Protein Expression Publications

  1. Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (2024). LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea.  Nature Communications. 2024 Aug 8 , 15 .
  2. Lal M., Kesselman E., Wachtel E., Kleinerman O., Peleg Y., Albeck S., Majhi K., Sheves M. & Patchornik G. (2024). His-tag based supramolecular biopolymerization.  Scientific Reports. 2024 Nov 16 , 14 .
  3. Peri L., Matzov D., Huxley D. R., Rainish A., Fierro F., Sapir L., Pfeiffer T., Waterloo L., Hübner H., Peleg Y., Gmeiner P., McCormick P. J., Weikert D., Niv M. Y. & Shalev-Benami M. (2024). A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR.  Nature Communications. 2024 Nov 18 , 15 .
  4. Sen S., Bhowmik P., Tiwari S., Peleg Y. & Bandyopadhyay B. (2024). Versatility of reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) from diagnosis of early pathological infection to mutation detection in organisms.  Molecular Biology Reports. 2024 Jan 25 , 51 (1).
  5. Quinn S., Zhang N., Fenton T. A., Brusel M., Muruganandam P., Peleg Y., Giladi M., Haitin Y., Lerche H., Bassan H., Liu Y., Ben-Shalom R. & Rubinstein M. (2024). Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy.  Biochimica et Biophysica Acta - Molecular Basis of Disease. 2024 Jun , 1870 (5).
  6. Halfin O., Avram L., Albeck S., Unger T., Motiei L. & Margulies D. (2024). Unnatural enzyme activation by a metal-responsive regulatory protein.  Chemical Science. 2024 Aug 5 , 15 (35):14209-14217.
  7. Osher E., Anis Y., Singer-Shapiro R., Urshanski N., Unger T., Albeck S., Bogin O., Weisinger G., Kohen F., Valevski A., Fattal-Valevski A., Sagi L., Weitman M., Shenberger Y., Sagiv N., Navon R., Wilchek M. & Stern N. (2024). Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein.  Molecular Therapy Methods and Clinical Development. 2024 Sept 12 , 32 (3).
  8. Berman P., de Haro L. A., Cavaco A. R., Panda S., Dong Y., Kuzmich N., Lichtenstein G., Peleg Y., Harat H., Jozwiak A., Cai J., Heinig U., Meir S., Rogachev I. & Aharoni A. (2024). The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction.  Molecular Plant. 2024 Jun 3 , 17 (7):1129-1150.
  9. Pokorna S., Khersonsky O., Lipsh-Sokolik R., Goldenzweig A., Nielsen R., Ashani Y., Peleg Y., Unger T., Albeck S., Dym O., Tirosh A., Tarayra R., Hocquemiller M., Laufer R., Ben-Dor S., Silman I., Sussman J. L., Fleishman S. J. & Futerman A. H. (2023). Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.  FEBS Journal. 2023 Jul , 290 (13):3383-3399.
  10. Dym O., Aggarwal N., Ashani Y., Leader H., Albeck S., Unger T., Hamer-Rogotner S., Silman I., Tawfik D. S. & Sussman J. L. (2023). The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.  Acta Crystallographica Section D: Structural Biology. 2023 Nov , 79 (Pt 11):992-1009.
  11. Schütz A., Bernhard F., Berrow N., Buyel J. F., Ferreira-da-Silva F., Haustraete J., van den Heuvel J., Hoffmann J. E., de Marco A., Peleg Y., Suppmann S., Unger T., Vanhoucke M., Witt S. & Remans K. (2023). A concise guide to choosing suitable gene expression systems for recombinant protein production.  STAR Protocols. 2023 Dec 15 , 4 (4).
  12. Schütz A., Bernhard F., Berrow N., Buyel J. F., Ferreira-da-Silva F., Haustraete J., van den Heuvel J., Hoffmann J. E., de Marco A., Peleg Y., Suppmann S., Unger T., Vanhoucke M., Witt S. & Remans K. (2023). A concise guide to choosing suitable gene expression systems for recombinant protein production.  STAR Protocols. 2023 Dec 15 , 4 (4).
  13. Oranges M., Giannoulis A., Vanyushkina A., Sirkis Y. F., Dalaloyan A., Unger T., Su X. C., Sharon M. & Goldfarb D. (2023). C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains.  Biophysical Journal. 2023 Dec 10 , .
  14. Khersonsky O., Goldsmith M., Zaretsky I., Hamer-Rogotner S., Dym O., Unger T., Yona M., Fridmann-Sirkis Y. & Fleishman S. J. (2023). Stable Mammalian Serum Albumins Designed for Bacterial Expression.  Journal of Molecular Biology. 2023 Sept 1 , 435 (17).
  15. Khersonsky O., Goldsmith M., Zaretsky I., Hamer-Rogotner S., Dym O., Unger T., Yona M., Fridmann-Sirkis Y. & Fleishman S. J. (2023). Stable Mammalian Serum Albumins Designed for Bacterial Expression.  Journal of Molecular Biology. 2023 Sept 1 , 435 (17).
  16. Franz F., Tapia-Rojo R., Winograd-Katz S., Boujemaa-Paterski R., Li W., Unger T., Albeck S., Aponte-Santamaria C., Garcia-Manyes S., Medalia O., Geiger B. & Gräter F. (2023). Allosteric activation of vinculin by talin.  Nature Communications. 2023 Jul 18 , 14 (1).
  17. Pokorna S., Khersonsky O., Lipsh-Sokolik R., Goldenzweig A., Nielsen R., Ashani Y., Peleg Y., Unger T., Albeck S., Dym O., Tirosh A., Tarayra R., Hocquemiller M., Laufer R., Ben-Dor S., Silman I., Sussman J. L., Fleishman S. J. & Futerman A. H. (2023). Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.  FEBS Journal. 2023 Jul , 290 (13):3383-3399.
  18. Gould N. L., Scherer G. R., Carvalho S., Shurrush K., Kayyal H., Edry E., Elkobi A., David O., Foqara M., Thakar D., Pavesi T., Sharma V., Walker M., Maitland M., Dym O., Albeck S., Peleg Y., Germain N., Babaev I., Sharir H., Lalzar M., Shklyar B., Hazut N., Khamaisy M., Lévesque M., Lajoie G., Avoli M., Amitai G., Lefker B., Subramanyam C., Shilton B., Barr H. & Rosenblum K. (2023). Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimers disease phenotype in mice.  Journal of Clinical Investigation. 2023 Oct 2 , 133 (19).
  19. Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (2022). Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea.  The journal of Biological chemistry. 2022 May 1 , 298 (5).
  20. Yifrach E., HolbrookSmith D., Bürgi J., Othman A., Eisenstein M., Roermund C. W., Visser W., Tirosh A., Rudowitz M., Bibi C., Galor S., Weill U., Fadel A., Peleg Y., Erdmann R., Waterham H. R., Wanders R. J. A., Wilmanns M., Zamboni N., Schuldiner M. & Zalckvar E. (2022). Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions.  Molecular Systems Biology. 2022 Sept , 18 (9).