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April 27, 2017
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Date:10ThursdayMarch 2022Lecture
Jerusalem's Elite during the 7th century BCE : A Macro and Micro view from Giv'ati Parking Lot Excavations
More information Time 11:30 - 12:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Yuval Gadot
Department of Archaeology and Ancient Near Eastern Civilizations, Tel Aviv UniversityOrganizer Scientific Archeology UnitHomepage Contact -
Date:10ThursdayMarch 2022Lecture
Seminar for PhD thesis defense
More information Time 12:00 - 13:00Title "Dynamic rewiring of peroxisomal functions during changing metabolic needs of the cell"Location Zoom: https://weizmann.zoom.us/j/93020565048?pwd=V2F6aUFRVzBBTDFlM3JuQkhkY09aQT09 Meeting ID: 930 2056 5048 Password: 744219Lecturer Mira Rosenthal Organizer Department of Molecular GeneticsContact -
Date:10ThursdayMarch 2022Lecture
Brain-computer interfaces for basic science
More information Time 12:30 - 13:30Title Hybrid SeminarLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Byron Yu
Carnegie Mellon University, PittsburghOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Abstract: Brain-computer interfaces (BCI) translate neural a...» Abstract: Brain-computer interfaces (BCI) translate neural activity into movements of a computer cursor or robotic limb. BCIs are known for their ability to assist paralyzed patients. A lesser known, but increasingly important, use of BCIs is their ability to further our basic scientific understanding of brain function. In particular, BCIs are providing insights into the neural mechanisms underlying sensorimotor control that are currently difficult to obtain using limb movements. In this talk, I will demonstrate how a BCI can be leveraged to study how the brain learns. Specifically, I will address why learning some tasks is easier than others, as well as how populations of neurons change their activity in concert during learning.
Brief bio: Byron Yu received the B.S. degree in Electrical Engineering and Computer Sciences from the University of California, Berkeley in 2001.
He received the M.S. and Ph.D. degrees in Electrical Engineering in 2003 and 2007, respectively, from Stanford University. From 2007 to 2009, he was a postdoctoral fellow jointly in Electrical Engineering and Neuroscience at Stanford University and at the Gatsby Computational Neuroscience Unit, University College London. He then joined the faculty of Carnegie Mellon University in 2010, where he is a Professor in Electrical & Computer Engineering and Biomedical Engineering, and the Gerard G. Elia Career Development Professor. He is broadly interested in how large populations of neurons process information, from encoding sensory stimuli to driving motor actions.
His group develops and applies novel statistical algorithms and uses brain-computer interfaces to study brain function.
Link-
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421
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Date:10ThursdayMarch 2022Lecture
Canceled ! - The microbiome as part of the tumor ecosystem
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Ravid Straussman
Department of Molecular Cell Biology • Faculty of BiologyOrganizer Dwek Institute for Cancer Therapy ResearchContact -
Date:13SundayMarch 2022Lecture
WIS-Q Seminar
More information Time All dayTitle Rotem Arnon-FriedmanOrganizer Department of Condensed Matter PhysicsContact -
Date:13SundayMarch 2022Lecture
Cracking the olfactory code using behavior
More information Time 10:00 - 11:00Title Hybrid SeminarLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Dmitry Rinberg
Dept of Neuroscience and Physiology, NYUOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Two of the most fundamental questions of sensory neuroscienc...» Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by neuronal activity? and 2) what features of this activity are read out to guide behavior? The first question has been the subject of a large body of work across different sensory modalities. The second question remains a significant challenge, since one needs to establish a causal link between neuronal activity and behavior.
In olfaction, it has been proposed that information about odors is encoded in spatial distribution of receptor activation and the next level mitral/tufted cells, as well as in their relative timing and synchrony. However, the role of different features of neural activity in guiding behavior remains unknown. Using mouse olfaction as a model system, we developed both technological and conceptual approaches to study sensory coding by perturbing neural activity at different levels of information processing during sensory driven behavioral tasks. We developed methods for both one-photon spatiotemporal pattern stimulation using digital mirror devices at the glomerulus level in the olfactory bulb, and two-photon holographic pattern stimulation deeper in the brain, at the level of mitral/tufted cells. Using these techniques, we performed quantitative behavioral experiments to, first, measure psychophysical limits of the readability of different features of the neural code, and, second, to quantify their behavioral relevance. Based on these results, we built a detailed mathematical model of the behavioral relevance of the different features of spatiotemporal neural activity. Our approach can be potentially generalized to other sensory systems.
