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פברואר 18, 2016
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Date:18שלישינובמבר 2025הרצאה
Reverse Engineering Anti-Aging Interventions from Pharmaco-biology in Model Organisms: AI for Systems Biology of Aging?
More information שעה 15:00 - 16:00כותרת AI for Systems Biology of Aging?מיקום Botnar auditoriumמרצה Dr. Leon Peshkin
Principal Research Scientist in Systems Biology, Harvard Medical Schoolמארגן מכון סגול לאריכות ימיםצרו קשר תקציר Show full text abstract about The aging process represents one of biology's most comp...» The aging process represents one of biology's most complex system-level phenomena. A major challenge is moving from observing its correlates to identifying its fundamental, targetable bottlenecks. In this talk, I will explore a reverse-engineering approach, using pharmacological interventions in model organisms to deconstruct the mechanisms of aging and pinpoint promising avenues for intervention. I will discuss how we can leverage existing biological data and what new, targeted measurements are required to fill critical gaps. A key question is the selection of appropriate model organisms that offer the right balance of physiological complexity, experimental tractability, and translational relevance for aging research. Furthermore, I will examine the role of artificial intelligence in this endeavor: while AI excels at finding generalizable patterns, its success is critically dependent on the quality and nature of the underlying data—an area where significant improvements are needed. I will present examples from my work across multiple species, including the development of a scalable high-throughput platform for pharmaco-biology in Daphnia. This system allows us to characterize drug-induced perturbations and link them to lifespan and healthspan outcomes. We will discuss a computational framework to regress macro-phenotypes to the molecular pathways. Finally, I will outline central challenges in the field and propose concrete directions for researchers interested in joining the effort to reverse engineer aging. -
Date:19רביעינובמבר 2025הרצאה
2025-2026 Spotlight on Science Seminar Series by Dr. Tal Ilani (Chemical & Structural Biology)
More information שעה 12:30 - 14:00כותרת My Gut Feeling: How Redox Protects Intestinal Liningמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Tal Ilani צרו קשר תקציר Show full text abstract about Being in the right place at the right time is essential for ...» Being in the right place at the right time is essential for enzymes carrying out chemical reactions in cells. For example, enzymes that introduce S–S (disulfide) bonds during protein folding must operate in the intracellular compartment where their substrate proteins are synthesized (endoplasmic reticulum). One disulfide-introducing enzyme, Quiescin Sulfhydryl Oxidase 1 (QSOX1), drew our attention because it resides in a “wrong” location: a downstream compartment containing already folded proteins (Golgi apparatus). Setting out to understand why QSOX1 is found in an unusual place in cells, I discovered a previously unrecognized role for disulfide catalysis: in addition to assisting in protein folding, disulfides can also function as reversible molecular switches that regulate enzyme activity. I found that a family of sugar-adding enzymes (sialyltransferases), located in the same compartment as QSOX1, depend on local disulfide catalysis to remain active. This redox control mechanism is essential for maintaining the integrity of the intestinal mucosal layer, establishing QSOX1 as a key factor in promoting and preserving colon health. -
Date:19רביעינובמבר 2025הרצאה
Genetic analysis of breast cancer in the mouse mammary gland
More information שעה 14:00 - 15:00מיקום Candiotty,
Auditoriumמרצה Prof. Sean Egan מארגן המכון לחקר הטיפול בסרטן עש דואק -
Date:19רביעינובמבר 2025אירועים אקדמיים
Workshop: Data management plan for EU grants
More information שעה 14:30 - 16:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
290Cצרו קשר תקציר Show full text abstract about Effective data management throughout the lifecycle of a stud...» Effective data management throughout the lifecycle of a study is a major time saver, and it preserves the reproducibility of the work.For these reasons, data management plans are a requirement of all major funders.We invite you to participate in a workshop with a focus on the composition of data management plans and the available services to support it.Target audience: Anyone who is interested in improving the reproducibility of their work, for themselves, their colleagues, or collaborators. Registration will be appreciated: https://tinyurl.com/yd5znvuz -
Date:20חמישינובמבר 2025סימפוזיונים
Physics Colloquium
More information שעה 11:15 - 12:30כותרת Dark matter detectors: WIMPs and other creaturesמיקום Weissman Auditoriumמרצה Prof. Ranny Budnik תקציר Show full text abstract about Direct detection searches for dark matter have advanced rema...» Direct detection searches for dark matter have advanced remarkably over the past decades, with experimental sensitivities improving by an order of magnitude every few years. This rapid progress has not only expanded the explored dark matter parameter space but also enabled measurements and observations of "standard" physics that were considered out of reach until recently.In this talk, I will present an overview of the XENONnT experiment, highlighting its latest results on dark matter and more, and will take a glance at the future of large-scale WIMP detectors. I will then discuss several new directions in the search for light dark matter and other emerging detector concepts that are now moving from ideas to experimental design. -
Date:20חמישינובמבר 2025הרצאה
Vision and AI
More information שעה 12:15 - 13:15כותרת FlowEdit: Inversion-Free Text-Based Editing Using Pre-Trained Flow Models (ICCV 2025 Best Student Paper)מיקום בניין יעקב זיסקינד
Room 1 - 1 חדרמרצה Vladimir Kulikov
Technionמארגן המחלקה למדעי המחשב ומתמטיקה שימושיתצרו קשר תקציר Show full text abstract about Editing real images using a pre-trained text-to-image (T2I) ...» Editing real images using a pre-trained text-to-image (T2I) diffusion/flow model often involves inverting the image into its corresponding noise map. However, inversion by itself is typically insufficient for obtaining satisfactory results, and therefore many methods additionally intervene in the sampling process. Such methods achieve improved results but are not seamlessly transferable between model architectures. Here, we introduce FlowEdit, a text-based editing method for pre-trained T2I flow models, which is inversion-free, optimization-free and model agnostic. Our method constructs an ODE that directly maps between the source and target distributions (corresponding to the source and target text prompts) and achieves a lower transport cost than the inversion approach. This leads to state-of-the-art results, as we illustrate with Stable Diffusion 3 and FLUX.
