Genomics, Sandbox Publications

  1. Barzilay Y., Eyal Z., Noy Y., Varsano N., Olender T., Bera S., Lerer-Goldshtein T., Kedmi M., Porat Z., Pinkas I., Levin-Zaidman S., Dezorella N. & Gur D. (2025). Specialized molecular pathways drive the formation of light-scattering assemblies in leucophores.  Proceedings of the National Academy of Sciences - PNAS. 2025 Jun 3 , 122 (22).
  2. Yilmaz A., Gurhan G., Comar M. Y., Viukov S., Serfaty I., Gayretli M., Golenchenko S., Lokshtanov D., Ashouokhi S., Polanco A., Berlad I., Ha T. W., Aguilera-Castrejon A., Tarazi S., Cohen M., Livnat N., Kumar K., Cholakkal H., Levy N., Yosef N., Khatib N., Kakun R. R., Kedmi M., Nachman I. B., Keren-Shaul H., Addadi Y., Orenbuch A. H., Korovin K., Molchadsky A., Hochedlinger K., Gafni O., Maza I., Novershtern N., Oldak B. & Hanna J. H. (2025). Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs.  Cell Stem Cell. 2025 Aug 7 , 32 (10):1545-1562.e12.
  3. Furer N., Rappoport N., Milman O., Tavor S., Lifshitz A., Bercovich A., Ben-Kiki O., Danin A., Kedmi M., Shipony Z., Lipson D., Meiri E., Yanai G., Shapira S., Arber N., Berdichevsky S., Tyner J., Joshi S., Landau D., Ganesan S., Dusaj N., Chamely P., Kaushansky N., Chapal-Ilani N., Shamir R., Tanay A. & Shlush L. (2025). A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics.  Nature Medicine. 2025 Jun 27 , 31 (7):2442-2451.
  4. Greenwald A. C., Darnell N. G., Hoefflin R., Simkin D., Mount C. W., Gonzalez Castro L. N., Harnik Y., Dumont S., Hirsch D., Nomura M., Talpir T., Kedmi M., Goliand I., Medici G., Laffy J., Li B., Mangena V., Keren-Shaul H., Weller M., Addadi Y., Neidert M. C., Suvà M. L. & Tirosh I. (2024). Integrative spatial analysis reveals a multi-layered organization of glioblastoma.  Cell. 2024 May 9 , 187 (10):2485-2501.e26.
  5. Liu J., Stoler-Barak L., Hezroni-Bravyi H., Biram A., Lebon S., Davidzohn N., Kedmi M., Chemla M., Pilzer D., Cohen M., Brenner O., Biton M. & Shulman Z. (2024). Turbinate-homing IgA-secreting cells originate in the nasal lymphoid tissues.  Nature. 2024 Jul 31 , 632 (8025):637-646.
  6. Harnik Y., Yakubovsky O., Hoefflin R., Novoselsky R., Bahar Halpern K., Barkai T., Korem Kohanim Y., Egozi A., Golani O., Addadi Y., Kedmi M., Keidar Haran T., Levin Y., Savidor A., Keren-Shaul H., Mayer C., Pencovich N., Pery R., Shouval D. S., Tirosh I., Nachmany I. & Itzkovitz S. (2024). A spatial expression atlas of the adult human proximal small intestine.  Nature. 2024 Aug 29 , 632 (8027):1101-1109.
  7. Nevo S., Frenkel N., Kadouri N., Gome T., Rosenthal N., Givony T., Avin A., Peligero Cruz C., Kedmi M., Lindzen M., Ben Dor S., Damari G., Porat Z., Haffner-Krausz R., Keren-Shaul H., Yarden Y., Munitz A., Leshkowitz D., Goldfarb Y. & Abramson J. (2024). Tuft cells and fibroblasts promote thymus regeneration through ILC2-mediated type 2 immune response.  Science Immunology. 2024 Jan , 9 (91).
  8. Givony T., Leshkowitz D., Del Castillo D., Nevo S., Kadouri N., Dassa B., Gruper Y., Khalaila R., Ben-Nun O., Gome T., Dobeš J., Ben-Dor S., Kedmi M., Keren-Shaul H., Heffner-Krausz R., Porat Z., Golani O., Addadi Y., Brenner O., Lo D. D., Goldfarb Y. & Abramson J. (2023). Thymic mimetic cells function beyond self-tolerance.  Nature. 2023 Oct 5 , 622 (7981):164172.
  9. Oldak B., Wildschutz E., Bondarenko V., Comar M., Zhao C., Aguilera-Castrejon A., Tarazi S., Viukov S., Pham T. X. A., Ashouokhi S., Lokshtanov D., Roncato F., Ariel E., Rose M., Livnat N., Shani T., Joubran C., Cohen R., Addadi Y., Chemla M., Kedmi M., Keren-Shaul H., Pasque V., Petropoulos S., Lanner F., Novershtern N. & Hanna J. H. (2023). Complete human day 14 post-implantation embryo models from naive ES cells.  Nature. 2023 Oct 19 , 622 (7983):562-573.