Link:
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421
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Date:13SundayMarch 2022Lecture
Drugging the early secretory pathway: Regulation of the Endoplasmic Reticulum (ER) and ER exit sites in cellular homeostasis
More information Time 11:00 - 12:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Alison Forrester
Institute Curie, Paris, FranceOrganizer Department of Biomolecular SciencesContact -
Date:14MondayMarch 2022Lecture
Ph.D thesis defense: Zoom: "Polymer beads as interfacial obstacles in fibre-reinforced composites"
More information Time 10:00 - 11:00Lecturer Carol Rodricks
under the supervision of Prof. Daniel WagnerOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/93495966390?pwd=T3hDNX...» Zoom Link: https://weizmann.zoom.us/j/93495966390?pwd=T3hDNXY1WFh6bFpIbDh3OEFxZlcwZz09
The fibre-matrix interface plays a vital role in the overall mechanical behaviour of a fibre-reinforced composite, but the classical approach to improving the interface through chemical sizing is limited by material properties. Achieving a simultaneous improvement in strength and toughness in a composite is a particular challenge since these properties are mutually exclusive, and the chemical modification of the interface often results in one property being improved at the expense of the other. In contrast, the geometrical modification of the fibre-matrix interface to allow for mechanisms such as mechanical interlocking of components is a promising approach to resolving this challenge. This study explores a novel type of topographical obstacle – polymer droplets at the fibre-matrix interface. Discrete epoxy droplets are deposited onto glass fibres and embedded in an epoxy matrix to form model composites. The effect of the interfacial epoxy droplets is investigated using single fibre experiments.
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Date:14MondayMarch 2022Colloquia
The multi-scale structure of chromatin in the nucleus
More information Time 11:00 - 12:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Yuval Garini
Faculty of Biomedical Engineering, TechnionOrganizer Faculty of ChemistryHomepage Contact Abstract Show full text abstract about The DNA in a human cell which is ~2 meters long is packed in...» The DNA in a human cell which is ~2 meters long is packed in a ~10 μm radius nucleus. It is immersed in a condensed soup of proteins, RNA and enzymes and it is highly dynamic, while it must stay organized to prevent chromosome entanglement and for ensuring proper genome expression.
Studying this nanometer – micrometer scale structure requires to use both high spatial and temporal resolutions and we combine comprehensive live-cell and molecular methods.
I will discuss the latest findings on the chromatin organization, the role of lamin A that we found to be of major importance and the functionality of the structure, both for physical properties, and for its functionality on gene expression. -
Date:15TuesdayMarch 2022Lecture
Stem Cells, Regeneration and Aging Seminar
More information Time 09:00 - 10:30Title From single cells to tissues' dynamics in development and ageingLocation Max and Lillian Candiotty BuildingLecturer Prof. Amos Tanay Contact -
Date:15TuesdayMarch 2022Lecture
Stretch-induced growth in the nervous system
More information Time 10:00 - 10:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Agostina Di-Pizio
Dept. of Biomolecular Sciences - WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about During embryogenesis, neurons grow to reach their target cel...» During embryogenesis, neurons grow to reach their target cells by growth one directed axon elongation. At later stages of development, stretch-induced growth plays a major role in the maturation of embryonic processes into long nerves. I am testing the effects of mechanical stretch on adult sensory neurons with the aim to elucidate the molecular mechanisms that regulate stretch-induced growth. -
Date:15TuesdayMarch 2022Lecture
Taking Importin beta1 to the BAR
More information Time 10:30 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Didi-Andreas Song
Dept. of Biomolecular Sciences - WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about The nucleocytoplasmic transport factor importin β1 has criti...» The nucleocytoplasmic transport factor importin β1 has critical roles in the transport of injury-regulated cargos in peripheral neurons. I employed biotinylation by antibody recognition (BAR) to identify axonal importin β1 cargos in primary neurons. Axon focused BAR proteomics suggests a new role of importin β1 in long-distance fatty acid signaling in injured neurons. -
Date:16WednesdayMarch 2022Lecture
Zoom: "Spinning Driven Dynamic Nuclear Polarization with Optical Pumping"
More information Time 15:00 - 16:00Lecturer Dr. Frederic Mentink-Vigier
National High Magnetic Field Laboratory, TallahasseeOrganizer Clore Institute for High-Field Magnetic Resonance Imaging and SpectroscopyContact -
Date:20SundayMarch 2022Lecture
Four disruptive technologies that are revolutionizing sensing of the oceans
More information Time 11:00 - 11:00Location https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09Lecturer Emmanuel Boss Organizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about The maker movement (cheap electronics + sharing), automated ...» The maker movement (cheap electronics + sharing), automated microscopy, autonomous platforms and small footprint satellites have been revolutionizing oceanography, opening a variety of new avenues for research and requiring a different education model. In this talk I will summarize a few activities my lab has been involved in that are associated with these disruptive technologies and why I am very optimistic for the future of our field in the coming years.
