לוח שנה משולב

Many natural and industrial settings involve dilute systems of reacting particles transported by an unsteady fluid flow. We consider the simple case of an annihilation process A + A → Ø with a given rate when two particles are within a finite radius of interaction. The system is described in terms of the joint n-point number spatial density that it is shown to obey a hierarchy of transport equations. An analytic solution is obtained in either the dilute or the long-time limit by using a Lagrangian approach where statistical averages are performed along non-reacting trajectories. In this limit, we show that the moments of the number of particles have an exponential decay rather than the algebraic prediction of standard mean-field approaches. The effective reaction rate is then related to Lagrangian pair statistics by a large-deviation principle. A phenomenological model is introduced to study the qualitative behavior of the effective rate as a function of the interaction length, the degree of chaoticity of the dynamics and the compressibility of the carrier flow. Exact computations, obtained via a Feynman-Kac approach, in a smooth, compressible, random delta-correlated-in-time Gaussian velocity field support the proposed heuristic approach.
(joint work with M. Cencini and G. Krstulovic)

Transient receptor potential (TRP) channels constitute a large superfamily of polymodal channel proteins with diverse roles in many transduction and sensory pathways. These channels participate in most sensory modalities (e.g. vision, taste, temperature, pain, pheromone detection) and they either open directly in response to ligands or physical stimuli (e.g. temperature, osmotic pressure, or noxious substances) or, indirectly, downstream of a signal transduction cascade. TRP channels form an evolutionary conserved novel cation channel family consisting of seven subfamilies, which include nearly 30 human members. The founding member of this family was found in Drosophila and was designated TRP by Minke. TRP channels are classified into seven related subfamilies designated TRPC (Canonical or classical), TRPM (Melastatin), TRPN (NompC), TRPV (Vanilloid receptor), TRPA (ANKTM1), TRPP (Polycystin) and TRPML (Mucolipin). Our studies in Drosophila shed new light on the properties of the TRP channels by showing that a constitutive ATP-dependent process is required to keep these channels closed in the dark, a requirement that would make them sensitive to metabolic stress. Since mammalian TRP channels are heavily expressed in the brain, neuronal damage due to ischemia may involves activation of TRP channels.