Bio:
Vladimir Kulikov, PhD student at the Technion, supervised by Prof. Tomer Michaeli. Currently studying Generative Models with emphasis on Computer Vision. -
Date:20חמישינובמבר 2025הרצאה
Geometric Functional Analysis and Probability Seminar
More information שעה 13:30 - 14:30כותרת Tilings and Cluster Algebras for the Amplituhedronמיקום בניין יעקב זיסקינד
Room 155 - חדר 155מרצה Tsviqa Lakrec
Genevaמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר תקציר Show full text abstract about In 2005, Britto, Cachazo, Feng and Witten (BCFW) gave a recu...» In 2005, Britto, Cachazo, Feng and Witten (BCFW) gave a recursion relation for computing scattering amplitudes in N = 4 super Yang–Mills theory. In 2013, Golden, Goncharov, Spradlin, Vergu and Volovich discovered in the scattering amplitudes of this theory a cluster algebraic structure. The amplituhedron A(n,k,m) is a geometric object, introduced by Arkani-Hamed and Trnka in 2013, conjectured to encode scattering amplitudes in planar N = 4 super Yang–Mills. In this talk, I will discuss the amplituhedron and how both the aforementioned BCFW recursion and cluster algebra structures originate in its geometry.
Based on joint works with Even-Zohar, Parisi, Sherman-Bennett, Tessler and Williams. -
Date:20חמישינובמבר 2025הרצאה
The Digital Transformation of Pathology: Opportunities and Challenges for Cancer Research
More information שעה 14:00 - 15:00מיקום Candiotty
Auditoriumמרצה Hanni Naor מארגן המכון לחקר הטיפול בסרטן עש דואק -
Date:23ראשוןנובמבר 2025הרצאה
At the Edge of Hydrology: Decoding Water Extremes in Arid Landscapes (from Space)
More information שעה 11:00 - 12:00מיקום בניין המנהלה ע"ש סטון
Zacks Hallמרצה Moshe Armon מארגן המחלקה למדעי כדור הארץ וכוכבי הלכתתקציר Show full text abstract about Despite covering over a third of Earth’s land surface, arid ...» Despite covering over a third of Earth’s land surface, arid regions remain among the least understood hydrological environments. Practically every component of the desert water cycle is more poorly constrained than its counterpart in wetter regions. Yet deserts are home to over 20% of the global population and are disproportionately vulnerable to hydrometeorological hazards such as droughts, floods, and the accelerating impacts of climate change. A better understanding of the desert water cycle is therefore not only a scientific challenge, but a critical need for sustainable water resource and risk management in drylands.In this talk, I will present three studies that illuminate different aspects of the desert water cycle:(a) how satellite observations can be used to infer the (underwater) topography — and thus the water volume — of remote desert lakes;(b) what atmospheric ingredients link moisture, rain, and floods in the hyperarid Sahara, and how these relate to the desert's paleo- (and future?) climate; and(c) how misjudged flood risk management on the desert margin contributed to the deadliest hydrometeorological disaster of the 21st century in Derna, Libya.Together, these studies illustrate how unconventional combinations of satellite data and modelling can overcome the challenges of limited in situ observations to reconstruct, quantify, and ultimately understand hydrological processes in deserts. They also challenge longstanding assumptions about runoff generation and risk mitigation in arid regions, pushing the boundaries of what we thought we could know in some of the world's most water-scarce landscapes. -
Date:23ראשוןנובמבר 2025הרצאה
Cracking the rRNA variation code in human health and disease
More information שעה 11:00 - 12:00מיקום Benoziyo Bldg. for Biological Sciences - Biochemistry Auditorium
Biochemistry Auditorium - 191cמרצה Dr. Daphna Rothschild
Department of Genetics, Stanford University -
Date:23ראשוןנובמבר 2025הרצאה
The Clore Center for Biological Physics
More information שעה 13:15 - 14:30כותרת Hamiltonian hydrodynamics of 2D active matterמיקום ספרית הפיסיקה על שם נלה וליאון בנוזיומרצה Dr. Naomi Oppenheimer
Lunch at 12:45צרו קשר תקציר Show full text abstract about I will describe two biologically inspired systems that&n...» I will describe two biologically inspired systems that can be analyzed using the same hydrodynamic Hamiltonian formalism. The first is ATP synthase proteins, which rotate in a biological membrane. The second is swimming micro-organisms such as bacteria or algae confined to a two-dimensional film. I will show that in both cases, the active systems self-assemble into distinct structural states --- the rotating proteins rearrange into a hexagonal lattice, whereas the micro-swimmers evolve into a zig-zag configuration with a particular tilt. While the two systems differ both on the microscopic, local interaction, as well as the emerging, global structure, their dynamics originate from similar geometrical conservation laws applicable to a broad class of fluid flows. I will present experiments and simulations in which the Hamiltonian is perturbed, leading to different and surprising steady-state configurations. Time permitting, I will show that higher-order force distributions lead to the aggregation of an ensemble of particles. -
