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פברואר 01, 2019
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Date:31ראשוןינואר 2021הרצאה
Live imaging of chromatin distribution reveals novel principles of nuclear architecture and chromatin compartmentalization”.
More information שעה 11:00 - 12:00מרצה Prof. Talila Volk
Dept. Molecular Genetics, WISמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/91657907719?pwd=M2...» Zoom Link:
https://weizmann.zoom.us/j/91657907719?pwd=M2F2WlRKWGRuUHlxN0tNWFhZVUVzZz09
The genetic material of live organisms is packed and stored within the nucleus. It contains DNA wrapped around the nucleosomes, which then organized into chromatin fibers that partition into distinct compartments, which eventually fill the entire nucleus. Chromatin three dimensional topology is essential for proper accessibility of transcription factors, which control tissue-specific gene expression programs. Whereas chromatin partition into specific domains has been described in cells in culture conditions, information regarding chromatin 3 dimensional distribution in tissues within live organisms is still missing. We have imaged the chromatin in muscle fibers of live, intact Drosophila larvae, and revealed its 3 dimensional structure. Our results demonstrate novel 3 dimensional architecture of the chromatin which is evolutionary conserved, and has important implications on the regulation of gene expression. -
Date:31ראשוןינואר 2021הרצאה
Simulating Chemistry from Atoms to Devices: Next-Generation Reactive Molecular Dynamics
More information שעה 14:00 - 15:00מרצה Dr. David Furman
Dept. Chemistry, University of Cambridgeמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/97142508810?pwd=S2...» Zoom Link:
https://weizmann.zoom.us/j/97142508810?pwd=S2Voc3BMYnh6RmFTYUxLbUFjQXRGZz09
Until recently, computational studies of chemical reactivity were exclusively dealt with using quantum mechanical approaches, which severely limited the system's size and accessible time scales for simulation.
To bypass the need to solve Schrodinger's equation, and facilitate large-scale simulations for up to millions of atoms, both accurate and efficient models of the chemical bond have to be constructed.
I will present recent advances in the field of modeling chemical reactions in large-scale, complex systems (i.e. "dirty chemistry"), with a particular focus on ReaxFF reactive molecular dynamics.
Prominent applications from recent years will be highlighted, including: (a) discovery of the underlying operation principles of a novel laser-based mass-spectrometry technique,
and (b) prediction of the surprising chemistry that leads to the formation of several key precursors to biomolecules of life upon the collapse of a "primordial bubble".
Finally, I will present a new ReaxFF formulation that opens exciting new avenues for orders of magnitude more accurate simulations for long time scales.
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Date:02שלישיפברואר 2021הרצאה
Adventures in the Critical Zone: from carbon fluxes to wildfires
More information שעה 10:00 - 10:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Antonello Provenzale מארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:02שלישיפברואר 2021הרצאה
Dust as a nutrient source to the globally important cyanobacterium Trichodesmium
More information שעה 11:30 - 12:30כותרת Guest Seminar via zoomמיקום https://weizmann.zoom.us/j/95618583887?pwd=VDdCaWlLTkFjR1JYNmxmUVJoU0JtZz09 Password: 239905מרצה Prof. Yeala Shaked
Department of Earth Sciences, Hebrew University of Jerusalem & The Interuniversity Institute for Marine Sciences, Eilat.מארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:04חמישיפברואר 2021הרצאה
Multiome and More: Next Generation Genomic Technologies in Weizmann Core Facilities
More information שעה 09:00 - 10:00מיקום ZOOMמרצה Dr. Hadas Keren-Shaul
Genomics Unitמארגן המחלקה לתשתיות מחקר מדעי החייםדף בית צרו קשר -
Date:04חמישיפברואר 2021הרצאה
Targeted protein degradation for the treatment of cancer
More information שעה 14:00 - 15:00מרצה Benjamin Ebert, MD, PhD
Chair for the Department of Medical Oncology at Dana-Farber Cancer Institute, Boston.מארגן המכון לחקר הטיפול בסרטן עש דואקצרו קשר -
Date:07ראשוןפברואר 202111חמישיפברואר 2021כנסים
FRISNO 16
More information שעה 08:00 - 08:00מיקום Ein Gediיושב ראש Dan Oronדף בית -
