לוח שנה משולב

The notion of a quantum jump is almost synonymous, in the public mind, with all things quantum mechanical. It comes to us as an echo from the very earliest days of the “old quantum theory”. My talk will trace the quantum jump from these early beginnings to its use as a building block of stochastic Shroedinger equations in modern quantum optics. Experi-ments with trapped ions and microwave photons in a box provide simple illustrations of the ideas.

RECENT ADVANCES IN AUTOMATED OLIGOSACCHARIDE AND GLYCOPEPTIDE SYNTHESIS

Mattan Hurevich,a and Peter H. Seeberger.a,b

aDepartment of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm,Germany and bFreie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany.

The automated solid-phase synthesis of oligopeptides and oligonucleotides had an immense impact on biochemical research and has fulfilled the growing demand of the scientific community to study short biopolymers and their biological, biophysical and mechanical characteristics.
There is a major interest in developing robust methods for the synthesis of glycopeptides and oligosaccharides as their chemical synthesis requires compatible solutions for challenges associate with glycan assembly. The quest for solid phase strategy suitable for oligosaccharide and glycopeptide synthesis is still in the critical and stimulating stage of continuous development.
Automated solid-phase oligosaccharide synthesis has been developed to provide ready to use complex carbohydrates to the research community.1 Many important chemical and technological milestones have been achieved in the process of creating a reliable automated oligosaccharide synthesis system.
The developments in the automated solid-phase synthesis of oligosaccharides emphasize the contribution of adjacent fields such as NMR and flow chemistry to carbohydrate synthesis.
The synthesis of sialosides,2 arabinofuranosides,3 polymannosides, and glycopeptides4 using automated solid phase platform will be presented. This study demonstrates that the new generation of oligosaccharide synthesizers overcome many technical and chemical hurdles and simplifies the synthesis of ready to conjugate oligosaccharides5 and glycopeptides.

References:
[1] Plante, O. J.; Palmacci, E. R.; Seeberger, P. H. Science 2001, 291, 1523-1527; Calin, O.; Eller, S.; Seeberger, P.H. 2013 Angew. Chem Int. Ed, 2013, 52, 5862-5865
[2] Esposito, D.; Hurevich, M.; Castagner, B.; Wang, C. C.; Seeberger, P. H. Beilstein J. Org. Chem. 2012, 8, 1601-1609.
[3] Kandasamy, J.; Hurevich, M.; Seeberger, P. H. Chem. Commun., 2013, 49, 4453-4455.
[4] Hurevich, M.; Seeberger, P. H. Chem. Commun., 2014, 50, 1851-1853.
[5] Krock, L.; Esposito, D.; Castagner, B.; Wang, C. C.; Bindschadler, P.; Seeberger, P. H. Chem. Sci. 2012, 3, 1617-1622.