Date:24שנינובמבר 2025סימפוזיונים
Annual Gerhard Schmidt Lecture
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Emanuel Peled דף בית -
Date:24שנינובמבר 2025הרצאה
PhD Defense Seminar – Oz Ben Joseph (Prof. Assaf Gal Lab)
More information שעה 11:00 - 12:00כותרת (Prof. Assaf Gal Lab)מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו למדעי הצמח
690מארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:24שנינובמבר 2025הרצאה
PhD Thesis Defense Hernan Rubinstein (Prof. Yonatan Stelzer Lab)
More information שעה 14:00 - 16:00כותרת Decoding the Role of Cellular Communication on Cell-fate Decisions During Early Mammalian Developmentמיקום Schmidt Hallמארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר -
Date:24שנינובמבר 2025הרצאה
Superalgebra Theory and Representations Seminar
More information שעה 14:00 - 15:00כותרת Generalized electrical Lie algebrasמיקום גולדסמית-מתמטיקה
Room 108 - חדר 108מרצה Arkady Berenstein
University of Oregon, Eugeneמארגן המחלקה למתמטיקהצרו קשר תקציר Show full text abstract about My talk is based on joint work with Azat Gainutdinov and Vas...» My talk is based on joint work with Azat Gainutdinov and Vassily Gorbounov, in which we generalize in several ways the electrical Lie algebras originally introduced by Lam and Pylyavskyy. To each semisimple or Kac-Moody Lie algebra g we associate a family of flat deformations of its nilpotent part parametrized by the points of the Cartan subalgebra of g. If g=sl_n, then the generic electrical Lie algebra is sp_{n-1}, which is simple if n is odd. Similar situation is with other classical lie algebras, for instance if g=sp_{2n}, then its generic electrical Lie algebra is sp_n\oplus sp_{n-1}, which is never semisimple.
If time permits, I will explain the ``edge models" of electrical Lie algebras in semisimple and affine case, where the deformation parameters can be viewed as edge weights of the Dynkin diagram of g. -
Date:25שלישינובמבר 2025הרצאה
Molybdenum metabolism: From genes and protein structures to an FDA-approved therapy of a deadly human disease
More information שעה 10:00 - 12:00מיקום • Benoziyo Bldg. for Biological Sciences
Biochemistry Auditorium - 191cמרצה Prof. Ralf R. Mendel
Dept. of Molecular and Cell Biology of Plants, Faculty of Life Sciences, Braunschweig University of Technology -
Date:25שלישינובמבר 2025הרצאה
Unlock the future of Drug Discovery: Hit Identification & Profiling in WuXi Biology
More information שעה 11:00 - 12:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
Cafeteriaמרצה Moran Jerabek-Willemsen, Global Director Biophysics/Head of Hit ID & Profiling צרו קשר תקציר Show full text abstract about In this presentation, we will begin with an overview of wide...» In this presentation, we will begin with an overview of widely used screening technologies in drug discovery, including :High-throughput screening (HTS), DNA-encoded library screenings (DEL), mRNA display and Fragment-based screenings. In Addition we will then introduce the uHTS Dianthus, an ultra-high-throughput (uHTS) affinity-based screening platform capable of evaluating up to 500, 000 ligands within two weeks, offering exceptional speed and sensitivity for biophysical interaction studies. In addition, we will present a series of case studies highlighting our experience in characterizing small molecule binding across a range of therapeutic modalities, including: Molecular glues, Peptides, Covalent molecules -
Date:25שלישינובמבר 2025הרצאה
Computational trade-offs as a core principle of brain function
More information שעה 12:30 - 13:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Yuval Hart מארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Abstract: Prioritizing computational principles offers a pro...» Abstract: Prioritizing computational principles offers a promising strategy to link neural activity, computation, and behavior. In this talk, I will focus on computational trade-offs as a core principle of brain function. Pareto optimality posits that systems optimized for multiple, competing goals are constrained to a low-dimensional manifold, the Pareto front, that captures the trade-offs shaping their organization. I will present theory and data supporting the Pareto framework: First, we apply this