Date:07ראשוןפברואר 2021הרצאה
Seminar for PhD thesis defense - Revital Ravid
More information שעה 10:00 - 10:00מיקום Zoom: https://weizmann.zoom.us/j/93902912475?pwd=dHdiallsOVlPaFRuSUgxWWZCSmZDUT09 Meeting ID: 939 0291 2475 Password: 443935מרצה Revital Ravid מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:08שניפברואר 2021סימפוזיונים
Crystallization Mechanisms: Classical, Nonclassical, and Beyond
More information שעה 11:00 - 12:00מיקום https://weizmann.zoom.us/j/98063488104?pwd=N3VqTC9sU1A4RHVDZ1dhOGVxbU1iUT09מרצה Prof. Boris Rybtchinski
Department of Molecular Chemistry & Materials Scienceמארגן הפקולטה לכימיהצרו קשר תקציר Show full text abstract about Understanding how order evolves during crystallization repre...» Understanding how order evolves during crystallization represents a long-standing challenge. We will describe our recent studies on crystallization of organic molecules and proteins by cryo-TEM imaging and cryo-STEM tomography. They reveal mechanisms, in which order evolution proceeds via diverse pathways, including various intermediate states. Based on these findings, we suggest a general outlook on molecular crystallization. -
Date:09שלישיפברואר 2021הרצאה
How autophagy comes to the rescue upon ribosome stalling
More information שעה 11:30 - 12:30כותרת Guest Seminar via Zoomמיקום https://weizmann.zoom.us/j/99370653950?pwd=N3FHcmNmR3diRjJUUWRwS0UvK1RXdz09 password: 849159מרצה Dr. Yasin Dagdas
Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Vienna, Austriaמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:09שלישיפברואר 2021הרצאה
On places and borders in the brain
More information שעה 12:00 - 13:00מרצה Prof. Dori Derdikman
Faculty of Medicine, Technion, Haifaמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about While various forms of cells have been found in relation to ...» While various forms of cells have been found in relation to the hippocampus cognitive map and navigation system, how these cells are formed and what is read from them is still a mystery. In the current lecture I will talk about several projects which tackle these issues. First, I will show how the formation of border cells in the cognitive map is related to a coordinate transformation, second I will discuss the interaction between the reward system (VTA) and the hippocampus. Finally, I will describe a project using place cells as a proxy for associative memory for assessing deficits in Alzheimer's disease.
Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
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Date:09שלישיפברואר 2021אירועים אקדמיים
ישיבת המועצה המדעית
More information שעה 14:00 - 16:30צרו קשר -
Date:11חמישיפברואר 2021הרצאה
MICRO-ECO Microbial Biology Student Club
More information שעה 14:00 - 15:00כותרת Talk and discussion via zoomמיקום https://weizmann .zoom.us/j/95982706813?pwd= dFdrSzdYZUp0NIQwSDVnVWNLWUV4UT09מרצה Dr. Andre Pellerin and Dr. Flora J. Vincent
BGU and WISצרו קשר -
Date:14ראשוןפברואר 2021הרצאה
“Transcription Factors Binding and the Regulation of Gene Expression: Lessons from Single-Molecule Experiments”
More information שעה 11:00 - 12:00מרצה Prof. Ariel Kaplan
Faculty of Biomedical Engineering, Technionמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/94661424796?pwd=U0Z1Yj...» Zoom Link: https://weizmann.zoom.us/j/94661424796?pwd=U0Z1YjdsbGUrV29STEZlMVhweUtXUT09
All our cells contain the same genetic information, encoded in the sequence of nucleotides that compose our DNA. The identity of different cells, and their response to different stimuli, is therefore controlled by processes regulating which subset of genes is “expressed” at a specific cell and a specific time. The first step in gene expression regulation is the binding of a special family of proteins, called transcription factors, to specific sequences in regulatory regions in the DNA. Packaging of the DNA into the dense structure of chromatin, and chemical modifications of the DNA, provide the cell with the possibility of dynamically modulating expression but add additional layers of complexity to the process in ways that are not fully understood. In my talk, I will report on our work using single-molecule optical tweezers assays to study how the thermodynamics and kinetics of transcription factor binding are modulated by these different layers of information.
