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January 01, 2015
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Date:06TuesdayJuly 2021Lecture
Halite deposition in the Dead Sea: Direct observations and lessons for thick halite sequences in the geological record
More information Time 10:00 - 11:00Location https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09Lecturer Ido Sirota
Institute of Earth Sciences The Hebrew University of JerusalemOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Layered halite sequences were deposited in deep hypersaline ...» Layered halite sequences were deposited in deep hypersaline basins throughout the geological record. These sequences are of research interest for hydrocarbon extraction, mineral exploration, tectonics and structural geology and paleoclimate research. Modern analogs and the processes leading to deposition of thick halite sequences were studied only through analyses of the common modern, shallow environments, which are fundamentally different in their nature from halite-depositing, deep waterbodies. Thus, the spatiotemporal evolution of halite sequences remained ambiguous. I will present, first, a study of the active precipitation of halite layers from the only modern analog in the world for deep, halite-precipitating basin; the hypersaline Dead Sea. Then the implications of these results to the geological record will be emphasized. Novel in situ observations in the Dead Sea link seasonal hydroclimatic conditions, thermohaline stratification, halite saturation, and the characteristics of the actively forming halite layers. The main findings of this study are: (a) Halite deposition dynamics is directly related to the development of the thermohaline stratification and it is primarily temperature controlled; it is counter-intuitive to the common approach that focus on the role of the hydrological budget in the study of hypersaline environments. (b) A pronounced depth dependency of the degree of halite saturation and halite deposition. (c) A well-defined seasonality of halite deposition on the deep lakefloor. (d) Preferential halite accumulation at the deep, hypolimnetic lake floor (>25m depth) due to intensive halite dissolution at the shallow epilimnetic lakefloor, and its re-deposition at depth, in a process termed “halite focusing”. (e) Halite accumulates at high rates in the deep lakefloor, doubling (or even more) the expected thickness without halite focusing. (f) Freshwater inflows further amplify halite thickness at the drier parts of the lake. These findings provide insights and quantify the processes required for reconstructing past hypersaline environments from halite sequences, in the Dead Sea and worldwide. -
Date:06TuesdayJuly 2021Lecture
Intermolecular Interactions: Surfaces, Molecules and Molecular Solids
More information Time 11:00 - 12:00Title HYBRID departmental seminarLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Dr. A. Daniel Boese
University of Graz, Graz, AustriaOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:06TuesdayJuly 2021Lecture
Conservation of TIR immune signaling in bacteria and plants
More information Time 11:30 - 12:30Title Guest Seminar via ZoomLocation https://weizmann.zoom.us/j/94920680518?pwd=MDhOVUZsQWRaMGZSYndIME5lZGtRdz09 Password 151190Lecturer Gal Ofir
Prof. Rotem Sorek's Lab., Department of Molecular Genetics, WISOrganizer Department of Plant and Environmental SciencesContact -
Date:07WednesdayJuly 2021Lecture
SAERI - Sustainability and Energy Research Initiative seminar series
More information Time 13:00 - 14:00Location via zoomLecturer Prof. Alice Larkin
Head of the School of Engineering and a researcher in the Tyndall Centre for Climate Change Research, University of Manchester, UKOrganizer Weizmann School of ScienceContact -
Date:08ThursdayJuly 2021Lecture
Love the neighbor – Unraveling the tumor microenvironment using multiplexed imaging
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Dr. Leeat Keren
Department of Molecular Cell Biology, Weizmann Institute of ScienceOrganizer Dwek Institute for Cancer Therapy ResearchContact -
Date:12MondayJuly 2021Lecture
Special Guest Seminar
More information Time 11:00 - 12:00Title The ribosome supracomplex: a new therapeutic target in viral infection and neurodegenerationLocation Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Ranen Aviner
Stanford UniversityOrganizer Department of Biomolecular SciencesContact -
Date:12MondayJuly 2021Lecture
Special Guest Seminar
More information Time 15:00 - 16:30Title Beyond Darwin: understanding cancer persister cellsLecturer Dr. Yaara Oren Contact -