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Date:20SundayMarch 2022Lecture
PhD defense seminar by Martino Maddalena (Moshe Oren Lab)
More information Time 11:00 - 12:30Title THE IMPACT OF TP53 MISSENSE MUTATIONS ON PDACLecturer Martino Maddalena
Moshe Oren's LabOrganizer Department of Molecular Cell BiologyHomepage Contact -
Date:20SundayMarch 2022Lecture
A geologic perspective on anthropogenic climate change
More information Time 13:00 - 14:00Title SAERI ZOOM Lecture- Sustainability and Energy Research Initiative lecture seriesLocation via Zoom onlyLecturer Prof. Itay Halevy
Department of Earth & Planetary Sciences Weizmann Institute of ScienceOrganizer Weizmann School of ScienceContact -
Date:21MondayMarch 2022Lecture
PhD defense seminar by Lian Narunsky Haziza (Ravid Straussman lab)
More information Time 14:00 - 15:30Title Pan-cancer analyses of the tumor mycobiome and its clinical effectsLecturer Lian Narunsky Haziza
Zoom link: https://weizmann.zoom.us/j/99845157696?pwd=cGxLeHVicmJpS0ZCTDJSTVVUWWJiUT09Organizer Department of Molecular Cell BiologyHomepage Contact -
Date:22TuesdayMarch 2022Lecture
“Re-rendering Reality”
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Tali Dekel
Faculty of Mathematics and Computer Science, WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about We all capture the world around us through digital data such...» We all capture the world around us through digital data such as images, videos and sound. However, in many cases, we are interested in certain properties of the data that are either not available or difficult to perceive directly from the input signal. My goal is to “Re-render Reality”, i.e., develop algorithms that analyze digital signals and then create a new version of it that allows us to see and hear better. In this talk, I’ll present a variety of methodologies aimed at enhancing the way we perceive our world through modified, re-rendered output. These works combine ideas from signal processing, optimization, computer graphics, and machine learning, and address a wide range of applications. More specifically, I’ll demonstrate how we can automatically associate objects in a video with complex scene elements that are related to th! em (e.g., associate objects with their shadows or reflections), or transfer the visual appearance of objects in one image to semantically related objects in a different image. -
Date:22TuesdayMarch 2022Academic Events
Scientific Council Meeting
More information Time 14:00 - 16:00Contact -
Date:24ThursdayMarch 2022Lecture
The impact of metabolic processes at the brain’s choroid plexus and of the gut microbiome on Alzheimer’s disease manifestation
More information Time 16:00 - 16:00Title Student Seminar - PhD Thesis Defense -ZOOM-Lecturer Afroditi Tsitsou-Kampeli
Prof. Michal Schwartz Lab Dept of Brain SciencesOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The immune system and the gut microbiome are becoming major ...» The immune system and the gut microbiome are becoming major players in chronic neurodegenerative conditions. One of the key interfaces between the brain and the immune system with an impact on brain function is the choroid plexus (CP). The CP interface is central to the maintenance of brain homeostasis by exerting a plethora of different biological processes. However, in aging and Alzheimer’s disease (AD), interferon type-I (IFN-I) signaling accumulates at the CP and impedes part of its beneficial function by inducing a CP-pro-aging signature. My research contributed to the finding that IFN-I signaling at the CP induces an aging-like signature in microglia and impedes cognitive abilities in middle-aged mice in a microglia-dependent manner. In addition, I demonstrated that the brain-specific enzyme, cholesterol 24-hydroxylase (CYP46A1), is expressed by the CP epithelium and that its product, 24-hydroxycholesterol (24-OH), downregulates CP-pro-inflammatory signatures. Furthermore, in AD, CP CYP46A1 protein levels were decreased in both mice and humans and overexpression of Cyp46a1 at the CP in 5xFAD mice reversed brain inflammation, microglial dysfunction signatures, and cognitive loss. Finally, while the pro-inflammatory cytokine TNF-α impaired CP Cyp46a1 expression in vitro, boosting systemic immunity in vivo increased its levels in an IFNGR2-dependent manner. These results highlight CYP46A1 at the CP as a remote regulator of brain inflammation, which diminishes with neurodegeneration, but is amenable to rescue. Focusing on the gut microbiome, I found that 5xFAD mice devoid of microbiome exhibited a striking decrease of long-term spatial memory deficit and increased synaptic and neuronal survival. Spatial memory deficit in 5xFAD mice kept in germ free (GF) or specific-pathogen free (SPF) conditions, negatively correlated with the abundance of 2-hydroxypyridine, while systemic, chronic supply of 2-hydroxypyridine in SPF 5xFAD mice improved spatial memory deficits in comparison to phosphate-buffered saline (PBS)-supplied 5xFAD mice. Overall, these findings demonstrate a microbiome-dependent effect on AD pathology in the 5xFAD mouse model and suggest a connection between 2-hydroxypyridine and AD manifestation. In general, this research thesis addresses novel aspects of choroid plexus and gut microbiome metabolism and their relation to AD progression.
Zoom link
https://weizmann.zoom.us/j/98658552127?pwd=ZkZmWTBkd1AxZ0xPbGlpU3FPUWpzUT09
Meeting ID:986 5855 2127
Password:495213