Crystallisation and Structure Determination Publications

  1. Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (2020). Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.  Molecular Biology and Evolution. 2020 Apr , 37 (4):1133-1147.
  2. Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (2020). A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis.  Current Biology. 2020 Jun 22 , 30 (12):2248-2259.
  3. Novichkova D. A., Lushchekina S., Dym O., Masson P., Silman I. & Sussman J. L. (2019). The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.  Chemico-Biological Interactions. 2019 Aug 25 , 309 .
  4. Karbat I., Altman-Gueta H., Fine S., Szanto T., Hamer-Rogotner S., Dym O., Frolow F., Gordon D., Panyi G., Gurevitz M. & Reuveny E. (2019). Pore-modulating toxins exploit inherent slow inactivation to block K+ channels.  Proceedings of the National Academy of Sciences of the United States of America. 2019 Sept 10 , 116 (37):18700-18709.
  5. Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2019). Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.  PLoS Computational Biology. 2019 Aug 23 , 15 (8).
  6. Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019). RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.  Oncogene. 2019 Mar 28 , 38 (13):2432-2434.
  7. Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (2018). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 2018 Oct 4 , 72 (1):178-186.e5.
  8. Karniel A., Mrusek D., Steinchen W., Dym O., Bange G. & Bibi E. (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.  Journal of Molecular Biology. 2018 May 25 , 430 (11):1607-1620.
  9. Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018). Ultrahigh specificity in a network of computationally designed protein-interaction pairs.  Nature Communications. 2018 Dec 11 , 9 (1).
  10. Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (2018). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 2018 Jul 17 , 9 .
  11. Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J. L., Tawfik D. S. & Fleishman S. J. (2018). Erratum: Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (Molecular Cell (2016) 63(2) (337–346)(S109727651630243X)(10.1016/j.molcel.2016.06.012)).  Molecular Cell. 2018 Apr 19 , 70 (2):380.
  12. Kantaev R., Riven I., Goldenzweig A., Barak Y., Dym O., Peleg Y., Albeck S., Fleishman S. J. & Haran G. (2018). Manipulating the Folding Landscape of a Multi-Domain Protein.  Journal of Physical Chemistry B. 2018 Dec 13 , 122 (49):11030-11038.
  13. Cohen-Khait R., Dym O., Hamer-Rogotner S. & Schreiber G. (2017). Promiscuous Protein Binding as a Function of Protein Stability.  Structure (London, England : 1993). 2017 Dec 5 , 25 (12):1867-1874.e3.
  14. Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (2017). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct 10 , 114 (41):10900-10905.
  15. Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (2017). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 2017 Apr 18 , 89 (8):4708-4715.
  16. Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (2016). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.  Cell. 2016 Jan 28 , 164 (3):476-486.
  17. Bednarczyk D., Dym O., Prabahar V., Peleg Y., Pike D. H. & Noy D. (2016). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016 Jun 6 , 55 (24):6901-6905.
  18. Dym O., Song W., Felder C., Roth E., Shnyrov V., Ashani Y., Xu Y., Joosten R. P., Weiner L., Sussman J. & Silman I. (2016). The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.  Protein Science. 2016 Jun , 25 (6):1096-1114.
  19. Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (2016). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 2016 Jul 21 , 63 (2):337-346.
  20. Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Garcia Arroyo A. A. & Sagi I. (2015). Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.  Structure. 2015 Jan , 23 (1):104-115.