Date:19MondayJuly 2021Colloquia
Developing first-principles methods to study force- and stress-enabled mechanochemistry
More information Time 11:00 - 12:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Andrew M. Rappe
University of PennsylvaniaOrganizer Faculty of ChemistryContact Abstract Show full text abstract about A wide variety of chemical transformations can be induced by...» A wide variety of chemical transformations can be induced by the application of force or stress to reactive systems. In some cases, these reactions are undesired, including some tribochemical (friction-induced) reactions and bond-breaking in polymers under stress. A large and growing set of examples shows that mechanochemistry can be harnessed for useful chemical transformations, making the case for mechanochemistry as a general-purpose tool to advance chemical innovation. In order to realize this vision, we require greater understanding of how force and stress can be focused on particular bonds and reaction coordinates, and how this enhances chemical reactivity and selectivity. In this talk, I will outline strategies for applying stress to quantum-mechanical models of reactive chemical systems and for understanding the resulting mechanochemical reaction pathways. I will also describe the development of interatomic potential models that can enable larger-scale models of mechanochemical and piezoelectric effects in molecules, 2D materials, and polar solids. -
Date:20TuesdayJuly 2021Lecture
Defense metabolites: from eco systems to growth
More information Time 10:00 - 11:00Title Guest Seminar via ZoomLocation https://weizmann.zoom.us/j/94920680518?pwd=MDhOVUZsQWRaMGZSYndIME5lZGtRdz09 Password 151190Lecturer Ella Katz
Lab of Prof. Dan Kliebenstein, Department of Plant Sciences, UC Davis, USAOrganizer Department of Plant and Environmental SciencesContact -
Date:20TuesdayJuly 2021Lecture
Special guest seminar with Dr. Inna Ricardo-Lax
More information Time 12:00 - 13:00Title Efficient replication and single cycle delivery of SARS-CoV2 repliconsLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Inna Ricardo-Lax Organizer Department of Molecular GeneticsContact -
Date:22ThursdayJuly 2021Lecture
Imm Guest Seminar: Dr. Yael David will lecture on " Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools."
More information Time 11:00 - 12:00Location Wolfson Building for Biological ResearchLecturer Dr. Yael David
Assistant Member Chemical Biology Program Memorial Sloan Kettering Cancer Center New York, NYOrganizer Department of Systems ImmunologyContact -
Date:23FridayJuly 2021Cultural Events
Nathan's friends
More information Time 20:00 - 22:45Title Israeli festive summerLocation Michael Sela AuditoriumContact -
Date:25SundayJuly 2021Lecture
A few lessons that nanoparticles can teach us about non-equilibrium properties of crystallization
More information Time 10:00 - 11:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Assaf Ben Moshe, Ana Naamat
Dept Molecular Chemistry and Materials Science, WISOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about The fact that many crystals are not in equilibrium is quite ...» The fact that many crystals are not in equilibrium is quite obvious and not very surprising. Yet, this often complicates our attempts to understand some of their most fundamental properties, such as for instance, their overall morphology. To further add to this complexity, non-equilibrium properties are nowadays studied in crystals made out of building blocks that consume energy and actively propel (i.e., active matter).
Despite some complications that exist when trying to make analogies between the behavior of bulk crystals and their nanoscale analogs, the latter offer many advantages when studying kinetic aspects of crystal formation, in both “conventional” as well as “active” crystals. In my talk I will present two different cases where nanocrystals are used in order to shed light on some of these aspects. The first story dates all the way back to the 19th century and the seminal work by Louis Pasteur on crystals that exhibit chiral macroscopic shapes when made out of chiral building blocks. Using a model system of tellurium nanocrystals, I was able to show that the reason for chiral shape formation in crystals composed of chiral building blocks might not always be as trivial as expected. In the second part of the talk, I will present the first steps I took on an ongoing journey to understand the diffusion of extremely small (sub 10 nm) chemically propelled nanocrystals. This is meant to pave the way to ultimately use them as building blocks for non-equilibrium active crystalline matter.