  10. Kragesteen B. K., Giladi A., David E., Halevi S., Geirsdóttir L., Lempke O. M., Li B., Bapst A. M., Xie K., Katzenelenbogen Y., Dahl S. L., Sheban F., Gurevich-Shapiro A., Zada M., Phan T. S., Avellino R., Wang S., Barboy O., Shlomi-Loubaton S., Winning S., Markwerth P. P., Dekalo S., Keren-Shaul H., Kedmi M., Sikora M., Fandrey J., Korneliussen T. S., Prchal J. T., Rosenzweig B., Yutkin V., Racimo F., Willerslev E., Gur C., Wenger R. H. & Amit I. (2023). The transcriptional and regulatory identity of erythropoietin producing cells.  Nature Medicine. 2023 May , 29 :1191-1200.
  11. Leshkowitz D., Kedmi M., Fried Y., Pilzer D., Keren-Shaul H., Ainbinder E. & Dassa B. (2022). Exploring differential exon usage via short- and long-read RNA sequencing strategies.  Open Biology. 2022 Sept 28 , 12 (9).
  12. Lopez R., Li B., Keren-Shaul H., Boyeau P., Kedmi M., Pilzer D., Jelinski A., Yofe I., David E., Wagner A., Ergen C., Addadi Y., Golani O., Ronchese F., Jordan M. I., Amit I. & Yosef N. (2022). DestVI identifies continuums of cell types in spatial transcriptomics data.  Nature biotechnology. 2022 Sept , 40 (9):1360-1369.
  13. Tarazi S., Aguilera Castrejon A., Joubran C., Ghanem N., Ashouokhi S., Roncato F., Wildschutz E., Haddad M., Oldak B., Gomez-Cesar E., Livnat N., Viukov S., Lukshtanov D., Naveh Tassa S., Rose M., Issaq - Hanna S., Raanan C., Brenner O. J., Kedmi M., Keren-Shaul H., Lapidot T., Maza I., Novershtern N. & Hanna J. (. (2022). Post-Gastrulation Synthetic Embryos Generated Ex Utero from Mouse Naïve ESCs.  Cell. 2022 Sept 1 , 185 (18):3290-3306.e25.
  14. Kedmi M., Sas-Chen A. & Yarden Y. (2015). MicroRNAs and growth factors: An alliance propelling tumor progression.  Journal of Clinical Medicine. 2015 Aug 13 , 4 (8):1578-1599.
  15. Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Lapidot T., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. (2015). Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.  Science Signaling. 2015 Jan 20 , 8 (360).
  16. Cohen-Dvashi H., Ben Chetrit C. N., Russell R., Carvalho S., Lauriola M., Nisani S., Mancini M., Nataraj N., Kedmi M., Roth L., Koestler W., Zeisel A., Yitzhaky A., Zylberg J., Tarcic G., Eilam R., Wigelman Y., Will R., Lavi S., Porat Z., Wiemann S., Ricardo S., Schmitt F., Caldas C. & Yarden Y. (2015). Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression.  EMBO Molecular Medicine. 2015 Mar 1 , 7 (3):299-314.
  17. Kedmi M., Ben Chetrit C. N., Koerner C., Mancini M., Ben-Moshe N. B., Lauriola M., Lavi S., Biagioni F., Carvalho S., Cohen-Dvashi H., Schmitt F., Wiemann S., Blandino G. & Yarden Y. (2015). EGF induces microRNAs that target suppressors of cell migration: MiR-15b targets MTSS1 in breast cancer.  Science Signaling. 2015 Mar 17 , 8 (368):ra29.
  18. Lauriola M., Enuka Y., Zeisel A., D'Uva G., Roth L., Sharon-Sevilla M., Lindzen M., Sharma K., Nevo N., Carvalho S., Cohen-Dvashi H., Kedmi M., Ben Chetrit C. N., Chen A., Solmi R., Wiemann S., Schmitt F., Domany E. & Yarden Y. (2014). Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment.  Nature Communications. 2014, 5 .
  19. Blandino G., Fazi F., Donzelli S., Kedmi M., Sas-Chen A., Muti P., Strano S. & Yarden Y. (2014). Tumor suppressor microRNAs: A novel non-coding alliance against cancer.  FEBS Letters. 2014 Aug 19 , 588 (16):2639-2652.
  20. Ben-Moshe N. B., Avraham R., Kedmi M., Zeisel A., Yitzhaky A., Yarden Y. & Domany E. (2012). Context-specific microRNA analysis: Identification of functional microRNAs and their mRNA targets.  Nucleic Acids Research. 2012 Nov , 40 (21):10614-10627.