Protein Analysis Publications

  1. Gonen A., Harats D., Rabinkov A., Miron T., Mirelman D., Wilchek M., Weiner L., Ulman E., Levkovitz H., Ben-Shushan D. & Shaish A. (2005). The antiatherogenic effect of allicin: Possible mode of action.  Pathobiology. 2005, 72 (6):325-334.
  2. Oron-Herman M., Rosenthal T., Mirelman D., Miron T., Rabinkov A., Wilchek M. & Sela B. (2005). The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome.  Atherosclerosis. 2005 Dec , 183 (2):238-243.
  3. Arditti F., Rabinkov A., Miron T., Reisner Y., Berrebi A., Wilchek M. & Mirelman D. (2005). Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate.  Molecular Cancer Therapeutics. 2005 Feb 15 , 4 (2):325-331.
  4. Shadkchan Y., Shemesh E., Mirelman D., Miron T., Rabinkov A., Wilchek M. & Osherov N. (2004). Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis.  Journal of Antimicrobial Chemotherapy. 2004 May , 53 (5):832-836.
  5. Miron T., Bercovici T., Rabinkov A., Wilchek M. & Mirelman D. (2004). [H-3]Allicin: preparation and applications.  Analytical Biochemistry. 2004 Aug , 331 (2):364-369.
  6. Patya M., Zahalka M., Vanichkin A., Rabinkov A., Miron T., Mirelman D., Wilchek M., Lander H. & Novogrodsky A. (2004). Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21(ras).  International Immunology. 2004 Feb , 16 (2):275-281.
  7. Sela U., Ganor S., Hecht I., Brill A., Miron T., Rabinkov A., Wilchek M., Mirelman D., Lider O. & Hershkoviz R. (2004). Allicin inhibits SDF-1 alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression.  Immunology. 2004 Apr , 111 (4):391-399.
  8. Miron T., Rabinkov A., Peleg E., Rosenthal T., Mirelman D. & Wilchek M. (2004). Allylmercaptocaptopril: A new antihypertensive drug.  American Journal of Hypertension. 2004 Jan , 17 (1):71-73.
  9. Miron T., Mironchik M., Mirelman D., Wilchek M. & Rabinkov A. (2003). Inhibition of tumor growth by a novel approach: In situ allicin generation using targeted alliinase delivery.  Molecular Cancer Therapeutics. 2003 Dec , 2 (12):1295-1301.
  10. Elkayam A., Mirelman D., Peleg E., Wilchek M., Miron T., Rabinkov A., Oron-Herman M. & Rosenthal T. (2003). The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats.  American Journal of Hypertension. 2003 Dec , 16 (12):1053-1056.
  11. Miron T., Rabinkov A., Peleg E., Rosenthal T., Mirelman D. & Wilchek M. (2003). Allylmercapto-captopril, a new antihypertensive drug, its preparation and properties.  American Journal of Hypertension. 2003 May , 16 (5):128A-128A.
  12. Millard C., Shnyrov V., Newstead S., Shin I., Roth E., Silman I. & Weiner L. (2003). Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.  Protein Science. 2003 Oct , 12 (10):2337-2347.
  13. Shimon L., Rabinkov A., Miron T., Mirelman D., Wilchek M. & Frolow F. (2002). Alliin lyase (alliinase) from garlic (Allium sativum): crystallization and preliminary X-ray characterization.  Acta Crystallographica Section D-Biological Crystallography. 2002 Aug , 58 :1335-1337.
  14. Shin I., Wachtel E., Roth E., Bon C., Silman I. & Weiner L. (2002). Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?.  Protein Science. 2002, 11 (8):2022-2032.
  15. Miron T., Shin I., Feigenblat G., Weiner L., Mirelman D., Wilchek M. & Rabinkov A. (2002). A spectrophotometric assay for allicin, alliin, and aliinase (alliin lyase) with a chromogenic thiol: reaction of 4-mercaptopyridine with thiosulfinates.  Analytical Biochemistry. 2002 Aug , 307 (1):76-83.
  16. Miron T., Shin I., Feigenblat G., Weiner L., Mirelman D., Wilchek M. & Rabinkov A. (2002). A spectrophotometric assay for allicin, alliin, and aliinase (alliin lyase) with a chromogenic thiol: reaction of 4-mercaptopyridine with thiosulfinates.  Analytical Biochemistry. 2002 Aug , 307 (1):76-83.
  17. De Ferrari F. G., Canales M., Shin I., Weiner L., Silman I. & Inestrosa N. (2001). A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation.  Biochemistry. 2001 Sept , 40 (35):10447-10457.
  18. Elkayam A., Mirelman D., Peleg E., Wilchek M., Miron T., Rabinkov A., Sadetzki S. & Rosenthal T. (2001). The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats.  American Journal of Hypertension. 2001 Apr , 14 (4):377-381.
  19. Tchernychev B., Rabinkov A., Miron T. & Wilchek M. (2000). Natural antibodies against alliinase in human serum and polyclonal antibodies elicited in rabbit share the same immunogenic determinants.  Immunology Letters. 2000 Jan , 71 (1):43-47.
  20. Miron T., Rabinkov A., Mirelman D., Wilchek M. & Weiner L. (2000). The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity.  Biochimica Et Biophysica Acta-Biomembranes. 2000 Jan , 1463 (1):20-30.