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Date:14ראשוןפברואר 2021הרצאה
What’s beyond my water bill? The environmental impacts of the drinking water system in Israel - Implications for adopting life cycle thinking
More information שעה 13:00 - 14:00כותרת SAERI - Sustainability and Energy Research Initiative seminar seriesמיקום https://weizmann.zoom.us/j/95851113132?pwd=Ym1UZVJoQlVDdm1hWXNCdXY5M25qUT09מרצה Dr. Vered Blass
The Porter School of the Environment and Earth Sciences, Head of Innovations in Industrial Ecology Lab, Tel Aviv University, Israelמארגן בית הספר למחקר - מכון ויצמן למדעצרו קשר -
Date:14ראשוןפברואר 2021הרצאה
Molecular Genetics Departmental Seminar
More information שעה 13:00 - 13:00כותרת Finding new targets: the evolutionary fate of Transcription Factor paralogsמיקום https://weizmann.zoom.us/j/91052387562?pwd=b2FpVG9UQTdROUVVaXRIK0pKa2hZdz09מרצה Tamar Gera מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:15שניפברואר 2021הרצאה
Ph.D thesis defense: Tuning the shape memory effect in polyurethanes by amorphous and crystalline mechanisms"
More information שעה 14:30 - 15:30מרצה Asaf Nisenbaum מארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/92088510918?pwd=bW11Rk...» Zoom Link: https://weizmann.zoom.us/j/92088510918?pwd=bW11Rk1TKzEzeFdES3NJS1VCaTE4Zz09 -
Date:16שלישיפברואר 2021הרצאה
Styles and rates of landscape evolution away from tectonic-plate boundaries: examples from southern Africa
More information שעה 10:00 - 10:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Shlomy Vainer מארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:16שלישיפברואר 2021הרצאה
Avoiding H+ overload - the unusual mechanisms of pH homeostasis in calcifying coccolithophores
More information שעה 11:30 - 12:30כותרת Guest Seminar via Zoomמיקום https://weizmann.zoom.us/j/91429388335?pwd=QlY4cTUwWE9tNG8xbE5xdUdwb0xNQT09 Password: 109974מרצה Dr. Glen Wheeler
Marine Biological Association, Plymouth, UKמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:16שלישיפברואר 2021הרצאה
Sleep: sensory disconnection and memory consolidation
More information שעה 12:30 - 13:30מרצה Prof. Yuval Nir
Dept of Physiology and Pharmacology Sackler School of Medicine Tel Aviv Universityמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about A fundamental feature of sleep is that a sensory stimulu...»
A fundamental feature of sleep is that a sensory stimulus does not reliably affect behavior or subjective experience. What mediates such “sensory disconnection”? Do similar processes occur during anesthesia, cognitive lapses, and some neuropsychiatric disorders?
In a series of studies in humans and rodents, we compared neuronal responses to identical auditory stimuli across wakefulness and sleep. In A1, early single-neuron spiking responses are largely comparable across wakefulness, natural sleep, and light anesthesia. However, robust differences emerge in downstream high-level regions and late-responding neurons, and in top-down response signatures, suggesting that sleep impairs effective cortical connectivity. We reconcile the apparent discrepancy with the classic “thalamic gating” notion by showing that in contrast to natural sleep, deep anesthesia does lead to attenuation already in A1.
Next, we show that reduced locus coeruleus-noradrenaline (LC-NE) activity during sleep mediates sensory disconnection. We find that in freely behaving rats, LC-NE activity is a key mechanism that determines the likelihood of sensory-evoked awakenings (SEA): the level of ongoing tonic LC activity during sleep anticipates SEAs, while minimal optogenetic LC activation or silencing increases and decreases SEA, respectively. In humans, pharmacological manipulation of NE levels modulates sensory perception and late sensory responses, suggesting that NE links sensory awareness to external world events. We are exploring novel methods such as transcutaneous vagal nerve stimulation to modulate LC-NE non-invasively in humans.
In the last part of the talk I will present recent results on sleep and memory consolidation. Using unilateral olfactory stimulation during sleep we find that ‘local’ targeted memory reactivation (TMR) in human sleep selectively promotes specific memories associated with regional sleep oscillations. In epilepsy patients implanted with depth electrodes we investigate the effects of intracranial electrical closed loop stimulation during sleep on memory and hippocampal-neocortical dialogue at single-neuron resolution.
Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070