framework to large-scale whole-brain functional data in humans (resting-state fMRI dataset, N=1200) and demonstrate that individual differences in the brain's functional connectome lie on a robust triangle. We show that this triangle, interpreted using network analysis, clinical data, and task performance, reflects fundamental information-processing trade-offs. Second, we show that the Pareto front is an efficient representation for task-related brain dynamics. Third, we characterize the constraints of a control mechanism on Pareto manifolds, suggest a potential representation for it, and infer its possible breakdown points. Finally, we show evidence from ADHD and Alzheimer's disease supporting these theoretical predictions. If time allows, I will briefly present how ASD variation can be cast as a computational trade-off between accurate encoding and fast adaptation. Together, these findings demonstrate that trade-offs can account for diverse patterns of neural function and dysfunction, underscoring the Pareto framework's role as a key computational principle for understanding brain and cognition. -
Date:26רביעינובמבר 2025הרצאה
iSCAR Seminar
More information שעה 09:00 - 10:00כותרת Immune Regulation of Cardiac Regeneration and Repairמיקום בניין ע"ש מקס ולילאן קנדיוטי
Auditoriumמרצה Eldad Tzahor מארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:26רביעינובמבר 2025הרצאה
Machine Learning and Statistics Seminar
More information שעה 11:15 - 12:15כותרת Statistics-Powered ML: Reliable Black-Box Inference from Untrusted Dataמיקום בניין יעקב זיסקינד
Lecture Hall - Room 1 - אולם הרצאות חדר 1מרצה Yaniv Romano
Technionמארגן המחלקה למדעי המחשב ומתמטיקה שימושיתצרו קשר תקציר Show full text abstract about AI systems are increasingly shaping people’s lives, opportun...» AI systems are increasingly shaping people’s lives, opportunities, and scientific progress. But how can we trust the inferences of such complex, black-box systems? This question becomes even more urgent in the presence of two core challenges that are ubiquitous in high-stakes applications: data scarcity and test-time distribution shift. These issues not only limit the utility of AI systems but can also lead to misleading conclusions and unexpected failures.
In response to these challenges, this talk explores how fundamental statistical principles and modern ML can empower one another to enable trustworthy and practically useful inferences.
The first part focuses on reliable inference under limited data. I’ll introduce a framework that safely enhances the sample efficiency of any statistical inference procedure—such as conformal prediction and hypothesis testing—by adaptively leveraging synthetic data (e.g., from generative models). Crucially, this approach provides distribution-free error control guarantees without imposing any assumptions on the quality of the synthetic data. I'll demonstrate its broad applicability across diverse domains, from reliable protein structure prediction to principled win-rate evaluation of large reasoning models.
The second part enhances model robustness to drifting data. I'll introduce a new approach to test-time training, grounded in sequential statistical testing. Building on conformal betting martingales, I’ll first present a principled monitoring tool to detect data drifts. Using this tool, I’ll derive a rigorous ‘anti-drift correction’ mechanism grounded in (online) optimal transport principles. This mechanism forms the foundation of a self-training scheme that promotes invariance to dynamically changing environments. I'll outline the key ideas and expand on technical details, if time permits.
Bio
Yaniv Romano is an associate professor in the Departments of Electrical and Computer Engineering and Computer Science at the Technion. Previously, he was a postdoctoral scholar in the Department of Statistics at Stanford University. Yaniv holds a PhD, MSc, and BSc in Electrical Engineering, all from the Technion. His super-resolution technology, invented with Peyman Milanfar, has been integrated into Google’s flagship products, including the Pixel phone. His uncertainty quantification technique, developed with Emmanuel Candes, was employed by The Washington Post to estimate outstanding votes during the U.S. presidential election.
Yaniv has received several honors and awards, including the ERC Starting Grant, the SIAG/IS Early Career Prize, the Sheila Samson Prime Minister’s Prize (Researcher Recruitment Prize), the IEEE Signal Processing Society Best Paper Award, the Alon Scholarship, the Krill Prize for Excellence in Scientific Research, and the Henry Taub Prize for Academic Excellence. Yaniv is a member of the Young Israel Academy.
