed ion beam imaging (MIBI) is a novel approach to immunohistochemistry (IHC) that uses secondary ion mass spectrometry (SIMS) and antibodies labeled with elemental mass tags to visualize dozens of proteins simultaneously in a single tissue section. MIBI is compatible with standard formalin-fixed, paraffin-embedded (FFPE) tissue specimens, the most common sample type in clinical repositories worldwide, and can achieve single molecule sensitivity across a five log dynamic range at resolutions equivalent to brightfield microscopy. In recent work, MIBI was validated for imaging breast tumor tissue sections stained with clinically relevant metal-conjugated antibodies via side-by-side comparison with an FDA-approved quantitative image analysis platform. Since that time, my lab has validated over sixty antibodies and has constructed a 45-plex MIBI panel for characterizing phenotypic and epigenetic features of epithelial, stromal, and infiltrating immune cells in clinical breast tumor biopsies. Analogous approaches with metal conjugated oligonucleotides have also been used for multiplexed DNA and RNA ISH. Finally, to permit broader use of this method, we have designed and constructed novel instrumentation optimized for MIBI that is capable of super resolution imaging and one hundred fold faster sample throughput. Taken together, these tools are being used by lab to comprehensively enumerate immune cell populations in normal and neoplastic solid tissues, to develop clinical classifiers for predicting disease progression in pre-invasive cancer lesions, and to discover epigenetic drivers of epithelial to mesenchymal transition.
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Date:02WednesdaySeptember 2015Lecture
“Recent advances in optical bio-sensing”
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Alexei Nabok
Materials Engineering Research Institute, Sheffield Hallam UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:02WednesdaySeptember 2015Lecture
Chemical Physics Guest Seminar
More information Time 13:00 - 13:00Location Perlman Chemical Sciences BuildingLecturer Richard Rosenberg
Argonne National LabOrganizer Department of Chemical and Biological PhysicsContact -
Date:06SundaySeptember 2015Lecture
Rapid and context-dependent plasticity of human olfactory functions
More information Time 12:15 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Johan Lundstrom
Dept of Clinical Neuroscience, Karolinska Institute, StockholmOrganizer Department of Brain SciencesContact -
Date:07MondaySeptember 2015Colloquia
Life Sciences Colloquium
More information Time 11:00 - 12:00Title Real-time identification of mutations that affect mammalian immunityLocation Dolfi and Lola Ebner AuditoriumLecturer Prof. Bruce Beutler
UT Southwestern Medical Center Center for the Genetics of Host DefenseContact -
Date:07MondaySeptember 2015Lecture
Tropomyosins: Master regulators of the actin cytoskeleton and a new target for chemotherapy
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Peter Gunning
School of Medical Sciences, University of New South Wales, AustraliaOrganizer Department of Immunology and Regenerative BiologyContact -
Date:08TuesdaySeptember 2015Lecture
Rapid Advances in Pediatric Body MRI
More information Time 11:00 - 12:00Location Max and Lillian Candiotty BuildingLecturer Prof. Michael Lustig
University of California Berkeley, Department of Electrical Engineering and Computer Sciences,Organizer Department of Immunology and Regenerative BiologyContact -
Date:08TuesdaySeptember 2015Lecture
Achieving mechanistic understanding in membrane protein systems using Cryo-electron microscopy: case studies of the HIV-1 core formation and human P-glycoprotein
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Gabriel A. Frank
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIHOrganizer Department of Chemical and Structural BiologyContact -
Date:08TuesdaySeptember 2015Lecture
“Operating Systems, Apps, and Novel Chromatin Structures for the Regulation of Our Genes”
More information Time 14:00 - 15:00Location Camelia Botnar BuildingLecturer Prof. James T. Kadonaga
Section of Molecular Biology, Division of Biological Sciences University of California San DiegoOrganizer Department of Biomolecular SciencesContact -
Date:08TuesdaySeptember 2015Lecture
Faculty of Life Sciences Alumni Event
More information Time 19:00 - 22:30Organizer Faculty of BiologyContact -
Date:09WednesdaySeptember 2015Conference
33rd Annual IVS Conference
More information Time All dayLocation The David Lopatie Conference CentreChairperson Sidney CohenHomepage Contact -
Date:09WednesdaySeptember 2015Lecture
Pentaquarks, doubly heavy exotic baryons and mesons and how to look for them
More information Time 11:00 - 11:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Prof. Marek Karliner
Tel Aviv UniversityOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about I discuss the recent theoretical prediction and the experime...» I discuss the recent theoretical prediction and the experimental confirmation by LHCb of an exotic baryon which contains five quarks, including hidden charm. This discovery can best be understood in the context of earlier discoveries of doubly heavy exotic mesons. When viewed this way, the discov-ery of the new exotic baryon strongly suggest existence of many more analogous exotic states, with both charmed and bottom quarks. Specific predictions are given for masses and decay modes
of these states, as well as possible ways to observe them in experiments.
