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Affymetrix Human Transcriptome Array 2.0, New Transcriptome Analysis Software (TAC) and Comparisons to RNA-Seq!
Research has shown that the tens of thousands of human genes contain hundreds of thousands of exons, which produce hundreds of thousands of different transcript isoforms. Until now, measuring and analyzing these transcript isoforms has been nearly impossible due to technology limitations, sample input requirements, and lack of analysis capabilities/tools.
Designed to empower next-generation expression profiling studies, GeneChip Human Transcriptome Array 2.0 (HTA 2.0) provides the ability to go beyond gene-level expression profiling by providing the coverage and accuracy required to accurately detect all known transcript isoforms produced by a gene.
This high-resolution array design contains >6.0 million probes covering coding transcripts and non-coding transcripts. 70% of the probes on this array cover exons for coding transcripts, and the remaining 30% of probes on the array cover exon-exon splice junctions and non-coding transcripts.
The free TAC software is designed and intended for investigators allowing quick and easy visualization and detection of the transcriptome.
In this talk I will try to illustrate how most researchers who run RNA-Seq do not sequence deep enough and are missing important changes which are easily accessible on microarrays.

Amos Grundwag
Manager, Genomics and BioInformatics.
Biotechnology Department.
Eisenberg Bros. Ltd.
Tel: +972 (0)3 9777037
Mobile: +972 (0)528 910960

What is an optimal particle shape for scattering, e.g., shape causing minimal extinction among those of equal volume and randomly oriented? Guided by the isoperimetric property of a sphere, relevant in the geometrical optics limit of scattering by large particles, we examine an analogous question in the low frequency (induced dipole moment) approximation, seeking to disentangle electric and geometric contributions. To that end, a simple proof is supplied of spherical optimality for a coated ellipsoidal particle and a monotonic increase with asphericity is shown in the low frequency regime for orientation-averaged induced dipole moments and scattering cross-sections. Physical insight is obtained from the Rayleigh-Gans (transparent) limit and eccentricity expansions. We propose linking low and high frequency regime in a single sweeping minimum principle valid for all size parameters, provided that reasonable size distributions wash out the Mie resonances. This proposal is further supported by the sum rule for integrated extinction. Implications for environmental remote sensing are discussed throughout the talk.

Spin based properties, applications, and devices are commonly related to magnetic effects and to magnetic materials. However, we established that chiral organic molecules can act as spin filters for photoelectrons transmission, in electron transfer, and in electron transport. The new effect, termed Chiral Induced Spin Selectivity (CISS), has interesting implications for the production of new types of spintronics devices and on electron transfer in biological systems.
The basic effect, and its applications and implications, will be presented.