Crystallisation and Structure Determination
Publications
Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (2020).
A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis.Current Biology.2020 Jun 22
,
30
(12):2248-2259.
Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (2020).
Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.Molecular Biology and Evolution.2020 Apr
,
37
(4):1133-1147.
Novichkova D. A., Lushchekina S., Dym O., Masson P., Silman I. & Sussman J. L. (2019).
The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.Chemico-Biological Interactions.2019 Aug 25
,
309
.
Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019).
RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.Oncogene.2019 Mar 28
,
38
(13):2432-2434.
Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2019).
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.PLoS Computational Biology.2019 Aug 23
,
15
(8).
Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (2018).
Highly active enzymes by automated combinatorial backbone assembly and sequence design.Nature Communications.2018 Jul 17
,
9
.
Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (2018).
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.Molecular Cell.2018 Oct 4
,
72
(1):178-186.e5.
Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018).
Ultrahigh specificity in a network of computationally designed protein-interaction pairs.Nature Communications.2018 Dec 11
,
9
(1).
Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (2017).
Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.Analytical Chemistry.2017 Apr 18
,
89
(8):4708-4715.
Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (2016).
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Molecular Cell.2016 Jul 21
,
63
(2):337-346.
Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (2016).
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.Cell.2016 Jan 28
,
164
(3):476-486.
Dym O., Song W., Felder C., Roth E., Shnyrov V., Ashani Y., Xu Y., Joosten R. P., Weiner L., Sussman J. & Silman I. (2016).
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.Protein Science.2016 Jun 1
,
25
(6):1096-1114.
Zimhony O., Schwarz A., Raitses-Gurevich M., Peleg Y., Dym O., Albeck S., Burstein Y. & Shakked Z. (2015).
AcpM, the meromycolate extension Acyl carrier protein of mycobacterium tuberculosis, is activated by the 4′-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.Biochemistry.2015 Apr 14
,
54
(14):2360-2371.
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (2015).
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.Structure.2015 Jan 6
,
23
(1):104-115.