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ספטמבר 01, 2016
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Date:21רביעידצמבר 2016הרצאה
Chemical Physics Department Guest Seminar
More information שעה 10:00 - 10:00כותרת Second-law-like constraints on higher energy moments in small open quantum systemsמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr Raam Uzdin
Hebrew University of Jerusalemמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about Quantum thermodynamics deals with thermodynamic effects and ...» Quantum thermodynamics deals with thermodynamic effects and thermodynamic constraints (e.g. the 2nd law) that emerge in out-of-equilibrium microscopic open quantum systems, and in microscopic heat machines. Presently, the technology developed for quantum computing is sufficient for exploring quantum thermodynamic experimentally (new experimental results will be shown). On top of the second law, thermodynamic resource theory predicts additional mathematical constraints on thermal transformation of microscopic systems. Unlike the second law, these constraints cannot be related to thermodynamic observables. Consequently, they are useful for some theoretical purposes, but not for making concrete predictions on realistic scenarios. In this talk I will present a new formalism that yields additional “seconds laws” that follow the logic and structure of the standard 2nd law. While the 2nd law deals with the first moment of the energy (average heat, average work), the observables in the new laws are higher moments of the energy. I will show several scenarios where these laws provide concrete answers to “blind spots” that are not addressed by the standard 2nd law. In other cases tighter bounds are obtained compared to the standard 2nd law. Potentially, this formalism can significantly extend the thermodynamic framework, and put additional practical bounds on thermal transformations and microscopic heat machines. Finally, I will discuss the connection to quantum coherence measures and list several research directions. -
Date:21רביעידצמבר 2016הרצאה
Adaptive Plasticity by Individual-Specific Improvisation
More information שעה 10:00 - 10:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Yoav Soen
Dept. of Biomolecular Sciencesצרו קשר -
Date:21רביעידצמבר 2016הרצאה
"Neuronal Gtf2i-dependent myelination deficits as a novel pathophysiological mechanism in Williams syndrome"
More information שעה 14:00 - 14:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Boaz Barak
Brain and Cognitive Sciences, McGovern Institute, MITמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Williams syndrome (WS) is a neurodevelopmental disorder caus...» Williams syndrome (WS) is a neurodevelopmental disorder caused by a heterozygous microdeletion of about 26 genes from chromosomal region 7q11.23, characterized by hypersociability and unique neurocognitive abnormalities. Of those deleted, general transcription factor II-i (Gtf2i), has been shown to affect hypersociability in WS, although the cell type and neural circuitry critical for the hypersociability are poorly understood. To dissect neural circuitry related to hypersociability in WS and to characterize the neuron-autonomous role of Gtf2i we conditionally knockedout Gtf2i in forebrain excitatory neurons and found this recapitulate WS features, including increased sociability and anxiety and neuroanatomical defects. Unexpectedly, we found that in the mutant mouse cortex 70% of the significantly downregulated genes were involved in myelination, together with a reduction in mature oligodendrocyte cells number, disrupted myelin ultrastructure and fine motor deficits. Analyzing the transcriptome in human frontal cortex, we found similar downregulation of myelination-related genes, suggesting a novel pathophysiological mechanism in WS, based on neuron-oligodendrocytes signaling deficits. Overall, our data detail the cellular processes that may lead to the WS typical phenotype and developmental abnormalities, and suggest new paths to explore and treat WS, as well as social and cognitive abnormalities.
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Date:22חמישידצמבר 2016הרצאה
The regulatory role of short structural variants and the implication to neurodegenerative diseases in aging
More information שעה 10:00 - 10:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Ornit Chiba-Falek
Department of Neurology Bryan Alzheimer's Disease Research Center and Center for Genomic and Computational Biology Duke University Medical Centerמארגן המחלקה לגנטיקה מולקולריתצרו קשר תקציר Show full text abstract about In the post genome-wide association studies (GWAS) era we ar...» In the post genome-wide association studies (GWAS) era we are shifting gears toward translation of genetic disease loci to molecular mechanisms of pathogenesis and pinpointing the causal genetic factors and their functional effects. It has been suggested that changes, even subtle, in the expression levels of wild-type genes in the brain can, over years, lead to neurodegenerative diseases. Moreover, differences in gene expression profiles between brain tissues from neurodegenerative disease patients compared to healthy controls have been reported. Short structural variants (SSVs) are short genomic variants ( -
Date:22חמישידצמבר 2016הרצאה
Molecular Neuroscience Forum Seminar
More information שעה 10:00 - 11:00כותרת The regulatory role of short structural variants and the implication to neurodegenerative diseases in agingמיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Ornit Chiba-Falek
Duke Universityמארגן המחלקה למדעים ביומולקולרייםדף בית צרו קשר -
Date:22חמישידצמבר 2016הרצאה
Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS
More information שעה 11:00 - 11:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Eran Hornstein
Department of Molecular Genetics, Weizmann Institute of Scienceמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:22חמישידצמבר 2016סימפוזיונים
Physics Colloquium
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Aharon kapitulnik
Ips plenaryמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about TBA ...» TBA -
Date:25ראשוןדצמבר 2016הרצאה
MCB Dept. Hanukah event farewell and greeting our new head dept.