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Date:26MondayJuly 2021Lecture
Our Changing Atmosphere: Carbon, Consequences, and Capture
More information Time 18:00 - 19:00Title SAERI - Sustainability and Energy Research Initiative seminar seriesLocation via zoomLecturer Prof. Jeffrey A. Reimer
Department of Chemical and Biomolecular Engineering University of California Berkeley, California, USAOrganizer Weizmann School of ScienceContact -
Date:27TuesdayJuly 2021Lecture
"IDP-membrane interactions in neurodegeneration and neuronal function”
More information Time 14:00 - 15:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. David Eliezer
Weill Cornell Medicine Graduate School of Medical Sciences, NY, USAOrganizer Department of Chemical and Structural BiologyContact -
Date:04WednesdayAugust 2021Lecture
Principles of functional circuit connectivity: Insights from the zebrafish optic tectum
More information Time 10:30 - 10:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. German Sumbre
École Normale Supérieure, FranceOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Spontaneous neuronal activity in sensory brain regions is sp...» Spontaneous neuronal activity in sensory brain regions is spatiotemporally structured, suggesting that this ongoing activity may have a functional role. Nevertheless, the neuronal interactions underlying these spontaneous activity patterns, and their biological relevance, remain elusive. We addressed these questions using two-photon and light-sheet Ca2+ imaging of intact zebrafish larvae to monitor the fine structure of the spontaneous activity in the zebrafish optic tectum (the fish's main visual center. We observed that the spontaneous activity was organized in topographically compact assemblies, grouping functionally similar neurons rather than merely neighboring ones, reflecting the tectal retinotopic map. Assemblies represent all-or-none-like sub-networks shaped by competitive dynamics, mechanisms advantageous for visual detection in noisy natural environments. Furthermore, the spontaneous activity structure also emerged in “naive” tecta (tecta of enucleated larvae before the retina connected to the tectum). We thus suggest that the formation of the tectal network circuitry is genetically prone for its functional role. This capability is an advantageous developmental strategy for the prompt execution of vital behaviors, such as escaping predators or catching prey, without requiring prior visual experience.
Mutant zebrafish larvae for the mecp2 gene display an abnormal spontaneous tectal activity, thus representing an ideal control to shed light on the biological relevance of the tectal functional connectivity. We found that the tectal assemblies limit the span of the visual responses, probably improving visual spatial resolution.
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Date:05ThursdayAugust 2021Lecture
A tale of four tales and more
More information Time 14:00 - 15:00Lecturer Prof. Eytan Ruppin
Chief, Cancer Data Science Lab, NCI, NIHOrganizer Dwek Institute for Cancer Therapy ResearchContact -
Date:16MondayAugust 2021Lecture
Special seminar with Dr. Yaara Oren
More information Time 15:00 - 16:00Title Beyond Darwin: understanding cancer persister cellsLecturer Dr. Yaara Oren
The Broad Institute and Harvard Medical SchoolOrganizer Department of Molecular GeneticsContact Abstract Show full text abstract about Despite favorable initial response to therapy, a third of ca...» Despite favorable initial response to therapy, a third of cancer patients will develop recurrent disease and succumb to it within five years of diagnosis. While there has been much progress in characterizing the pathways that contribute to stable genetic drug resistance, the mechanisms underlying early reversible resistance, also known as persisters-driven resistance, remain largely unknown. It has long been believed that persisters represent a subset of cells that happen to be non-proliferating at the time of treatment, and therefore can survive drugs that preferentially kill rapidly proliferating cells. However, in my talk I will describe a rare persister population which, despite not harboring any resistance-conferring mutation, can maintain proliferative capacity in the presence of drug. To study this rare, transiently-resistant, cycling persister population, we developed Watermelon, a high-complexity expressed barcode lentiviral library for simultaneous tracing of each cell’s clonal origin and proliferative and transcriptional states. We combine single cell transcriptomics with imaging and metabolomics to show that cycling and non-cycling persisters arise from different cell lineages with distinct transcriptional and metabolic programs. Finally, I will describe how by studying persister cells we can gain critical insights on cellular memory, fate, and evolution, which can guide the development of better anti-cancer treatments. -
Date:02ThursdaySeptember 2021Conference
The Israeli Society for Developmental Biology %u2013IsSDB meeting ECM, cytoskeleton and migration
More information Time 08:00 - 08:00Chairperson Oren Schuldiner -
Date:12SundaySeptember 2021Academic Events
Scientific Council meeting
More information Time 14:00 - 16:00Location The David Lopatie Conference CentreContact
