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October 05, 2015
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Date:24TuesdayNovember 2015Lecture
Mechanisms of functional reprogramming in the tumor microenvironment
More information Time 10:00 - 11:00Location Wolfson Building for Biological ResearchLecturer Prof. Ruth Scherz-Shouval
Dept. of Biological Chemistry-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about For tumors to expand, metastasize, and evade immune surveill...» For tumors to expand, metastasize, and evade immune surveillance, genetically transformed cancer cells must recruit non-malignant cells, including macrophages, fibroblasts and endothelial cells. These cells, collectively termed the tumor microenvironment, are reprogrammed to support the tumor at the expense of its host. Our group aims to elucidate the mechanisms by which tumors reprogram their local environments. Our hypothesis is that cancer cells hijack normal cytoprotective stress responses, and subvert them to enable stromal reprogramming. In my talk, I will discuss the role of Heat-shock Factor 1 (HSF1), master regulator of the heat-shock response, in this process. Across a broad range of human cancers, HSF1 is activated in cancer-associated fibroblasts (CAFs), where it drives a transcriptional program that supports the malignant potential of adjacent cancer cells. In early stage breast and lung cancer, high stromal HSF1 activation is strongly associated with poor patient outcome. Thus, tumors co-opt the ancient survival functions of HSF1 to orchestrate malignancy, with far-reaching therapeutic implications. -
Date:24TuesdayNovember 2015Lecture
(Computational) genomics of post-transcriptional regulation: from RNA-binding proteins to translation
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Uwe Ohler
Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Humboldt UniversityOrganizer Department of Systems ImmunologyContact -
Date:24TuesdayNovember 2015Lecture
THERMALIZATION AND CHAOS IN MATRIX MODELS
More information Time 10:30 - 10:30Location Neve ShalomLecturer VLADIMIR ROSENHAUS
UCSBOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Recently, Kitaev has proposed a variant of the Sachdev-Ye mo...» Recently, Kitaev has proposed a variant of the Sachdev-Ye model as a solvable model of holography. The SYK model correctly reproduces the Lyapunov exponent of a black hole, as computed from an out-of-time order 4-pt function. We will revisit some older matrix models, such as the one of Iizuka, Okuda, and Polchinski, and study the 4-pt function.. -
Date:24TuesdayNovember 2015Lecture
"Small Molecule Activation by Redox-Modulation in Multimetallic Iron Complexes”
More information Time 11:00 - 11:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Graham de Ruiter
California Institute of TechnologyOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:24TuesdayNovember 2015Lecture
“6D (1, 0) SCFTS AND THEIR COMPACTIFICATIONS: A HOLOGRAPHIC APPROACH”
More information Time 12:00 - 12:00Location Neve ShalomLecturer Achilleas Passias
MILANOOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about We discuss the AdS7/CFT6 correspondence with sixteen superch...» We discuss the AdS7/CFT6 correspondence with sixteen supercharges, focusing on the gravity side. The six-dimensional field theories are (1, 0) supersymmetric and represent the low-energy dynamics of NS5-D6-D8-brane configurations. The gravity duals are AdS7 solutions of massive IIA supergravity. In addition, we present lower-dimensional anti-deSitter solutions, as duals to compactifications of the sixdimensional field theories. -
Date:24TuesdayNovember 2015Lecture
MCB Student Seminar
More information Time 12:30 - 12:30Title Development of fenestrated blood capillaries in a neuro-endocrine interface A Glance into the Mechanobiology of Cell-Matrix InteractionsLocation Wolfson Building for Biological ResearchLecturer Lusi Gordon, Dr. Ayelet Lesman Organizer Department of Molecular Cell BiologyContact -
Date:24TuesdayNovember 2015Lecture
"What Have We Learned from MAS NMR on Biomaterial Interfaces: Examples from Bone-like Apatite and Bioinspired Silica"
More information Time 14:00 - 14:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Gil Goobes
Bar Ilan UniversityOrganizer Department of Chemical and Structural BiologyContact -
Date:25WednesdayNovember 2015Lecture
Detonation nanodiamond as attractive building block for nanotechnology
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. Alexander Vul
Ioffe Physical-Technical Institute, St.Petersburg, RussiaOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:25WednesdayNovember 2015Lecture
Detonation nanodiamond as attractive building block for nanotechnology
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. Alexander Vul
Ioffe Physical-Technical Institute, St.PetersburgOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:25WednesdayNovember 2015Lecture
The Higgs Mass in Compact Supersymmetry
More information Time 11:00 - 11:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Kohsaku Tobioka