More information שעה 10:00 - 10:30מיקום בניין וולפסון למחקר ביולוגימארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר -
Date:25ראשוןדצמבר 2016הרצאה
CORAL LANDSCAPES AT THE MICROSCALE
More information שעה 15:00 - 16:00מיקום בניין קמיליה בוטנארמרצה ORR SHAPIRO
Department of Food Quality & safety The Volcani Center, AROמארגן המחלקה לתשתיות מחקר מדעי החייםצרו קשר תקציר Show full text abstract about Coral Landscapes at the Microscale Orr Shapiro Reef build...» Coral Landscapes at the Microscale
Orr Shapiro
Reef building corals rely on a tightly regulated symbiosis between the coral animal, endocellular microalgae, and additional microbial components. The complex network of chemical and metabolic interactions is collectively known as a holobiont. Coral pathogens disrupt these interactions, leading to the breakdown of the symbiosis and death of the coral host. Over the past decades, under warming climate and increased anthropogenic pressure, coral disease outbreaks are becoming both more frequent and more widespread, raising concerns regarding the future of these important ecosystems. Elucidating the microscale processes underlying coral disease is inherently difficult due to the physical and biochemical complexity of the different microenvironments formed around and within the coral colony. In my talk I will present a number of microfluidic-based systems developed specifically to study corals, and coral-pathogen interactions, at the microscale, and the multiple new insights we have thus far gained from bringing this type of live-imaging approach into the study of reef building corals.
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Date:25ראשוןדצמבר 2016אירועי תרבות
קרקס מוסקבה - ניאון שואו
More information שעה 18:00 - 18:00מיקום אודיטוריום מיכאל סלעצרו קשר -
Date:26שנידצמבר 2016סימפוזיונים
Life Sciences Colloquium
More information שעה 11:00 - 12:00כותרת The importance of growing slowly: roles for redox-active “antibiotics” in microbial survival and developmentמיקום בניין קמיליה בוטנארמרצה Prof. Dianne K. Newman
Caltechצרו קשר -
Date:26שנידצמבר 2016סימפוזיונים
"Synthetic Single-Site Fe Nitrogenases: An Exciting Challenge in Catalyst Design"
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Jonas Peters
Caltechמארגן הפקולטה לכימיהצרו קשר -
Date:26שנידצמבר 2016הרצאה
Second-law-like constraints on higher energy moments in small open quantum systems
More information שעה 14:15 - 14:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Raam Uzdin
Technionמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about Quantum thermodynamics deals with thermodynamic effects and ...» Quantum thermodynamics deals with thermodynamic effects and thermodynamic constraints (e.g. the 2nd law) that emerge in out-of-equilibrium microscopic open quantum systems, and in microscopic heat machines. Presently, the technology developed for quantum computing is sufficient for exploring quantum thermodynamic experimentally (new experimental results will be shown). On top of the second law, thermodynamic resource theory predicts additional mathematical constraints on thermal transformation of microscopic systems. Unlike the second law, these constraints cannot be related to thermodynamic observables. Consequently, they are useful for some theoretical purposes, but not for making concrete predictions on realistic scenarios. In this talk I will present a new formalism that yields additional “seconds laws” that follow the logic and structure of the standard 2nd law. While the 2nd law deals with the first moment of the energy (average heat, average work), the observables in the new laws are higher moments of the energy. I will show several scenarios where these laws provide concrete answers to “blind spots” that are not addressed by the standard 2nd law. In other cases tighter bounds are obtained compared to the standard 2nd law. Potentially, this formalism can significantly extend the thermodynamic framework, and put additional practical bounds on thermal transformations and microscopic heat machines. Finally, I will discuss the connection to quantum coherence measures and list several research directions. -
Date:26שנידצמבר 2016הרצאה
Second-law-like constraints on higher energy moments in small open quantum systems
More information שעה 14:15 - 14:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Raam Uzdin
Technionמארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about Quantum thermodynamics deals with thermodynamic effects and ...» Quantum thermodynamics deals with thermodynamic effects and thermodynamic constraints (e.g. the 2nd law) that emerge in out-of-equilibrium microscopic open quantum systems, and in microscopic heat machines. Presently, the technology developed for quantum computing is sufficient for exploring quantum thermodynamic experimentally (new experimental results will be shown). On top of the second law, thermodynamic resource theory predicts additional mathematical constraints on thermal transformation of microscopic systems. Unlike the second law, these constraints cannot be related to thermodynamic observables. Consequently, they are useful for some theoretical purposes, but not for making concrete predictions on realistic scenarios. In this talk I will present a new formalism that yields additional “seconds laws” that follow the logic and structure of the standard 2nd law. While the 2nd law deals with the first moment of the energy (average heat, average work), the observables in the new laws are higher moments of the energy. I will show several scenarios where these laws provide concrete answers to “blind spots” that are not addressed by the standard 2nd law. In other cases tighter bounds are obtained compared to the standard 2nd law. Potentially, this formalism can significantly extend the thermodynamic framework, and put additional practical bounds on thermal transformations and microscopic heat machines. Finally, I will discuss the connection to quantum coherence measures and list several research directions. -
Date:27שלישידצמבר 2016הרצאה
Synthetic Ecology: Building Microbial Communities from the Bottom Up
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Dr. Jonathan Friedman
Physics of Living Systems, Department of Physics, MIT, Cambridge, USAמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:27שלישידצמבר 2016הרצאה
Stimulus-specific adaptation in auditory cortex: models, data, and surprises
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Eli Nelken
ELSC and the Dept of Neurobiology Silberman Institute of Life Sciences, Hebrew University, Jerusalemמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Stimulus specific adaptation (SSA) is the decrease in the re...» Stimulus specific adaptation (SSA) is the decrease in the responses to a repeated sound which generalizes only partially to other sounds. I discuss our recent attempts to study the mechanisms underlying SSA. First, using well-controlled broadband stimuli, we show that responses in IC and MGB roughly agree with a simple model of input adaptation leading to SSA, while in auditory cortex neurons adapt in a manner that more stimulus-specific. Second, I will show our attempts to study the spatial organization of SSA, as well as the finer property of deviance sensitivity, in mouse auditory cortex, as well as our preliminary data on the role of inhibitory interneurons in shaping cortical SSA. -
Date:27שלישידצמבר 2016הרצאה
Contact inhibition of locomotion drives the even spreading of ECM during Drosophila embryogenesis
More information שעה 14:00 - 14:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Brian Stramer
Randall Division of Cell & Molecular Biophysics, Kings College London, UKמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:27שלישידצמבר 2016הרצאה
" Visualizing the Molecular Sociology in Cells and Tissues: Cryo-FIB Preparations Aimed at in situ Cryo-Electron Tomography”
More information שעה 14:00 - 14:00מיקום בניין הלן ומילטון קימלמןמרצה Dr. Julia Mahamid
Department of Molecular Structural Biology Max Planck Institute of Biochemistry Germanyמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:27שלישידצמבר 2016הרצאה
Algebraic Geometry and Representation Theory Seminar
More information שעה 17:20 - 17:20כותרת TESTמרצה test
testמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:28רביעידצמבר 2016הרצאה
Molecular classification of cells in the mouse brain revealed by single-cell RNAseq
More information שעה 09:30 - 09:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Amit Zeisel
Molecular Neurobiology, MBB, Karolinska Institute, Swedenמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about The mammalian central nervous system is arguably the most co...» The mammalian central nervous system is arguably the most complex system studied in biology. Normal function of the brain relies on the assembly of a diverse set of cell-types, including most prominently neurons, but also glial cells and vasculature. We developed and applied large-scale single-cell RNA sequencing for unbiased molecular cell-type classification in various regions of the mouse brain. I will describe our initial work on the somatosensory cortex and hippocampus CA1, and later give examples about heterogeneity in the oligodendrocyte lineage across the CNS. These results and our ongoing efforts demonstrate how detailed information about cell-types in the brain may contribute to understand brain function.