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Date:09WednesdaySeptember 2015Lecture
Diabetic Pancreatic Beta cells: To be or not to be
More information Time 14:00 - 14:00Location Max and Lillian Candiotty BuildingLecturer Prof. Danielle Melloul
Hadassa Medical Center, JerusalemOrganizer Department of Immunology and Regenerative BiologyContact -
Date:10ThursdaySeptember 2015Cultural Events
Ukraine culture Festival
More information Time 19:00 - 22:00Location Michael Sela AuditoriumContact -
Date:16WednesdaySeptember 201518FridaySeptember 2015Conference
Single cell genomics
More information Time All dayLocation UtrechtChairperson Hadas Keren-ShaulHomepage Contact -
Date:17ThursdaySeptember 2015Lecture
Molecules, glass & light
More information Time 13:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Alina Karabchevsky
Optoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UKOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about In this seminar, I will introduce the fundamentals of guided...» In this seminar, I will introduce the fundamentals of guided optics. A brief overview will be given over design, fabrication and characterization of integrated optical components and microfluidic channels. I will focus on the conceptual importance of the integrated optics and surface modification for chemo- and bio-applications. The potential of disorder-enhanced photonics in vibrational spectroscopy on waveguides will be discussed and new directions will be proposed. Vibrational spectroscopy relies on absorption of electromagnetic radiation by molecular vibrations. It is a powerful tool for drawing information on molecular structure and dynamics. In the first part of the talk I will present an intriguing physical effect of disorder-enhanced absorption of light by molecular overtones of amines in a: 1) silicate channel waveguide and 2) microtapered fiber with adsorbed gold nanoparticles. Due to the guides’ surface modification, aromatic rings tend to stack together, and N-H bonds in amines form hydrogen bonds with each other. This 8 nm thick multilayer structure of lamellar liquid crystal shape leads to the switch from ballistic to diffusive propagation of light which results in the enhanced absorption. I will also address a dynamics of absorption as a function of time of adsorption of the organic molecules on waveguide. These phenomena are expected to find application in organic solution based optical sensors for detection of explosive materials and diagnostics of psychoactive stimulants based on amines. In the second part of the talk, I will present a theoretical study of composite plasmonic waveguide structures for design of integrated optical components and Purcell enhanced chemiluminescence in a microfluidic channel. -
Date:17ThursdaySeptember 2015Cultural Events
Yuval Hamevulbal - children's theater
More information Time 17:30 - 19:30Title Mr. agvaniaLocation Michael Sela AuditoriumHomepage Contact -
Date:21MondaySeptember 2015Lecture
Understanding serous ovarian cancer: will prevention and early detection be possible?
More information Time 14:00 - 14:00Location de-Picciotto Loby Room #25Lecturer Dr. Keren Levanon
Ovarian Cancer Research Lab, Head SHEBA Medical Center, Tel-HashomerOrganizer Department of Immunology and Regenerative BiologyContact -
Date:21MondaySeptember 2015Cultural Events
Researcher’s Night
More information Time 17:30 - 22:00Location Michael Sela AuditoriumContact -
Date:30WednesdaySeptember 2015Cultural Events
Cinderella - children's theater
More information Time 11:30 - 13:00Location Michael Sela AuditoriumHomepage Contact