Weizmann/TAUOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about The current LHC results make weak scale supersymmetry diffic...» The current LHC results make weak scale supersymmetry difficult due to relatively heavy mass of the discovered Higgs boson and the null results of new particle searches. Geometrical supersymmetry breaking from extra dimensions, Scherk-Schwarz mechanism, is possible to accommodate such situations. A concrete example, the Compact Supersymmetry model, has a compressed spectrum ameliorating the LHC bounds and large mixing in the top and scalar top quark sector with |A_t |∼2m_t ̃ which radiatively raises the Higgs mass. While the zero mode contributions of the model has been considered, in this paper we calculate the Kaluza-Klein tower effect to the Higgs mass. Although such contributions are naively expected to be as small as a percent level for 10 TeV Kaluza-Klein modes, we find the effect significantly enhances the radiative correction to the Higgs quartic coupling by from 10 to 50 %. This is mainly because the top quark wave function is pushed out from the brane, which makes the top Yukawa coupling to depend on higher powers in the Higgs field for a fixed top mass. As a result the Higgs mass is enhanced up to 15 GeV from the previous calculation. We also show the whole parameter space is testable at the LHC run II. -
Date:25WednesdayNovember 2015Lecture
Genomics of drug sensitivty in leukemia and lymphoma
More information Time 11:30 - 11:30Title Special Guest SeminarLocation Wolfson Building for Biological ResearchLecturer Prof. Dr. med. Thorsten Zenz
National Center for Tumor Disease (NCT), HeidelbergOrganizer Department of Molecular Cell BiologyContact -
Date:25WednesdayNovember 2015Lecture
The Higgs Mass in the MSSM at two-loop order beyond MFV
More information Time 13:00 - 13:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Yael Shadmi
TechnionOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Soft supersymmetry-breaking terms provide a wealth of new po...» Soft supersymmetry-breaking terms provide a wealth of new potential sources of flavour violation, which lead to very tight constraints from precision experiments. This has posed a challenge to construct flavour models to both explain the structure of the Standard Model Yukawa couplings and how their consequent predictions for patterns in the soft supersymmetry-breaking terms do not violate these constraints. While such models have been studied in great detail, the impact of flavour violating soft terms on the Higgs mass at the two-loop level has been assumed to be small or negligible. In this letter, we show that large flavour violation in the up-squark sector can give a positive or negative shift to the SM-like Higgs of several GeV, without being in conflict with any other observation. We investigate in which regions of the parameter space these effects can be expected. -
Date:25WednesdayNovember 2015Lecture
Shining light on the gut microbiota-host interactions
More information Time 13:30 - 13:30Location Wolfson Building for Biological ResearchLecturer Dr. Naama Geva-Zatorsky
Department of Microbiology and Immunology, Harvard Medical School, USAOrganizer Department of Molecular Cell BiologyContact -
Date:25WednesdayNovember 2015Lecture
Serum albumin based biomaterials: From free-standing cell scaffolds to charge conduction
More information Time 14:00 - 14:00Location Perlman Chemical Sciences BuildingLecturer Dr. Nadav Amdursky
Imperial College, LondonOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:26ThursdayNovember 2015Colloquia
Was Einstein Right? A Centennial Assessment
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Clifford Will
Washington UniversityOrganizer Faculty of PhysicsContact Abstract Show full text abstract about A century after Einstein’s formulation of general relativity...» A century after Einstein’s formulation of general relativity, a remarkably diverse set of preci-sion experiments has established it as the ``standard model’’ for gravitational physics. Yet it might not be the final word. We review the array of measurements that have verified general relativity in the laboratory, in the solar system and in binary pulsars. We then describe some of the opportunities and challenges involved in testing Einstein’s great theory in strong-field regimes, in gravitational waves, and in cosmology.
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Date:26ThursdayNovember 2015Lecture
Pelletron lecture series - by invitation
More information Time 16:00 - 17:45Location PelletronContact -
Date:26ThursdayNovember 2015Cultural Events
This City - Hip Hop Musical
More information Time 21:00 - 22:30Location Michael Sela AuditoriumHomepage Contact -
Date:27FridayNovember 2015Cultural Events
The doctor and the patient - Dr. Tzachi Ben Zion and Yair Nitzani
More information Time 21:00 - 21:00Title Entertainment showLocation Michael Sela AuditoriumHomepage Contact -
Date:28SaturdayNovember 2015Cultural Events
Ze Broadway, Buba
More information Time 20:00 - 22:30Location Michael Sela AuditoriumContact -
Date:29SundayNovember 2015Lecture
RNA-mediated regulation of quorum sensing in bacteria
More information Time All dayLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Maya Shamir
Rotem Sorek's group, Dept. of Molecular GeneticsOrganizer Department of Molecular GeneticsContact